2j8a - Revision history

OCA at 09:35, 9 May 2024

2024-05-09T09:35:22Z

← Older revision		Revision as of 09:35, 9 May 2024
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	<StructureSection load='2j8a' size='340' side='right'caption='[[2j8a]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='2j8a' size='340' side='right'caption='[[2j8a]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2j8a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J8A FirstGlance]. <br>		<table><tr><td colspan='2'>[[2j8a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J8A FirstGlance]. <br>
	</td></tr><tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"~~><span class~~=~~'plainlinks'~~>~~[https://en.wikipedia.org/wiki/Histone-lysine_N~~-~~methyltransferase Histone-lysine N-methyltransferase]~~, ~~with EC number~~ [~~https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43~~] ~~</span>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j8a OCA], [https://pdbe.org/2j8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j8a RCSB], [https://www.ebi.ac.uk/pdbsum/2j8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j8a ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j8a OCA], [https://pdbe.org/2j8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j8a RCSB], [https://www.ebi.ac.uk/pdbsum/2j8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j8a ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/SET1_YEAST SET1_YEAST] Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.<ref>PMID:11742990</ref> <ref>PMID:11751634</ref> <ref>PMID:11752412</ref> <ref>PMID:11805083</ref> <ref>PMID:11818070</ref> <ref>PMID:12060701</ref> <ref>PMID:12353038</ref> <ref>PMID:12845608</ref> <ref>PMID:14636589</ref> <ref>PMID:15949446</ref> <ref>PMID:9398665</ref> <ref>PMID:9988274</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j8a ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j8a ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	The yeast Set1 histone H3 lysine 4 (H3K4) methyltransferase contains, in addition to its catalytic SET domain, a conserved RNA recognition motif (RRM1). We present here the crystal structure and the secondary structure assignment in solution of the Set1 RRM1. Although RRM1 has the expected betaalphabetabetaalphabeta RRM-fold, it lacks the typical RNA-binding features of these modules. RRM1 is not able to bind RNA by itself in vitro, but a construct combining RRM1 with a newly identified downstream RRM2 specifically binds RNA. In vivo, H3K4 methylation is not affected by a point mutation in RRM2 that preserves Set1 stability but affects RNA binding in vitro. In contrast mutating RRM1 destabilizes Set1 and leads to an increase of dimethylation of H3K4 at the 5'-coding region of active genes at the expense of trimethylation, whereas both, dimethylation decreases at the 3'-coding region. Taken together, our results suggest that Set1 RRMs bind RNA, but Set1 RNA-binding activity is not linked to H3K4 methylation.

	Structural characterization of Set1 RNA recognition motifs and their role in histone H3 lysine 4 methylation.,Tresaugues L, Dehe PM, Guerois R, Rodriguez-Gil A, Varlet I, Salah P, Pamblanco M, Luciano P, Quevillon-Cheruel S, Sollier J, Leulliot N, Couprie J, Tordera V, Zinn-Justin S, Chavez S, van Tilbeurgh H, Geli V J Mol Biol. 2006 Jun 23;359(5):1170-81. Epub 2006 May 9. PMID:16787775<ref>PMID:16787775</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 2j8a" style="background-color:#fffaf0;"></div>~~

