2gom - Revision history

OCA at 09:28, 14 February 2024

2024-02-14T09:28:54Z

← Older revision		Revision as of 09:28, 14 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2gom]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_Mu50 Staphylococcus aureus subsp. aureus Mu50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GOM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GOM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2gom]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_Mu50 Staphylococcus aureus subsp. aureus Mu50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GOM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GOM FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gom OCA], [https://pdbe.org/2gom PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gom RCSB], [https://www.ebi.ac.uk/pdbsum/2gom PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gom ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.25Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gom OCA], [https://pdbe.org/2gom PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gom RCSB], [https://www.ebi.ac.uk/pdbsum/2gom PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gom ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/FIB_STAAM FIB_STAAM] Binds to host fibrinogen (By similarity).		[https://www.uniprot.org/uniprot/FIB_STAAM FIB_STAAM] Binds to host fibrinogen (By similarity).
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	To provide insight into bacterial suppression of complement-mediated immunity, we present here structures of a bacterial complement inhibitory protein, both free and bound to its complement target. The 1.25-A structure of the complement component C3-inhibitory domain of Staphylococcus aureus extracellular fibrinogen-binding protein (Efb-C) demonstrated a helical motif involved in complement regulation, whereas the 2.2-A structure of Efb-C bound to the C3d domain of human C3 allowed insight into the recognition of complement proteins by invading pathogens. Our structure-function studies provided evidence for a previously unrecognized mode of complement inhibition whereby Efb-C binds to native C3 and alters the solution conformation of C3 in a way that renders it unable to participate in successful 'downstream' activation of the complement response.

	A structural basis for complement inhibition by Staphylococcus aureus.,Hammel M, Sfyroera G, Ricklin D, Magotti P, Lambris JD, Geisbrecht BV Nat Immunol. 2007 Apr;8(4):430-7. Epub 2007 Mar 11. PMID:17351618<ref>PMID:17351618</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 2gom" style="background-color:#fffaf0;"></div>~~

	==See Also==		==See Also==
	*[[Fibrinogen binding protein\|Fibrinogen binding protein]]		*[[Fibrinogen binding protein\|Fibrinogen binding protein]]
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 10:38, 14 December 2022

2022-12-14T10:38:38Z

← Older revision		Revision as of 10:38, 14 December 2022
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	<StructureSection load='2gom' size='340' side='right'caption='[[2gom]], [[Resolution\|resolution]] 1.25Å' scene=''>		<StructureSection load='2gom' size='340' side='right'caption='[[2gom]], [[Resolution\|resolution]] 1.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2gom]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Staam Staam~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GOM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GOM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2gom]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_Mu50 Staphylococcus aureus subsp. aureus Mu50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GOM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GOM FirstGlance]. <br>
	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2gox\|2gox]]</div></td></tr>~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gom OCA], [https://pdbe.org/2gom PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gom RCSB], [https://www.ebi.ac.uk/pdbsum/2gom PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gom ProSAT]</span></td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">efb ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=158878 STAAM])</td></tr>~~
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gom OCA], [https://pdbe.org/2gom PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gom RCSB], [https://www.ebi.ac.uk/pdbsum/2gom PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gom ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/~~FIB_STAAU FIB_STAAU]~~] Binds to host fibrinogen.		[https://www.uniprot.org/uniprot/FIB_STAAM FIB_STAAM] Binds to host fibrinogen (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Staam~~]]		[[Category: Staphylococcus aureus subsp. aureus Mu50]]
	[[Category: Geisbrecht~~, B V~~]]		[[Category: Geisbrecht BV]]
	[[Category: Hammel, M]]		[[Category: Hammel M]]
	~~[[Category: Cell adhesion-toxin complex]]~~
	~~[[Category: Three-helix closed bundle with left-hand twist~~]]

