2ius - Revision history

OCA at 09:29, 9 May 2024

2024-05-09T09:29:46Z

← Older revision		Revision as of 09:29, 9 May 2024
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	<StructureSection load='2ius' size='340' side='right'caption='[[2ius]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2ius' size='340' side='right'caption='[[2ius]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ius]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IUS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IUS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ius]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IUS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IUS FirstGlance]. <br>
	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[2iuu\|2iuu]]~~, [[~~2iut~~\|~~2iut~~]]~~</div>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ius FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ius OCA], [https://pdbe.org/2ius PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ius RCSB], [https://www.ebi.ac.uk/pdbsum/2ius PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ius ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ius FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ius OCA], [https://pdbe.org/2ius PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ius RCSB], [https://www.ebi.ac.uk/pdbsum/2ius PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ius ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/FTSK_ECOLI FTSK_ECOLI]] Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif. Stoppage of translocation is accompanied by a reduction in ATPase activity. Also stimulates topoisomerase 4 activity. Required for the targeting of FtsQ, FtsL and FtsI to the septum.<ref>PMID:9829960</ref> <ref>PMID:9723913</ref> <ref>PMID:11703663</ref> <ref>PMID:11832210</ref> <ref>PMID:15522074</ref> <ref>PMID:16553881</ref> <ref>PMID:18363794</ref> <ref>PMID:19246541</ref> <ref>PMID:19854947</ref> <ref>PMID:20081205</ref> <ref>PMID:21371996</ref>		[https://www.uniprot.org/uniprot/FTSK_ECOLI FTSK_ECOLI] Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif. Stoppage of translocation is accompanied by a reduction in ATPase activity. Also stimulates topoisomerase 4 activity. Required for the targeting of FtsQ, FtsL and FtsI to the septum.<ref>PMID:9829960</ref> <ref>PMID:9723913</ref> <ref>PMID:11703663</ref> <ref>PMID:11832210</ref> <ref>PMID:15522074</ref> <ref>PMID:16553881</ref> <ref>PMID:18363794</ref> <ref>PMID:19246541</ref> <ref>PMID:19854947</ref> <ref>PMID:20081205</ref> <ref>PMID:21371996</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]		[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Lowe, J]]		[[Category: Lowe J]]
	[[Category: Massey~~, T H~~]]		[[Category: Massey TH]]
	[[Category: Mercogliano~~, C P~~]]		[[Category: Mercogliano CP]]
	[[Category: Sherratt~~, D J~~]]		[[Category: Sherratt DJ]]
	[[Category: Yates, J]]		[[Category: Yates J]]
	~~[[Category: Aaa atpase]]~~
	~~[[Category: Atp-binding]]~~
	~~[[Category: Cell cycle]]~~
	~~[[Category: Cell division]]~~
	~~[[Category: Chromosome partition]]~~
	~~[[Category: Divisome]]~~
	~~[[Category: Dna translocation]]~~
	~~[[Category: Dna-binding]]~~
	~~[[Category: Hexameric ring]]~~
	~~[[Category: Inner membrane]]~~
	~~[[Category: Kop]]~~
	~~[[Category: Membrane]]~~
	~~[[Category: Membrane protein]]~~
	~~[[Category: Nucleotide-binding]]~~
	~~[[Category: Transmembrane~~]]

OCA at 10:32, 12 January 2022

2022-01-12T10:32:48Z

← Older revision		Revision as of 10:32, 12 January 2022
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	<StructureSection load='2ius' size='340' side='right'caption='[[2ius]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2ius' size='340' side='right'caption='[[2ius]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ius]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IUS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2IUS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ius]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IUS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IUS FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iuu\|2iuu]], [[2iut\|2iut]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2iuu\|2iuu]], [[2iut\|2iut]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2ius FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ius OCA], [~~http~~://pdbe.org/2ius PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ius RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ius PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ius ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ius FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ius OCA], [https://pdbe.org/2ius PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ius RCSB], [https://www.ebi.ac.uk/pdbsum/2ius PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ius ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/FTSK_ECOLI FTSK_ECOLI]] Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif. Stoppage of translocation is accompanied by a reduction in ATPase activity. Also stimulates topoisomerase 4 activity. Required for the targeting of FtsQ, FtsL and FtsI to the septum.<ref>PMID:9829960</ref> <ref>PMID:9723913</ref> <ref>PMID:11703663</ref> <ref>PMID:11832210</ref> <ref>PMID:15522074</ref> <ref>PMID:16553881</ref> <ref>PMID:18363794</ref> <ref>PMID:19246541</ref> <ref>PMID:19854947</ref> <ref>PMID:20081205</ref> <ref>PMID:21371996</ref>		[[https://www.uniprot.org/uniprot/FTSK_ECOLI FTSK_ECOLI]] Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif. Stoppage of translocation is accompanied by a reduction in ATPase activity. Also stimulates topoisomerase 4 activity. Required for the targeting of FtsQ, FtsL and FtsI to the septum.<ref>PMID:9829960</ref> <ref>PMID:9723913</ref> <ref>PMID:11703663</ref> <ref>PMID:11832210</ref> <ref>PMID:15522074</ref> <ref>PMID:16553881</ref> <ref>PMID:18363794</ref> <ref>PMID:19246541</ref> <ref>PMID:19854947</ref> <ref>PMID:20081205</ref> <ref>PMID:21371996</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:51, 8 April 2020

