2fvu - Revision history

OCA at 09:25, 14 February 2024

2024-02-14T09:25:33Z

← Older revision		Revision as of 09:25, 14 February 2024
Line 3:		Line 3:
	<StructureSection load='2fvu' size='340' side='right'caption='[[2fvu]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2fvu' size='340' side='right'caption='[[2fvu]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fvu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FVU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fvu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FVU FirstGlance]. <br>
	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~SIR3 (~~[~~https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5~~&~~id=4932 ATCC 18824])~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fvu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fvu OCA], [https://pdbe.org/2fvu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fvu RCSB], [https://www.ebi.ac.uk/pdbsum/2fvu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fvu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fvu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fvu OCA], [https://pdbe.org/2fvu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fvu RCSB], [https://www.ebi.ac.uk/pdbsum/2fvu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fvu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/SIR3_YEAST SIR3_YEAST]] The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form.		[https://www.uniprot.org/uniprot/SIR3_YEAST SIR3_YEAST] The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fvu ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fvu ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Previous work has shown that the N terminus of the Saccharomyces cerevisiae Sir3 protein is crucial for the function of Sir3 in transcriptional silencing. Here, we show that overexpression of N-terminal fragments of Sir3 in strains lacking the full-length protein can lead to some silencing of HML and HMR. Sir3 contains a BAH (bromo-adjacent homology) domain at its N terminus. Overexpression of this domain alone can lead to silencing as long as Sir1 is overexpressed and Sir2 and Sir4 are present. Overexpression of the closely related Orc1 BAH domain can also silence in the absence of any Sir3 protein. A previously characterized hypermorphic sir3 mutation, D205N, greatly improves silencing by the Sir3 BAH domain and allows it to bind to DNA and oligonucleosomes in vitro. A previously uncharacterized region in the Sir1 N terminus is required for silencing by both the Sir3 and Orc1 BAH domains. The structure of the Sir3 BAH domain has been determined. In the crystal, the molecule multimerizes in the form of a left-handed superhelix. This superhelix may be relevant to the function of the BAH domain of Sir3 in silencing.

	Structure and function of the Saccharomyces cerevisiae Sir3 BAH domain.,Connelly JJ, Yuan P, Hsu HC, Li Z, Xu RM, Sternglanz R Mol Cell Biol. 2006 Apr;26(8):3256-65. PMID:16581798<ref>PMID:16581798</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 2fvu" style="background-color:#fffaf0;"></div>~~
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Atcc 18824]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Xu, R M~~]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: ~~Mainly beta]]~~		[[Category: Xu RM]]
	~~[[Category: Transcription~~]]

OCA at 15:34, 3 March 2021

2021-03-03T15:34:25Z

← Older revision		Revision as of 15:34, 3 March 2021
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	==Structure of the yeast Sir3 BAH domain==		==Structure of the yeast Sir3 BAH domain==
	<StructureSection load='2fvu' size='340' side='right' caption='[[2fvu]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2fvu' size='340' side='right'caption='[[2fvu]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fvu]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2FVU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fvu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FVU FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SIR3 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SIR3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2fvu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fvu OCA], [~~http~~://pdbe.org/2fvu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2fvu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2fvu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2fvu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fvu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fvu OCA], [https://pdbe.org/2fvu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fvu RCSB], [https://www.ebi.ac.uk/pdbsum/2fvu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fvu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/SIR3_YEAST SIR3_YEAST]] The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form.		[[https://www.uniprot.org/uniprot/SIR3_YEAST SIR3_YEAST]] The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
			[[Category: Large Structures]]
	[[Category: Xu, R M]]		[[Category: Xu, R M]]
	[[Category: Mainly beta]]		[[Category: Mainly beta]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 06:58, 20 June 2018

2018-06-20T06:58:15Z

← Older revision		Revision as of 06:58, 20 June 2018
Line 1:		Line 1:

	==Structure of the yeast Sir3 BAH domain==		==Structure of the yeast Sir3 BAH domain==
	<StructureSection load='2fvu' size='340' side='right' caption='[[2fvu]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2fvu' size='340' side='right' caption='[[2fvu]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2fvu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FVU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fvu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FVU FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SIR3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SIR3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fvu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fvu OCA], [http://pdbe.org/2fvu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fvu RCSB], [http://www.ebi.ac.uk/pdbsum/2fvu PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fvu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fvu OCA], [http://pdbe.org/2fvu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fvu RCSB], [http://www.ebi.ac.uk/pdbsum/2fvu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2fvu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fv/2fvu_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fv/2fvu_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 09:20, 8 February 2016

2016-02-08T09:20:46Z

← Older revision		Revision as of 09:20, 8 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fvu ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:08, 10 September 2015

2015-09-10T10:08:34Z

← Older revision		Revision as of 10:08, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2fvu' size='340' side='right' caption='[[2fvu]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2fvu' size='340' side='right' caption='[[2fvu]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fvu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FVU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fvu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FVU FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SIR3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ~~Saccharomyces cerevisiae~~])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SIR3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fvu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fvu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fvu RCSB], [http://www.ebi.ac.uk/pdbsum/2fvu PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fvu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fvu OCA], [http://pdbe.org/2fvu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fvu RCSB], [http://www.ebi.ac.uk/pdbsum/2fvu PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2fvu" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Saccharomyces cerevisiae~~]]		[[Category: Atcc 18824]]
	[[Category: Xu, R M]]		[[Category: Xu, R M]]
	[[Category: Mainly beta]]		[[Category: Mainly beta]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 22:16, 24 December 2014