OCA at 19:11, 10 March 2021

2021-03-10T19:11:47Z

← Older revision		Revision as of 19:11, 10 March 2021
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	==Crystal structure of Efb-C from Staphylococcus aureus==		==Crystal structure of Efb-C from Staphylococcus aureus==
	<StructureSection load='2gom' size='340' side='right' caption='[[2gom]], [[Resolution\|resolution]] 1.25Å' scene=''>		<StructureSection load='2gom' size='340' side='right'caption='[[2gom]], [[Resolution\|resolution]] 1.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2gom]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Staam Staam]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GOM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2GOM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2gom]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staam Staam]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GOM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GOM FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gox\|2gox]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2gox\|2gox]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">efb ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=158878 STAAM])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">efb ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=158878 STAAM])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2gom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gom OCA], [~~http~~://pdbe.org/2gom PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2gom RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2gom PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2gom ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gom OCA], [https://pdbe.org/2gom PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gom RCSB], [https://www.ebi.ac.uk/pdbsum/2gom PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gom ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/FIB_STAAU FIB_STAAU]] Binds to host fibrinogen.		[[https://www.uniprot.org/uniprot/FIB_STAAU FIB_STAAU]] Binds to host fibrinogen.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Staam]]		[[Category: Staam]]
	[[Category: Geisbrecht, B V]]		[[Category: Geisbrecht, B V]]

OCA at 07:20, 20 June 2018

2018-06-20T07:20:32Z

← Older revision		Revision as of 07:20, 20 June 2018
Line 1:		Line 1:

	==Crystal structure of Efb-C from Staphylococcus aureus==		==Crystal structure of Efb-C from Staphylococcus aureus==
	<StructureSection load='2gom' size='340' side='right' caption='[[2gom]], [[Resolution\|resolution]] 1.25Å' scene=''>		<StructureSection load='2gom' size='340' side='right' caption='[[2gom]], [[Resolution\|resolution]] 1.25Å' scene=''>
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	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gox\|2gox]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gox\|2gox]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">efb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=158878 STAAM])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">efb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=158878 STAAM])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gom OCA], [http://pdbe.org/2gom PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2gom RCSB], [http://www.ebi.ac.uk/pdbsum/2gom PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gom OCA], [http://pdbe.org/2gom PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2gom RCSB], [http://www.ebi.ac.uk/pdbsum/2gom PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2gom ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 10:13, 11 September 2015

2015-09-11T10:13:28Z

← Older revision		Revision as of 10:13, 11 September 2015
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	<StructureSection load='2gom' size='340' side='right' caption='[[2gom]], [[Resolution\|resolution]] 1.25Å' scene=''>		<StructureSection load='2gom' size='340' side='right' caption='[[2gom]], [[Resolution\|resolution]] 1.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2gom]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Staphylococcus_aureus_subsp._aureus_mu50 Staphylococcus aureus subsp. aureus mu50~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GOM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GOM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2gom]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staam Staam]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GOM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GOM FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gox\|2gox]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gox\|2gox]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">efb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=158878 ~~Staphylococcus aureus subsp. aureus Mu50~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">efb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=158878 STAAM])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gom OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gom RCSB], [http://www.ebi.ac.uk/pdbsum/2gom PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gom OCA], [http://pdbe.org/2gom PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2gom RCSB], [http://www.ebi.ac.uk/pdbsum/2gom PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2gom" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Staphylococcus aureus subsp. aureus mu50~~]]		[[Category: Staam]]
	[[Category: Geisbrecht, B V]]		[[Category: Geisbrecht, B V]]
	[[Category: Hammel, M]]		[[Category: Hammel, M]]
	[[Category: Cell adhesion-toxin complex]]		[[Category: Cell adhesion-toxin complex]]
	[[Category: Three-helix closed bundle with left-hand twist]]		[[Category: Three-helix closed bundle with left-hand twist]]

