2j4e - Revision history

OCA at 14:33, 13 December 2023

2023-12-13T14:33:54Z

← Older revision		Revision as of 14:33, 13 December 2023
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	<StructureSection load='2j4e' size='340' side='right'caption='[[2j4e]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2j4e' size='340' side='right'caption='[[2j4e]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2j4e]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[2j4e]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J4E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=ITT:INOSINE+5-TRIPHOSPHATE'>ITT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2car\|2car]]</div></td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=ITT:INOSINE+5-TRIPHOSPHATE'>ITT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Nucleoside-triphosphate_diphosphatase Nucleoside-triphosphate diphosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.19 3.6.1.19] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j4e OCA], [https://pdbe.org/2j4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j4e RCSB], [https://www.ebi.ac.uk/pdbsum/2j4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j4e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j4e OCA], [https://pdbe.org/2j4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j4e RCSB], [https://www.ebi.ac.uk/pdbsum/2j4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j4e ProSAT]</span></td></tr>
	</table>		</table>
			== Disease ==
			[https://www.uniprot.org/uniprot/ITPA_HUMAN ITPA_HUMAN] Defects in ITPA are the cause of inosine triphosphate pyrophosphohydrolase deficiency (ITPAD) [MIM:[https://omim.org/entry/613850 613850]. It is a common inherited trait characterized by the abnormal accumulation of inosine triphosphate (ITP) in erythrocytes and also leukocytes and fibroblasts. The pathological consequences of ITPA deficiency, if any, are unknown. However, it might have pharmacogenomic implications and be related to increased drug toxicity of purine analog drugs. Note=Three different human populations have been reported with respect to their ITPase activity: high, mean (25% of high) and low activity. The variant Thr-32 is associated with complete loss of enzyme activity, may be by altering the local secondary structure of the protein. Heterozygotes for this polymorphism have 22.5% of the control activity: this is consistent with a dimeric structure of the enzyme.[:]<ref>PMID:12384777</ref> <ref>PMID:12436200</ref>
			== Function ==
			[https://www.uniprot.org/uniprot/ITPA_HUMAN ITPA_HUMAN] Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.<ref>PMID:17090528</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Nucleoside-triphosphate diphosphatase]]~~		[[Category: Arrowsmith C]]
	[[Category: Arrowsmith, C]]		[[Category: Berglund H]]
	~~[[Category: Berg, S Van Den~~]]		[[Category: Busam R]]
	[[Category: Berglund, H]]		[[Category: Collins R]]
	[[Category: Busam, R]]		[[Category: Edwards A]]
	[[Category: Collins, R]]		[[Category: Ehn M]]
	[[Category: Edwards, A]]		[[Category: Flodin S]]
	[[Category: Ehn, M]]		[[Category: Flores A]]
	[[Category: Flodin, S]]		[[Category: Graslund S]]
	[[Category: Flores, A]]		[[Category: Hallberg BM]]
	[[Category: Graslund, S]]		[[Category: Hammarstrom M]]
	[[Category: Hallberg~~, B M~~]]		[[Category: Hogbom M]]
	[[Category: Hammarstrom, M]]		[[Category: Holmbergschiavone L]]
	[[Category: Hogbom, M]]		[[Category: Kotenyova T]]
	[[Category: Holmbergschiavone, L]]		[[Category: Kursula P]]
	[[Category: Kotenyova, T]]		[[Category: Landry R]]
	[[Category: Kursula, P]]		[[Category: Loppnau P]]
	[[Category: Landry, R]]		[[Category: Magnusdottir A]]
	[[Category: Loppnau, P]]		[[Category: Nilsson-Ehle P]]
	[[Category: Magnusdottir, A]]		[[Category: Nordlund P]]
	[[Category: Nilsson-Ehle, P]]		[[Category: Nyman T]]
	[[Category: Nordlund, P]]		[[Category: Ogg D]]
	[[Category: Nyman, T]]		[[Category: Persson C]]
	[[Category: Ogg, D]]		[[Category: Sagemark J]]
	[[Category: Persson, C]]		[[Category: Schuler H]]
	[[Category: Sagemark, J]]		[[Category: Stenmark P]]
	[[Category: Schuler, H]]		[[Category: Sundstrom M]]
	[[Category: Stenmark, P]]		[[Category: Thorsell AG]]
	[[Category: Sundstrom, M]]		[[Category: Uppenberg J]]
	[[Category: Thorsell~~, A G~~]]		[[Category: Van Den Berg S]]
	[[Category: Uppenberg, J]]		[[Category: Wallden K]]
	[[Category: ~~Wallden, K~~]]		[[Category: Weigelt J]]
	[[Category: ~~Weigelt, J~~]]
	[[Category: ~~Disease mutation]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: Imp]]~~
	~~[[Category: Inosine triphosphatase deficiency]]~~
	~~[[Category: Inosine triphosphate pyrophosphohydrolase]]~~
	~~[[Category: Itp]]~~
	~~[[Category: Nucleotide metabolism~~]]

