2hey - Revision history

OCA at 01:01, 21 November 2024

2024-11-21T01:01:11Z

← Older revision		Revision as of 01:01, 21 November 2024
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	<StructureSection load='2hey' size='340' side='right'caption='[[2hey]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2hey' size='340' side='right'caption='[[2hey]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2hey]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~] and [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HEY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2hey]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HEY FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
	~~<tr id='related'><td class="sblockLbl~~">~~<b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;'>[[2hev\|2hev]]~~, [[~~2hew~~\|~~2hew~~]]~~</div>~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~Tnfsf4, Ox40l, Txgp1l ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=10090 LK3 transgenic mice]), TNFRSF4, TXGP1L ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hey OCA], [https://pdbe.org/2hey PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hey RCSB], [https://www.ebi.ac.uk/pdbsum/2hey PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hey ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hey OCA], [https://pdbe.org/2hey PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hey RCSB], [https://www.ebi.ac.uk/pdbsum/2hey PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hey ProSAT]</span></td></tr>
	</table>		</table>
	~~== Function ==~~
	[[https://www.uniprot.org/uniprot/TNFL4_MOUSE TNFL4_MOUSE]] Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. [[https://www.uniprot.org/uniprot/TNR4_HUMAN TNR4_HUMAN]] Receptor for TNFSF4/OX40L/GP34.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/he/2hey_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/he/2hey_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Lk3 transgenic mice~~]]		[[Category: Mus musculus]]
	[[Category: Hymowitz~~, S G]]~~		[[Category: Hymowitz SG]]
	~~[[Category: Co-stimulator]]~~
	~~[[Category: Cytokine]]~~
	~~[[Category: Receptor-ligan complex]]~~
	~~[[Category: Tnfsf~~]]

OCA at 07:38, 17 March 2021

2021-03-17T07:38:28Z

← Older revision		Revision as of 07:38, 17 March 2021
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	==Crystal structure of murine OX40L bound to human OX40==		==Crystal structure of murine OX40L bound to human OX40==
	<StructureSection load='2hey' size='340' side='right' caption='[[2hey]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2hey' size='340' side='right'caption='[[2hey]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2hey]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human] and [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2HEY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2hey]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human] and [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HEY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hev\|2hev]], [[2hew\|2hew]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2hev\|2hev]], [[2hew\|2hew]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tnfsf4, Ox40l, Txgp1l ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), TNFRSF4, TXGP1L ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tnfsf4, Ox40l, Txgp1l ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), TNFRSF4, TXGP1L ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2hey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hey OCA], [~~http~~://pdbe.org/2hey PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2hey RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2hey PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2hey ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hey OCA], [https://pdbe.org/2hey PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hey RCSB], [https://www.ebi.ac.uk/pdbsum/2hey PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hey ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/TNFL4_MOUSE TNFL4_MOUSE]] Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. [[~~http~~://www.uniprot.org/uniprot/TNR4_HUMAN TNR4_HUMAN]] Receptor for TNFSF4/OX40L/GP34.		[[https://www.uniprot.org/uniprot/TNFL4_MOUSE TNFL4_MOUSE]] Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. [[https://www.uniprot.org/uniprot/TNR4_HUMAN TNR4_HUMAN]] Receptor for TNFSF4/OX40L/GP34.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[Tumor necrosis factor receptor\|Tumor necrosis factor receptor]]		*[[Tumor necrosis factor receptor 3D structures\|Tumor necrosis factor receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Hymowitz, S G]]		[[Category: Hymowitz, S G]]

OCA at 06:43, 27 June 2018

2018-06-27T06:43:18Z

← Older revision		Revision as of 06:43, 27 June 2018
Line 1:		Line 1:

	==Crystal structure of murine OX40L bound to human OX40==		==Crystal structure of murine OX40L bound to human OX40==
	<StructureSection load='2hey' size='340' side='right' caption='[[2hey]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2hey' size='340' side='right' caption='[[2hey]], [[Resolution\|resolution]] 2.00Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hev\|2hev]], [[2hew\|2hew]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hev\|2hev]], [[2hew\|2hew]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tnfsf4, Ox40l, Txgp1l ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), TNFRSF4, TXGP1L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tnfsf4, Ox40l, Txgp1l ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), TNFRSF4, TXGP1L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hey OCA], [http://pdbe.org/2hey PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2hey RCSB], [http://www.ebi.ac.uk/pdbsum/2hey PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hey OCA], [http://pdbe.org/2hey PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2hey RCSB], [http://www.ebi.ac.uk/pdbsum/2hey PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2hey ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/he/2hey_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/he/2hey_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 21:18, 7 February 2016

2016-02-07T21:18:37Z

← Older revision		Revision as of 21:18, 7 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hey ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:04, 10 September 2015

2015-09-10T05:04:17Z

← Older revision		Revision as of 05:04, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2hey' size='340' side='right' caption='[[2hey]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2hey' size='340' side='right' caption='[[2hey]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2hey]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~] and [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HEY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2hey]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HEY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hev\|2hev]], [[2hew\|2hew]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hev\|2hev]], [[2hew\|2hew]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tnfsf4, Ox40l, Txgp1l ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~]), TNFRSF4, TXGP1L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tnfsf4, Ox40l, Txgp1l ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), TNFRSF4, TXGP1L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hey OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hey RCSB], [http://www.ebi.ac.uk/pdbsum/2hey PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hey OCA], [http://pdbe.org/2hey PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2hey RCSB], [http://www.ebi.ac.uk/pdbsum/2hey PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2hey" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Tumor necrosis factor receptor\|Tumor necrosis factor receptor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: ~~Mus musculus~~]]		[[Category: Lk3 transgenic mice]]
	[[Category: Hymowitz, S G]]		[[Category: Hymowitz, S G]]
	[[Category: Co-stimulator]]		[[Category: Co-stimulator]]

