2fws - Revision history

OCA at 18:57, 29 May 2024

2024-05-29T18:57:33Z

← Older revision		Revision as of 18:57, 29 May 2024
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	==First Ca2+ binding domain of the Na,Ca-exchanger (NCX1)==		==First Ca2+ binding domain of the Na,Ca-exchanger (NCX1)==
	<StructureSection load='2fws' size='340' side='right'caption='[[2fws~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='2fws' size='340' side='right'caption='[[2fws]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fws]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Canlf Canlf~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FWS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FWS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fws]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FWS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FWS FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[2fwu\|2fwu]]~~<~~/div></td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></~~td><td class="sblockDat"~~>~~NCX1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9615 CANLF])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fws OCA], [https://pdbe.org/2fws PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fws RCSB], [https://www.ebi.ac.uk/pdbsum/2fws PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fws ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fws OCA], [https://pdbe.org/2fws PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fws RCSB], [https://www.ebi.ac.uk/pdbsum/2fws PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fws ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/~~NAC1_CANFA NAC1_CANFA~~]~~] Rapidly transports~~ Ca(2+) during excitation-contraction coupling. Ca(2+) ~~is extruded~~ from the cell during ~~relaxation~~ so as to ~~prevent overloading~~ of ~~intracellular stores~~.		[https://www.uniprot.org/uniprot/NAC1_CANLF NAC1_CANLF] Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:1700476, PubMed:1785844, PubMed:9486131, PubMed:17962412). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions (By similarity).[UniProtKB:P70414]<ref>PMID:1700476</ref> <ref>PMID:1785844</ref> <ref>PMID:17962412</ref> <ref>PMID:19332552</ref> <ref>PMID:9486131</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Canlf~~]]		[[Category: Canis lupus familiaris]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Aelen, J]]		[[Category: Aelen J]]
	[[Category: Hilge, M]]		[[Category: Hilge M]]
	[[Category: Vuister~~, G W]]~~		[[Category: Vuister GW]]
	~~[[Category: Beta-bulge]]~~
	~~[[Category: Beta-sandwich]]~~
	~~[[Category: Ca2+ binding]]~~
	~~[[Category: Cis-proline]]~~
	~~[[Category: Greek key]]~~
	~~[[Category: Metal transport regulator~~]]

OCA at 15:35, 3 March 2021

2021-03-03T15:35:04Z

← Older revision		Revision as of 15:35, 3 March 2021
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	==First Ca2+ binding domain of the Na,Ca-exchanger (NCX1)==		==First Ca2+ binding domain of the Na,Ca-exchanger (NCX1)==
	<StructureSection load='2fws' size='340' side='right' caption='[[2fws]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2fws' size='340' side='right'caption='[[2fws]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fws]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Canlf Canlf]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FWS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2FWS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fws]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Canlf Canlf]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FWS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FWS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fwu\|2fwu]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2fwu\|2fwu]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NCX1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9615 CANLF])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NCX1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9615 CANLF])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2fws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fws OCA], [~~http~~://pdbe.org/2fws PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2fws RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2fws PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2fws ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fws OCA], [https://pdbe.org/2fws PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fws RCSB], [https://www.ebi.ac.uk/pdbsum/2fws PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fws ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/NAC1_CANFA NAC1_CANFA]] Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores.		[[https://www.uniprot.org/uniprot/NAC1_CANFA NAC1_CANFA]] Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Canlf]]		[[Category: Canlf]]
			[[Category: Large Structures]]
	[[Category: Aelen, J]]		[[Category: Aelen, J]]
	[[Category: Hilge, M]]		[[Category: Hilge, M]]

OCA at 06:48, 20 June 2018

2018-06-20T06:48:23Z

← Older revision		Revision as of 06:48, 20 June 2018
Line 1:		Line 1:

	==First Ca2+ binding domain of the Na,Ca-exchanger (NCX1)==		==First Ca2+ binding domain of the Na,Ca-exchanger (NCX1)==
	<StructureSection load='2fws' size='340' side='right' caption='[[2fws]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2fws' size='340' side='right' caption='[[2fws]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fws]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Canfa Canfa~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FWS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FWS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fws]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canlf Canlf]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FWS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FWS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fwu\|2fwu]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fwu\|2fwu]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NCX1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9615 ~~CANFA~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NCX1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9615 CANLF])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fws OCA], [http://pdbe.org/2fws PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fws RCSB], [http://www.ebi.ac.uk/pdbsum/2fws PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fws OCA], [http://pdbe.org/2fws PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fws RCSB], [http://www.ebi.ac.uk/pdbsum/2fws PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2fws ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fw/2fws_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fw/2fws_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Canfa~~]]		[[Category: Canlf]]
	[[Category: Aelen, J]]		[[Category: Aelen, J]]
	[[Category: Hilge, M]]		[[Category: Hilge, M]]

OCA at 23:23, 9 February 2016

2016-02-09T23:23:13Z

← Older revision		Revision as of 23:23, 9 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fws ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 03:04, 11 September 2015

2015-09-11T03:04:11Z

← Older revision		Revision as of 03:04, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2fws' size='340' side='right' caption='[[2fws]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2fws' size='340' side='right' caption='[[2fws]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fws]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Canis_lupus_familiaris Canis lupus familiaris~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FWS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FWS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fws]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canfa Canfa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FWS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FWS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fwu\|2fwu]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fwu\|2fwu]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NCX1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9615 ~~Canis lupus familiaris~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NCX1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9615 CANFA])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fws OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fws RCSB], [http://www.ebi.ac.uk/pdbsum/2fws PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fws OCA], [http://pdbe.org/2fws PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fws RCSB], [http://www.ebi.ac.uk/pdbsum/2fws PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2fws" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Canis lupus familiaris~~]]		[[Category: Canfa]]
	[[Category: Aelen, J]]		[[Category: Aelen, J]]
	[[Category: Hilge, M]]		[[Category: Hilge, M]]

OCA at 10:12, 25 December 2014

2014-12-25T10:12:54Z

← Older revision		Revision as of 10:12, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fws]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FWS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FWS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fws]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FWS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FWS FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fwu\|2fwu]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fwu\|2fwu]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NCX1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9615 Canis lupus familiaris])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NCX1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9615 Canis lupus familiaris])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fws OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fws RCSB], [http://www.ebi.ac.uk/pdbsum/2fws PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fws OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fws RCSB], [http://www.ebi.ac.uk/pdbsum/2fws PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/NAC1_CANFA NAC1_CANFA]] Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Canis lupus familiaris]]		[[Category: Canis lupus familiaris]]
	[[Category: Aelen, J.]]		[[Category: Aelen, J]]
	[[Category: Hilge, M.]]		[[Category: Hilge, M]]
	[[Category: Vuister, G W.]]		[[Category: Vuister, G W]]
	[[Category: Beta-bulge]]		[[Category: Beta-bulge]]
	[[Category: Beta-sandwich]]		[[Category: Beta-sandwich]]

OCA at 09:17, 30 September 2014

2014-09-30T09:17:27Z

← Older revision		Revision as of 09:17, 30 September 2014
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	[[Image:~~2fws~~.~~png~~\|~~left~~\|~~200px~~]]		==First Ca2+ binding domain of the Na,Ca-exchanger (NCX1)==
			<StructureSection load='2fws' size='340' side='right' caption='[[2fws]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2fws]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FWS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FWS FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fwu\|2fwu]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NCX1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9615 Canis lupus familiaris])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fws OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fws RCSB], [http://www.ebi.ac.uk/pdbsum/2fws PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fw/2fws_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The plasma membrane Na+/Ca2+ exchanger (NCX) is almost certainly the major Ca2+ extrusion mechanism in cardiac myocytes. Binding of Na+ and Ca2+ ions to its large cytosolic loop regulates ion transport of the exchanger. We determined the solution structures of two Ca2+ binding domains (CBD1 and CBD2) that, together with an alpha-catenin-like domain (CLD), form the regulatory exchanger loop. CBD1 and CBD2 are very similar in the Ca2+ bound state and describe the Calx-beta motif. Strikingly, in the absence of Ca2+, the upper half of CBD1 unfolds while CBD2 maintains its structural integrity. Together with a 7-fold higher affinity for Ca2+, this suggests that CBD1 is the primary Ca2+ sensor. Specific point mutations in either domain largely allow the interchange of their functionality and uncover the mechanism underlying Ca2+ sensing in NCX.

