2fro - Revision history

OCA at 14:36, 29 December 2021

2021-12-29T14:36:36Z

← Older revision		Revision as of 14:36, 29 December 2021
Line 4:		Line 4:
	<StructureSection load='2fro' size='340' side='right'caption='[[2fro]]' scene=''>		<StructureSection load='2fro' size='340' side='right'caption='[[2fro]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2FRO FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FRO FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca.weizmann.ac~~.~~il/oca-docs~~/fgij/fg.htm?mol=2fro FirstGlance], [~~http~~://www.ebi.ac.uk/pdbsum/2fro PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2fro ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fro FirstGlance], [https://www.ebi.ac.uk/pdbsum/2fro PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fro ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 11:04, 27 March 2020

2020-03-27T11:04:37Z

← Older revision		Revision as of 11:04, 27 March 2020
Line 2:		Line 2:

	==MODEL OF THE BETA-CARBON PROCESSING ENZYMES AND ACYL CARRIER PROTEIN OF MODULAR POLYKETIDE SYNTHASES==		==MODEL OF THE BETA-CARBON PROCESSING ENZYMES AND ACYL CARRIER PROTEIN OF MODULAR POLYKETIDE SYNTHASES==
	<StructureSection load='2fro' size='340' side='right' caption='[[2fro]]' scene=''>		<StructureSection load='2fro' size='340' side='right'caption='[[2fro]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FRO FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FRO FirstGlance]. <br>
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Theoretical Model]]		[[Category: Theoretical Model]]
			[[Category: Large Structures]]
	[[Category: Keatinge-Clay, A T]]		[[Category: Keatinge-Clay, A T]]
	[[Category: Stroud, R M]]		[[Category: Stroud, R M]]

OCA at 07:00, 20 June 2018

2018-06-20T07:00:46Z

← Older revision		Revision as of 07:00, 20 June 2018
Line 5:		Line 5:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FRO FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FRO FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fro FirstGlance], [http://www.ebi.ac.uk/pdbsum/2fro PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fro FirstGlance], [http://www.ebi.ac.uk/pdbsum/2fro PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2fro ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:36, 11 February 2016

2016-02-11T10:36:24Z

← Older revision		Revision as of 10:36, 11 February 2016
Line 1:		Line 1:
			{{Theoretical_model}}

	==MODEL OF THE BETA-CARBON PROCESSING ENZYMES AND ACYL CARRIER PROTEIN OF MODULAR POLYKETIDE SYNTHASES==		==MODEL OF THE BETA-CARBON PROCESSING ENZYMES AND ACYL CARRIER PROTEIN OF MODULAR POLYKETIDE SYNTHASES==
	<StructureSection load='2fro' size='340' side='right' caption='[[2fro]]' scene=''>		<StructureSection load='2fro' size='340' side='right' caption='[[2fro]]' scene=''>
Line 18:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Theoretical Model]]
	[[Category: Keatinge-Clay, A T]]		[[Category: Keatinge-Clay, A T]]
	[[Category: Stroud, R M]]		[[Category: Stroud, R M]]

OCA at 07:44, 11 September 2015

2015-09-11T07:44:12Z

← Older revision		Revision as of 07:44, 11 September 2015
Line 13:		Line 13:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2fro" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:40, 10 October 2014

2014-10-10T05:40:12Z

← Older revision		Revision as of 05:40, 10 October 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FRO FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FRO FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fro FirstGlance], [http://www.ebi.ac.uk/pdbsum/2fro PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fro FirstGlance], [http://www.ebi.ac.uk/pdbsum/2fro PDBsum]</span></td></tr>
	<table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 04:37, 29 September 2014

