2igr - Revision history

OCA at 08:12, 30 October 2024

2024-10-30T08:12:32Z

← Older revision		Revision as of 08:12, 30 October 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2igr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hyalophora_cecropia Hyalophora cecropia]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IGR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2igr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hyalophora_cecropia Hyalophora cecropia]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IGR FirstGlance]. <br>
	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2igr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2igr OCA], [https://pdbe.org/2igr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2igr RCSB], [https://www.ebi.ac.uk/pdbsum/2igr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2igr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2igr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2igr OCA], [https://pdbe.org/2igr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2igr RCSB], [https://www.ebi.ac.uk/pdbsum/2igr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2igr ProSAT]</span></td></tr>

OCA at 18:11, 18 October 2023

2023-10-18T18:11:28Z

← Older revision		Revision as of 18:11, 18 October 2023
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	==Solution structure of CB1a, a novel anticancer peptide derived from natural antimicrobial peptide cecropin B==		==Solution structure of CB1a, a novel anticancer peptide derived from natural antimicrobial peptide cecropin B==
	<StructureSection load='2igr' size='340' side='right'caption='[[2igr~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='2igr' size='340' side='right'caption='[[2igr]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2igr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IGR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2igr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hyalophora_cecropia Hyalophora cecropia]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IGR FirstGlance]. <br>
	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=NH2:AMINO+GROUP'>NH2</scene~~></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1d9j\|1d9j]], [[1d9m\|1d9m]], [[1d9o\|1d9o]], [[1d9p\|1d9p]]~~</~~div~~></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2igr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2igr OCA], [https://pdbe.org/2igr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2igr RCSB], [https://www.ebi.ac.uk/pdbsum/2igr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2igr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2igr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2igr OCA], [https://pdbe.org/2igr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2igr RCSB], [https://www.ebi.ac.uk/pdbsum/2igr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2igr ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Hyalophora cecropia]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Wu, J M]]		[[Category: Wu J-M]]
	~~[[Category: Anticancer peptide]]~~
	~~[[Category: Antimicrobial peptide]]~~
	~~[[Category: Cecropin]]~~
	~~[[Category: Cecropin fingerprint sequence]]~~
	~~[[Category: De novo protein]]~~
	~~[[Category: Lipid binding protein]]~~
	~~[[Category: Ploycationic peptide~~]]

OCA at 10:27, 12 January 2022

2022-01-12T10:27:21Z

← Older revision		Revision as of 10:27, 12 January 2022
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	<StructureSection load='2igr' size='340' side='right'caption='[[2igr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2igr' size='340' side='right'caption='[[2igr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2igr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IGR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2IGR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2igr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IGR FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d9j\|1d9j]], [[1d9m\|1d9m]], [[1d9o\|1d9o]], [[1d9p\|1d9p]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1d9j\|1d9j]], [[1d9m\|1d9m]], [[1d9o\|1d9o]], [[1d9p\|1d9p]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2igr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2igr OCA], [~~http~~://pdbe.org/2igr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2igr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2igr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2igr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2igr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2igr OCA], [https://pdbe.org/2igr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2igr RCSB], [https://www.ebi.ac.uk/pdbsum/2igr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2igr ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:45, 8 April 2020

2020-04-08T07:45:38Z

← Older revision		Revision as of 07:45, 8 April 2020
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	==Solution structure of CB1a, a novel anticancer peptide derived from natural antimicrobial peptide cecropin B==		==Solution structure of CB1a, a novel anticancer peptide derived from natural antimicrobial peptide cecropin B==
	<StructureSection load='2igr' size='340' side='right' caption='[[2igr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2igr' size='340' side='right'caption='[[2igr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2igr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IGR OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2IGR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2igr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IGR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2IGR FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d9j\|1d9j]], [[1d9m\|1d9m]], [[1d9o\|1d9o]], [[1d9p\|1d9p]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d9j\|1d9j]], [[1d9m\|1d9m]], [[1d9o\|1d9o]], [[1d9p\|1d9p]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2igr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2igr OCA], [http://pdbe.org/2igr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2igr RCSB], [http://www.ebi.ac.uk/pdbsum/2igr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2igr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2igr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2igr OCA], [http://pdbe.org/2igr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2igr RCSB], [http://www.ebi.ac.uk/pdbsum/2igr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2igr ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Wu, J M]]		[[Category: Wu, J M]]
	[[Category: Anticancer peptide]]		[[Category: Anticancer peptide]]

OCA at 08:41, 4 July 2018

2018-07-04T08:41:25Z

← Older revision		Revision as of 08:41, 4 July 2018
Line 1:		Line 1:

	==Solution structure of CB1a, a novel anticancer peptide derived from natural antimicrobial peptide cecropin B==		==Solution structure of CB1a, a novel anticancer peptide derived from natural antimicrobial peptide cecropin B==
	<StructureSection load='2igr' size='340' side='right' caption='[[2igr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2igr' size='340' side='right' caption='[[2igr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
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	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d9j\|1d9j]], [[1d9m\|1d9m]], [[1d9o\|1d9o]], [[1d9p\|1d9p]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d9j\|1d9j]], [[1d9m\|1d9m]], [[1d9o\|1d9o]], [[1d9p\|1d9p]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2igr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2igr OCA], [http://pdbe.org/2igr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2igr RCSB], [http://www.ebi.ac.uk/pdbsum/2igr PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2igr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2igr OCA], [http://pdbe.org/2igr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2igr RCSB], [http://www.ebi.ac.uk/pdbsum/2igr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2igr ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 03:02, 10 September 2015

