2ipt - Revision history

OCA at 01:04, 21 November 2024

2024-11-21T01:04:35Z

← Older revision		Revision as of 01:04, 21 November 2024
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ip/2ipt_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ip/2ipt_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 10:14, 30 August 2023

2023-08-30T10:14:47Z

← Older revision		Revision as of 10:14, 30 August 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ipt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IPT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IPT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ipt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IPT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IPT FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ACM:ACETAMIDE'>ACM</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2ipu\|2ipu]], [[2iq9\|2iq9]], [[2iqa\|2iqa]], [[2iqb\|2iqb]]~~</~~div~~></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACM:ACETAMIDE'>ACM</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ipt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ipt OCA], [https://pdbe.org/2ipt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ipt RCSB], [https://www.ebi.ac.uk/pdbsum/2ipt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ipt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ipt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ipt OCA], [https://pdbe.org/2ipt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ipt RCSB], [https://www.ebi.ac.uk/pdbsum/2ipt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ipt ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/A2NHM3_MOUSE A2NHM3_MOUSE]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Dealwis, C]]		[[Category: Dealwis C]]
	[[Category: Gardberg~~, A S]]~~		[[Category: Gardberg AS]]
	~~[[Category: Abeta]]~~
	~~[[Category: Cdr]]~~
	~~[[Category: Immune system]]~~
	~~[[Category: Wwddd~~]]

OCA at 10:30, 12 January 2022

2022-01-12T10:30:18Z

← Older revision		Revision as of 10:30, 12 January 2022
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	<StructureSection load='2ipt' size='340' side='right'caption='[[2ipt]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2ipt' size='340' side='right'caption='[[2ipt]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ipt]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IPT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2IPT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ipt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IPT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IPT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACM:ACETAMIDE'>ACM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACM:ACETAMIDE'>ACM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ipu\|2ipu]], [[2iq9\|2iq9]], [[2iqa\|2iqa]], [[2iqb\|2iqb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ipu\|2ipu]], [[2iq9\|2iq9]], [[2iqa\|2iqa]], [[2iqb\|2iqb]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2ipt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ipt OCA], [~~http~~://pdbe.org/2ipt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ipt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ipt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ipt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ipt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ipt OCA], [https://pdbe.org/2ipt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ipt RCSB], [https://www.ebi.ac.uk/pdbsum/2ipt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ipt ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	==See Also==		==See Also==
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
			*[[Sandbox 20009\|Sandbox 20009]]
			*[[3D structures of non-human antibody\|3D structures of non-human antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:48, 8 April 2020

2020-04-08T07:48:47Z

← Older revision		Revision as of 07:48, 8 April 2020
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	==PFA1 Fab Fragment==		==PFA1 Fab Fragment==
	<StructureSection load='2ipt' size='340' side='right' caption='[[2ipt]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2ipt' size='340' side='right'caption='[[2ipt]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ipt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IPT OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2IPT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ipt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IPT OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2IPT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACM:ACETAMIDE'>ACM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACM:ACETAMIDE'>ACM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ipu\|2ipu]], [[2iq9\|2iq9]], [[2iqa\|2iqa]], [[2iqb\|2iqb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ipu\|2ipu]], [[2iq9\|2iq9]], [[2iqa\|2iqa]], [[2iqb\|2iqb]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ipt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ipt OCA], [http://pdbe.org/2ipt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ipt RCSB], [http://www.ebi.ac.uk/pdbsum/2ipt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ipt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2ipt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ipt OCA], [http://pdbe.org/2ipt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ipt RCSB], [http://www.ebi.ac.uk/pdbsum/2ipt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ipt ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Dealwis, C]]		[[Category: Dealwis, C]]

OCA at 08:24, 4 July 2018

2018-07-04T08:24:07Z

← Older revision		Revision as of 08:24, 4 July 2018
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	==PFA1 Fab Fragment==		==PFA1 Fab Fragment==
	<StructureSection load='2ipt' size='340' side='right' caption='[[2ipt]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2ipt' size='340' side='right' caption='[[2ipt]], [[Resolution\|resolution]] 2.00Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACM:ACETAMIDE'>ACM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACM:ACETAMIDE'>ACM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ipu\|2ipu]], [[2iq9\|2iq9]], [[2iqa\|2iqa]], [[2iqb\|2iqb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ipu\|2ipu]], [[2iq9\|2iq9]], [[2iqa\|2iqa]], [[2iqb\|2iqb]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ipt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ipt OCA], [http://pdbe.org/2ipt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ipt RCSB], [http://www.ebi.ac.uk/pdbsum/2ipt PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ipt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ipt OCA], [http://pdbe.org/2ipt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ipt RCSB], [http://www.ebi.ac.uk/pdbsum/2ipt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ipt ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ip/2ipt_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ip/2ipt_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	==See Also==		==See Also==
	*[[Antibody\|Antibody]]		*[[Antibody 3D structures\|Antibody 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:51, 8 February 2016

