2jay - Revision history

OCA at 14:41, 13 December 2023

2023-12-13T14:41:01Z

← Older revision		Revision as of 14:41, 13 December 2023
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	<StructureSection load='2jay' size='340' side='right'caption='[[2jay]], [[Resolution\|resolution]] 1.99Å' scene=''>		<StructureSection load='2jay' size='340' side='right'caption='[[2jay]], [[Resolution\|resolution]] 1.99Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jay]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Myctu Myctu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JAY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JAY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jay]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JAY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JAY FirstGlance]. <br>
	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[2fhg\|2fhg]]~~, [[~~2fhh~~\|~~2fhh~~]]~~</div></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.99Å</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Proteasome_endopeptidase_complex Proteasome endopeptidase complex], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.25.1 3.~~4.25.1] </span>~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jay FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jay OCA], [https://pdbe.org/2jay PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jay RCSB], [https://www.ebi.ac.uk/pdbsum/2jay PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jay ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jay FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jay OCA], [https://pdbe.org/2jay PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jay RCSB], [https://www.ebi.ac.uk/pdbsum/2jay PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jay ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/~~PSB_MYCTO PSB_MYCTO]~~] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.		[https://www.uniprot.org/uniprot/PSB_MYCTU PSB_MYCTU] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The M.tuberculosis proteasome is able to cleave oligopeptides not only after hydrophobic but also after basic, acidic and small neutral residues. Among the identified substrates of the M.tuberculosis proteasome are the pupylated FabD, PanB and Mpa proteins. One function of the proteasome is to contribute to M.tuberculosis ability to resist killing by host macrophages, since the core proteasome is essential for persistence of the pathogen during the chronic phase of infection in mice. The mechanism of protection against bactericidal chemistries of the host's immune response probably involves the degradation of proteins that are irreversibly oxidized, nitrated, or nitrosated.<ref>PMID:16468985</ref> <ref>PMID:18059281</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[Proteasome 3D structures\|Proteasome 3D structures]]		*[[Proteasome 3D structures\|Proteasome 3D structures]]
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Myctu]]~~		[[Category: Mycobacterium tuberculosis H37Rv]]
	~~[[Category: Proteasome endopeptidase complex~~]]		[[Category: Bartunik HD]]
	[[Category: Bartunik~~, H D~~]]		[[Category: Oberschall A]]
	[[Category: Oberschall, A]]		[[Category: Strizhov N]]
	[[Category: Strizhov, N]]
	~~[[Category: Hydrolase]]~~
	~~[[Category: Proteasome~~]]

OCA at 08:05, 19 January 2022

2022-01-19T08:05:48Z

← Older revision		Revision as of 08:05, 19 January 2022
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	<StructureSection load='2jay' size='340' side='right'caption='[[2jay]], [[Resolution\|resolution]] 1.99Å' scene=''>		<StructureSection load='2jay' size='340' side='right'caption='[[2jay]], [[Resolution\|resolution]] 1.99Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jay]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JAY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2JAY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jay]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JAY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JAY FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fhg\|2fhg]], [[2fhh\|2fhh]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2fhg\|2fhg]], [[2fhh\|2fhh]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Proteasome_endopeptidase_complex Proteasome endopeptidase complex], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.25.1 3.4.25.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Proteasome_endopeptidase_complex Proteasome endopeptidase complex], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.25.1 3.4.25.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2jay FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jay OCA], [~~http~~://pdbe.org/2jay PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2jay RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2jay PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2jay ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jay FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jay OCA], [https://pdbe.org/2jay PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jay RCSB], [https://www.ebi.ac.uk/pdbsum/2jay PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jay ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/PSB_MYCTO PSB_MYCTO]] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.		[[https://www.uniprot.org/uniprot/PSB_MYCTO PSB_MYCTO]] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:45, 15 April 2020