2015-09-10T03:02:38Z

← Older revision		Revision as of 03:02, 10 September 2015
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	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d9j\|1d9j]], [[1d9m\|1d9m]], [[1d9o\|1d9o]], [[1d9p\|1d9p]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d9j\|1d9j]], [[1d9m\|1d9m]], [[1d9o\|1d9o]], [[1d9p\|1d9p]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2igr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2igr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2igr RCSB], [http://www.ebi.ac.uk/pdbsum/2igr PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2igr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2igr OCA], [http://pdbe.org/2igr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2igr RCSB], [http://www.ebi.ac.uk/pdbsum/2igr PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2igr" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:46, 16 January 2015

2015-01-16T08:46:45Z

← Older revision		Revision as of 08:46, 16 January 2015
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Wu, J M.]]		[[Category: Wu, J M]]
	[[Category: Anticancer peptide]]		[[Category: Anticancer peptide]]
	[[Category: Antimicrobial peptide]]		[[Category: Antimicrobial peptide]]

OCA at 15:41, 12 October 2014

2014-10-12T15:41:03Z

← Older revision		Revision as of 15:41, 12 October 2014
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	[[~~Image~~:~~2igr~~.~~png~~\|~~left~~\|~~200px~~]]		==Solution structure of CB1a, a novel anticancer peptide derived from natural antimicrobial peptide cecropin B==
			<StructureSection load='2igr' size='340' side='right' caption='[[2igr]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2igr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IGR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IGR FirstGlance]. <br>
			</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d9j\|1d9j]], [[1d9m\|1d9m]], [[1d9o\|1d9o]], [[1d9p\|1d9p]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2igr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2igr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2igr RCSB], [http://www.ebi.ac.uk/pdbsum/2igr PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Several natural antimicrobial peptides including cecropins, magainins and melittins have been found to kill cancer cells. However, their efficacy may not be adequate for their development as anticancer agents. In this study, we used a natural antimicrobial peptide, cecropin B (CB), as a template to generate a novel anticancer peptide. Cecropin B is an amphipathic and polycationic peptide derived from the hemolymph of Hyalophora cecropia with well-known antimicrobial and cytolytic properties. The signature pattern of cecropins is W-x-(0,2)-[KDN]-x-{L}-K-[KRE]-[LI]-E-[RKN] (PROSITE: PS00268), and this signature sequence is located at N-terminus of CB. CB1a was constructed by repeating the N-terminal ten amino acids of CB three times and including a hinge near C-terminus. The circular dichroism spectra showed that CB1a is unstructured in aqueous solution, but adopt a helical conformation in membrane-like environment. The solution structure of CB1a in a polar solvent was also studied by NMR. CB1a formed a helix-hinge-helix in 20% HFIP solution, and it was found the bent angle between two helical segments was induced ranging from 60 degrees to 110 degrees . A heparin-binding motif is located in the central part of helix 1. Isothermal titration calorimetry reveals the association constant of CB1a bound to low molecular weight heparin is 1.66 x 10(5)M(-1) at physiological ionic strength at 25 degrees C. Binding of CB1a to heparin produces a large conformational change toward a more structural state. CB1a demonstrated promising activity against several cancer cells but low toxicity against non-cancer cells. The IC(50) of CB1a on leukemia and stomach carcinoma cells were in the range of 2-8-fold lower than those of CB. Besides, CB1a exhibited low hemolytic activity against human red blood cells. Due to these properties, CB1a has the potential to become a promising anticancer agent.

	~~{{STRUCTURE_2igr\| PDB=2igr \| SCENE= }}~~		Structure and function of a custom anticancer peptide, CB1a.,Wu JM, Jan PS, Yu HC, Haung HY, Fang HJ, Chang YI, Cheng JW, Chen HM Peptides. 2009 May;30(5):839-48. Epub 2009 Feb 13. PMID:19428759<ref>PMID:19428759</ref>

	~~===Solution structure of CB1a~~, a ~~novel anticancer peptide derived from natural antimicrobial peptide cecropin B===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_19428759}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2igr]] is a 1 chain structure. Full experimental information is available from [http://oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2IGR OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:019428759<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Wu, J M.]]		[[Category: Wu, J M.]]
	[[Category: Anticancer peptide]]		[[Category: Anticancer peptide]]

OCA: Protected "2igr" [edit=sysop:move=sysop]

2013-01-07T14:47:08Z

Protected "2igr" [edit=sysop:move=sysop]

← Older revision	Revision as of 14:47, 7 January 2013
(No difference)

OCA at 14:47, 7 January 2013

2013-01-07T14:47:05Z

← Older revision		Revision as of 14:47, 7 January 2013
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	[[Image:2igr.png\|left\|200px]]		[[Image:2igr.png\|left\|200px]]

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	{{STRUCTURE_2igr\| PDB=2igr \| SCENE= }}		{{STRUCTURE_2igr\| PDB=2igr \| SCENE= }}

	===Solution structure of CB1a, a novel anticancer peptide derived from natural antimicrobial peptide cecropin B===		===Solution structure of CB1a, a novel anticancer peptide derived from natural antimicrobial peptide cecropin B===


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	{{ABSTRACT_PUBMED_19428759}}		{{ABSTRACT_PUBMED_19428759}}

	==About this Structure==		==About this Structure==
	~~2IGR~~ is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IGR OCA].		[[2igr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IGR OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~19428759~~</ref><references group="xtra"/>		<ref group="xtra">PMID:019428759</ref><references group="xtra"/>
	[[Category: Wu, J M.]]		[[Category: Wu, J M.]]
	[[Category: Anticancer peptide]]		[[Category: Anticancer peptide]]
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	[[Category: Lipid binding protein]]		[[Category: Lipid binding protein]]
	[[Category: Ploycationic peptide]]		[[Category: Ploycationic peptide]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 1 11:04:47 2010''~~