OCA at 14:59, 25 December 2014

2014-12-25T14:59:38Z

← Older revision		Revision as of 14:59, 25 December 2014
Line 1:		Line 1:
	[[~~Image~~:~~2gom~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of Efb-C from Staphylococcus aureus==
			<StructureSection load='2gom' size='340' side='right' caption='[[2gom]], [[Resolution\|resolution]] 1.25Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2gom]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_mu50 Staphylococcus aureus subsp. aureus mu50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GOM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GOM FirstGlance]. <br>
			</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gox\|2gox]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">efb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=158878 Staphylococcus aureus subsp. aureus Mu50])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gom OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gom RCSB], [http://www.ebi.ac.uk/pdbsum/2gom PDBsum]</span></td></tr>
			</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/FIB_STAAU FIB_STAAU]] Binds to host fibrinogen.
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			To provide insight into bacterial suppression of complement-mediated immunity, we present here structures of a bacterial complement inhibitory protein, both free and bound to its complement target. The 1.25-A structure of the complement component C3-inhibitory domain of Staphylococcus aureus extracellular fibrinogen-binding protein (Efb-C) demonstrated a helical motif involved in complement regulation, whereas the 2.2-A structure of Efb-C bound to the C3d domain of human C3 allowed insight into the recognition of complement proteins by invading pathogens. Our structure-function studies provided evidence for a previously unrecognized mode of complement inhibition whereby Efb-C binds to native C3 and alters the solution conformation of C3 in a way that renders it unable to participate in successful 'downstream' activation of the complement response.

	~~{{STRUCTURE_2gom\| PDB=2gom \| SCENE= }}~~		A structural basis for complement inhibition by Staphylococcus aureus.,Hammel M, Sfyroera G, Ricklin D, Magotti P, Lambris JD, Geisbrecht BV Nat Immunol. 2007 Apr;8(4):430-7. Epub 2007 Mar 11. PMID:17351618<ref>PMID:17351618</ref>

	~~===Crystal structure~~ of ~~Efb-C from Staphylococcus aureus===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	~~{{ABSTRACT_PUBMED_17351618}}~~		==See Also==
			*[[Fibrinogen binding protein\|Fibrinogen binding protein]]
	==~~About this Structure~~==		== References ==
	[[~~2gom]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus~~]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GOM OCA~~].		<references/>
			__TOC__
	==~~Reference~~==		</StructureSection>
	<~~ref group="xtra">PMID:017351618<~~/~~ref~~><~~references group="xtra"~~/>		[[Category: Staphylococcus aureus subsp. aureus mu50]]
	[[Category: Staphylococcus aureus]]		[[Category: Geisbrecht, B V]]
	[[Category: Geisbrecht, B V.]]		[[Category: Hammel, M]]
	[[Category: Hammel, M.]]
	[[Category: Cell adhesion-toxin complex]]		[[Category: Cell adhesion-toxin complex]]
	[[Category: Three-helix closed bundle with left-hand twist]]		[[Category: Three-helix closed bundle with left-hand twist]]

OCA: Protected "2gom" [edit=sysop:move=sysop]

2013-01-07T15:19:02Z

Protected "2gom" [edit=sysop:move=sysop]

← Older revision	Revision as of 15:19, 7 January 2013
(No difference)

OCA at 15:18, 7 January 2013

2013-01-07T15:18:58Z

← Older revision		Revision as of 15:18, 7 January 2013
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	~~{{Seed}}~~
	[[Image:2gom.png\|left\|200px]]		[[Image:2gom.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2gom", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2gom\| PDB=2gom \| SCENE= }}		{{STRUCTURE_2gom\| PDB=2gom \| SCENE= }}

	===Crystal structure of Efb-C from Staphylococcus aureus===		===Crystal structure of Efb-C from Staphylococcus aureus===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_17351618}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 17351618 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_17351618}}		{{ABSTRACT_PUBMED_17351618}}

	==About this Structure==		==About this Structure==
	~~2GOM is a~~ [[~~Single protein~~]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GOM OCA].		[[2gom]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GOM OCA].

