2fva - Revision history

OCA at 14:37, 29 December 2021

2021-12-29T14:37:38Z

← Older revision		Revision as of 14:37, 29 December 2021
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	<StructureSection load='2fva' size='340' side='right'caption='[[2fva]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2fva' size='340' side='right'caption='[[2fva]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fva]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Spiol Spiol]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2FVA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fva]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Spiol Spiol]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FVA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PNS:4-PHOSPHOPANTETHEINE'>PNS</scene>, <scene name='pdbligand=STE:STEARIC+ACID'>STE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PNS:4-PHOSPHOPANTETHEINE'>PNS</scene>, <scene name='pdbligand=STE:STEARIC+ACID'>STE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ava\|2ava]], [[2fve\|2fve]], [[2fvf\|2fvf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ava\|2ava]], [[2fve\|2fve]], [[2fvf\|2fvf]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2fva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fva OCA], [~~http~~://pdbe.org/2fva PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2fva RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2fva PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2fva ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fva OCA], [https://pdbe.org/2fva PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fva RCSB], [https://www.ebi.ac.uk/pdbsum/2fva PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fva ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/ACP1_SPIOL ACP1_SPIOL]] Carrier of the growing fatty acid chain in fatty acid biosynthesis.[HAMAP-Rule:MF_01217]		[[https://www.uniprot.org/uniprot/ACP1_SPIOL ACP1_SPIOL]] Carrier of the growing fatty acid chain in fatty acid biosynthesis.[HAMAP-Rule:MF_01217]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 11:06, 27 March 2020

2020-03-27T11:06:02Z

← Older revision		Revision as of 11:06, 27 March 2020
Line 1:		Line 1:

	==Structure of 18:0-ACP with docked fatty acid==		==Structure of 18:0-ACP with docked fatty acid==
	<StructureSection load='2fva' size='340' side='right' caption='[[2fva]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2fva' size='340' side='right'caption='[[2fva]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fva]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Spiol Spiol]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FVA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fva]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Spiol Spiol]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FVA FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Spiol]]		[[Category: Spiol]]
	[[Category: Fox, B G]]		[[Category: Fox, B G]]

OCA at 07:28, 20 June 2018

2018-06-20T07:28:41Z

← Older revision		Revision as of 07:28, 20 June 2018
Line 1:		Line 1:

	==Structure of 18:0-ACP with docked fatty acid==		==Structure of 18:0-ACP with docked fatty acid==
	<StructureSection load='2fva' size='340' side='right' caption='[[2fva]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2fva' size='340' side='right' caption='[[2fva]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PNS:4-PHOSPHOPANTETHEINE'>PNS</scene>, <scene name='pdbligand=STE:STEARIC+ACID'>STE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PNS:4-PHOSPHOPANTETHEINE'>PNS</scene>, <scene name='pdbligand=STE:STEARIC+ACID'>STE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ava\|2ava]], [[2fve\|2fve]], [[2fvf\|2fvf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ava\|2ava]], [[2fve\|2fve]], [[2fvf\|2fvf]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fva OCA], [http://pdbe.org/2fva PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fva RCSB], [http://www.ebi.ac.uk/pdbsum/2fva PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fva OCA], [http://pdbe.org/2fva PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fva RCSB], [http://www.ebi.ac.uk/pdbsum/2fva PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2fva ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fv/2fva_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fv/2fva_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fva ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 01:08, 12 September 2015

2015-09-12T01:08:52Z

← Older revision		Revision as of 01:08, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='2fva' size='340' side='right' caption='[[2fva]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2fva' size='340' side='right' caption='[[2fva]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fva]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Spinacia_oleracea Spinacia oleracea~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FVA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fva]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Spiol Spiol]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FVA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PNS:4-PHOSPHOPANTETHEINE'>PNS</scene>, <scene name='pdbligand=STE:STEARIC+ACID'>STE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PNS:4-PHOSPHOPANTETHEINE'>PNS</scene>, <scene name='pdbligand=STE:STEARIC+ACID'>STE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ava\|2ava]], [[2fve\|2fve]], [[2fvf\|2fvf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ava\|2ava]], [[2fve\|2fve]], [[2fvf\|2fvf]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fva OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fva RCSB], [http://www.ebi.ac.uk/pdbsum/2fva PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fva OCA], [http://pdbe.org/2fva PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fva RCSB], [http://www.ebi.ac.uk/pdbsum/2fva PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2fva" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Spinacia oleracea~~]]		[[Category: Spiol]]
	[[Category: Fox, B G]]		[[Category: Fox, B G]]
	[[Category: Markley, J L]]		[[Category: Markley, J L]]

