2ft0 - Revision history

OCA at 09:31, 30 August 2023

2023-08-30T09:31:44Z

← Older revision		Revision as of 09:31, 30 August 2023
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	<StructureSection load='2ft0' size='340' side='right'caption='[[2ft0]], [[Resolution\|resolution]] 1.66Å' scene=''>		<StructureSection load='2ft0' size='340' side='right'caption='[[2ft0]], [[Resolution\|resolution]] 1.66Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ft0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Ecol6 Ecol6~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FT0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FT0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ft0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_CFT073 Escherichia coli CFT073]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FT0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FT0 FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.66Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[2fs5\|2fs5]]~~<~~/div></td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene></td></tr>
	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">wecd ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=199310 ECOL6])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ft0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ft0 OCA], [https://pdbe.org/2ft0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ft0 RCSB], [https://www.ebi.ac.uk/pdbsum/2ft0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ft0 ProSAT], [https://www.topsan.org/Proteins/BSGI/2ft0 TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ft0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ft0 OCA], [https://pdbe.org/2ft0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ft0 RCSB], [https://www.ebi.ac.uk/pdbsum/2ft0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ft0 ProSAT], [https://www.topsan.org/Proteins/BSGI/2ft0 TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/WECD_ECOL6 WECD_ECOL6]] Catalyzes the acetylation of dTDP-fucosamine (dTDP-4-amino-4,6-dideoxy-D-galactose) to dTDP-Fuc4NAc, which is utilized in the biosynthesis of the enterobacterial common antigen (ECA).[HAMAP-Rule:MF_02027]<ref>PMID:16855251</ref>		[https://www.uniprot.org/uniprot/WECD_ECOL6 WECD_ECOL6] Catalyzes the acetylation of dTDP-fucosamine (dTDP-4-amino-4,6-dideoxy-D-galactose) to dTDP-Fuc4NAc, which is utilized in the biosynthesis of the enterobacterial common antigen (ECA).[HAMAP-Rule:MF_02027]<ref>PMID:16855251</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Ecol6~~]]		[[Category: Escherichia coli CFT073]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Structural genomic]]~~		[[Category: Hung MN]]
	[[Category: Hung~~, M N~~]]		[[Category: Matte A]]
	[[Category: Matte, A]]		[[Category: Munger C]]
	[[Category: Munger, C]]		[[Category: Nadeau G]]
	[[Category: Nadeau, G]]		[[Category: Rangarajan E]]
	[[Category: Rangarajan, E]]		[[Category: Sulea T]]
	[[Category: Sulea, T]]
	~~[[Category: Bsgi]]~~
	~~[[Category: Gnat fold acetyltransferase]]~~
	~~[[Category: Transferase~~]]

OCA at 15:33, 3 March 2021

2021-03-03T15:33:07Z

← Older revision		Revision as of 15:33, 3 March 2021
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	==Crystal structure of TDP-fucosamine acetyltransferase (WecD)- complex with acetyl-CoA==		==Crystal structure of TDP-fucosamine acetyltransferase (WecD)- complex with acetyl-CoA==
	<StructureSection load='2ft0' size='340' side='right' caption='[[2ft0]], [[Resolution\|resolution]] 1.66Å' scene=''>		<StructureSection load='2ft0' size='340' side='right'caption='[[2ft0]], [[Resolution\|resolution]] 1.66Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ft0]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Ecol6 Ecol6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FT0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2FT0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ft0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecol6 Ecol6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FT0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FT0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fs5\|2fs5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2fs5\|2fs5]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">wecd ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=199310 ECOL6])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">wecd ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=199310 ECOL6])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ft0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ft0 OCA], [~~http~~://pdbe.org/2ft0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ft0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ft0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ft0 ProSAT], [~~http~~://www.topsan.org/Proteins/BSGI/2ft0 TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ft0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ft0 OCA], [https://pdbe.org/2ft0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ft0 RCSB], [https://www.ebi.ac.uk/pdbsum/2ft0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ft0 ProSAT], [https://www.topsan.org/Proteins/BSGI/2ft0 TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/WECD_ECOL6 WECD_ECOL6]] Catalyzes the acetylation of dTDP-fucosamine (dTDP-4-amino-4,6-dideoxy-D-galactose) to dTDP-Fuc4NAc, which is utilized in the biosynthesis of the enterobacterial common antigen (ECA).[HAMAP-Rule:MF_02027]<ref>PMID:16855251</ref>		[[https://www.uniprot.org/uniprot/WECD_ECOL6 WECD_ECOL6]] Catalyzes the acetylation of dTDP-fucosamine (dTDP-4-amino-4,6-dideoxy-D-galactose) to dTDP-Fuc4NAc, which is utilized in the biosynthesis of the enterobacterial common antigen (ECA).[HAMAP-Rule:MF_02027]<ref>PMID:16855251</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Ecol6]]		[[Category: Ecol6]]
			[[Category: Large Structures]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Hung, M N]]		[[Category: Hung, M N]]

