2ft3 - Revision history

OCA at 09:45, 25 December 2024

2024-12-25T09:45:06Z

← Older revision		Revision as of 09:45, 25 December 2024
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ft/2ft3_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ft/2ft3_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 09:31, 30 August 2023

2023-08-30T09:31:46Z

← Older revision		Revision as of 09:31, 30 August 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ft3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FT3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FT3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ft3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FT3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FT3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.4Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ft3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ft3 OCA], [https://pdbe.org/2ft3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ft3 RCSB], [https://www.ebi.ac.uk/pdbsum/2ft3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ft3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ft3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ft3 OCA], [https://pdbe.org/2ft3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ft3 RCSB], [https://www.ebi.ac.uk/pdbsum/2ft3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ft3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/PGS1_BOVIN PGS1_BOVIN]] May be involved in collagen fiber assembly.		[https://www.uniprot.org/uniprot/PGS1_BOVIN PGS1_BOVIN] May be involved in collagen fiber assembly.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Bergmann~~, E M~~]]		[[Category: Bergmann EM]]
	[[Category: Dodd~~, C M~~]]		[[Category: Dodd CM]]
	[[Category: Scott~~, P G]]~~		[[Category: Scott PG]]
	~~[[Category: Dimer interface]]~~
	~~[[Category: Proteoglycan]]~~
	~~[[Category: Signaling protein]]~~
	~~[[Category: Structural protein~~]]

OCA at 14:36, 29 December 2021

2021-12-29T14:36:59Z

← Older revision		Revision as of 14:36, 29 December 2021
Line 3:		Line 3:
	<StructureSection load='2ft3' size='340' side='right'caption='[[2ft3]], [[Resolution\|resolution]] 3.40Å' scene=''>		<StructureSection load='2ft3' size='340' side='right'caption='[[2ft3]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ft3]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FT3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2FT3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ft3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FT3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FT3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ft3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ft3 OCA], [~~http~~://pdbe.org/2ft3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ft3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ft3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ft3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ft3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ft3 OCA], [https://pdbe.org/2ft3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ft3 RCSB], [https://www.ebi.ac.uk/pdbsum/2ft3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ft3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/PGS1_BOVIN PGS1_BOVIN]] May be involved in collagen fiber assembly.		[[https://www.uniprot.org/uniprot/PGS1_BOVIN PGS1_BOVIN]] May be involved in collagen fiber assembly.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 11:05, 27 March 2020

2020-03-27T11:05:09Z

← Older revision		Revision as of 11:05, 27 March 2020
Line 1:		Line 1:

	==Crystal structure of the biglycan dimer core protein==		==Crystal structure of the biglycan dimer core protein==
	<StructureSection load='2ft3' size='340' side='right' caption='[[2ft3]], [[Resolution\|resolution]] 3.40Å' scene=''>		<StructureSection load='2ft3' size='340' side='right'caption='[[2ft3]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ft3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FT3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FT3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ft3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FT3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FT3 FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
			[[Category: Large Structures]]
	[[Category: Bergmann, E M]]		[[Category: Bergmann, E M]]
	[[Category: Dodd, C M]]		[[Category: Dodd, C M]]

OCA at 06:44, 20 June 2018

2018-06-20T06:44:57Z

← Older revision		Revision as of 06:44, 20 June 2018
Line 1:		Line 1:

	==Crystal structure of the biglycan dimer core protein==		==Crystal structure of the biglycan dimer core protein==
	<StructureSection load='2ft3' size='340' side='right' caption='[[2ft3]], [[Resolution\|resolution]] 3.40Å' scene=''>		<StructureSection load='2ft3' size='340' side='right' caption='[[2ft3]], [[Resolution\|resolution]] 3.40Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2ft3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FT3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FT3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ft3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FT3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FT3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ft3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ft3 OCA], [http://pdbe.org/2ft3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ft3 RCSB], [http://www.ebi.ac.uk/pdbsum/2ft3 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ft3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ft3 OCA], [http://pdbe.org/2ft3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ft3 RCSB], [http://www.ebi.ac.uk/pdbsum/2ft3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ft3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ft/2ft3_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ft/2ft3_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 04:06, 7 February 2016