OCA at 21:49, 25 December 2014

2014-12-25T21:49:31Z

← Older revision		Revision as of 21:49, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fva]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Spinacia_oleracea Spinacia oleracea]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FVA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fva]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Spinacia_oleracea Spinacia oleracea]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FVA FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PNS:4-PHOSPHOPANTETHEINE'>PNS</scene>, <scene name='pdbligand=STE:STEARIC+ACID'>STE</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PNS:4-PHOSPHOPANTETHEINE'>PNS</scene>, <scene name='pdbligand=STE:STEARIC+ACID'>STE</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ava\|2ava]], [[2fve\|2fve]], [[2fvf\|2fvf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ava\|2ava]], [[2fve\|2fve]], [[2fvf\|2fvf]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fva OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fva RCSB], [http://www.ebi.ac.uk/pdbsum/2fva PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fva OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fva RCSB], [http://www.ebi.ac.uk/pdbsum/2fva PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/ACP1_SPIOL ACP1_SPIOL]] Carrier of the growing fatty acid chain in fatty acid biosynthesis.[HAMAP-Rule:MF_01217]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Spinacia oleracea]]		[[Category: Spinacia oleracea]]
	[[Category: Fox, B G.]]		[[Category: Fox, B G]]
	[[Category: Markley, J L.]]		[[Category: Markley, J L]]
	[[Category: Zornetzer, G A.]]		[[Category: Zornetzer, G A]]
	[[Category: 4-helix bundle]]		[[Category: 4-helix bundle]]
	[[Category: Biosynthetic protein]]		[[Category: Biosynthetic protein]]

OCA at 09:07, 30 September 2014

2014-09-30T09:07:10Z

← Older revision		Revision as of 09:07, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2fva~~.~~png~~\|~~left~~\|~~200px~~]]		==Structure of 18:0-ACP with docked fatty acid==
			<StructureSection load='2fva' size='340' side='right' caption='[[2fva]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2fva]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Spinacia_oleracea Spinacia oleracea]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FVA FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PNS:4-PHOSPHOPANTETHEINE'>PNS</scene>, <scene name='pdbligand=STE:STEARIC+ACID'>STE</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ava\|2ava]], [[2fve\|2fve]], [[2fvf\|2fvf]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fva OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fva RCSB], [http://www.ebi.ac.uk/pdbsum/2fva PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fv/2fva_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Acyl carrier protein (ACP) is a cofactor in a variety of biosynthetic pathways, including fatty acid metabolism. Thus, it is of interest to determine structures of physiologically relevant ACP-fatty acid complexes. We report here the NMR solution structures of spinach ACP with decanoate (10:0-ACP) and stearate (18:0-ACP) attached to the 4'-phosphopantetheine prosthetic group. The protein in the fatty acid complexes adopts a single conformer, unlike apo- and holo-ACP, which interconvert in solution between two major conformers. The protein component of both 10:0- and 18:0-ACP adopts the four-helix bundle topology characteristic of ACP, and a fatty acid binding cavity was identified in both structures. Portions of the protein close in space to the fatty acid and the 4'-phosphopantetheine were identified using filtered/edited NOESY experiments. A docking protocol was used to generate protein structures containing bound fatty acid for 10:0- and 18:0-ACP. In both cases, the predominant structure contained fatty acid bound down the center of the helical bundle, in agreement with the location of the fatty acid binding pockets. These structures demonstrate the conformational flexibility of spinach ACP and suggest how the protein changes to accommodate its myriad binding partners.

	~~{{STRUCTURE_2fva\| PDB=2fva \| SCENE= }}~~		Solution structures of spinach acyl carrier protein with decanoate and stearate.,Zornetzer GA, Fox BG, Markley JL Biochemistry. 2006 Apr 25;45(16):5217-27. PMID:16618110<ref>PMID:16618110</ref>

	~~===Structure~~ of ~~18:0-ACP with docked fatty acid===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16618110}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2fva]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Spinacia_oleracea Spinacia oleracea]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2FVA OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:016618110<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Spinacia oleracea]]		[[Category: Spinacia oleracea]]
	[[Category: Fox, B G.]]		[[Category: Fox, B G.]]