OCA at 06:56, 20 June 2018

2018-06-20T06:56:49Z

← Older revision		Revision as of 06:56, 20 June 2018
Line 1:		Line 1:

	==Crystal structure of TDP-fucosamine acetyltransferase (WecD)- complex with acetyl-CoA==		==Crystal structure of TDP-fucosamine acetyltransferase (WecD)- complex with acetyl-CoA==
	<StructureSection load='2ft0' size='340' side='right' caption='[[2ft0]], [[Resolution\|resolution]] 1.66Å' scene=''>		<StructureSection load='2ft0' size='340' side='right' caption='[[2ft0]], [[Resolution\|resolution]] 1.66Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fs5\|2fs5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fs5\|2fs5]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">wecd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=199310 ECOL6])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">wecd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=199310 ECOL6])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ft0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ft0 OCA], [http://pdbe.org/2ft0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ft0 RCSB], [http://www.ebi.ac.uk/pdbsum/2ft0 PDBsum], [http://www.topsan.org/Proteins/BSGI/2ft0 TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ft0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ft0 OCA], [http://pdbe.org/2ft0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ft0 RCSB], [http://www.ebi.ac.uk/pdbsum/2ft0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ft0 ProSAT], [http://www.topsan.org/Proteins/BSGI/2ft0 TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ft/2ft0_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ft/2ft0_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 04:32, 10 February 2016

2016-02-10T04:32:36Z

← Older revision		Revision as of 04:32, 10 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ft0 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:24, 11 September 2015

2015-09-11T05:24:58Z

← Older revision		Revision as of 05:24, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2ft0' size='340' side='right' caption='[[2ft0]], [[Resolution\|resolution]] 1.66Å' scene=''>		<StructureSection load='2ft0' size='340' side='right' caption='[[2ft0]], [[Resolution\|resolution]] 1.66Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ft0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli_cft073 Escherichia coli cft073~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FT0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FT0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ft0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecol6 Ecol6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FT0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FT0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fs5\|2fs5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fs5\|2fs5]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">wecd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=199310 ~~Escherichia coli CFT073~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">wecd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=199310 ECOL6])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ft0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ft0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ft0 RCSB], [http://www.ebi.ac.uk/pdbsum/2ft0 PDBsum], [http://www.topsan.org/Proteins/BSGI/2ft0 TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ft0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ft0 OCA], [http://pdbe.org/2ft0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ft0 RCSB], [http://www.ebi.ac.uk/pdbsum/2ft0 PDBsum], [http://www.topsan.org/Proteins/BSGI/2ft0 TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/~~Q8FBQ3_ECOL6 Q8FBQ3_ECOL6~~]] Catalyzes the acetylation of dTDP-fucosamine (dTDP-4-amino-4,6-dideoxy-D-galactose) to dTDP-Fuc4NAc, which is utilized in the biosynthesis of the enterobacterial common antigen (ECA).		[[http://www.uniprot.org/uniprot/WECD_ECOL6 WECD_ECOL6]] Catalyzes the acetylation of dTDP-fucosamine (dTDP-4-amino-4,6-dideoxy-D-galactose) to dTDP-Fuc4NAc, which is utilized in the biosynthesis of the enterobacterial common antigen (ECA).[HAMAP-Rule:MF_02027]<ref>PMID:16855251</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2ft0" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Escherichia coli cft073~~]]		[[Category: Ecol6]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Hung, M N]]		[[Category: Hung, M N]]