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Atcc 18824]]~~
	~~[[Category: Histone-lysine N-methyltransferase]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Chavez, S]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Couprie, J]]		[[Category: Chavez S]]
	[[Category: Dehe~~, P M~~]]		[[Category: Couprie J]]
	[[Category: Geli, V]]		[[Category: Dehe PM]]
	[[Category: Guerois, R]]		[[Category: Geli V]]
	[[Category: Leulliot, N]]		[[Category: Guerois R]]
	[[Category: Luciano, P]]		[[Category: Leulliot N]]
	[[Category: Pamblanco, M]]		[[Category: Luciano P]]
	[[Category: Quevillon-Cheruel, S]]		[[Category: Pamblanco M]]
	[[Category: Rodriguez-Gil, A]]		[[Category: Quevillon-Cheruel S]]
	[[Category: Salah, P]]		[[Category: Rodriguez-Gil A]]
	[[Category: Sollier, J]]		[[Category: Salah P]]
	[[Category: ~~Tilbeurgh, H Van~~]]		[[Category: Sollier J]]
	[[Category: ~~Tordera, V~~]]		[[Category: Tordera V]]
	[[Category: ~~Tresaugues, L~~]]		[[Category: Tresaugues L]]
	[[Category: Varlet, I]]		[[Category: Van Tilbeurgh H]]
	[[Category: Zinn-Justin, S]]		[[Category: Varlet I]]
	~~[[Category: Chromosomal protein]]~~		[[Category: Zinn-Justin S]]
	~~[[Category: Histone methyltransferase]]~~
	~~[[Category: Methyltransferase]]~~
	~~[[Category: Nuclear protein]]~~
	~~[[Category: Rrm fold]]~~
	~~[[Category: Telomere]]~~
	~~[[Category: Transferase~~]]

OCA at 08:04, 19 January 2022

2022-01-19T08:04:07Z

← Older revision		Revision as of 08:04, 19 January 2022
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	<StructureSection load='2j8a' size='340' side='right'caption='[[2j8a]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='2j8a' size='340' side='right'caption='[[2j8a]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2j8a]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J8A OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2J8A FirstGlance]. <br>		<table><tr><td colspan='2'>[[2j8a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J8A FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2j8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j8a OCA], [~~http~~://pdbe.org/2j8a PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2j8a RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2j8a PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2j8a ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j8a OCA], [https://pdbe.org/2j8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j8a RCSB], [https://www.ebi.ac.uk/pdbsum/2j8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j8a ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:43, 15 April 2020

2020-04-15T07:43:28Z

← Older revision		Revision as of 07:43, 15 April 2020
Line 1:		Line 1:

	==X-ray structure of the N-terminus RRM domain of Set1==		==X-ray structure of the N-terminus RRM domain of Set1==
	<StructureSection load='2j8a' size='340' side='right' caption='[[2j8a]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='2j8a' size='340' side='right'caption='[[2j8a]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2j8a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J8A OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2J8A FirstGlance]. <br>		<table><tr><td colspan='2'>[[2j8a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J8A OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2J8A FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2j8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j8a OCA], [http://pdbe.org/2j8a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j8a RCSB], [http://www.ebi.ac.uk/pdbsum/2j8a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2j8a ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2j8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j8a OCA], [http://pdbe.org/2j8a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j8a RCSB], [http://www.ebi.ac.uk/pdbsum/2j8a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2j8a ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 28:		Line 28:

	==See Also==		==See Also==
	*[[Histone methyltransferase\|Histone methyltransferase]]		*[[Histone methyltransferase 3D structures\|Histone methyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
	[[Category: Histone-lysine N-methyltransferase]]		[[Category: Histone-lysine N-methyltransferase]]
			[[Category: Large Structures]]
	[[Category: Chavez, S]]		[[Category: Chavez, S]]
	[[Category: Couprie, J]]		[[Category: Couprie, J]]

OCA at 06:37, 11 July 2018

2018-07-11T06:37:15Z

← Older revision		Revision as of 06:37, 11 July 2018
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	==X-~~RAY STRUCTURE OF THE~~ N-~~TERMINUS~~ RRM ~~DOMAIN OF SET1~~==
			==X-ray structure of the N-terminus RRM domain of Set1==
	<StructureSection load='2j8a' size='340' side='right' caption='[[2j8a]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='2j8a' size='340' side='right' caption='[[2j8a]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2j8a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J8A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J8A FirstGlance]. <br>		<table><tr><td colspan='2'>[[2j8a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J8A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J8A FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j8a OCA], [http://pdbe.org/2j8a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j8a RCSB], [http://www.ebi.ac.uk/pdbsum/2j8a PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j8a OCA], [http://pdbe.org/2j8a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j8a RCSB], [http://www.ebi.ac.uk/pdbsum/2j8a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2j8a ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j8/2j8a_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j8/2j8a_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j8a ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:32, 11 September 2015

