2ixt - Revision history

OCA at 07:40, 9 October 2024

2024-10-09T07:40:33Z

← Older revision		Revision as of 07:40, 9 October 2024
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ix/2ixt_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ix/2ixt_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 14:29, 13 December 2023

2023-12-13T14:29:11Z

← Older revision		Revision as of 14:29, 13 December 2023
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	<StructureSection load='2ixt' size='340' side='right'caption='[[2ixt]], [[Resolution\|resolution]] 0.80Å' scene=''>		<StructureSection load='2ixt' size='340' side='right'caption='[[2ixt]], [[Resolution\|resolution]] 0.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ixt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Bacillus_sphaericus Bacillus~~ sphaericus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IXT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ixt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lysinibacillus_sphaericus Lysinibacillus sphaericus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IXT FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 0.8Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1ea7\|1ea7]]~~</~~div~~></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ixt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ixt OCA], [https://pdbe.org/2ixt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ixt RCSB], [https://www.ebi.ac.uk/pdbsum/2ixt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ixt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ixt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ixt OCA], [https://pdbe.org/2ixt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ixt RCSB], [https://www.ebi.ac.uk/pdbsum/2ixt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ixt ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/Q9S3L6_LYSSH Q9S3L6_LYSSH]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Bacillus sphaericus]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Almog, O~~]]		[[Category: Lysinibacillus sphaericus]]
	[[Category: ~~Godin, N~~]]		[[Category: Almog O]]
	[[Category: ~~Gonzalez, A~~]]		[[Category: Godin N]]
	[[Category: ~~Hydrolase]]~~		[[Category: Gonzalez A]]
	~~[[Category: Serine protease]]~~
	~~[[Category: Subtilisin like protease~~]]

OCA at 10:05, 12 May 2021

2021-05-12T10:05:54Z

← Older revision		Revision as of 10:05, 12 May 2021
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	<StructureSection load='2ixt' size='340' side='right'caption='[[2ixt]], [[Resolution\|resolution]] 0.80Å' scene=''>		<StructureSection load='2ixt' size='340' side='right'caption='[[2ixt]], [[Resolution\|resolution]] 0.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ixt]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bacillus_sphaericus Bacillus sphaericus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2IXT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ixt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_sphaericus Bacillus sphaericus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IXT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ea7\|1ea7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ea7\|1ea7]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ixt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ixt OCA], [~~http~~://pdbe.org/2ixt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ixt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ixt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ixt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ixt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ixt OCA], [https://pdbe.org/2ixt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ixt RCSB], [https://www.ebi.ac.uk/pdbsum/2ixt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ixt ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	==See Also==		==See Also==
	*[[Subtilisin\|Subtilisin]]		*[[Subtilisin 3D structures\|Subtilisin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:21, 24 July 2019

2019-07-24T07:21:19Z

← Older revision		Revision as of 07:21, 24 July 2019
Line 1:		Line 1:

	==SPHERICASE==		==SPHERICASE==
	<StructureSection load='2ixt' size='340' side='right' caption='[[2ixt]], [[Resolution\|resolution]] 0.80Å' scene=''>		<StructureSection load='2ixt' size='340' side='right'caption='[[2ixt]], [[Resolution\|resolution]] 0.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ixt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_sphaericus Bacillus sphaericus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IXT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ixt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_sphaericus Bacillus sphaericus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IXT FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Bacillus sphaericus]]		[[Category: Bacillus sphaericus]]
			[[Category: Large Structures]]
	[[Category: Almog, O]]		[[Category: Almog, O]]
	[[Category: Godin, N]]		[[Category: Godin, N]]

OCA at 07:18, 11 July 2018

2018-07-11T07:18:17Z

← Older revision		Revision as of 07:18, 11 July 2018
Line 1:		Line 1:

	==SPHERICASE==		==SPHERICASE==
	<StructureSection load='2ixt' size='340' side='right' caption='[[2ixt]], [[Resolution\|resolution]] 0.80Å' scene=''>		<StructureSection load='2ixt' size='340' side='right' caption='[[2ixt]], [[Resolution\|resolution]] 0.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ixt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Lysinibacillus_sphaericus Lysinibacillus~~ sphaericus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IXT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ixt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_sphaericus Bacillus sphaericus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IXT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ea7\|1ea7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ea7\|1ea7]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ixt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ixt OCA], [http://pdbe.org/2ixt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ixt RCSB], [http://www.ebi.ac.uk/pdbsum/2ixt PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ixt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ixt OCA], [http://pdbe.org/2ixt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ixt RCSB], [http://www.ebi.ac.uk/pdbsum/2ixt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ixt ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ix/2ixt_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ix/2ixt_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Lysinibacillus~~ sphaericus]]		[[Category: Bacillus sphaericus]]
	[[Category: Almog, O]]		[[Category: Almog, O]]
	[[Category: Godin, N]]		[[Category: Godin, N]]

OCA at 21:18, 9 February 2016

2016-02-09T21:18:24Z

← Older revision		Revision as of 21:18, 9 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ixt ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 02:07, 11 September 2015