OCA at 18:19, 24 December 2014

2014-12-24T18:19:28Z

← Older revision		Revision as of 18:19, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2hey]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HEY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2hey]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HEY FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hev\|2hev]], [[2hew\|2hew]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hev\|2hev]], [[2hew\|2hew]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tnfsf4, Ox40l, Txgp1l ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), TNFRSF4, TXGP1L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tnfsf4, Ox40l, Txgp1l ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), TNFRSF4, TXGP1L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hey OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hey RCSB], [http://www.ebi.ac.uk/pdbsum/2hey PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hey OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hey RCSB], [http://www.ebi.ac.uk/pdbsum/2hey PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/TNFL4_MOUSE TNFL4_MOUSE]] Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. [[http://www.uniprot.org/uniprot/TNR4_HUMAN TNR4_HUMAN]] Receptor for TNFSF4/OX40L/GP34.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Hymowitz, S G.]]		[[Category: Hymowitz, S G]]
	[[Category: Co-stimulator]]		[[Category: Co-stimulator]]
	[[Category: Cytokine]]		[[Category: Cytokine]]
	[[Category: Receptor-ligan complex]]		[[Category: Receptor-ligan complex]]
	[[Category: Tnfsf]]		[[Category: Tnfsf]]

OCA at 08:55, 30 September 2014

2014-09-30T08:55:26Z

← Older revision		Revision as of 08:55, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2hey~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of murine OX40L bound to human OX40==
			<StructureSection load='2hey' size='340' side='right' caption='[[2hey]], [[Resolution\|resolution]] 2.00Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2hey]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HEY FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hev\|2hev]], [[2hew\|2hew]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tnfsf4, Ox40l, Txgp1l ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), TNFRSF4, TXGP1L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hey OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hey RCSB], [http://www.ebi.ac.uk/pdbsum/2hey PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/he/2hey_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			OX40 is a T cell costimulator activated by OX40L. Blockade of the OX40L-OX40 interaction has ameliorative effects in animal models of T cell pathologies. In order to better understand the interaction between OX40 and OX40L, we have determined the crystal structure of murine OX40L and of the human OX40-OX40L complex at 1.45 and 2.4 A, respectively. These structures show that OX40L is an unusually small member of the tumor necrosis factor superfamily (TNFSF). The arrangement of the OX40L protomers forming the functional trimer is atypical and differs from that of other members by a 15 degrees rotation of each protomer with respect to the trimer axis, resulting in an open assembly. Site-directed changes of the interfacial residues of OX40L suggest this interface lacks a single "hot spot" and that instead, binding energy is dispersed over at least two distinct areas. These structures demonstrate the structural plasticity of TNFSF members and their interactions with receptors.

	~~{{STRUCTURE_2hey\| PDB=2hey \| SCENE= }}~~		The crystal structure of the costimulatory OX40-OX40L complex.,Compaan DM, Hymowitz SG Structure. 2006 Aug;14(8):1321-30. PMID:16905106<ref>PMID:16905106</ref>

	~~===Crystal structure~~ of ~~murine OX40L bound to human OX40===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16905106}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2hey]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens] and [http://en~~.~~wikipedia.org~~/~~wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEY OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:016905106<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]

OCA: Protected "2hey" [edit=sysop:move=sysop]

2013-01-07T11:15:19Z

Protected "2hey" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:15, 7 January 2013
(No difference)

OCA at 11:15, 7 January 2013

2013-01-07T11:15:16Z

← Older revision		Revision as of 11:15, 7 January 2013
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	~~{{Seed}}~~
	[[Image:2hey.png\|left\|200px]]		[[Image:2hey.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2hey", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2hey\| PDB=2hey \| SCENE= }}		{{STRUCTURE_2hey\| PDB=2hey \| SCENE= }}

	===Crystal structure of murine OX40L bound to human OX40===		===Crystal structure of murine OX40L bound to human OX40===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16905106}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 16905106 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_16905106}}		{{ABSTRACT_PUBMED_16905106}}

	==About this Structure==		==About this Structure==
	~~2HEY~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEY OCA].		[[2hey]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEY OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16905106~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016905106</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
Line 31:		Line 19:
	[[Category: Receptor-ligan complex]]		[[Category: Receptor-ligan complex]]
	[[Category: Tnfsf]]		[[Category: Tnfsf]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 16:35:02 2009''~~

OCA at 14:35, 16 February 2009

2009-02-16T14:35:04Z

← Older revision		Revision as of 14:35, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
	2HEY is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEY OCA].		2HEY is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEY OCA].

	==Reference==		==Reference==
	~~The crystal structure of the costimulatory OX40-OX40L complex., Compaan DM, Hymowitz SG, Structure. 2006 Aug;14(8):1321-30.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16905106 16905106]~~		<ref group="xtra">PMID:16905106</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	~~[[Category: Protein complex]]~~
	[[Category: Hymowitz, S G.]]		[[Category: Hymowitz, S G.]]
	[[Category: Co-stimulator]]		[[Category: Co-stimulator]]
Line 33:		Line 32:
	[[Category: Tnfsf]]		[[Category: Tnfsf]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Jul 27 19~~:48:~~12 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 16:35:02 2009''