OCA: Protected "2fva" [edit=sysop:move=sysop]

2013-01-07T14:02:48Z

Protected "2fva" [edit=sysop:move=sysop]

← Older revision	Revision as of 14:02, 7 January 2013
(No difference)

OCA at 14:02, 7 January 2013

2013-01-07T14:02:45Z

← Older revision		Revision as of 14:02, 7 January 2013
Line 1:		Line 1:
	~~{{Seed}}~~
	[[Image:2fva.png\|left\|200px]]		[[Image:2fva.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2fva", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2fva\| PDB=2fva \| SCENE= }}		{{STRUCTURE_2fva\| PDB=2fva \| SCENE= }}

	===Structure of 18:0-ACP with docked fatty acid===		===Structure of 18:0-ACP with docked fatty acid===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16618110}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 16618110 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_16618110}}		{{ABSTRACT_PUBMED_16618110}}

	==About this Structure==		==About this Structure==
	~~2FVA~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Spinacia_oleracea Spinacia oleracea]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVA OCA].		[[2fva]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Spinacia_oleracea Spinacia oleracea]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVA OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16618110~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016618110</ref><references group="xtra"/>
	[[Category: Spinacia oleracea]]		[[Category: Spinacia oleracea]]
	[[Category: Fox, B G.]]		[[Category: Fox, B G.]]
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	[[Category: Zornetzer, G A.]]		[[Category: Zornetzer, G A.]]
	[[Category: 4-helix bundle]]		[[Category: 4-helix bundle]]
			[[Category: Biosynthetic protein]]
	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Wed Feb 18 08:55:08 2009''~~

OCA at 06:55, 18 February 2009

2009-02-18T06:55:09Z

← Older revision		Revision as of 06:55, 18 February 2009
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	==About this Structure==		==About this Structure==
	2FVA is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Spinacia_oleracea Spinacia oleracea]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVA OCA].		2FVA is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Spinacia_oleracea Spinacia oleracea]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVA OCA].

	==Reference==		==Reference==
	~~Solution structures of spinach acyl carrier protein with decanoate and stearate., Zornetzer GA, Fox BG, Markley JL, Biochemistry. 2006 Apr 25;45(16):5217-27.~~ PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~16618110 16618110]~~		<ref group="xtra">PMID:16618110</ref><references group="xtra"/>
	~~[[Category: Single protein]]~~
	[[Category: Spinacia oleracea]]		[[Category: Spinacia oleracea]]
	[[Category: Fox, B G.]]		[[Category: Fox, B G.]]
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	[[Category: 4-helix bundle]]		[[Category: 4-helix bundle]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 15~~:07:~~29 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 08:55:08 2009''

OCA at 12:07, 29 July 2008

2008-07-29T12:07:33Z

← Older revision		Revision as of 12:07, 29 July 2008
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	[[Image:2fva.~~gif~~\|left\|200px]]		{{Seed}}
			[[Image:2fva.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_2fva\| PDB=2fva \| SCENE= }}		{{STRUCTURE_2fva\| PDB=2fva \| SCENE= }}

	~~'''~~Structure of 18:0-ACP with docked fatty acid~~'''~~		===Structure of 18:0-ACP with docked fatty acid===


	~~==Overview==~~		<!--
	~~Acyl carrier protein (ACP) is a cofactor in a variety of biosynthetic pathways~~, ~~including fatty acid metabolism. Thus~~, ~~it is of interest~~ to ~~determine structures of physiologically relevant ACP-fatty acid complexes. We report here~~ the ~~NMR solution structures of spinach ACP with decanoate~~ (10:~~0-ACP) and stearate (18:0-ACP) attached to the 4'-phosphopantetheine prosthetic group~~. ~~The protein in the fatty acid complexes adopts a single conformer, unlike apo- and holo-ACP, which interconvert in solution between two major conformers~~. ~~The protein component of both 10:0- and 18:0-ACP adopts the four-helix bundle topology characteristic of ACP~~, ~~and a fatty acid binding cavity was identified in both structures. Portions of the protein close in space to the fatty acid and~~ the ~~4'-phosphopantetheine were identified using filtered/edited NOESY experiments~~. ~~A docking protocol was used to generate protein structures containing bound fatty acid for 10:0~~- ~~and 18:0~~-ACP. In both cases, the predominant structure contained fatty acid bound down the center of the helical bundle, in agreement with the location of the fatty acid binding pockets. These structures demonstrate the conformational flexibility of spinach ACP and suggest how the protein changes to accommodate its myriad binding partners.		The line below this paragraph, {{ABSTRACT_PUBMED_16618110}}, adds the Publication Abstract to the page
			(as it appears on PubMed at http://www.pubmed.gov), where 16618110 is the PubMed ID number.
			-->
			{{ABSTRACT_PUBMED_16618110}}

	==About this Structure==		==About this Structure==
	2FVA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Spinacia_oleracea Spinacia oleracea]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVA OCA].		2FVA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Spinacia_oleracea Spinacia oleracea]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVA OCA].

	==Reference==		==Reference==
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	[[Category: Zornetzer, G A.]]		[[Category: Zornetzer, G A.]]
	[[Category: 4-helix bundle]]		[[Category: 4-helix bundle]]
	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 04~~:20:45 2008''
			''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:07:29 2008''