OCA at 11:49, 25 December 2014

2014-12-25T11:49:06Z

← Older revision		Revision as of 11:49, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ft0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_cft073 Escherichia coli cft073]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FT0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FT0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ft0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_cft073 Escherichia coli cft073]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FT0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FT0 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fs5\|2fs5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fs5\|2fs5]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">wecd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=199310 Escherichia coli CFT073])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">wecd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=199310 Escherichia coli CFT073])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ft0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ft0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ft0 RCSB], [http://www.ebi.ac.uk/pdbsum/2ft0 PDBsum], [http://www.topsan.org/Proteins/BSGI/2ft0 TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ft0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ft0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ft0 RCSB], [http://www.ebi.ac.uk/pdbsum/2ft0 PDBsum], [http://www.topsan.org/Proteins/BSGI/2ft0 TOPSAN]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/Q8FBQ3_ECOL6 Q8FBQ3_ECOL6]] Catalyzes the acetylation of dTDP-fucosamine (dTDP-4-amino-4,6-dideoxy-D-galactose) to dTDP-Fuc4NAc, which is utilized in the biosynthesis of the enterobacterial common antigen (ECA).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli cft073]]		[[Category: Escherichia coli cft073]]
	[[Category: ~~BSGI, Montreal-Kingston Bacterial~~ Structural ~~Genomics Initiative.~~]]		[[Category: Structural genomic]]
	[[Category: Hung, M N.]]		[[Category: Hung, M N]]
	[[Category: Matte, A.]]		[[Category: Matte, A]]
	[[Category: Munger, C.]]		[[Category: Munger, C]]
	[[Category: Nadeau, G.]]		[[Category: Nadeau, G]]
	[[Category: Rangarajan, E.]]		[[Category: Rangarajan, E]]
	[[Category: Sulea, T.]]		[[Category: Sulea, T]]
	[[Category: Bsgi]]		[[Category: Bsgi]]
	[[Category: Gnat fold acetyltransferase]]		[[Category: Gnat fold acetyltransferase]]
	~~[[Category: Montreal-kingston bacterial structural genomics initiative]]~~
	~~[[Category: Structural genomic]]~~
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 08:38, 30 September 2014

2014-09-30T08:38:42Z

← Older revision		Revision as of 08:38, 30 September 2014
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	[[Image:~~2ft0~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of TDP-fucosamine acetyltransferase (WecD)- complex with acetyl-CoA==
			<StructureSection load='2ft0' size='340' side='right' caption='[[2ft0]], [[Resolution\|resolution]] 1.66Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2ft0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_cft073 Escherichia coli cft073]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FT0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FT0 FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fs5\|2fs5]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">wecd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=199310 Escherichia coli CFT073])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ft0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ft0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ft0 RCSB], [http://www.ebi.ac.uk/pdbsum/2ft0 PDBsum], [http://www.topsan.org/Proteins/BSGI/2ft0 TOPSAN]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ft/2ft0_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Enterobacterial common antigen (ECA) is a polysaccharide found on the outer membrane of virtually all gram-negative enteric bacteria and consists of three sugars, N-acetyl-d-glucosamine, N-acetyl-d-mannosaminuronic acid, and 4-acetamido-4,6-dideoxy-d-galactose, organized into trisaccharide repeating units having the sequence -->3)-alpha-d-Fuc4NAc-(1-->4)-beta-d-ManNAcA-(1-->4)-alpha-d-GlcNAc-(1-->. While the precise function of ECA is unknown, it has been linked to the resistance of Shiga-toxin-producing Escherichia coli (STEC) O157:H7 to organic acids and the resistance of Salmonella enterica to bile salts. The final step in the synthesis of 4-acetamido-4,6-dideoxy-d-galactose, the acetyl-coenzyme A (CoA)-dependent acetylation of the 4-amino group, is carried out by TDP-fucosamine acetyltransferase (WecD). We have determined the crystal structure of WecD in apo form at a 1.95-Angstrom resolution and bound to acetyl-CoA at a 1.66-Angstrom resolution. WecD is a dimeric enzyme, with each monomer adopting the GNAT N-acetyltransferase fold, common to a number of enzymes involved in acetylation of histones, aminoglycoside antibiotics, serotonin, and sugars. The crystal structure of WecD, however, represents the first structure of a GNAT family member that acts on nucleotide sugars. Based on this cocrystal structure, we have used flexible docking to generate a WecD-bound model of the acetyl-CoA-TDP-fucosamine tetrahedral intermediate, representing the structure during acetyl transfer. Our structural data show that WecD does not possess a residue that directly functions as a catalytic base, although Tyr208 is well positioned to function as a general acid by protonating the thiolate anion of coenzyme A.

