2fxt - Revision history

OCA at 09:25, 14 February 2024

2024-02-14T09:25:42Z

← Older revision		Revision as of 09:25, 14 February 2024
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	<StructureSection load='2fxt' size='340' side='right'caption='[[2fxt]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='2fxt' size='340' side='right'caption='[[2fxt]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fxt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FXT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FXT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fxt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FXT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FXT FirstGlance]. <br>
	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~TIM44 (~~[~~https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5~~&~~id=4932 ATCC 18824])~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.2Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fxt OCA], [https://pdbe.org/2fxt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fxt RCSB], [https://www.ebi.ac.uk/pdbsum/2fxt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fxt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fxt OCA], [https://pdbe.org/2fxt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fxt RCSB], [https://www.ebi.ac.uk/pdbsum/2fxt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fxt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/TIM44_YEAST TIM44_YEAST]] Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 and its co-chaperone (MGE1) to drive protein translocation into the matrix using ATP as an energy source.		[https://www.uniprot.org/uniprot/TIM44_YEAST TIM44_YEAST] Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 and its co-chaperone (MGE1) to drive protein translocation into the matrix using ATP as an energy source.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fxt ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fxt ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	The protein transports from the cell cytosol to the mitochondria matrix are carried out by the translocase of the outer membrane (TOM) complex and the translocase of the inner membrane (TIM) complexes. Tim44p is an essential mitochondrial peripheral membrane protein and a major component of TIM23 translocon. Tim44p can tightly associate with the inner mitochondrial membrane. To investigate the mechanism by which Tim44p functions in the TIM23 translocon to deliver the mitochondrial protein precursors, we have determined the crystal structure of the yeast Tim44p C-terminal domain to 3.2A resolution using the MAD method. The Tim44p C-terminal domain forms a monomer in the crystal structure and contains six alpha-helices and four antiparallel beta-strands. A large hydrophobic pocket was identified on the Tim44p structure surface. The N-terminal helix A1 is positively charged and the helix A1 protrudes out from the Tim44p main body.

	Crystal structure of yeast mitochondrial peripheral membrane protein Tim44p C-terminal domain.,Josyula R, Jin Z, Fu Z, Sha B J Mol Biol. 2006 Jun 9;359(3):798-804. Epub 2006 Apr 27. PMID:16647716<ref>PMID:16647716</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 2fxt" style="background-color:#fffaf0;"></div>~~
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Atcc 18824]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Josyula, R~~]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: ~~Sha, B~~]]		[[Category: Josyula R]]
	[[Category: ~~Mitochondrial translocase]]~~		[[Category: Sha B]]
	~~[[Category: Protein transport~~]]

OCA at 15:35, 3 March 2021

2021-03-03T15:35:32Z

← Older revision		Revision as of 15:35, 3 March 2021
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	==Crystal Structure of Yeast Tim44==		==Crystal Structure of Yeast Tim44==
	<StructureSection load='2fxt' size='340' side='right' caption='[[2fxt]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='2fxt' size='340' side='right'caption='[[2fxt]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fxt]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FXT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2FXT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fxt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FXT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FXT FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TIM44 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TIM44 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2fxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fxt OCA], [~~http~~://pdbe.org/2fxt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2fxt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2fxt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2fxt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fxt OCA], [https://pdbe.org/2fxt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fxt RCSB], [https://www.ebi.ac.uk/pdbsum/2fxt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fxt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/TIM44_YEAST TIM44_YEAST]] Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 and its co-chaperone (MGE1) to drive protein translocation into the matrix using ATP as an energy source.		[[https://www.uniprot.org/uniprot/TIM44_YEAST TIM44_YEAST]] Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 and its co-chaperone (MGE1) to drive protein translocation into the matrix using ATP as an energy source.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fx/2fxt_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fx/2fxt_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
			[[Category: Large Structures]]
	[[Category: Josyula, R]]		[[Category: Josyula, R]]
	[[Category: Sha, B]]		[[Category: Sha, B]]
	[[Category: Mitochondrial translocase]]		[[Category: Mitochondrial translocase]]
	[[Category: Protein transport]]		[[Category: Protein transport]]

OCA at 07:45, 18 October 2017

2017-10-18T07:45:37Z

← Older revision		Revision as of 07:45, 18 October 2017
Line 1:		Line 1:

	==Crystal Structure of Yeast Tim44==		==Crystal Structure of Yeast Tim44==
	<StructureSection load='2fxt' size='340' side='right' caption='[[2fxt]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='2fxt' size='340' side='right' caption='[[2fxt]], [[Resolution\|resolution]] 3.20Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2fxt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FXT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FXT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fxt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FXT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FXT FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TIM44 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TIM44 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fxt OCA], [http://pdbe.org/2fxt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fxt RCSB], [http://www.ebi.ac.uk/pdbsum/2fxt PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fxt OCA], [http://pdbe.org/2fxt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fxt RCSB], [http://www.ebi.ac.uk/pdbsum/2fxt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2fxt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fxt ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:39, 11 September 2015

2015-09-11T10:39:39Z

← Older revision		Revision as of 10:39, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2fxt' size='340' side='right' caption='[[2fxt]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='2fxt' size='340' side='right' caption='[[2fxt]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fxt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FXT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FXT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fxt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FXT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FXT FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TIM44 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ~~Saccharomyces cerevisiae~~])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TIM44 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fxt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fxt RCSB], [http://www.ebi.ac.uk/pdbsum/2fxt PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fxt OCA], [http://pdbe.org/2fxt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fxt RCSB], [http://www.ebi.ac.uk/pdbsum/2fxt PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2fxt" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Saccharomyces cerevisiae~~]]		[[Category: Atcc 18824]]
	[[Category: Josyula, R]]		[[Category: Josyula, R]]
	[[Category: Sha, B]]		[[Category: Sha, B]]
	[[Category: Mitochondrial translocase]]		[[Category: Mitochondrial translocase]]
	[[Category: Protein transport]]		[[Category: Protein transport]]

OCA at 15:20, 25 December 2014

2014-12-25T15:20:52Z

← Older revision		Revision as of 15:20, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fxt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FXT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FXT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fxt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FXT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FXT FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TIM44 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TIM44 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fxt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fxt RCSB], [http://www.ebi.ac.uk/pdbsum/2fxt PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fxt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fxt RCSB], [http://www.ebi.ac.uk/pdbsum/2fxt PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/TIM44_YEAST TIM44_YEAST]] Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 and its co-chaperone (MGE1) to drive protein translocation into the matrix using ATP as an energy source.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Josyula, R.]]		[[Category: Josyula, R]]
	[[Category: Sha, B.]]		[[Category: Sha, B]]
	[[Category: Mitochondrial translocase]]		[[Category: Mitochondrial translocase]]
	[[Category: Protein transport]]		[[Category: Protein transport]]

OCA at 07:56, 30 September 2014

2014-09-30T07:56:31Z

← Older revision		Revision as of 07:56, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2fxt~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal Structure of Yeast Tim44==
			<StructureSection load='2fxt' size='340' side='right' caption='[[2fxt]], [[Resolution\|resolution]] 3.20Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2fxt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FXT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FXT FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TIM44 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fxt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fxt RCSB], [http://www.ebi.ac.uk/pdbsum/2fxt PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fx/2fxt_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The protein transports from the cell cytosol to the mitochondria matrix are carried out by the translocase of the outer membrane (TOM) complex and the translocase of the inner membrane (TIM) complexes. Tim44p is an essential mitochondrial peripheral membrane protein and a major component of TIM23 translocon. Tim44p can tightly associate with the inner mitochondrial membrane. To investigate the mechanism by which Tim44p functions in the TIM23 translocon to deliver the mitochondrial protein precursors, we have determined the crystal structure of the yeast Tim44p C-terminal domain to 3.2A resolution using the MAD method. The Tim44p C-terminal domain forms a monomer in the crystal structure and contains six alpha-helices and four antiparallel beta-strands. A large hydrophobic pocket was identified on the Tim44p structure surface. The N-terminal helix A1 is positively charged and the helix A1 protrudes out from the Tim44p main body.

	~~{{STRUCTURE_2fxt\| PDB=2fxt \| SCENE= }}~~		Crystal structure of yeast mitochondrial peripheral membrane protein Tim44p C-terminal domain.,Josyula R, Jin Z, Fu Z, Sha B J Mol Biol. 2006 Jun 9;359(3):798-804. Epub 2006 Apr 27. PMID:16647716<ref>PMID:16647716</ref>

	~~===Crystal Structure~~ of ~~Yeast Tim44===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16647716}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2fxt]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2FXT OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:016647716<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Josyula, R.]]		[[Category: Josyula, R.]]