2016-02-07T04:06:04Z

← Older revision		Revision as of 04:06, 7 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ft3 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 21:37, 9 September 2015

2015-09-09T21:37:49Z

← Older revision		Revision as of 21:37, 9 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2ft3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FT3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FT3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ft3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FT3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FT3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ft3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ft3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ft3 RCSB], [http://www.ebi.ac.uk/pdbsum/2ft3 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ft3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ft3 OCA], [http://pdbe.org/2ft3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ft3 RCSB], [http://www.ebi.ac.uk/pdbsum/2ft3 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2ft3" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:43, 24 December 2014

2014-12-24T07:43:01Z

← Older revision		Revision as of 07:43, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ft3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FT3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FT3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ft3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FT3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FT3 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ft3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ft3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ft3 RCSB], [http://www.ebi.ac.uk/pdbsum/2ft3 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ft3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ft3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ft3 RCSB], [http://www.ebi.ac.uk/pdbsum/2ft3 PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/PGS1_BOVIN PGS1_BOVIN]] May be involved in collagen fiber assembly.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Bergmann, E M.]]		[[Category: Bergmann, E M]]
	[[Category: Dodd, C M.]]		[[Category: Dodd, C M]]
	[[Category: Scott, P G.]]		[[Category: Scott, P G]]
	[[Category: Dimer interface]]		[[Category: Dimer interface]]
	[[Category: Proteoglycan]]		[[Category: Proteoglycan]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
	[[Category: Structural protein]]		[[Category: Structural protein]]

OCA at 08:27, 30 September 2014

2014-09-30T08:27:23Z

← Older revision		Revision as of 08:27, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2ft3~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of the biglycan dimer core protein==
			<StructureSection load='2ft3' size='340' side='right' caption='[[2ft3]], [[Resolution\|resolution]] 3.40Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2ft3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FT3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FT3 FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ft3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ft3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ft3 RCSB], [http://www.ebi.ac.uk/pdbsum/2ft3 PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ft/2ft3_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Biglycan and decorin are two closely related proteoglycans whose protein cores contain leucine-rich repeats flanked by disulfides. We have previously shown that decorin is dimeric both in solution and in crystal structures. In this study we determined whether biglycan dimerizes and investigated the role of dimerization in the folding and stability of these proteoglycans. We used light scattering to show that biglycan is dimeric in solution and solved the crystal structure of the glycoprotein core of biglycan at 3.40-angstroms resolution. This structure reveals that biglycan dimerizes in the same way as decorin, i.e. by apposition of the concave inner surfaces of the leucine-rich repeat domains. We demonstrate that low concentrations of guanidinium chloride denature biglycan and decorin but that the denaturation is completely reversible following removal of the guanidinium chloride, as assessed by circular dichroism spectroscopy. Furthermore, the rate of refolding is dependent on protein concentration, demonstrating that it is not a unimolecular process. Upon heating, decorin shows a single structural transition at a T(m) of 45-46 degrees C but refolds completely upon cooling to 25 degrees C. This property of decorin enabled us to show both by calorimetry and light scattering that dimer to monomer transition coincided with unfolding and monomer to dimer transition coincided with refolding; thus these processes are inextricably linked. We further conclude that folded monomeric biglycan or decorin cannot exist in solution. This implies novel interrelated functions for the parallel beta sheet faces of these leucine-rich repeat proteoglycans, including dimerization and stabilization of protein folding.

	~~{{STRUCTURE_2ft3\| PDB=2ft3 \| SCENE= }}~~		Crystal structure of the biglycan dimer and evidence that dimerization is essential for folding and stability of class I small leucine-rich repeat proteoglycans.,Scott PG, Dodd CM, Bergmann EM, Sheehan JK, Bishop PN J Biol Chem. 2006 May 12;281(19):13324-32. Epub 2006 Mar 17. PMID:16547006<ref>PMID:16547006</ref>

	~~===Crystal structure~~ of the ~~biglycan dimer core protein===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16547006}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2ft3]] is a 6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bos_taurus Bos taurus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2FT3 OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:016547006<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Bergmann, E M.]]		[[Category: Bergmann, E M.]]

OCA: Protected "2ft3" [edit=sysop:move=sysop]

2013-01-07T10:51:50Z

Protected "2ft3" [edit=sysop:move=sysop]

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