2ify - Revision history

OCA at 09:02, 21 February 2024

2024-02-21T09:02:57Z

← Older revision		Revision as of 09:02, 21 February 2024
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	<StructureSection load='2ify' size='340' side='right'caption='[[2ify]], [[Resolution\|resolution]] 2.38Å' scene=''>		<StructureSection load='2ify' size='340' side='right'caption='[[2ify]], [[Resolution\|resolution]] 2.38Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ify]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_cereus_var._anthracis"_(cohn_1872)_smith_et_al._1946 "bacillus cereus var.~~ anthracis~~" (cohn 1872) smith et al. 1946~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IFY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IFY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ify]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IFY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IFY FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.38Å</td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>gpmI, gpmA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~1392~~ "~~Bacillus cereus var. anthracis~~" ~~(Cohn 1872) Smith et al. 1946])</td~~><~~/tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Phosphoglycerate_mutase Phosphoglycerate mutase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.1 5.4.2.1]~~ </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ify FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ify OCA], [https://pdbe.org/2ify PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ify RCSB], [https://www.ebi.ac.uk/pdbsum/2ify PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ify ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ify FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ify OCA], [https://pdbe.org/2ify PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ify RCSB], [https://www.ebi.ac.uk/pdbsum/2ify PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ify ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/GPMI_BACAN GPMI_BACAN]] Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity).		[https://www.uniprot.org/uniprot/GPMI_BACAN GPMI_BACAN] Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ify ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ify ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Phosphoglycerate mutases (PGMs) catalyze the isomerization of 2- and 3-phosphoglycerates and are essential for glucose metabolism in most organisms. This study reports the production, structure, and molecular dynamics analysis of Bacillus anthracis cofactor-independent PGM (iPGM). The three-dimensional structure of B. anthracis PGM is composed of two structural and functional domains, the phosphatase and transferase. The structural relationship between these two domains is different than in the B. stearothermophilus iPGM structure determined previously. However, the structures of the two domains of B. anthracis iPGM show a high degree of similarity to those in B. stearothermophilus iPGM. The novel domain arrangement in B. anthracis iPGM and the dynamic property of these domains is directly linked to the mechanism of enzyme catalysis, in which substrate binding is proposed to result in close association of the two domains. The structure of B. anthracis iPGM and the molecular dynamics of this structure provide unique insight into the mechanism of iPGM catalysis, in particular the roles of changes in coordination geometry of the enzyme's two bivalent metal ions and the regulation of this enzyme's activity by changes in intracellular pH during spore formation and germination in Bacillus species.

	Structure and molecular mechanism of Bacillus anthracis cofactor-independent phosphoglycerate mutase: a crucial enzyme for spores and growing cells of Bacillus species.,Nukui M, Mello LV, Littlejohn JE, Setlow B, Setlow P, Kim K, Leighton T, Jedrzejas MJ Biophys J. 2007 Feb 1;92(3):977-88. Epub 2006 Nov 3. PMID:17085493<ref>PMID:17085493</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 2ify" style="background-color:#fffaf0;"></div>~~

	==See Also==		==See Also==
	*[[Phosphoglycerate mutase 3D structures\|Phosphoglycerate mutase 3D structures]]		*[[Phosphoglycerate mutase 3D structures\|Phosphoglycerate mutase 3D structures]]
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Bacillus anthracis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Phosphoglycerate mutase]]~~		[[Category: Jedrzejas MJ]]
	[[Category: Jedrzejas~~, M J~~]]		[[Category: Littlejohn JE]]
	[[Category: Littlejohn~~, J E~~]]		[[Category: Nukui M]]
	[[Category: Nukui, M]]
	~~[[Category: Bacillus anthracis]]~~
	~~[[Category: Catalysis]]~~
	~~[[Category: Catalytic mechanism]]~~
	~~[[Category: Glygolysis]]~~
	~~[[Category: Gram-posotive bacteria]]~~
	~~[[Category: Isomerase]]~~
	~~[[Category: Phosphoglycerate]]~~
	~~[[Category: Spore~~]]

