2hak - Revision history

OCA at 08:50, 25 October 2023

2023-10-25T08:50:39Z

← Older revision		Revision as of 08:50, 25 October 2023
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	<StructureSection load='2hak' size='340' side='right'caption='[[2hak]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='2hak' size='340' side='right'caption='[[2hak]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2hak]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HAK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HAK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2hak]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HAK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HAK FirstGlance]. <br>
	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1zmu\|1zmu]], [[1zmv\|1zmv]], [[1zmw\|1zmw]], [[1y8g\|1y8g]]</div></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">MARK1 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])</td></tr>~~
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hak OCA], [https://pdbe.org/2hak PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hak RCSB], [https://www.ebi.ac.uk/pdbsum/2hak PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hak ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hak OCA], [https://pdbe.org/2hak PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hak RCSB], [https://www.ebi.ac.uk/pdbsum/2hak PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hak ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[https://www.uniprot.org/uniprot/MARK1_HUMAN MARK1_HUMAN]] Note=Genetic variations in MARK1 may be associated with susceptibility to autism. MARK1 is overexpressed in the prefrontal cortex of patients with autism and causes changes in the function of cortical dendrites.		[https://www.uniprot.org/uniprot/MARK1_HUMAN MARK1_HUMAN] Note=Genetic variations in MARK1 may be associated with susceptibility to autism. MARK1 is overexpressed in the prefrontal cortex of patients with autism and causes changes in the function of cortical dendrites.
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/MARK1_HUMAN MARK1_HUMAN]] Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).<ref>PMID:11433294</ref> <ref>PMID:17573348</ref>		[https://www.uniprot.org/uniprot/MARK1_HUMAN MARK1_HUMAN] Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).<ref>PMID:11433294</ref> <ref>PMID:17573348</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Non-specific serine/threonine protein kinase]]~~		[[Category: Mandelkow E]]
	[[Category: Mandelkow, E]]		[[Category: Mandelkow E-M]]
	[[Category: Mandelkow, E M]]		[[Category: Marx A]]
	[[Category: Marx, A]]		[[Category: Mueller J]]
	[[Category: Mueller, J]]		[[Category: Nugoor C]]
	[[Category: Nugoor, C]]		[[Category: Panneerselvam S]]
	[[Category: Panneerselvam, S]]
	~~[[Category: Kin1]]~~
	~~[[Category: Mark]]~~
	~~[[Category: Par-1]]~~
	~~[[Category: Serine/threonine protein kinase]]~~
	~~[[Category: Signaling protein]]~~
	~~[[Category: Transferase]]~~
	~~[[Category: Uba domain~~]]

OCA at 07:35, 17 March 2021

2021-03-17T07:35:18Z

← Older revision		Revision as of 07:35, 17 March 2021
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	==Catalytic and ubiqutin-associated domains of MARK1/PAR-1==		==Catalytic and ubiqutin-associated domains of MARK1/PAR-1==
	<StructureSection load='2hak' size='340' side='right' caption='[[2hak]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='2hak' size='340' side='right'caption='[[2hak]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2hak]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HAK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2HAK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2hak]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HAK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HAK FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zmu\|1zmu]], [[1zmv\|1zmv]], [[1zmw\|1zmw]], [[1y8g\|1y8g]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1zmu\|1zmu]], [[1zmv\|1zmv]], [[1zmw\|1zmw]], [[1y8g\|1y8g]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MARK1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MARK1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2hak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hak OCA], [~~http~~://pdbe.org/2hak PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2hak RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2hak PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2hak ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hak OCA], [https://pdbe.org/2hak PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hak RCSB], [https://www.ebi.ac.uk/pdbsum/2hak PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hak ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[~~http~~://www.uniprot.org/uniprot/MARK1_HUMAN MARK1_HUMAN]] Note=Genetic variations in MARK1 may be associated with susceptibility to autism. MARK1 is overexpressed in the prefrontal cortex of patients with autism and causes changes in the function of cortical dendrites.		[[https://www.uniprot.org/uniprot/MARK1_HUMAN MARK1_HUMAN]] Note=Genetic variations in MARK1 may be associated with susceptibility to autism. MARK1 is overexpressed in the prefrontal cortex of patients with autism and causes changes in the function of cortical dendrites.
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/MARK1_HUMAN MARK1_HUMAN]] Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).<ref>PMID:11433294</ref> <ref>PMID:17573348</ref>		[[https://www.uniprot.org/uniprot/MARK1_HUMAN MARK1_HUMAN]] Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).<ref>PMID:11433294</ref> <ref>PMID:17573348</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ha/2hak_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ha/2hak_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 2hak" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2hak" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Serine/threonine protein kinase 3D structures\|Serine/threonine protein kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Mandelkow, E]]		[[Category: Mandelkow, E]]

