2grf - Revision history

OCA at 08:08, 13 August 2026

2026-08-13T08:08:40Z

← Older revision		Revision as of 08:08, 13 August 2026
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gr/2grf_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gr/2grf_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 09:46, 30 August 2023

2023-08-30T09:46:13Z

← Older revision		Revision as of 09:46, 30 August 2023
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	<StructureSection load='2grf' size='340' side='right'caption='[[2grf]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2grf' size='340' side='right'caption='[[2grf]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2grf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GRF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2grf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Anadara_inaequivalvis Anadara inaequivalvis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GRF FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[4sdh\|4sdh]], [[2grh\|2grh]], [[2grz\|2grz]]~~</~~div~~></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2grf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2grf OCA], [https://pdbe.org/2grf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2grf RCSB], [https://www.ebi.ac.uk/pdbsum/2grf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2grf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2grf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2grf OCA], [https://pdbe.org/2grf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2grf RCSB], [https://www.ebi.ac.uk/pdbsum/2grf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2grf ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/GLB1_ANAIN GLB1_ANAIN]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Anadara inaequivalvis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Knapp~~, J E~~]]		[[Category: Knapp JE]]
	[[Category: Pahl, R]]		[[Category: Pahl R]]
	[[Category: Royer~~, W E~~]]		[[Category: Royer Jr WE]]
	[[Category: Srajer, V]]		[[Category: Srajer V]]
	~~[[Category: Allostery]]~~
	~~[[Category: Cooperativity]]~~
	~~[[Category: Heme protein]]~~
	~~[[Category: Hemoglobin]]~~
	~~[[Category: Invertebrate]]~~
	~~[[Category: Oxygen storage-transport complex]]~~
	~~[[Category: Oxygen-binding]]~~
	~~[[Category: Oxygen-transport~~]]

OCA at 17:35, 20 October 2021

2021-10-20T17:35:56Z

← Older revision		Revision as of 17:35, 20 October 2021
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	<StructureSection load='2grf' size='340' side='right'caption='[[2grf]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2grf' size='340' side='right'caption='[[2grf]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2grf]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Anain Anain]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GRF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2GRF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2grf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GRF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4sdh\|4sdh]], [[2grh\|2grh]], [[2grz\|2grz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4sdh\|4sdh]], [[2grh\|2grh]], [[2grz\|2grz]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2grf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2grf OCA], [~~http~~://pdbe.org/2grf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2grf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2grf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2grf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2grf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2grf OCA], [https://pdbe.org/2grf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2grf RCSB], [https://www.ebi.ac.uk/pdbsum/2grf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2grf ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Anain]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Knapp, J E]]		[[Category: Knapp, J E]]

OCA at 11:19, 27 March 2020

2020-03-27T11:19:04Z

← Older revision		Revision as of 11:19, 27 March 2020
Line 1:		Line 1:

	==Crystal structure of Scapharca inaequivalvis HBI, M37V mutant in the absence of ligand==		==Crystal structure of Scapharca inaequivalvis HBI, M37V mutant in the absence of ligand==
	<StructureSection load='2grf' size='340' side='right' caption='[[2grf]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2grf' size='340' side='right'caption='[[2grf]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2grf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Anain Anain]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GRF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GRF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2grf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Anain Anain]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GRF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GRF FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Anain]]		[[Category: Anain]]
			[[Category: Large Structures]]
	[[Category: Knapp, J E]]		[[Category: Knapp, J E]]
	[[Category: Pahl, R]]		[[Category: Pahl, R]]

OCA at 06:58, 20 June 2018

2018-06-20T06:58:25Z

← Older revision		Revision as of 06:58, 20 June 2018
Line 1:		Line 1:

	==Crystal structure of Scapharca inaequivalvis HBI, M37V mutant in the absence of ligand==		==Crystal structure of Scapharca inaequivalvis HBI, M37V mutant in the absence of ligand==
	<StructureSection load='2grf' size='340' side='right' caption='[[2grf]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2grf' size='340' side='right' caption='[[2grf]], [[Resolution\|resolution]] 2.10Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4sdh\|4sdh]], [[2grh\|2grh]], [[2grz\|2grz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4sdh\|4sdh]], [[2grh\|2grh]], [[2grz\|2grz]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2grf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2grf OCA], [http://pdbe.org/2grf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2grf RCSB], [http://www.ebi.ac.uk/pdbsum/2grf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2grf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2grf OCA], [http://pdbe.org/2grf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2grf RCSB], [http://www.ebi.ac.uk/pdbsum/2grf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2grf ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gr/2grf_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gr/2grf_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2grf ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:11, 11 September 2015

2015-09-11T09:11:16Z

← Older revision		Revision as of 09:11, 11 September 2015
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	<StructureSection load='2grf' size='340' side='right' caption='[[2grf]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2grf' size='340' side='right' caption='[[2grf]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2grf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Scapharca_inaequivalvis Scapharca inaequivalvis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GRF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GRF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2grf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Anain Anain]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GRF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GRF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4sdh\|4sdh]], [[2grh\|2grh]], [[2grz\|2grz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4sdh\|4sdh]], [[2grh\|2grh]], [[2grz\|2grz]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2grf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2grf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2grf RCSB], [http://www.ebi.ac.uk/pdbsum/2grf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2grf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2grf OCA], [http://pdbe.org/2grf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2grf RCSB], [http://www.ebi.ac.uk/pdbsum/2grf PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2grf" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Scapharca inaequivalvis~~]]		[[Category: Anain]]
	[[Category: Knapp, J E]]		[[Category: Knapp, J E]]
	[[Category: Pahl, R]]		[[Category: Pahl, R]]