	~~{{STRUCTURE_2ft0\| PDB=2ft0 \| SCENE= }}~~		Crystal structure of TDP-fucosamine acetyltransferase (WecD) from Escherichia coli, an enzyme required for enterobacterial common antigen synthesis.,Hung MN, Rangarajan E, Munger C, Nadeau G, Sulea T, Matte A J Bacteriol. 2006 Aug;188(15):5606-17. PMID:16855251<ref>PMID:16855251</ref>

	~~===Crystal structure~~ of ~~TDP-fucosamine acetyltransferase (WecD)- complex with acetyl-CoA===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16855251}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2ft0]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli_cft073 Escherichia coli cft073]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2FT0 OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:016855251<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Escherichia coli cft073]]		[[Category: Escherichia coli cft073]]
	[[Category: BSGI, Montreal-Kingston Bacterial Structural Genomics Initiative.]]		[[Category: BSGI, Montreal-Kingston Bacterial Structural Genomics Initiative.]]

OCA: Protected "2ft0" [edit=sysop:move=sysop]

2013-01-07T11:01:32Z

Protected "2ft0" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:01, 7 January 2013
(No difference)

OCA at 11:01, 7 January 2013

2013-01-07T11:01:30Z

← Older revision		Revision as of 11:01, 7 January 2013
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	~~{{Seed}}~~
	[[Image:2ft0.png\|left\|200px]]		[[Image:2ft0.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2ft0", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2ft0\| PDB=2ft0 \| SCENE= }}		{{STRUCTURE_2ft0\| PDB=2ft0 \| SCENE= }}

	===Crystal structure of TDP-fucosamine acetyltransferase (WecD)- complex with acetyl-CoA===		===Crystal structure of TDP-fucosamine acetyltransferase (WecD)- complex with acetyl-CoA===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16855251}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 16855251 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_16855251}}		{{ABSTRACT_PUBMED_16855251}}

	==About this Structure==		==About this Structure==
	~~2FT0~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/~~Escherichia_coli~~ Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FT0 OCA].		[[2ft0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_cft073 Escherichia coli cft073]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FT0 OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16855251~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016855251</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli cft073]]
	[[Category: BSGI, Montreal-Kingston Bacterial Structural Genomics Initiative.]]		[[Category: BSGI, Montreal-Kingston Bacterial Structural Genomics Initiative.]]
	[[Category: Hung, M N.]]		[[Category: Hung, M N.]]
Line 36:		Line 24:
	[[Category: Montreal-kingston bacterial structural genomics initiative]]		[[Category: Montreal-kingston bacterial structural genomics initiative]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
			[[Category: Transferase]]
	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 15:27:39 2009''~~

OCA at 13:27, 17 February 2009

2009-02-17T13:27:40Z

← Older revision		Revision as of 13:27, 17 February 2009
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	==Reference==		==Reference==
	Crystal structure of TDP-fucosamine acetyltransferase (WecD) from Escherichia coli, an enzyme required for enterobacterial common antigen synthesis., Hung MN, Rangarajan E, Munger C, Nadeau G, Sulea T, Matte A, J Bacteriol. 2006 Aug;188(15):5606-17. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16855251 16855251]~~		<ref group="xtra">PMID:16855251</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: BSGI, Montreal-Kingston Bacterial Structural Genomics Initiative.]]		[[Category: BSGI, Montreal-Kingston Bacterial Structural Genomics Initiative.]]
Line 37:		Line 37:
	[[Category: Structural genomic]]		[[Category: Structural genomic]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Nov 16 11~~:00:~~16 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 15:27:39 2009''