OCA at 08:01, 19 January 2022

2022-01-19T08:01:17Z

← Older revision		Revision as of 08:01, 19 January 2022
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	<StructureSection load='2j4e' size='340' side='right'caption='[[2j4e]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2j4e' size='340' side='right'caption='[[2j4e]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2j4e]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J4E OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2J4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[2j4e]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J4E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=ITT:INOSINE+5-TRIPHOSPHATE'>ITT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=ITT:INOSINE+5-TRIPHOSPHATE'>ITT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2car\|2car]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2car\|2car]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Nucleoside-triphosphate_diphosphatase Nucleoside-triphosphate diphosphatase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.19 3.6.1.19] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Nucleoside-triphosphate_diphosphatase Nucleoside-triphosphate diphosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.19 3.6.1.19] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2j4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j4e OCA], [~~http~~://pdbe.org/2j4e PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2j4e RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2j4e PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2j4e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j4e OCA], [https://pdbe.org/2j4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j4e RCSB], [https://www.ebi.ac.uk/pdbsum/2j4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j4e ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:39, 15 April 2020

2020-04-15T07:39:45Z

← Older revision		Revision as of 07:39, 15 April 2020
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	==THE ITP COMPLEX OF HUMAN INOSINE TRIPHOSPHATASE==		==THE ITP COMPLEX OF HUMAN INOSINE TRIPHOSPHATASE==
	<StructureSection load='2j4e' size='340' side='right' caption='[[2j4e]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2j4e' size='340' side='right'caption='[[2j4e]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2j4e]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J4E OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2J4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[2j4e]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J4E OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2J4E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=ITT:INOSINE+5-TRIPHOSPHATE'>ITT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=ITT:INOSINE+5-TRIPHOSPHATE'>ITT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2car\|2car]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2car\|2car]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nucleoside-triphosphate_diphosphatase Nucleoside-triphosphate diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.19 3.6.1.19] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nucleoside-triphosphate_diphosphatase Nucleoside-triphosphate diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.19 3.6.1.19] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2j4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j4e OCA], [http://pdbe.org/2j4e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j4e RCSB], [http://www.ebi.ac.uk/pdbsum/2j4e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2j4e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2j4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j4e OCA], [http://pdbe.org/2j4e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j4e RCSB], [http://www.ebi.ac.uk/pdbsum/2j4e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2j4e ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Nucleoside-triphosphate diphosphatase]]		[[Category: Nucleoside-triphosphate diphosphatase]]
	[[Category: Arrowsmith, C]]		[[Category: Arrowsmith, C]]

OCA at 06:38, 11 July 2018

2018-07-11T06:38:05Z

← Older revision		Revision as of 06:38, 11 July 2018
Line 1:		Line 1:

	==THE ITP COMPLEX OF HUMAN INOSINE TRIPHOSPHATASE==		==THE ITP COMPLEX OF HUMAN INOSINE TRIPHOSPHATASE==
	<StructureSection load='2j4e' size='340' side='right' caption='[[2j4e]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2j4e' size='340' side='right' caption='[[2j4e]], [[Resolution\|resolution]] 2.80Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2car\|2car]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2car\|2car]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nucleoside-triphosphate_diphosphatase Nucleoside-triphosphate diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.19 3.6.1.19] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nucleoside-triphosphate_diphosphatase Nucleoside-triphosphate diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.19 3.6.1.19] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j4e OCA], [http://pdbe.org/2j4e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j4e RCSB], [http://www.ebi.ac.uk/pdbsum/2j4e PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j4e OCA], [http://pdbe.org/2j4e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j4e RCSB], [http://www.ebi.ac.uk/pdbsum/2j4e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2j4e ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j4/2j4e_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j4/2j4e_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 05:46, 9 February 2016