OCA: Protected "2fxt" [edit=sysop:move=sysop]

2013-01-07T10:29:02Z

Protected "2fxt" [edit=sysop:move=sysop]

← Older revision	Revision as of 10:29, 7 January 2013
(No difference)

OCA at 10:28, 7 January 2013

2013-01-07T10:28:58Z

← Older revision		Revision as of 10:28, 7 January 2013
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	~~{{Seed}}~~
	[[Image:2fxt.png\|left\|200px]]		[[Image:2fxt.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2fxt", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2fxt\| PDB=2fxt \| SCENE= }}		{{STRUCTURE_2fxt\| PDB=2fxt \| SCENE= }}

	===Crystal Structure of Yeast Tim44===		===Crystal Structure of Yeast Tim44===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16647716}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 16647716 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_16647716}}		{{ABSTRACT_PUBMED_16647716}}

	==About this Structure==		==About this Structure==
	~~2FXT~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FXT OCA].		[[2fxt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FXT OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16647716~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016647716</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Josyula, R.]]		[[Category: Josyula, R.]]
	[[Category: Sha, B.]]		[[Category: Sha, B.]]
	[[Category: Mitochondrial translocase]]		[[Category: Mitochondrial translocase]]
			[[Category: Protein transport]]
	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 20:08:49 2009''~~

OCA at 18:08, 17 February 2009

2009-02-17T18:08:50Z

← Older revision		Revision as of 18:08, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
	2FXT is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FXT OCA].		2FXT is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FXT OCA].

	==Reference==		==Reference==
	~~Crystal structure of yeast mitochondrial peripheral membrane protein Tim44p C-terminal domain., Josyula R, Jin Z, Fu Z, Sha B, J Mol Biol. 2006 Jun 9;359(3):798-804. Epub 2006 Apr 27.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16647716 16647716]~~		<ref group="xtra">PMID:16647716</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	~~[[Category: Single protein]]~~
	[[Category: Josyula, R.]]		[[Category: Josyula, R.]]
	[[Category: Sha, B.]]		[[Category: Sha, B.]]
	[[Category: Mitochondrial translocase]]		[[Category: Mitochondrial translocase]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 03~~:59:~~50 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 20:08:49 2009''

OCA at 00:59, 29 July 2008

2008-07-29T00:59:58Z

← Older revision		Revision as of 00:59, 29 July 2008
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	[[Image:2fxt.~~jpg~~\|left\|200px]]		{{Seed}}
			[[Image:2fxt.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_2fxt\| PDB=2fxt \| SCENE= }}		{{STRUCTURE_2fxt\| PDB=2fxt \| SCENE= }}

	~~'''~~Crystal Structure of Yeast Tim44~~'''~~		===Crystal Structure of Yeast Tim44===


	~~==Overview==~~		<!--
	The ~~protein transports from~~ the ~~cell cytosol~~ to the ~~mitochondria matrix are carried out by the translocase of the outer membrane~~ (~~TOM) complex and the translocase of the inner membrane (TIM) complexes~~. ~~Tim44p is an essential mitochondrial peripheral membrane protein and a major component of TIM23 translocon~~. ~~Tim44p can tightly associate with the inner mitochondrial membrane. To investigate the mechanism by which Tim44p functions in the TIM23 translocon to deliver the mitochondrial protein precursors~~, ~~we have determined~~ the ~~crystal structure of the yeast Tim44p C-terminal domain to 3~~.~~2A resolution using the MAD method. The Tim44p C~~-~~terminal domain forms a monomer in the crystal structure and contains six alpha~~-helices and four antiparallel beta-strands. A large hydrophobic pocket was identified on the Tim44p structure surface. The N-terminal helix A1 is positively charged and the helix A1 protrudes out from the Tim44p main body.		The line below this paragraph, {{ABSTRACT_PUBMED_16647716}}, adds the Publication Abstract to the page
			(as it appears on PubMed at http://www.pubmed.gov), where 16647716 is the PubMed ID number.
			-->
			{{ABSTRACT_PUBMED_16647716}}

	==About this Structure==		==About this Structure==
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	[[Category: Sha, B.]]		[[Category: Sha, B.]]
	[[Category: Mitochondrial translocase]]		[[Category: Mitochondrial translocase]]
	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 04~~:25:47 2008''
			''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:59:50 2008''