	==Reference==		==Reference==
	~~A structural basis for complement inhibition by Staphylococcus aureus., Hammel M, Sfyroera G, Ricklin D, Magotti P, Lambris JD, Geisbrecht BV, Nat Immunol. 2007 Apr;8(4):430-7. Epub 2007 Mar 11.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17351618 17351618]~~		<ref group="xtra">PMID:017351618</ref><references group="xtra"/>
	~~[[Category: Single protein]]~~
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Geisbrecht, B V.]]		[[Category: Geisbrecht, B V.]]
	[[Category: Hammel, M.]]		[[Category: Hammel, M.]]
			[[Category: Cell adhesion-toxin complex]]
	[[Category: Three-helix closed bundle with left-hand twist]]		[[Category: Three-helix closed bundle with left-hand twist]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:32:26 2008''~~

OCA at 00:32, 29 July 2008

2008-07-29T00:32:30Z

← Older revision		Revision as of 00:32, 29 July 2008
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	[[Image:2gom.~~jpg~~\|left\|200px]]		{{Seed}}
			[[Image:2gom.png\|left\|200px]]

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	{{STRUCTURE_2gom\| PDB=2gom \| SCENE= }}		{{STRUCTURE_2gom\| PDB=2gom \| SCENE= }}

	~~'''~~Crystal structure of Efb-C from Staphylococcus aureus~~'''~~		===Crystal structure of Efb-C from Staphylococcus aureus===


	~~==Overview==~~		<!--
	~~To provide insight into bacterial suppression of complement-mediated immunity~~, ~~we present here structures of a bacterial complement inhibitory protein~~, ~~both free and bound~~ to ~~its complement target~~. ~~The 1~~.~~25-A structure of the complement component C3-inhibitory domain of Staphylococcus aureus extracellular fibrinogen-binding protein (Efb-C~~) ~~demonstrated a helical motif involved in complement regulation~~, ~~whereas~~ the 2.2-~~A structure of Efb~~-C bound to the C3d domain of human C3 allowed insight into the recognition of complement proteins by invading pathogens. Our structure-function studies provided evidence for a previously unrecognized mode of complement inhibition whereby Efb-C binds to native C3 and alters the solution conformation of C3 in a way that renders it unable to participate in successful 'downstream' activation of the complement response.		The line below this paragraph, {{ABSTRACT_PUBMED_17351618}}, adds the Publication Abstract to the page
			(as it appears on PubMed at http://www.pubmed.gov), where 17351618 is the PubMed ID number.
			-->
			{{ABSTRACT_PUBMED_17351618}}

	==About this Structure==		==About this Structure==
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	[[Category: Hammel, M.]]		[[Category: Hammel, M.]]
	[[Category: Three-helix closed bundle with left-hand twist]]		[[Category: Three-helix closed bundle with left-hand twist]]
	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 05~~:20:33 2008''
			''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:32:26 2008''

OCA at 02:20, 4 May 2008

2008-05-04T02:20:33Z

← Older revision		Revision as of 02:20, 4 May 2008
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	[[Image:2gom.jpg\|left\|200px]]		[[Image:2gom.jpg\|left\|200px]]

	~~{{Structure~~		<!--
	~~\|PDB= 2gom \|SIZE=350\|CAPTION= <scene name='initialview01'>2gom</scene>~~, ~~resolution 1~~.~~25Å~~		The line below this paragraph, containing "STRUCTURE_2gom", creates the "Structure Box" on the page.
	~~\|SITE=~~		You may change the PDB parameter (which sets the PDB file loaded into the applet)
	~~\|LIGAND=~~		or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
	~~\|ACTIVITY=~~		or leave the SCENE parameter empty for the default display.
	~~\|GENE= efb~~ (~~[http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus]~~)		-->
	~~\|DOMAIN=~~		{{STRUCTURE_2gom\| PDB=2gom \| SCENE= }}
	~~\|RELATEDENTRY=[[2gox\|2GOX]]~~
	\|~~RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol~~=2gom ~~FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id~~=~~2gom OCA], [http://www.ebi.ac.uk/pdbsum/2gom PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gom RCSB]</span>~~
	}}

	'''Crystal structure of Efb-C from Staphylococcus aureus'''		'''Crystal structure of Efb-C from Staphylococcus aureus'''
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	[[Category: Geisbrecht, B V.]]		[[Category: Geisbrecht, B V.]]
	[[Category: Hammel, M.]]		[[Category: Hammel, M.]]
	[[Category: ~~three~~-helix closed bundle with left-hand twist]]		[[Category: Three-helix closed bundle with left-hand twist]]
			''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:20:33 2008''
	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Mar 31 03~~:19:27 2008''