OCA at 11:15, 31 March 2021

2021-03-31T11:15:21Z

← Older revision		Revision as of 11:15, 31 March 2021
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	==Structure of Bacillus anthracis cofactor-independent phosphoglucerate mutase==		==Structure of Bacillus anthracis cofactor-independent phosphoglucerate mutase==
	<StructureSection load='2ify' size='340' side='right' caption='[[2ify]], [[Resolution\|resolution]] 2.38Å' scene=''>		<StructureSection load='2ify' size='340' side='right'caption='[[2ify]], [[Resolution\|resolution]] 2.38Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ify]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_cereus_var._anthracis"_(cohn_1872)_smith_et_al._1946 "bacillus cereus var. anthracis" (cohn 1872) smith et al. 1946]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IFY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2IFY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ify]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_cereus_var._anthracis"_(cohn_1872)_smith_et_al._1946 "bacillus cereus var. anthracis" (cohn 1872) smith et al. 1946]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IFY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IFY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gpmI, gpmA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 "Bacillus cereus var. anthracis" (Cohn 1872) Smith et al. 1946])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gpmI, gpmA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 "Bacillus cereus var. anthracis" (Cohn 1872) Smith et al. 1946])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Phosphoglycerate_mutase Phosphoglycerate mutase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.1 5.4.2.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phosphoglycerate_mutase Phosphoglycerate mutase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.1 5.4.2.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ify FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ify OCA], [~~http~~://pdbe.org/2ify PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ify RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ify PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ify ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ify FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ify OCA], [https://pdbe.org/2ify PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ify RCSB], [https://www.ebi.ac.uk/pdbsum/2ify PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ify ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/GPMI_BACAN GPMI_BACAN]] Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity).		[[https://www.uniprot.org/uniprot/GPMI_BACAN GPMI_BACAN]] Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[Phosphoglycerate ~~Mutase~~\|Phosphoglycerate ~~Mutase~~]]		*[[Phosphoglycerate mutase 3D structures\|Phosphoglycerate mutase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Phosphoglycerate mutase]]		[[Category: Phosphoglycerate mutase]]
	[[Category: Jedrzejas, M J]]		[[Category: Jedrzejas, M J]]

OCA at 08:09, 4 July 2018

2018-07-04T08:09:26Z

← Older revision		Revision as of 08:09, 4 July 2018
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	==Structure of Bacillus anthracis cofactor-independent phosphoglucerate mutase==		==Structure of Bacillus anthracis cofactor-independent phosphoglucerate mutase==
	<StructureSection load='2ify' size='340' side='right' caption='[[2ify]], [[Resolution\|resolution]] 2.38Å' scene=''>		<StructureSection load='2ify' size='340' side='right' caption='[[2ify]], [[Resolution\|resolution]] 2.38Å' scene=''>
Line 6:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gpmI, gpmA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 "Bacillus cereus var. anthracis" (Cohn 1872) Smith et al. 1946])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gpmI, gpmA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 "Bacillus cereus var. anthracis" (Cohn 1872) Smith et al. 1946])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoglycerate_mutase Phosphoglycerate mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.1 5.4.2.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoglycerate_mutase Phosphoglycerate mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.1 5.4.2.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ify FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ify OCA], [http://pdbe.org/2ify PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ify RCSB], [http://www.ebi.ac.uk/pdbsum/2ify PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ify FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ify OCA], [http://pdbe.org/2ify PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ify RCSB], [http://www.ebi.ac.uk/pdbsum/2ify PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ify ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/if/2ify_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/if/2ify_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ify ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:45, 11 September 2015

2015-09-11T16:45:03Z

← Older revision		Revision as of 16:45, 11 September 2015
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	<StructureSection load='2ify' size='340' side='right' caption='[[2ify]], [[Resolution\|resolution]] 2.38Å' scene=''>		<StructureSection load='2ify' size='340' side='right' caption='[[2ify]], [[Resolution\|resolution]] 2.38Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ify]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_anthracis Bacillus~~ anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IFY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IFY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ify]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_cereus_var._anthracis"_(cohn_1872)_smith_et_al._1946 "bacillus cereus var. anthracis" (cohn 1872) smith et al. 1946]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IFY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IFY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gpmI, gpmA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 Bacillus anthracis])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gpmI, gpmA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 "Bacillus cereus var. anthracis" (Cohn 1872) Smith et al. 1946])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoglycerate_mutase Phosphoglycerate mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.1 5.4.2.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoglycerate_mutase Phosphoglycerate mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.1 5.4.2.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ify FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ify OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ify RCSB], [http://www.ebi.ac.uk/pdbsum/2ify PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ify FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ify OCA], [http://pdbe.org/2ify PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ify RCSB], [http://www.ebi.ac.uk/pdbsum/2ify PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2ify" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Bacillus anthracis]]~~
	[[Category: Phosphoglycerate mutase]]		[[Category: Phosphoglycerate mutase]]
	[[Category: Jedrzejas, M J]]		[[Category: Jedrzejas, M J]]
	[[Category: Littlejohn, J E]]		[[Category: Littlejohn, J E]]
	[[Category: Nukui, M]]		[[Category: Nukui, M]]
			[[Category: Bacillus anthracis]]
	[[Category: Catalysis]]		[[Category: Catalysis]]
	[[Category: Catalytic mechanism]]		[[Category: Catalytic mechanism]]