2015-09-11T07:32:44Z

← Older revision		Revision as of 07:32, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2j8a' size='340' side='right' caption='[[2j8a]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='2j8a' size='340' side='right' caption='[[2j8a]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2j8a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J8A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J8A FirstGlance]. <br>		<table><tr><td colspan='2'>[[2j8a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J8A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J8A FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j8a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j8a RCSB], [http://www.ebi.ac.uk/pdbsum/2j8a PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j8a OCA], [http://pdbe.org/2j8a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j8a RCSB], [http://www.ebi.ac.uk/pdbsum/2j8a PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2j8a" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 31:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Atcc 18824]]
	[[Category: Histone-lysine N-methyltransferase]]		[[Category: Histone-lysine N-methyltransferase]]
	~~[[Category: Saccharomyces cerevisiae]]~~
	[[Category: Chavez, S]]		[[Category: Chavez, S]]
	[[Category: Couprie, J]]		[[Category: Couprie, J]]

OCA at 13:23, 19 January 2015

2015-01-19T13:23:45Z

← Older revision		Revision as of 13:23, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2j8a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J8A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J8A FirstGlance]. <br>		<table><tr><td colspan='2'>[[2j8a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J8A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J8A FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j8a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j8a RCSB], [http://www.ebi.ac.uk/pdbsum/2j8a PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j8a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j8a RCSB], [http://www.ebi.ac.uk/pdbsum/2j8a PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	[[Category: Histone-lysine N-methyltransferase]]		[[Category: Histone-lysine N-methyltransferase]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Chavez, S.]]		[[Category: Chavez, S]]
	[[Category: Couprie, J.]]		[[Category: Couprie, J]]
	[[Category: Dehe, P M.]]		[[Category: Dehe, P M]]
	[[Category: Geli, V.]]		[[Category: Geli, V]]
	[[Category: Guerois, R.]]		[[Category: Guerois, R]]
	[[Category: Leulliot, N.]]		[[Category: Leulliot, N]]
	[[Category: Luciano, P.]]		[[Category: Luciano, P]]
	[[Category: Pamblanco, M.]]		[[Category: Pamblanco, M]]
	[[Category: Quevillon-Cheruel, S.]]		[[Category: Quevillon-Cheruel, S]]
	[[Category: Rodriguez-Gil, A.]]		[[Category: Rodriguez-Gil, A]]
	[[Category: Salah, P.]]		[[Category: Salah, P]]
	[[Category: Sollier, J.]]		[[Category: Sollier, J]]
	[[Category: Tilbeurgh, H Van.]]		[[Category: Tilbeurgh, H Van]]
	[[Category: Tordera, V.]]		[[Category: Tordera, V]]
	[[Category: Tresaugues, L.]]		[[Category: Tresaugues, L]]
	[[Category: Varlet, I.]]		[[Category: Varlet, I]]
	[[Category: Zinn-Justin, S.]]		[[Category: Zinn-Justin, S]]
	[[Category: Chromosomal protein]]		[[Category: Chromosomal protein]]
	[[Category: Histone methyltransferase]]		[[Category: Histone methyltransferase]]