2015-09-11T02:07:37Z

← Older revision		Revision as of 02:07, 11 September 2015
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ea7\|1ea7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ea7\|1ea7]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ixt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ixt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ixt RCSB], [http://www.ebi.ac.uk/pdbsum/2ixt PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ixt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ixt OCA], [http://pdbe.org/2ixt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ixt RCSB], [http://www.ebi.ac.uk/pdbsum/2ixt PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2ixt" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 14:29, 19 January 2015

2015-01-19T14:29:10Z

← Older revision		Revision as of 14:29, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ixt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lysinibacillus_sphaericus Lysinibacillus sphaericus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IXT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ixt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lysinibacillus_sphaericus Lysinibacillus sphaericus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IXT FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ea7\|1ea7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ea7\|1ea7]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ixt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ixt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ixt RCSB], [http://www.ebi.ac.uk/pdbsum/2ixt PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ixt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ixt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ixt RCSB], [http://www.ebi.ac.uk/pdbsum/2ixt PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Lysinibacillus sphaericus]]		[[Category: Lysinibacillus sphaericus]]
	[[Category: Almog, O.]]		[[Category: Almog, O]]
	[[Category: Godin, N.]]		[[Category: Godin, N]]
	[[Category: Gonzalez, A.]]		[[Category: Gonzalez, A]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Serine protease]]		[[Category: Serine protease]]
	[[Category: Subtilisin like protease]]		[[Category: Subtilisin like protease]]

OCA at 04:52, 29 September 2014

2014-09-29T04:52:32Z

← Older revision		Revision as of 04:52, 29 September 2014
Line 1:		Line 1:
	[[Image:~~2ixt~~.~~png~~\|~~left~~\|~~200px~~]]		==SPHERICASE==
			<StructureSection load='2ixt' size='340' side='right' caption='[[2ixt]], [[Resolution\|resolution]] 0.80Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2ixt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lysinibacillus_sphaericus Lysinibacillus sphaericus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IXT FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ea7\|1ea7]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ixt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ixt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ixt RCSB], [http://www.ebi.ac.uk/pdbsum/2ixt PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ix/2ixt_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			We determine and compare the crystal structure of two proteases belonging to the subtilisin superfamily: S41, a cold-adapted serine protease produced by Antarctic bacilli, at 1.4 A resolution and Sph, a mesophilic serine protease produced by Bacillus sphaericus, at 0.8 A resolution. The purpose of this comparison was to find out whether multiple calcium ion binding is a molecular factor responsible for the adaptation of S41 to extreme low temperatures. We find that these two subtilisins have the same subtilisin fold with a root mean square between the two structures of 0.54 A. The final models for S41 and Sph include a calcium-loaded state of five ions bound to each of these two subtilisin molecules. None of these calcium-binding sites correlate with the high affinity known binding site (site A) found for other subtilisins. Structural analysis of the five calcium-binding sites found in these two crystal structures indicate that three of the binding sites have two side chains of an acidic residue coordinating the calcium ion, whereas the other two binding sites have either a main-chain carbonyl, or only one acidic residue side chain coordinating the calcium ion. Thus, we conclude that three of the sites are of high affinity toward calcium ions, whereas the other two are of low affinity. Because Sph is a mesophilic subtilisin and S41 is a psychrophilic subtilisin, but both crystal structures were found to bind five calcium ions, we suggest that multiple calcium ion binding is not responsible for the adaptation of S41 to low temperatures.

	~~{{STRUCTURE_2ixt\| PDB=2ixt \| SCENE= }}~~		The crystal structures of the psychrophilic subtilisin S41 and the mesophilic subtilisin Sph reveal the same calcium-loaded state.,Almog O, Gonzalez A, Godin N, de Leeuw M, Mekel MJ, Klein D, Braun S, Shoham G, Walter RL Proteins. 2009 Feb 1;74(2):489-96. PMID:18655058<ref>PMID:18655058</ref>

	~~===SPHERICASE===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_18655058}}~~

	~~==About this Structure==~~
	~~[[2ixt]] is~~ a ~~2 chain structure with sequence from [http://en.wikipedia~~.~~org/wiki/Lysinibacillus_sphaericus Lysinibacillus sphaericus]~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann.ac.il/oca-bin~~/~~ocashort?id=2IXT OCA].~~

	==See Also==		==See Also==
	*[[Subtilisin\|Subtilisin]]		*[[Subtilisin\|Subtilisin]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:018655058<~~/~~ref~~><~~ref group="xtra">PMID:014499610</ref><references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Lysinibacillus sphaericus]]		[[Category: Lysinibacillus sphaericus]]
	[[Category: Almog, O.]]		[[Category: Almog, O.]]

OCA at 15:10, 20 October 2012

2012-10-20T15:10:24Z

← Older revision		Revision as of 15:10, 20 October 2012
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	==About this Structure==		==About this Structure==
	[[2ixt]] is a 2 chain structure ~~of [[Subtilisin]]~~ with sequence from [http://en.wikipedia.org/wiki/Lysinibacillus_sphaericus Lysinibacillus sphaericus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXT OCA].		[[2ixt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lysinibacillus_sphaericus Lysinibacillus sphaericus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXT OCA].

	==See Also==		==See Also==