2gpu - Revision history

OCA at 09:45, 30 August 2023

2023-08-30T09:45:48Z

← Older revision		Revision as of 09:45, 30 August 2023
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	<StructureSection load='2gpu' size='340' side='right'caption='[[2gpu]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2gpu' size='340' side='right'caption='[[2gpu]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2gpu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GPU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GPU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2gpu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GPU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GPU FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=OHT:4~~-~~HYDROXYTAMOXIFEN'>OHT</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[2gp7\|2gp7]], [[2gpo\|2gpo]], [[2gpp\|2gpp]], [[2gpv\|2gpv]]~~</~~div></td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OHT:4-HYDROXYTAMOXIFEN'>OHT</scene></td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat"~~>~~ESRRG ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gpu OCA], [https://pdbe.org/2gpu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gpu RCSB], [https://www.ebi.ac.uk/pdbsum/2gpu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gpu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gpu OCA], [https://pdbe.org/2gpu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gpu RCSB], [https://www.ebi.ac.uk/pdbsum/2gpu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gpu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/ERR3_HUMAN ERR3_HUMAN]] Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity).<ref>PMID:19067653</ref> <ref>PMID:18063693</ref> <ref>PMID:11864604</ref>		[https://www.uniprot.org/uniprot/ERR3_HUMAN ERR3_HUMAN] Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity).<ref>PMID:19067653</ref> <ref>PMID:18063693</ref> <ref>PMID:11864604</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Consler~~, T G~~]]		[[Category: Consler TG]]
	[[Category: Lambert~~, M H~~]]		[[Category: Lambert MH]]
	[[Category: McKee~~, D D~~]]		[[Category: McKee DD]]
	[[Category: Miller~~, A B~~]]		[[Category: Miller AB]]
	[[Category: Nolte~~, R T~~]]		[[Category: Nolte RT]]
	[[Category: Osband-Miller~~, L A~~]]		[[Category: Osband-Miller LA]]
	[[Category: Wang, L]]		[[Category: Wang L]]
	[[Category: Willson~~, T M~~]]		[[Category: Willson TM]]
	[[Category: Zuercher~~, W J]]~~		[[Category: Zuercher WJ]]
	~~[[Category: Err]]~~
	~~[[Category: Errg]]~~
	~~[[Category: Esrrg]]~~
	~~[[Category: Estrogen related receptor]]~~
	~~[[Category: Nuclear receptor]]~~
	~~[[Category: Steroid receptor]]~~
	~~[[Category: Transcription~~]]

OCA at 19:13, 10 March 2021

2021-03-10T19:13:17Z

← Older revision		Revision as of 19:13, 10 March 2021
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	==Estrogen Related Receptor-gamma ligand binding domain complexed with 4-hydroxy-tamoxifen==		==Estrogen Related Receptor-gamma ligand binding domain complexed with 4-hydroxy-tamoxifen==
	<StructureSection load='2gpu' size='340' side='right' caption='[[2gpu]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2gpu' size='340' side='right'caption='[[2gpu]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2gpu]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GPU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2GPU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2gpu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GPU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GPU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OHT:4-HYDROXYTAMOXIFEN'>OHT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OHT:4-HYDROXYTAMOXIFEN'>OHT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gp7\|2gp7]], [[2gpo\|2gpo]], [[2gpp\|2gpp]], [[2gpv\|2gpv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2gp7\|2gp7]], [[2gpo\|2gpo]], [[2gpp\|2gpp]], [[2gpv\|2gpv]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ESRRG ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ESRRG ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2gpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gpu OCA], [~~http~~://pdbe.org/2gpu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2gpu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2gpu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2gpu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gpu OCA], [https://pdbe.org/2gpu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gpu RCSB], [https://www.ebi.ac.uk/pdbsum/2gpu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gpu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/ERR3_HUMAN ERR3_HUMAN]] Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity).<ref>PMID:19067653</ref> <ref>PMID:18063693</ref> <ref>PMID:11864604</ref>		[[https://www.uniprot.org/uniprot/ERR3_HUMAN ERR3_HUMAN]] Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity).<ref>PMID:19067653</ref> <ref>PMID:18063693</ref> <ref>PMID:11864604</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gp/2gpu_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gp/2gpu_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 2gpu" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2gpu" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Estrogen-related receptor 3D structures\|Estrogen-related receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Consler, T G]]		[[Category: Consler, T G]]
	[[Category: Lambert, M H]]		[[Category: Lambert, M H]]

OCA at 07:57, 18 October 2017

2017-10-18T07:57:56Z

← Older revision		Revision as of 07:57, 18 October 2017
Line 1:		Line 1:

	==Estrogen Related Receptor-gamma ligand binding domain complexed with 4-hydroxy-tamoxifen==		==Estrogen Related Receptor-gamma ligand binding domain complexed with 4-hydroxy-tamoxifen==
	<StructureSection load='2gpu' size='340' side='right' caption='[[2gpu]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2gpu' size='340' side='right' caption='[[2gpu]], [[Resolution\|resolution]] 1.70Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gp7\|2gp7]], [[2gpo\|2gpo]], [[2gpp\|2gpp]], [[2gpv\|2gpv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gp7\|2gp7]], [[2gpo\|2gpo]], [[2gpp\|2gpp]], [[2gpv\|2gpv]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ESRRG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ESRRG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gpu OCA], [http://pdbe.org/2gpu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2gpu RCSB], [http://www.ebi.ac.uk/pdbsum/2gpu PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gpu OCA], [http://pdbe.org/2gpu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2gpu RCSB], [http://www.ebi.ac.uk/pdbsum/2gpu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2gpu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gpu ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 2gpu" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2gpu" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Estrogen-related receptor\|Estrogen-related receptor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:05, 11 September 2015

2015-09-11T14:05:35Z

← Older revision		Revision as of 14:05, 11 September 2015
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	<StructureSection load='2gpu' size='340' side='right' caption='[[2gpu]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2gpu' size='340' side='right' caption='[[2gpu]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2gpu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GPU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GPU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2gpu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GPU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GPU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OHT:4-HYDROXYTAMOXIFEN'>OHT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OHT:4-HYDROXYTAMOXIFEN'>OHT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gp7\|2gp7]], [[2gpo\|2gpo]], [[2gpp\|2gpp]], [[2gpv\|2gpv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gp7\|2gp7]], [[2gpo\|2gpo]], [[2gpp\|2gpp]], [[2gpv\|2gpv]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ESRRG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ESRRG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gpu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gpu RCSB], [http://www.ebi.ac.uk/pdbsum/2gpu PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gpu OCA], [http://pdbe.org/2gpu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2gpu RCSB], [http://www.ebi.ac.uk/pdbsum/2gpu PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2gpu" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Consler, T G]]		[[Category: Consler, T G]]
	[[Category: Lambert, M H]]		[[Category: Lambert, M H]]

OCA at 17:28, 25 December 2014

2014-12-25T17:28:53Z

← Older revision		Revision as of 17:28, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2gpu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GPU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GPU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2gpu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GPU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GPU FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OHT:4-HYDROXYTAMOXIFEN'>OHT</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OHT:4-HYDROXYTAMOXIFEN'>OHT</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gp7\|2gp7]], [[2gpo\|2gpo]], [[2gpp\|2gpp]], [[2gpv\|2gpv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gp7\|2gp7]], [[2gpo\|2gpo]], [[2gpp\|2gpp]], [[2gpv\|2gpv]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ESRRG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ESRRG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gpu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gpu RCSB], [http://www.ebi.ac.uk/pdbsum/2gpu PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gpu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gpu RCSB], [http://www.ebi.ac.uk/pdbsum/2gpu PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/ERR3_HUMAN ERR3_HUMAN]] Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity).<ref>PMID:19067653</ref> <ref>PMID:18063693</ref> <ref>PMID:11864604</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Consler, T G.]]		[[Category: Consler, T G]]
	[[Category: Lambert, M H.]]		[[Category: Lambert, M H]]
	[[Category: McKee, D D.]]		[[Category: McKee, D D]]
	[[Category: Miller, A B.]]		[[Category: Miller, A B]]
	[[Category: Nolte, R T.]]		[[Category: Nolte, R T]]
	[[Category: Osband-Miller, L A.]]		[[Category: Osband-Miller, L A]]
	[[Category: Wang, L.]]		[[Category: Wang, L]]
	[[Category: Willson, T M.]]		[[Category: Willson, T M]]
	[[Category: Zuercher, W J.]]		[[Category: Zuercher, W J]]
	[[Category: Err]]		[[Category: Err]]
	[[Category: Errg]]		[[Category: Errg]]

OCA at 08:16, 30 September 2014

2014-09-30T08:16:11Z

← Older revision		Revision as of 08:16, 30 September 2014
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	~~{{STRUCTURE_2gpu\| PDB=2gpu \| SCENE= }}~~		==Estrogen Related Receptor-gamma ligand binding domain complexed with 4-hydroxy-tamoxifen==
	===Estrogen Related Receptor-gamma ligand binding domain complexed with 4-hydroxy-tamoxifen===		<StructureSection load='2gpu' size='340' side='right' caption='[[2gpu]], [[Resolution\|resolution]] 1.70Å' scene=''>
	~~{{ABSTRACT_PUBMED_16990259}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2gpu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GPU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GPU FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OHT:4-HYDROXYTAMOXIFEN'>OHT</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gp7\|2gp7]], [[2gpo\|2gpo]], [[2gpp\|2gpp]], [[2gpv\|2gpv]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ESRRG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gpu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gpu RCSB], [http://www.ebi.ac.uk/pdbsum/2gpu PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gp/2gpu_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			X-ray crystal structures of the ligand binding domain (LBD) of the estrogen-related receptor-gamma (ERRgamma) were determined that describe this receptor in three distinct states: unliganded, inverse agonist bound, and agonist bound. Two structures were solved for the unliganded state, the ERRgamma LBD alone, and in complex with a coregulator peptide representing a portion of receptor interacting protein 140 (RIP140). No significant differences were seen between these structures that both exhibited the conformation of ERRgamma seen in studies with other coactivators. Two structures were obtained describing the inverse agonist-bound state, the ERRgamma LBD with 4-hydroxytamoxifen (4-OHT), and the ERRgamma LBD with 4-OHT and a peptide representing a portion of the silencing mediator of retinoid and thyroid hormone action protein (SMRT). The 4-OHT structure was similar to other reported inverse agonist bound structures, showing reorientation of phenylalanine 435 and a displacement of the AF-2 helix relative to the unliganded structures with little other rearrangement occurring. No significant changes to the LBD appear to be induced by peptide binding with the addition of the SMRT peptide to the ERRgamma plus 4-OHT complex. The observed agonist-bound state contains the ERRgamma LBD, a ligand (GSK4716), and the RIP140 peptide and reveals an unexpected rearrangement of the phenol-binding residues. Thermal stability studies show that agonist binding leads to global stabilization of the ligand binding domain. In contrast to the conventional mechanism of nuclear receptor ligand activation, activation of ERRgamma by GSK4716 does not appear to involve a major rearrangement or significant stabilization of the C-terminal helix.