OCA at 04:30, 29 September 2014

2014-09-29T04:30:16Z

← Older revision		Revision as of 04:30, 29 September 2014
Line 1:		Line 1:
	[[Image:~~2j8a~~.~~png~~\|~~left~~\|~~200px~~]]		==X-RAY STRUCTURE OF THE N-TERMINUS RRM DOMAIN OF SET1==
			<StructureSection load='2j8a' size='340' side='right' caption='[[2j8a]], [[Resolution\|resolution]] 3.00Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2j8a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J8A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J8A FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j8a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j8a RCSB], [http://www.ebi.ac.uk/pdbsum/2j8a PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j8/2j8a_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The yeast Set1 histone H3 lysine 4 (H3K4) methyltransferase contains, in addition to its catalytic SET domain, a conserved RNA recognition motif (RRM1). We present here the crystal structure and the secondary structure assignment in solution of the Set1 RRM1. Although RRM1 has the expected betaalphabetabetaalphabeta RRM-fold, it lacks the typical RNA-binding features of these modules. RRM1 is not able to bind RNA by itself in vitro, but a construct combining RRM1 with a newly identified downstream RRM2 specifically binds RNA. In vivo, H3K4 methylation is not affected by a point mutation in RRM2 that preserves Set1 stability but affects RNA binding in vitro. In contrast mutating RRM1 destabilizes Set1 and leads to an increase of dimethylation of H3K4 at the 5'-coding region of active genes at the expense of trimethylation, whereas both, dimethylation decreases at the 3'-coding region. Taken together, our results suggest that Set1 RRMs bind RNA, but Set1 RNA-binding activity is not linked to H3K4 methylation.

	~~{{STRUCTURE_2j8a\| PDB=2j8a \| SCENE= }}~~		Structural characterization of Set1 RNA recognition motifs and their role in histone H3 lysine 4 methylation.,Tresaugues L, Dehe PM, Guerois R, Rodriguez-Gil A, Varlet I, Salah P, Pamblanco M, Luciano P, Quevillon-Cheruel S, Sollier J, Leulliot N, Couprie J, Tordera V, Zinn-Justin S, Chavez S, van Tilbeurgh H, Geli V J Mol Biol. 2006 Jun 23;359(5):1170-81. Epub 2006 May 9. PMID:16787775<ref>PMID:16787775</ref>

	~~===X-RAY STRUCTURE OF THE N-TERMINUS RRM DOMAIN OF SET1===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16787775}}~~

	~~==About this Structure==~~
	~~[[2j8a]] is~~ a ~~1 chain structure with sequence from [http://en.wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann.ac.il/oca-bin~~/~~ocashort?id=2J8A OCA].~~

	==See Also==		==See Also==
	*[[Histone methyltransferase\|Histone methyltransferase]]		*[[Histone methyltransferase\|Histone methyltransferase]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:016787775<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Histone-lysine N-methyltransferase]]		[[Category: Histone-lysine N-methyltransferase]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]

OCA at 17:08, 20 October 2012

2012-10-20T17:08:03Z

← Older revision		Revision as of 17:08, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[2j8a]] is a 1 chain structure ~~of [[Histone methyltransferase]]~~ with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J8A OCA].		[[2j8a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J8A OCA].

	==See Also==		==See Also==

OCA: Protected "2j8a" [edit=sysop:move=sysop]

2012-07-26T23:55:50Z

Protected "2j8a" [edit=sysop:move=sysop]

← Older revision	Revision as of 23:55, 26 July 2012
(No difference)

OCA at 23:55, 26 July 2012

2012-07-26T23:55:48Z

← Older revision		Revision as of 23:55, 26 July 2012
Line 1:		Line 1:
	~~{{Seed}}~~
	[[Image:2j8a.png\|left\|200px]]		[[Image:2j8a.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2j8a", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2j8a\| PDB=2j8a \| SCENE= }}		{{STRUCTURE_2j8a\| PDB=2j8a \| SCENE= }}

	===X-RAY STRUCTURE OF THE N-TERMINUS RRM DOMAIN OF SET1===		===X-RAY STRUCTURE OF THE N-TERMINUS RRM DOMAIN OF SET1===

			{{ABSTRACT_PUBMED_16787775}}

	==About this Structure==		==About this Structure==
	~~2J8A~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J8A OCA].		[[2j8a]] is a 1 chain structure of [[Histone methyltransferase]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J8A OCA].

			==See Also==
			*[[Histone methyltransferase\|Histone methyltransferase]]

			==Reference==
			<ref group="xtra">PMID:016787775</ref><references group="xtra"/>
	[[Category: Histone-lysine N-methyltransferase]]		[[Category: Histone-lysine N-methyltransferase]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
Line 41:		Line 41:
	[[Category: Telomere]]		[[Category: Telomere]]
	[[Category: Transferase]]		[[Category: Transferase]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:11:34 2009''~~