2020-04-08T07:51:36Z

← Older revision		Revision as of 07:51, 8 April 2020
Line 1:		Line 1:

	==E. coli FtsK motor domain==		==E. coli FtsK motor domain==
	<StructureSection load='2ius' size='340' side='right' caption='[[2ius]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2ius' size='340' side='right'caption='[[2ius]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ius]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IUS OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2IUS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ius]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IUS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2IUS FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iuu\|2iuu]], [[2iut\|2iut]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iuu\|2iuu]], [[2iut\|2iut]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ius FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ius OCA], [http://pdbe.org/2ius PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ius RCSB], [http://www.ebi.ac.uk/pdbsum/2ius PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ius ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2ius FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ius OCA], [http://pdbe.org/2ius PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ius RCSB], [http://www.ebi.ac.uk/pdbsum/2ius PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ius ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
			[[Category: Large Structures]]
	[[Category: Lowe, J]]		[[Category: Lowe, J]]
	[[Category: Massey, T H]]		[[Category: Massey, T H]]

OCA at 08:17, 4 July 2018

2018-07-04T08:17:07Z

← Older revision		Revision as of 08:17, 4 July 2018
Line 1:		Line 1:
	==E. ~~COLI FTSK MOTOR DOMAIN~~==
			==E. coli FtsK motor domain==
	<StructureSection load='2ius' size='340' side='right' caption='[[2ius]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2ius' size='340' side='right' caption='[[2ius]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ius]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IUS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IUS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ius]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IUS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IUS FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iuu\|2iuu]], [[2iut\|2iut]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iuu\|2iuu]], [[2iut\|2iut]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ius FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ius OCA], [http://pdbe.org/2ius PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ius RCSB], [http://www.ebi.ac.uk/pdbsum/2ius PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ius FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ius OCA], [http://pdbe.org/2ius PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ius RCSB], [http://www.ebi.ac.uk/pdbsum/2ius PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ius ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iu/2ius_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iu/2ius_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 04:37, 9 February 2016

2016-02-09T04:37:04Z

← Older revision		Revision as of 04:37, 9 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ius ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 18:41, 10 September 2015

2015-09-10T18:41:56Z

← Older revision		Revision as of 18:41, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2ius' size='340' side='right' caption='[[2ius]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2ius' size='340' side='right' caption='[[2ius]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ius]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IUS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IUS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ius]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IUS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IUS FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iuu\|2iuu]], [[2iut\|2iut]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iuu\|2iuu]], [[2iut\|2iut]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ius FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ius OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ius RCSB], [http://www.ebi.ac.uk/pdbsum/2ius PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ius FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ius OCA], [http://pdbe.org/2ius PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ius RCSB], [http://www.ebi.ac.uk/pdbsum/2ius PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2ius" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Escherichia~~ coli]]		[[Category: Bacillus coli migula 1895]]
	[[Category: Lowe, J]]		[[Category: Lowe, J]]
	[[Category: Massey, T H]]		[[Category: Massey, T H]]