	~~{{STRUCTURE_2fws\| PDB=2fws \| SCENE= }}~~		Ca2+ regulation in the Na+/Ca2+ exchanger involves two markedly different Ca2+ sensors.,Hilge M, Aelen J, Vuister GW Mol Cell. 2006 Apr 7;22(1):15-25. PMID:16600866<ref>PMID:16600866</ref>

	~~===First Ca2+ binding domain~~ of the ~~Na,Ca-exchanger (NCX1)===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16600866}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2fws]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Canis_lupus_familiaris Canis lupus familiaris]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2FWS OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:016600866<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Canis lupus familiaris]]		[[Category: Canis lupus familiaris]]
	[[Category: Aelen, J.]]		[[Category: Aelen, J.]]

OCA: Protected "2fws" [edit=sysop:move=sysop]

2013-01-07T14:11:55Z

Protected "2fws" [edit=sysop:move=sysop]

← Older revision	Revision as of 14:11, 7 January 2013
(No difference)

OCA at 14:11, 7 January 2013

2013-01-07T14:11:50Z

← Older revision		Revision as of 14:11, 7 January 2013
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	~~{{Seed}}~~
	[[Image:2fws.png\|left\|200px]]		[[Image:2fws.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2fws", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2fws\| PDB=2fws \| SCENE= }}		{{STRUCTURE_2fws\| PDB=2fws \| SCENE= }}

	===First Ca2+ binding domain of the Na,Ca-exchanger (NCX1)===		===First Ca2+ binding domain of the Na,Ca-exchanger (NCX1)===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16600866}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 16600866 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_16600866}}		{{ABSTRACT_PUBMED_16600866}}

	==About this Structure==		==About this Structure==
	~~2FWS~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FWS OCA].		[[2fws]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FWS OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16600866~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016600866</ref><references group="xtra"/>
	[[Category: Canis lupus familiaris]]		[[Category: Canis lupus familiaris]]
	[[Category: Aelen, J.]]		[[Category: Aelen, J.]]
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	[[Category: Cis-proline]]		[[Category: Cis-proline]]
	[[Category: Greek key]]		[[Category: Greek key]]
			[[Category: Metal transport regulator]]
	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 13:34:01 2009''~~

OCA at 11:34, 17 February 2009

2009-02-17T11:34:02Z

← Older revision		Revision as of 11:34, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
	2FWS is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FWS OCA].		2FWS is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FWS OCA].

	==Reference==		==Reference==
	~~Ca2+ regulation in the Na+/Ca2+ exchanger involves two markedly different Ca2+ sensors., Hilge M, Aelen J, Vuister GW, Mol Cell. 2006 Apr 7;22(1):15-25.~~ PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~16600866 16600866]~~		<ref group="xtra">PMID:16600866</ref><references group="xtra"/>
	[[Category: Canis lupus familiaris]]		[[Category: Canis lupus familiaris]]
	~~[[Category: Single protein]]~~
	[[Category: Aelen, J.]]		[[Category: Aelen, J.]]
	[[Category: Hilge, M.]]		[[Category: Hilge, M.]]
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	[[Category: Greek key]]		[[Category: Greek key]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 18~~:45:~~48 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 13:34:01 2009''