2014-12-24T22:16:40Z

← Older revision		Revision as of 22:16, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fvu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FVU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fvu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FVU FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SIR3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SIR3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fvu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fvu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fvu RCSB], [http://www.ebi.ac.uk/pdbsum/2fvu PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fvu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fvu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fvu RCSB], [http://www.ebi.ac.uk/pdbsum/2fvu PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/SIR3_YEAST SIR3_YEAST]] The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Xu, R M.]]		[[Category: Xu, R M]]
	[[Category: Mainly beta]]		[[Category: Mainly beta]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 07:54, 30 September 2014

2014-09-30T07:54:28Z

← Older revision		Revision as of 07:54, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2fvu~~.~~png~~\|~~left~~\|~~200px~~]]		==Structure of the yeast Sir3 BAH domain==
			<StructureSection load='2fvu' size='340' side='right' caption='[[2fvu]], [[Resolution\|resolution]] 2.00Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2fvu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FVU FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SIR3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fvu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fvu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fvu RCSB], [http://www.ebi.ac.uk/pdbsum/2fvu PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fv/2fvu_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Previous work has shown that the N terminus of the Saccharomyces cerevisiae Sir3 protein is crucial for the function of Sir3 in transcriptional silencing. Here, we show that overexpression of N-terminal fragments of Sir3 in strains lacking the full-length protein can lead to some silencing of HML and HMR. Sir3 contains a BAH (bromo-adjacent homology) domain at its N terminus. Overexpression of this domain alone can lead to silencing as long as Sir1 is overexpressed and Sir2 and Sir4 are present. Overexpression of the closely related Orc1 BAH domain can also silence in the absence of any Sir3 protein. A previously characterized hypermorphic sir3 mutation, D205N, greatly improves silencing by the Sir3 BAH domain and allows it to bind to DNA and oligonucleosomes in vitro. A previously uncharacterized region in the Sir1 N terminus is required for silencing by both the Sir3 and Orc1 BAH domains. The structure of the Sir3 BAH domain has been determined. In the crystal, the molecule multimerizes in the form of a left-handed superhelix. This superhelix may be relevant to the function of the BAH domain of Sir3 in silencing.

	~~{{STRUCTURE_2fvu\| PDB=2fvu \| SCENE= }}~~		Structure and function of the Saccharomyces cerevisiae Sir3 BAH domain.,Connelly JJ, Yuan P, Hsu HC, Li Z, Xu RM, Sternglanz R Mol Cell Biol. 2006 Apr;26(8):3256-65. PMID:16581798<ref>PMID:16581798</ref>

	~~===Structure~~ of the ~~yeast Sir3 BAH domain===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16581798}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2fvu]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2FVU OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:016581798<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Xu, R M.]]		[[Category: Xu, R M.]]
	[[Category: Mainly beta]]		[[Category: Mainly beta]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA: Protected "2fvu" [edit=sysop:move=sysop]

2013-01-07T10:26:44Z

Protected "2fvu" [edit=sysop:move=sysop]

← Older revision	Revision as of 10:26, 7 January 2013
(No difference)

OCA at 10:26, 7 January 2013

2013-01-07T10:26:39Z

← Older revision		Revision as of 10:26, 7 January 2013
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	~~{{Seed}}~~
	[[Image:2fvu.png\|left\|200px]]		[[Image:2fvu.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2fvu", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
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	{{STRUCTURE_2fvu\| PDB=2fvu \| SCENE= }}		{{STRUCTURE_2fvu\| PDB=2fvu \| SCENE= }}

	===Structure of the yeast Sir3 BAH domain===		===Structure of the yeast Sir3 BAH domain===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16581798}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 16581798 is the PubMed ID number.~~
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	{{ABSTRACT_PUBMED_16581798}}		{{ABSTRACT_PUBMED_16581798}}

	==About this Structure==		==About this Structure==
	~~2FVU~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVU OCA].		[[2fvu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVU OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16581798~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016581798</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Xu, R M.]]		[[Category: Xu, R M.]]
	[[Category: Mainly beta]]		[[Category: Mainly beta]]
			[[Category: Transcription]]
	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Mon Feb 16 20:55:48 2009''~~

OCA at 18:55, 16 February 2009

2009-02-16T18:55:49Z

← Older revision		Revision as of 18:55, 16 February 2009
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	==About this Structure==		==About this Structure==
	2FVU is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVU OCA].		2FVU is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVU OCA].

	==Reference==		==Reference==
	~~Structure and function of the Saccharomyces cerevisiae Sir3 BAH domain., Connelly JJ, Yuan P, Hsu HC, Li Z, Xu RM, Sternglanz R, Mol Cell Biol. 2006 Apr;26(8):3256-65.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16581798 16581798]~~		<ref group="xtra">PMID:16581798</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	~~[[Category: Single protein]]~~
	[[Category: Xu, R M.]]		[[Category: Xu, R M.]]
	[[Category: Mainly beta]]		[[Category: Mainly beta]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon ~~Jul 28 01~~:21:~~32 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 20:55:48 2009''