OCA at 04:28, 25 December 2014

2014-12-25T04:28:01Z

← Older revision		Revision as of 04:28, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ius]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IUS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IUS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ius]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IUS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IUS FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iuu\|2iuu]], [[2iut\|2iut]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iuu\|2iuu]], [[2iut\|2iut]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ius FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ius OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ius RCSB], [http://www.ebi.ac.uk/pdbsum/2ius PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ius FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ius OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ius RCSB], [http://www.ebi.ac.uk/pdbsum/2ius PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/FTSK_ECOLI FTSK_ECOLI]] Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif. Stoppage of translocation is accompanied by a reduction in ATPase activity. Also stimulates topoisomerase 4 activity. Required for the targeting of FtsQ, FtsL and FtsI to the septum.<ref>PMID:9829960</ref> <ref>PMID:9723913</ref> <ref>PMID:11703663</ref> <ref>PMID:11832210</ref> <ref>PMID:15522074</ref> <ref>PMID:16553881</ref> <ref>PMID:18363794</ref> <ref>PMID:19246541</ref> <ref>PMID:19854947</ref> <ref>PMID:20081205</ref> <ref>PMID:21371996</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Lowe, J.]]		[[Category: Lowe, J]]
	[[Category: Massey, T H.]]		[[Category: Massey, T H]]
	[[Category: Mercogliano, C P.]]		[[Category: Mercogliano, C P]]
	[[Category: Sherratt, D J.]]		[[Category: Sherratt, D J]]
	[[Category: Yates, J.]]		[[Category: Yates, J]]
	[[Category: Aaa atpase]]		[[Category: Aaa atpase]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]

OCA at 10:40, 30 September 2014

2014-09-30T10:40:30Z

← Older revision		Revision as of 10:40, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2ius~~.~~png~~\|~~left~~\|~~200px~~]]		==E. COLI FTSK MOTOR DOMAIN==
			<StructureSection load='2ius' size='340' side='right' caption='[[2ius]], [[Resolution\|resolution]] 2.70Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2ius]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IUS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IUS FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iuu\|2iuu]], [[2iut\|2iut]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ius FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ius OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ius RCSB], [http://www.ebi.ac.uk/pdbsum/2ius PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iu/2ius_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			FtsK is a DNA translocase that coordinates chromosome segregation and cell division in bacteria. In addition to its role as activator of XerCD site-specific recombination, FtsK can translocate double-stranded DNA (dsDNA) rapidly and directionally and reverse direction. We present crystal structures of the FtsK motor domain monomer, showing that it has a RecA-like core, the FtsK hexamer, and also showing that it is a ring with a large central annulus and a dodecamer consisting of two hexamers, head to head. Electron microscopy (EM) demonstrates the DNA-dependent existence of hexamers in solution and shows that duplex DNA passes through the middle of each ring. Comparison of FtsK monomer structures from two different crystal forms highlights a conformational change that we propose is the structural basis for a rotary inchworm mechanism of DNA translocation.

	~~{{STRUCTURE_2ius\| PDB=2ius \| SCENE= }}~~		Double-stranded DNA translocation: structure and mechanism of hexameric FtsK.,Massey TH, Mercogliano CP, Yates J, Sherratt DJ, Lowe J Mol Cell. 2006 Aug;23(4):457-69. PMID:16916635<ref>PMID:16916635</ref>

	~~===E. COLI FTSK MOTOR DOMAIN===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16916635}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2ius]] is~~ a ~~6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2IUS OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:016916635<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Lowe, J.]]		[[Category: Lowe, J.]]

OCA: Protected "2ius" [edit=sysop:move=sysop]

2013-01-07T12:29:32Z

Protected "2ius" [edit=sysop:move=sysop]

← Older revision	Revision as of 12:29, 7 January 2013
(No difference)

OCA at 12:29, 7 January 2013

2013-01-07T12:29:28Z

← Older revision		Revision as of 12:29, 7 January 2013
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	~~{{Seed}}~~
	[[Image:2ius.png\|left\|200px]]		[[Image:2ius.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2ius", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2ius\| PDB=2ius \| SCENE= }}		{{STRUCTURE_2ius\| PDB=2ius \| SCENE= }}

	===E. COLI FTSK MOTOR DOMAIN===		===E. COLI FTSK MOTOR DOMAIN===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16916635}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 16916635 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_16916635}}		{{ABSTRACT_PUBMED_16916635}}

	==About this Structure==		==About this Structure==
	~~2IUS~~ is a 6 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IUS OCA].		[[2ius]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IUS OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16916635~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016916635</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Lowe, J.]]		[[Category: Lowe, J.]]
Line 45:		Line 33:
	[[Category: Nucleotide-binding]]		[[Category: Nucleotide-binding]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 06:31:44 2009''~~