2016-02-08T09:51:10Z

← Older revision		Revision as of 09:51, 8 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ipt ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:23, 10 September 2015

2015-09-10T10:23:31Z

← Older revision		Revision as of 10:23, 10 September 2015
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACM:ACETAMIDE'>ACM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACM:ACETAMIDE'>ACM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ipu\|2ipu]], [[2iq9\|2iq9]], [[2iqa\|2iqa]], [[2iqb\|2iqb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ipu\|2ipu]], [[2iq9\|2iq9]], [[2iqa\|2iqa]], [[2iqb\|2iqb]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ipt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ipt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ipt RCSB], [http://www.ebi.ac.uk/pdbsum/2ipt PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ipt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ipt OCA], [http://pdbe.org/2ipt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ipt RCSB], [http://www.ebi.ac.uk/pdbsum/2ipt PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2ipt" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 08:28, 16 January 2015

2015-01-16T08:28:12Z

← Older revision		Revision as of 08:28, 16 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ipt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IPT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IPT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ipt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IPT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IPT FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACM:ACETAMIDE'>ACM</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACM:ACETAMIDE'>ACM</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ipu\|2ipu]], [[2iq9\|2iq9]], [[2iqa\|2iqa]], [[2iqb\|2iqb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ipu\|2ipu]], [[2iq9\|2iq9]], [[2iqa\|2iqa]], [[2iqb\|2iqb]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ipt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ipt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ipt RCSB], [http://www.ebi.ac.uk/pdbsum/2ipt PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ipt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ipt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ipt RCSB], [http://www.ebi.ac.uk/pdbsum/2ipt PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Dealwis, C.]]		[[Category: Dealwis, C]]
	[[Category: Gardberg, A S.]]		[[Category: Gardberg, A S]]
	[[Category: Abeta]]		[[Category: Abeta]]
	[[Category: Cdr]]		[[Category: Cdr]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Wwddd]]		[[Category: Wwddd]]

OCA at 02:30, 29 September 2014

2014-09-29T02:30:41Z

← Older revision		Revision as of 02:30, 29 September 2014
Line 1:		Line 1:
	[[Image:~~2ipt~~.~~png~~\|~~left~~\|~~200px~~]]		==PFA1 Fab Fragment==
			<StructureSection load='2ipt' size='340' side='right' caption='[[2ipt]], [[Resolution\|resolution]] 2.00Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2ipt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IPT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IPT FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACM:ACETAMIDE'>ACM</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ipu\|2ipu]], [[2iq9\|2iq9]], [[2iqa\|2iqa]], [[2iqb\|2iqb]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ipt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ipt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ipt RCSB], [http://www.ebi.ac.uk/pdbsum/2ipt PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ip/2ipt_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Amyloid aggregates of the amyloid-beta (Abeta) peptide are implicated in the pathology of Alzheimer's disease. Anti-Abeta monoclonal antibodies (mAbs) have been shown to reduce amyloid plaques in vitro and in animal studies. Consequently, passive immunization is being considered for treating Alzheimer's, and anti-Abeta mAbs are now in phase II trials. We report the isolation of two mAbs (PFA1 and PFA2) that recognize Abeta monomers, protofibrils, and fibrils and the structures of their antigen binding fragments (Fabs) in complex with the Abeta(1-8) peptide DAEFRHDS. The immunodominant EFRHD sequence forms salt bridges, hydrogen bonds, and hydrophobic contacts, including interactions with a striking WWDDD motif of the antigen binding fragments. We also show that a similar sequence (AKFRHD) derived from the human protein GRIP1 is able to cross-react with both PFA1 and PFA2 and, when cocrystallized with PFA1, binds in an identical conformation to Abeta(1-8). Because such cross-reactivity has implications for potential side effects of immunotherapy, our structures provide a template for designing derivative mAbs that target Abeta with improved specificity and higher affinity.

	~~{{STRUCTURE_2ipt\| PDB=2ipt \| SCENE= }}~~		Molecular basis for passive immunotherapy of Alzheimer's disease.,Gardberg AS, Dice LT, Ou S, Rich RL, Helmbrecht E, Ko J, Wetzel R, Myszka DG, Patterson PH, Dealwis C Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15659-64. Epub 2007 Sep 25. PMID:17895381<ref>PMID:17895381</ref>

	~~===PFA1 Fab Fragment===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_17895381}}~~

	~~==About this Structure==~~
	~~[[2ipt]] is~~ a ~~2 chain structure with sequence from [http://en.wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann.ac.il/oca-bin~~/~~ocashort?id=2IPT OCA].~~

	==See Also==		==See Also==
	*[[Antibody\|Antibody]]		*[[Antibody\|Antibody]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:017895381<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Dealwis, C.]]		[[Category: Dealwis, C.]]

OCA at 09:45, 20 October 2012

2012-10-20T09:45:47Z

← Older revision		Revision as of 09:45, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[2ipt]] is a 2 chain structure ~~of [[Antibody]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IPT OCA].		[[2ipt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IPT OCA].

	==See Also==		==See Also==