	~~==About this Structure==~~		X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation.,Wang L, Zuercher WJ, Consler TG, Lambert MH, Miller AB, Orband-Miller LA, McKee DD, Willson TM, Nolte RT J Biol Chem. 2006 Dec 8;281(49):37773-81. Epub 2006 Sep 21. PMID:16990259<ref>PMID:16990259</ref>
	~~[[2gpu]] is a 1 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2GPU OCA].~~
			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	==See Also==		==See Also==
	*[[Estrogen-related receptor\|Estrogen-related receptor]]		*[[Estrogen-related receptor\|Estrogen-related receptor]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:016990259<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Consler, T G.]]		[[Category: Consler, T G.]]

OCA at 09:33, 11 March 2013

2013-03-11T09:33:21Z

← Older revision		Revision as of 09:33, 11 March 2013
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	~~[[Image:2gpu.png\|left\|200px]]~~

	{{STRUCTURE_2gpu\| PDB=2gpu \| SCENE= }}		{{STRUCTURE_2gpu\| PDB=2gpu \| SCENE= }}

	===Estrogen Related Receptor-gamma ligand binding domain complexed with 4-hydroxy-tamoxifen===		===Estrogen Related Receptor-gamma ligand binding domain complexed with 4-hydroxy-tamoxifen===

	{{ABSTRACT_PUBMED_16990259}}		{{ABSTRACT_PUBMED_16990259}}

OCA: Protected "2gpu" [edit=sysop:move=sysop]

2013-01-07T13:19:18Z

Protected "2gpu" [edit=sysop:move=sysop]

← Older revision	Revision as of 13:19, 7 January 2013
(No difference)

OCA at 13:19, 7 January 2013

2013-01-07T13:19:16Z

← Older revision		Revision as of 13:19, 7 January 2013
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	~~{{Seed}}~~
	[[Image:2gpu.png\|left\|200px]]		[[Image:2gpu.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2gpu", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2gpu\| PDB=2gpu \| SCENE= }}		{{STRUCTURE_2gpu\| PDB=2gpu \| SCENE= }}

	===Estrogen Related Receptor-gamma ligand binding domain complexed with 4-hydroxy-tamoxifen===		===Estrogen Related Receptor-gamma ligand binding domain complexed with 4-hydroxy-tamoxifen===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16990259}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 16990259 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_16990259}}		{{ABSTRACT_PUBMED_16990259}}

	==About this Structure==		==About this Structure==
	~~2GPU~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GPU OCA].		[[2gpu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GPU OCA].

			==See Also==
			*[[Estrogen-related receptor\|Estrogen-related receptor]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16990259~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016990259</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Consler, T G.]]		[[Category: Consler, T G.]]
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	[[Category: Steroid receptor]]		[[Category: Steroid receptor]]
	[[Category: Transcription]]		[[Category: Transcription]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:13:25 2009''~~

OCA at 22:13, 17 February 2009

2009-02-17T22:13:26Z

← Older revision		Revision as of 22:13, 17 February 2009
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	==About this Structure==		==About this Structure==
	2GPU is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GPU OCA].		2GPU is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GPU OCA].

	==Reference==		==Reference==
	X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation., Wang L, Zuercher WJ, Consler TG, Lambert MH, Miller AB, Orband-Miller LA, McKee DD, Willson TM, Nolte RT, J Biol Chem. 2006 Dec 8;281(49):37773-81. Epub 2006 Sep 21. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16990259 16990259]~~		<ref group="xtra">PMID:16990259</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	~~[[Category: Single protein]]~~
	[[Category: Consler, T G.]]		[[Category: Consler, T G.]]
	[[Category: Lambert, M H.]]		[[Category: Lambert, M H.]]
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	[[Category: Transcription]]		[[Category: Transcription]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 07~~:33:~~34 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:13:25 2009''