2016-02-09T05:46:41Z

← Older revision		Revision as of 05:46, 9 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j4e ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 19:12, 10 September 2015

2015-09-10T19:12:58Z

← Older revision		Revision as of 19:12, 10 September 2015
Line 6:		Line 6:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2car\|2car]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2car\|2car]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nucleoside-triphosphate_diphosphatase Nucleoside-triphosphate diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.19 3.6.1.19] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nucleoside-triphosphate_diphosphatase Nucleoside-triphosphate diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.19 3.6.1.19] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j4e RCSB], [http://www.ebi.ac.uk/pdbsum/2j4e PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j4e OCA], [http://pdbe.org/2j4e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j4e RCSB], [http://www.ebi.ac.uk/pdbsum/2j4e PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2j4e" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:25, 19 January 2015

2015-01-19T13:25:23Z

← Older revision		Revision as of 13:25, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2j4e]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[2j4e]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J4E FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=ITT:INOSINE+5-TRIPHOSPHATE'>ITT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=ITT:INOSINE+5-TRIPHOSPHATE'>ITT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2car\|2car]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2car\|2car]]</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nucleoside-triphosphate_diphosphatase Nucleoside-triphosphate diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.19 3.6.1.19] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nucleoside-triphosphate_diphosphatase Nucleoside-triphosphate diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.19 3.6.1.19] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j4e RCSB], [http://www.ebi.ac.uk/pdbsum/2j4e PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j4e RCSB], [http://www.ebi.ac.uk/pdbsum/2j4e PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	[[Category: Human]]		[[Category: Human]]
	[[Category: Nucleoside-triphosphate diphosphatase]]		[[Category: Nucleoside-triphosphate diphosphatase]]
	[[Category: Arrowsmith, C.]]		[[Category: Arrowsmith, C]]
	[[Category: Berg, S Van Den.]]		[[Category: Berg, S Van Den]]
	[[Category: Berglund, H.]]		[[Category: Berglund, H]]
	[[Category: Busam, R.]]		[[Category: Busam, R]]
	[[Category: Collins, R.]]		[[Category: Collins, R]]
	[[Category: Edwards, A.]]		[[Category: Edwards, A]]
	[[Category: Ehn, M.]]		[[Category: Ehn, M]]
	[[Category: Flodin, S.]]		[[Category: Flodin, S]]
	[[Category: Flores, A.]]		[[Category: Flores, A]]
	[[Category: Graslund, S.]]		[[Category: Graslund, S]]
	[[Category: Hallberg, B M.]]		[[Category: Hallberg, B M]]
	[[Category: Hammarstrom, M.]]		[[Category: Hammarstrom, M]]
	[[Category: Hogbom, M.]]		[[Category: Hogbom, M]]
	[[Category: Holmbergschiavone, L.]]		[[Category: Holmbergschiavone, L]]
	[[Category: Kotenyova, T.]]		[[Category: Kotenyova, T]]
	[[Category: Kursula, P.]]		[[Category: Kursula, P]]
	[[Category: Landry, R.]]		[[Category: Landry, R]]
	[[Category: Loppnau, P.]]		[[Category: Loppnau, P]]
	[[Category: Magnusdottir, A.]]		[[Category: Magnusdottir, A]]
	[[Category: Nilsson-Ehle, P.]]		[[Category: Nilsson-Ehle, P]]
	[[Category: Nordlund, P.]]		[[Category: Nordlund, P]]
	[[Category: Nyman, T.]]		[[Category: Nyman, T]]
	[[Category: Ogg, D.]]		[[Category: Ogg, D]]
	[[Category: Persson, C.]]		[[Category: Persson, C]]
	[[Category: Sagemark, J.]]		[[Category: Sagemark, J]]
	[[Category: Schuler, H.]]		[[Category: Schuler, H]]
	[[Category: Stenmark, P.]]		[[Category: Stenmark, P]]
	[[Category: Sundstrom, M.]]		[[Category: Sundstrom, M]]
	[[Category: Thorsell, A G.]]		[[Category: Thorsell, A G]]
	[[Category: Uppenberg, J.]]		[[Category: Uppenberg, J]]
	[[Category: Wallden, K.]]		[[Category: Wallden, K]]
	[[Category: Weigelt, J.]]		[[Category: Weigelt, J]]
	[[Category: Disease mutation]]		[[Category: Disease mutation]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 05:18, 3 October 2014