OCA at 19:11, 25 December 2014

2014-12-25T19:11:14Z

← Older revision		Revision as of 19:11, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ify]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IFY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IFY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ify]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IFY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IFY FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gpmI, gpmA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 Bacillus anthracis])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gpmI, gpmA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 Bacillus anthracis])</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoglycerate_mutase Phosphoglycerate mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.1 5.4.2.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoglycerate_mutase Phosphoglycerate mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.1 5.4.2.1] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ify FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ify OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ify RCSB], [http://www.ebi.ac.uk/pdbsum/2ify PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ify FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ify OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ify RCSB], [http://www.ebi.ac.uk/pdbsum/2ify PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/GPMI_BACAN GPMI_BACAN]] Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Bacillus anthracis]]		[[Category: Bacillus anthracis]]
	[[Category: Phosphoglycerate mutase]]		[[Category: Phosphoglycerate mutase]]
	[[Category: Jedrzejas, M J.]]		[[Category: Jedrzejas, M J]]
	[[Category: Littlejohn, J E.]]		[[Category: Littlejohn, J E]]
	[[Category: Nukui, M~~.]]~~		[[Category: Nukui, M]]
	~~[[Category: Bacillus anthracis~~]]
	[[Category: Catalysis]]		[[Category: Catalysis]]
	[[Category: Catalytic mechanism]]		[[Category: Catalytic mechanism]]

OCA at 02:19, 29 September 2014

2014-09-29T02:19:18Z

← Older revision		Revision as of 02:19, 29 September 2014
Line 1:		Line 1:
	[[Image:~~2ify~~.~~png~~\|~~left~~\|~~200px~~]]		==Structure of Bacillus anthracis cofactor-independent phosphoglucerate mutase==
			<StructureSection load='2ify' size='340' side='right' caption='[[2ify]], [[Resolution\|resolution]] 2.38Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2ify]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IFY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IFY FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene><br>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gpmI, gpmA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 Bacillus anthracis])</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoglycerate_mutase Phosphoglycerate mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.1 5.4.2.1] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ify FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ify OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ify RCSB], [http://www.ebi.ac.uk/pdbsum/2ify PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/if/2ify_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Phosphoglycerate mutases (PGMs) catalyze the isomerization of 2- and 3-phosphoglycerates and are essential for glucose metabolism in most organisms. This study reports the production, structure, and molecular dynamics analysis of Bacillus anthracis cofactor-independent PGM (iPGM). The three-dimensional structure of B. anthracis PGM is composed of two structural and functional domains, the phosphatase and transferase. The structural relationship between these two domains is different than in the B. stearothermophilus iPGM structure determined previously. However, the structures of the two domains of B. anthracis iPGM show a high degree of similarity to those in B. stearothermophilus iPGM. The novel domain arrangement in B. anthracis iPGM and the dynamic property of these domains is directly linked to the mechanism of enzyme catalysis, in which substrate binding is proposed to result in close association of the two domains. The structure of B. anthracis iPGM and the molecular dynamics of this structure provide unique insight into the mechanism of iPGM catalysis, in particular the roles of changes in coordination geometry of the enzyme's two bivalent metal ions and the regulation of this enzyme's activity by changes in intracellular pH during spore formation and germination in Bacillus species.

	~~{{STRUCTURE_2ify\| PDB=2ify \| SCENE= }}~~		Structure and molecular mechanism of Bacillus anthracis cofactor-independent phosphoglycerate mutase: a crucial enzyme for spores and growing cells of Bacillus species.,Nukui M, Mello LV, Littlejohn JE, Setlow B, Setlow P, Kim K, Leighton T, Jedrzejas MJ Biophys J. 2007 Feb 1;92(3):977-88. Epub 2006 Nov 3. PMID:17085493<ref>PMID:17085493</ref>

	~~===Structure~~ of ~~Bacillus anthracis cofactor-independent phosphoglucerate mutase===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_17085493}}~~