2014-09-29T04:37:10Z

← Older revision		Revision as of 04:37, 29 September 2014
Line 1:		Line 1:
	~~{{Theoretical_model}}~~		==MODEL OF THE BETA-CARBON PROCESSING ENZYMES AND ACYL CARRIER PROTEIN OF MODULAR POLYKETIDE SYNTHASES==
			<StructureSection load='2fro' size='340' side='right' caption='[[2fro]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FRO FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fro FirstGlance], [http://www.ebi.ac.uk/pdbsum/2fro PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The structure of the ketoreductase (KR) from the first module of the erythromycin synthase with NADPH bound was solved to 1.79 A resolution. The 51 kDa domain has two subdomains, each similar to a short-chain dehydrogenase/reductase (SDR) monomer. One subdomain has a truncated Rossmann fold and serves a purely structural role stabilizing the other subdomain, which catalyzes the reduction of the beta-carbonyl of a polyketide and possibly the epimerization of an alpha-substituent. The structure enabled us to define the domain boundaries of KR, the dehydratase (DH), and the enoylreductase (ER). It also constrains the three-dimensional organization of these domains within a module, revealing that KR does not make dimeric contacts across the 2-fold axis of the module. The quaternary structure elucidates how substrates are shuttled between the active sites of polyketide synthases (PKSs), as well as related fatty acid synthases (FASs), and suggests how domains can be swapped to make hybrid synthases that produce novel polyketides.

	~~[[Image~~:~~2fro~~.~~png\|left\|200px]]~~		The structure of a ketoreductase determines the organization of the beta-carbon processing enzymes of modular polyketide synthases.,Keatinge-Clay AT, Stroud RM Structure. 2006 Apr;14(4):737-48. Epub 2006 Mar 23. PMID:16564177<ref>PMID:16564177</ref>

	~~{{STRUCTURE_2fro\| PDB=2fro \| SCENE= }}~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~===MODEL OF THE BETA-CARBON PROCESSING ENZYMES AND ACYL CARRIER PROTEIN OF MODULAR POLYKETIDE SYNTHASES===~~		== References ==
			<references/>
	~~{{ABSTRACT_PUBMED_16564177}}~~		__TOC__
			</StructureSection>
	==~~Reference~~==
	<~~ref group="xtra">PMID:016564177<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Keatinge-Clay, A T]]		[[Category: Keatinge-Clay, A T]]
	[[Category: Stroud, R M]]		[[Category: Stroud, R M]]

OCA: Protected "2fro" [edit=sysop:move=sysop]

2012-10-21T08:59:11Z

Protected "2fro" [edit=sysop:move=sysop]

← Older revision	Revision as of 08:59, 21 October 2012
(No difference)

OCA at 08:59, 21 October 2012

2012-10-21T08:59:08Z

← Older revision		Revision as of 08:59, 21 October 2012
Line 1:		Line 1:
	{{Theoretical_model}}		{{Theoretical_model}}
	~~{{Seed}}~~
	[[Image:2fro.png\|left\|200px]]		[[Image:2fro.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2fro", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2fro\| PDB=2fro \| SCENE= }}		{{STRUCTURE_2fro\| PDB=2fro \| SCENE= }}

	===MODEL OF THE BETA-CARBON PROCESSING ENZYMES AND ACYL CARRIER PROTEIN OF MODULAR POLYKETIDE SYNTHASES===		===MODEL OF THE BETA-CARBON PROCESSING ENZYMES AND ACYL CARRIER PROTEIN OF MODULAR POLYKETIDE SYNTHASES===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16564177}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 16564177 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_16564177}}		{{ABSTRACT_PUBMED_16564177}}

	~~==About this Structure==~~
	~~Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FRO OCA].~~

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16564177~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016564177</ref><references group="xtra"/>
	[[Category: Keatinge-Clay, A T]]		[[Category: Keatinge-Clay, A T]]
	[[Category: Stroud, R M]]		[[Category: Stroud, R M]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 07:24:02 2010''~~

OCA at 04:24, 8 April 2010

2010-04-08T04:24:03Z

@@ Line 1: / Line 1: @@
-'''Theoretical Model'''
+{{Theoretical_model}}
-The entry 2FRO is a Theoretical Model titled 'Model of the Beta-Carbon Processing Enzymes and Acyl Carrier Protein of Modular Polyketide Synthases'.
+<!--
-[[Category:Theoretical Model]]
+===MODEL OF THE BETA-CARBON PROCESSING ENZYMES AND ACYL CARRIER PROTEIN OF MODULAR POLYKETIDE SYNTHASES===
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 30 09:56:37 2008''
+<!--