OCA at 08:09, 18 October 2017

2017-10-18T08:09:00Z

← Older revision		Revision as of 08:09, 18 October 2017
Line 1:		Line 1:

	==Catalytic and ubiqutin-associated domains of MARK1/PAR-1==		==Catalytic and ubiqutin-associated domains of MARK1/PAR-1==
	<StructureSection load='2hak' size='340' side='right' caption='[[2hak]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='2hak' size='340' side='right' caption='[[2hak]], [[Resolution\|resolution]] 2.60Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MARK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MARK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hak OCA], [http://pdbe.org/2hak PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2hak RCSB], [http://www.ebi.ac.uk/pdbsum/2hak PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hak OCA], [http://pdbe.org/2hak PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2hak RCSB], [http://www.ebi.ac.uk/pdbsum/2hak PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2hak ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	</div>		</div>
	<div class="pdbe-citations 2hak" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2hak" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Serine/threonine protein kinase\|Serine/threonine protein kinase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:17, 10 February 2016

2016-02-10T06:17:23Z

← Older revision		Revision as of 06:17, 10 February 2016
Line 20:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hak ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:11, 11 September 2015

2015-09-11T06:11:53Z

← Older revision		Revision as of 06:11, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2hak' size='340' side='right' caption='[[2hak]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='2hak' size='340' side='right' caption='[[2hak]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2hak]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HAK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HAK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2hak]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HAK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HAK FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zmu\|1zmu]], [[1zmv\|1zmv]], [[1zmw\|1zmw]], [[1y8g\|1y8g]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zmu\|1zmu]], [[1zmv\|1zmv]], [[1zmw\|1zmw]], [[1y8g\|1y8g]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MARK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MARK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hak OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hak RCSB], [http://www.ebi.ac.uk/pdbsum/2hak PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hak OCA], [http://pdbe.org/2hak PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2hak RCSB], [http://www.ebi.ac.uk/pdbsum/2hak PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2hak" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Mandelkow, E]]		[[Category: Mandelkow, E]]

OCA at 08:15, 16 January 2015

2015-01-16T08:15:31Z

← Older revision		Revision as of 08:15, 16 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2hak]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HAK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HAK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2hak]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HAK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HAK FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zmu\|1zmu]], [[1zmv\|1zmv]], [[1zmw\|1zmw]], [[1y8g\|1y8g]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zmu\|1zmu]], [[1zmv\|1zmv]], [[1zmw\|1zmw]], [[1y8g\|1y8g]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MARK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MARK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hak OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hak RCSB], [http://www.ebi.ac.uk/pdbsum/2hak PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hak OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hak RCSB], [http://www.ebi.ac.uk/pdbsum/2hak PDBsum]</span></td></tr>
	<table>		</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/MARK1_HUMAN MARK1_HUMAN]] Note=Genetic variations in MARK1 may be associated with susceptibility to autism. MARK1 is overexpressed in the prefrontal cortex of patients with autism and causes changes in the function of cortical dendrites.		[[http://www.uniprot.org/uniprot/MARK1_HUMAN MARK1_HUMAN]] Note=Genetic variations in MARK1 may be associated with susceptibility to autism. MARK1 is overexpressed in the prefrontal cortex of patients with autism and causes changes in the function of cortical dendrites.
Line 39:		Line 39:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Mandelkow, E.]]		[[Category: Mandelkow, E]]
	[[Category: Mandelkow, E M.]]		[[Category: Mandelkow, E M]]
	[[Category: Marx, A.]]		[[Category: Marx, A]]
	[[Category: Mueller, J.]]		[[Category: Mueller, J]]
	[[Category: Nugoor, C.]]		[[Category: Nugoor, C]]
	[[Category: Panneerselvam, S.]]		[[Category: Panneerselvam, S]]
	[[Category: Kin1]]		[[Category: Kin1]]
	[[Category: Mark]]		[[Category: Mark]]