2014-10-03T05:18:01Z

@@ Line 1: / Line 1: @@
-{{STRUCTURE_2j4e|  PDB=2j4e  |  SCENE=  }}
+==THE ITP COMPLEX OF HUMAN INOSINE TRIPHOSPHATASE==
-===THE ITP COMPLEX OF HUMAN INOSINE TRIPHOSPHATASE===
+<StructureSection load='2j4e' size='340' side='right' caption='[[2j4e]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-{{ABSTRACT_PUBMED_17138556}}
+== Structural highlights ==
-==About this Structure==
+Crystal structure of human inosine triphosphatase. Substrate binding and implication of the inosine triphosphatase deficiency mutation P32T.,Stenmark P, Kursula P, Flodin S, Graslund S, Landry R, Nordlund P, Schuler H J Biol Chem. 2007 Feb 2;282(5):3182-7. Epub 2006 Nov 29. PMID:17138556<ref>PMID:17138556</ref>
-==Reference==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<ref group="xtra">PMID:017138556</ref><references group="xtra"/><references/>
+</div>
 [[Category: Human]]
 [[Category: Nucleoside-triphosphate diphosphatase]]

OCA at 11:54, 20 November 2013

2013-11-20T11:54:09Z

← Older revision		Revision as of 11:54, 20 November 2013
Line 4:		Line 4:

	==About this Structure==		==About this Structure==
	[[2j4e]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J4E OCA].		[[2j4e]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J4E OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:017138556</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:017138556</ref><references group="xtra"/><references/>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Nucleoside-triphosphate diphosphatase]]		[[Category: Nucleoside-triphosphate diphosphatase]]
	[[Category: Arrowsmith, C.]]		[[Category: Arrowsmith, C.]]
Line 23:		Line 23:
	[[Category: Hammarstrom, M.]]		[[Category: Hammarstrom, M.]]
	[[Category: Hogbom, M.]]		[[Category: Hogbom, M.]]
			[[Category: Holmbergschiavone, L.]]
	[[Category: Kotenyova, T.]]		[[Category: Kotenyova, T.]]
	[[Category: Kursula, P.]]		[[Category: Kursula, P.]]
Line 34:		Line 35:
	[[Category: Persson, C.]]		[[Category: Persson, C.]]
	[[Category: Sagemark, J.]]		[[Category: Sagemark, J.]]
	~~[[Category: Schiavone, L Holmberg.]]~~
	[[Category: Schuler, H.]]		[[Category: Schuler, H.]]
	[[Category: Stenmark, P.]]		[[Category: Stenmark, P.]]

OCA at 03:22, 25 March 2013

2013-03-25T03:22:20Z

← Older revision		Revision as of 03:22, 25 March 2013
Line 1:		Line 1:
	~~[[Image:2j4e.png\|left\|200px]]~~

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2j4e", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2j4e\| PDB=2j4e \| SCENE= }}		{{STRUCTURE_2j4e\| PDB=2j4e \| SCENE= }}

	===THE ITP COMPLEX OF HUMAN INOSINE TRIPHOSPHATASE===		===THE ITP COMPLEX OF HUMAN INOSINE TRIPHOSPHATASE===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_17138556}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 17138556 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_17138556}}		{{ABSTRACT_PUBMED_17138556}}

Line 22:		Line 7:

	==Reference==		==Reference==
	<ref group="xtra">PMID:017138556</ref><references group="xtra"/>		<ref group="xtra">PMID:017138556</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Nucleoside-triphosphate diphosphatase]]		[[Category: Nucleoside-triphosphate diphosphatase]]