OCA at 08:13, 16 January 2015

2015-01-16T08:13:37Z

← Older revision		Revision as of 08:13, 16 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2grf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Scapharca_inaequivalvis Scapharca inaequivalvis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GRF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GRF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2grf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Scapharca_inaequivalvis Scapharca inaequivalvis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GRF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GRF FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4sdh\|4sdh]], [[2grh\|2grh]], [[2grz\|2grz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4sdh\|4sdh]], [[2grh\|2grh]], [[2grz\|2grz]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2grf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2grf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2grf RCSB], [http://www.ebi.ac.uk/pdbsum/2grf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2grf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2grf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2grf RCSB], [http://www.ebi.ac.uk/pdbsum/2grf PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Scapharca inaequivalvis]]		[[Category: Scapharca inaequivalvis]]
	[[Category: Knapp, J E.]]		[[Category: Knapp, J E]]
	[[Category: Pahl, R.]]		[[Category: Pahl, R]]
	[[Category: Royer, W E.]]		[[Category: Royer, W E]]
	[[Category: Srajer, V.]]		[[Category: Srajer, V]]
	[[Category: Allostery]]		[[Category: Allostery]]
	[[Category: Cooperativity]]		[[Category: Cooperativity]]

OCA at 05:39, 29 September 2014

2014-09-29T05:39:56Z

← Older revision		Revision as of 05:39, 29 September 2014
Line 1:		Line 1:
	[[Image:~~2grf~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of Scapharca inaequivalvis HBI, M37V mutant in the absence of ligand==
			<StructureSection load='2grf' size='340' side='right' caption='[[2grf]], [[Resolution\|resolution]] 2.10Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2grf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Scapharca_inaequivalvis Scapharca inaequivalvis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GRF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GRF FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4sdh\|4sdh]], [[2grh\|2grh]], [[2grz\|2grz]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2grf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2grf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2grf RCSB], [http://www.ebi.ac.uk/pdbsum/2grf PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gr/2grf_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Protein allostery provides mechanisms for regulation of biological function at the molecular level. We present here an investigation of global, ligand-induced allosteric transition in a protein by time-resolved x-ray diffraction. The study provides a view of structural changes in single crystals of Scapharca dimeric hemoglobin as they proceed in real time, from 5 ns to 80 micros after ligand photodissociation. A tertiary intermediate structure forms rapidly (<5 ns) as the protein responds to the presence of an unliganded heme within each R-state protein subunit, with key structural changes observed in the heme groups, neighboring residues, and interface water molecules. This intermediate lays a foundation for the concerted tertiary and quaternary structural changes that occur on a microsecond time scale and are associated with the transition to a low-affinity T-state structure. Reversal of these changes shows a considerable lag as a T-like structure persists well after ligand rebinding, suggesting a slow T-to-R transition.

	~~{{STRUCTURE_2grf\| PDB=2grf \| SCENE= }}~~		Allosteric action in real time: time-resolved crystallographic studies of a cooperative dimeric hemoglobin.,Knapp JE, Pahl R, Srajer V, Royer WE Jr Proc Natl Acad Sci U S A. 2006 May 16;103(20):7649-54. Epub 2006 May 9. PMID:16684887<ref>PMID:16684887</ref>

	~~===Crystal structure~~ of ~~Scapharca inaequivalvis HBI, M37V mutant in~~ the ~~absence of ligand===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16684887}}~~

	~~==About this Structure==~~
	~~[[2grf]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Scapharca_inaequivalvis Scapharca inaequivalvis]~~. ~~Full crystallographic information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=2GRF OCA].~~

	==See Also==		==See Also==
	*[[Hemoglobin\|Hemoglobin]]		*[[Hemoglobin 3D structures\|Hemoglobin 3D structures]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:016684887<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Scapharca inaequivalvis]]		[[Category: Scapharca inaequivalvis]]
	[[Category: Knapp, J E.]]		[[Category: Knapp, J E.]]

OCA at 17:44, 20 October 2012

2012-10-20T17:44:12Z

← Older revision		Revision as of 17:44, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[2grf]] is a 2 chain structure ~~of [[Hemoglobin]]~~ with sequence from [http://en.wikipedia.org/wiki/Scapharca_inaequivalvis Scapharca inaequivalvis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GRF OCA].		[[2grf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Scapharca_inaequivalvis Scapharca inaequivalvis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GRF OCA].

	==See Also==		==See Also==

OCA: Protected "2grf" [edit=sysop:move=sysop]

2012-07-27T01:50:13Z

Protected "2grf" [edit=sysop:move=sysop]

← Older revision	Revision as of 01:50, 27 July 2012
(No difference)