OCA at 09:27, 30 September 2014

2014-09-30T09:27:53Z

← Older revision		Revision as of 09:27, 30 September 2014
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	~~{{STRUCTURE_2hak\| PDB=2hak \| SCENE= }}~~		==Catalytic and ubiqutin-associated domains of MARK1/PAR-1==
	===Catalytic and ubiqutin-associated domains of MARK1/PAR-1===		<StructureSection load='2hak' size='340' side='right' caption='[[2hak]], [[Resolution\|resolution]] 2.60Å' scene=''>
	~~{{ABSTRACT_PUBMED_16803889}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2hak]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HAK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HAK FirstGlance]. <br>
	==Disease==		</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zmu\|1zmu]], [[1zmv\|1zmv]], [[1zmw\|1zmw]], [[1y8g\|1y8g]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MARK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hak OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hak RCSB], [http://www.ebi.ac.uk/pdbsum/2hak PDBsum]</span></td></tr>
			<table>
			== Disease ==
	[[http://www.uniprot.org/uniprot/MARK1_HUMAN MARK1_HUMAN]] Note=Genetic variations in MARK1 may be associated with susceptibility to autism. MARK1 is overexpressed in the prefrontal cortex of patients with autism and causes changes in the function of cortical dendrites.		[[http://www.uniprot.org/uniprot/MARK1_HUMAN MARK1_HUMAN]] Note=Genetic variations in MARK1 may be associated with susceptibility to autism. MARK1 is overexpressed in the prefrontal cortex of patients with autism and causes changes in the function of cortical dendrites.
			== Function ==
			[[http://www.uniprot.org/uniprot/MARK1_HUMAN MARK1_HUMAN]] Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).<ref>PMID:11433294</ref> <ref>PMID:17573348</ref>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ha/2hak_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The microtubule-associated protein (MAP)/microtubule affinity regulating kinase (MARK)/Par-1 phosphorylates microtubule-associated proteins tau, MAP2, and MAP4 and is involved in the regulation of microtubule-based transport. Par-1, a homologue of MARK in Drosophila and Caenorhabditis elegans, is essential for the development of embryonic polarity. Four isoforms of MARK are found in humans. Recently, we reported the crystal structure of the catalytic and ubiquitin-associated domains of MARK2, an isoform enriched in brain (Panneerselvam, S., Marx, A., Mandelkow, E.-M., and Mandelkow, E. (2006) Structure 14, 173-183). It showed that the ubiquitin-associated domain (UBA) domain has an unusual fold and binds to the N-terminal lobe of the catalytic domain. This is at variance with a previous low resolution structure derived from small angle solution scattering (Jaleel, M., Villa, F., Deak, M., Toth, R., Prescott, A. R., Van Aalten, D. M., and Alessi, D. R. (2006) Biochem. J. 394, 545-555), which predicts binding of the UBA domain to the larger, C-terminal lobe. Here we report the crystal structure of the catalytic and UBA domain of another isoform, MARK1. Although the crystal packing of the two isoforms are unrelated, the overall conformations of the molecules are similar. Notably, the UBA domain has the same unusual conformation as in MARK2, and it binds at the same site. Remarkable differences occur in the catalytic domain at helix C, the catalytic loop, and the activation segment.