	~~==About this Structure==~~
	~~[[2ify]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bacillus_anthracis Bacillus anthracis]~~. ~~Full crystallographic information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=2IFY OCA].~~

	==See Also==		==See Also==
	*[[Bisphosphoglycerate mutase\|Bisphosphoglycerate mutase]]
	*[[Phosphoglycerate Mutase\|Phosphoglycerate Mutase]]		*[[Phosphoglycerate Mutase\|Phosphoglycerate Mutase]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:017085493<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Bacillus anthracis]]		[[Category: Bacillus anthracis]]
	[[Category: Phosphoglycerate mutase]]		[[Category: Phosphoglycerate mutase]]

OCA at 20:24, 20 October 2012

2012-10-20T20:24:02Z

← Older revision		Revision as of 20:24, 20 October 2012
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	==About this Structure==		==About this Structure==
	[[2ify]] is a 1 chain structure ~~of [[Bisphosphoglycerate mutase]] and [[Phosphoglycerate Mutase]]~~ with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IFY OCA].		[[2ify]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IFY OCA].

	==See Also==		==See Also==

OCA: Protected "2ify" [edit=sysop:move=sysop]

2012-07-27T10:21:44Z

Protected "2ify" [edit=sysop:move=sysop]

← Older revision	Revision as of 10:21, 27 July 2012
(No difference)

OCA at 10:21, 27 July 2012

2012-07-27T10:21:42Z

← Older revision		Revision as of 10:21, 27 July 2012
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	~~{{Seed}}~~
	[[Image:2ify.png\|left\|200px]]		[[Image:2ify.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2ify", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2ify\| PDB=2ify \| SCENE= }}		{{STRUCTURE_2ify\| PDB=2ify \| SCENE= }}

	===Structure of Bacillus anthracis cofactor-independent phosphoglucerate mutase===		===Structure of Bacillus anthracis cofactor-independent phosphoglucerate mutase===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_17085493}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 17085493 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_17085493}}		{{ABSTRACT_PUBMED_17085493}}

	==About this Structure==		==About this Structure==
	~~2IFY~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IFY OCA].		[[2ify]] is a 1 chain structure of [[Bisphosphoglycerate mutase]] and [[Phosphoglycerate Mutase]] with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IFY OCA].

			==See Also==
			*[[Bisphosphoglycerate mutase\|Bisphosphoglycerate mutase]]
			*[[Phosphoglycerate Mutase\|Phosphoglycerate Mutase]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~17085493~~</ref><references group="xtra"/>		<ref group="xtra">PMID:017085493</ref><references group="xtra"/>
	[[Category: Bacillus anthracis]]		[[Category: Bacillus anthracis]]
	[[Category: Phosphoglycerate mutase]]		[[Category: Phosphoglycerate mutase]]
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	[[Category: Glygolysis]]		[[Category: Glygolysis]]
	[[Category: Gram-posotive bacteria]]		[[Category: Gram-posotive bacteria]]
			[[Category: Isomerase]]
	[[Category: Phosphoglycerate]]		[[Category: Phosphoglycerate]]
	[[Category: Spore]]		[[Category: Spore]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 04:05:18 2009''~~

OCA at 02:05, 18 February 2009

2009-02-18T02:05:19Z

← Older revision		Revision as of 02:05, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
	2IFY is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IFY OCA].		2IFY is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IFY OCA].

	==Reference==		==Reference==
	Structure and molecular mechanism of Bacillus anthracis cofactor-independent phosphoglycerate mutase: a crucial enzyme for spores and growing cells of Bacillus species., Nukui M, Mello LV, Littlejohn JE, Setlow B, Setlow P, Kim K, Leighton T, Jedrzejas MJ, Biophys J. 2007 Feb 1;92(3):977-88. Epub 2006 Nov 3. PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~17085493 17085493]~~		<ref group="xtra">PMID:17085493</ref><references group="xtra"/>
	[[Category: Bacillus anthracis]]		[[Category: Bacillus anthracis]]
	[[Category: Phosphoglycerate mutase]]		[[Category: Phosphoglycerate mutase]]
	~~[[Category: Single protein]]~~
	[[Category: Jedrzejas, M J.]]		[[Category: Jedrzejas, M J.]]
	[[Category: Littlejohn, J E.]]		[[Category: Littlejohn, J E.]]
Line 38:		Line 37:
	[[Category: Spore]]		[[Category: Spore]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 10~~:17:~~14 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 04:05:18 2009''