	~~==Function==~~		Structural variations in the catalytic and ubiquitin-associated domains of microtubule-associated protein/microtubule affinity regulating kinase (MARK) 1 and MARK2.,Marx A, Nugoor C, Muller J, Panneerselvam S, Timm T, Bilang M, Mylonas E, Svergun DI, Mandelkow EM, Mandelkow E J Biol Chem. 2006 Sep 15;281(37):27586-99. Epub 2006 Jun 27. PMID:16803889<ref>PMID:16803889</ref>
	~~[[http://www.uniprot.org/uniprot/MARK1_HUMAN MARK1_HUMAN]] Serine/threonine~~-protein kinase ~~involved in cell polarity~~ and ~~microtubule dynamics regulation~~. ~~Phosphorylates DCX~~, ~~MAP2~~, ~~MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2~~, ~~MAP4 and MAPT/TAU at KXGS motifs~~, ~~causing detachment from microtubules~~, ~~and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics~~, ~~possibly by phosphorylating and regulating DCX~~. ~~Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins~~ (~~DVL1, DVL2 and/or DVL3~~).~~<ref>~~PMID:~~11433294</ref>~~<ref>PMID:~~17573348~~</ref>

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[2hak]] is~~ a ~~8 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:/~~/~~oca.weizmann.ac.il/oca-bin/ocashort?id=2HAK OCA].~~		</div>

	==~~Reference~~==		==See Also==
	~~<ref group~~=~~"xtra">PMID:016803889</ref><ref group~~=~~"xtra">PMID:016472737</ref>~~<references ~~group="xtra"~~/><~~references~~/>		*[[Serine/threonine protein kinase\|Serine/threonine protein kinase]]
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]

OCA at 01:20, 25 March 2013

2013-03-25T01:20:24Z

← Older revision		Revision as of 01:20, 25 March 2013
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	~~[[Image:2hak.png\|left\|200px]]~~

	{{STRUCTURE_2hak\| PDB=2hak \| SCENE= }}		{{STRUCTURE_2hak\| PDB=2hak \| SCENE= }}
			===Catalytic and ubiqutin-associated domains of MARK1/PAR-1===
			{{ABSTRACT_PUBMED_16803889}}

	===~~Catalytic~~ and ~~ubiqutin-associated domains~~ of ~~MARK1/PAR-1===~~		==Disease==
			[[http://www.uniprot.org/uniprot/MARK1_HUMAN MARK1_HUMAN]] Note=Genetic variations in MARK1 may be associated with susceptibility to autism. MARK1 is overexpressed in the prefrontal cortex of patients with autism and causes changes in the function of cortical dendrites.

	~~{{ABSTRACT_PUBMED_16803889}}~~		==Function==
			[[http://www.uniprot.org/uniprot/MARK1_HUMAN MARK1_HUMAN]] Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).<ref>PMID:11433294</ref><ref>PMID:17573348</ref>

	==About this Structure==		==About this Structure==
Line 11:		Line 13:

	==Reference==		==Reference==
	<ref group="xtra">PMID:016803889</ref><ref group="xtra">PMID:016472737</ref><references group="xtra"/>		<ref group="xtra">PMID:016803889</ref><ref group="xtra">PMID:016472737</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]

OCA at 12:33, 23 January 2013

2013-01-23T12:33:04Z

← Older revision		Revision as of 12:33, 23 January 2013
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	[[Image:2hak.png\|left\|200px]]		[[Image:2hak.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2hak", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2hak\| PDB=2hak \| SCENE= }}		{{STRUCTURE_2hak\| PDB=2hak \| SCENE= }}

	===Catalytic and ubiqutin-associated domains of MARK1/PAR-1===		===Catalytic and ubiqutin-associated domains of MARK1/PAR-1===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16803889}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 16803889 is the PubMed ID number.~~
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	{{ABSTRACT_PUBMED_16803889}}		{{ABSTRACT_PUBMED_16803889}}

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	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16803889~~</ref><ref group="xtra">PMID:~~16472737~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016803889</ref><ref group="xtra">PMID:016472737</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]

OCA: Protected "2hak" [edit=sysop:move=sysop]

2011-03-14T21:56:01Z

Protected "2hak" [edit=sysop:move=sysop]

← Older revision	Revision as of 21:56, 14 March 2011
(No difference)