2020-04-15T07:45:34Z

← Older revision		Revision as of 07:45, 15 April 2020
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	==Proteasome beta subunit PrcB from Mycobacterium tuberculosis==		==Proteasome beta subunit PrcB from Mycobacterium tuberculosis==
	<StructureSection load='2jay' size='340' side='right' caption='[[2jay]], [[Resolution\|resolution]] 1.99Å' scene=''>		<StructureSection load='2jay' size='340' side='right'caption='[[2jay]], [[Resolution\|resolution]] 1.99Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jay]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JAY OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JAY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jay]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JAY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2JAY FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fhg\|2fhg]], [[2fhh\|2fhh]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fhg\|2fhg]], [[2fhh\|2fhh]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proteasome_endopeptidase_complex Proteasome endopeptidase complex], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.25.1 3.4.25.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proteasome_endopeptidase_complex Proteasome endopeptidase complex], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.25.1 3.4.25.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jay FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jay OCA], [http://pdbe.org/2jay PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jay RCSB], [http://www.ebi.ac.uk/pdbsum/2jay PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jay ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2jay FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jay OCA], [http://pdbe.org/2jay PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jay RCSB], [http://www.ebi.ac.uk/pdbsum/2jay PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jay ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	==See Also==		==See Also==
	*[[Proteasome\|Proteasome]]		*[[Proteasome 3D structures\|Proteasome 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Myctu]]		[[Category: Myctu]]
	[[Category: Proteasome endopeptidase complex]]		[[Category: Proteasome endopeptidase complex]]

OCA at 06:33, 11 July 2018

2018-07-11T06:33:23Z

← Older revision		Revision as of 06:33, 11 July 2018
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	==~~PROTEASOME BETA SUBUNIT PRCB FROM MYCOBACTERIUM TUBERCULOSIS~~==
			==Proteasome beta subunit PrcB from Mycobacterium tuberculosis==
	<StructureSection load='2jay' size='340' side='right' caption='[[2jay]], [[Resolution\|resolution]] 1.99Å' scene=''>		<StructureSection load='2jay' size='340' side='right' caption='[[2jay]], [[Resolution\|resolution]] 1.99Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
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	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fhg\|2fhg]], [[2fhh\|2fhh]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fhg\|2fhg]], [[2fhh\|2fhh]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proteasome_endopeptidase_complex Proteasome endopeptidase complex], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.25.1 3.4.25.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proteasome_endopeptidase_complex Proteasome endopeptidase complex], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.25.1 3.4.25.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jay FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jay OCA], [http://pdbe.org/2jay PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jay RCSB], [http://www.ebi.ac.uk/pdbsum/2jay PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jay FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jay OCA], [http://pdbe.org/2jay PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jay RCSB], [http://www.ebi.ac.uk/pdbsum/2jay PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jay ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ja/2jay_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ja/2jay_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 14:20, 8 February 2016

2016-02-08T14:20:38Z

← Older revision		Revision as of 14:20, 8 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jay ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

OCA at 12:24, 10 September 2015

2015-09-10T12:24:57Z

← Older revision		Revision as of 12:24, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2jay' size='340' side='right' caption='[[2jay]], [[Resolution\|resolution]] 1.99Å' scene=''>		<StructureSection load='2jay' size='340' side='right' caption='[[2jay]], [[Resolution\|resolution]] 1.99Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jay]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis Mycobacterium tuberculosis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JAY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JAY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jay]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JAY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JAY FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fhg\|2fhg]], [[2fhh\|2fhh]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fhg\|2fhg]], [[2fhh\|2fhh]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proteasome_endopeptidase_complex Proteasome endopeptidase complex], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.25.1 3.4.25.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proteasome_endopeptidase_complex Proteasome endopeptidase complex], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.25.1 3.4.25.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jay FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jay OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jay RCSB], [http://www.ebi.ac.uk/pdbsum/2jay PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jay FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jay OCA], [http://pdbe.org/2jay PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jay RCSB], [http://www.ebi.ac.uk/pdbsum/2jay PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/~~PSB_MYCTU PSB_MYCTU~~]] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The M.tuberculosis proteasome is able to cleave oligopeptides not only after hydrophobic but also after basic, acidic and small neutral residues. Among the identified substrates of the M.tuberculosis proteasome are the pupylated FabD, PanB and Mpa proteins. One function of the proteasome is to contribute to M.tuberculosis ability to resist killing by host macrophages, since the core proteasome is essential for persistence of the pathogen during the chronic phase of infection in mice. The mechanism of protection against bactericidal chemistries of the host's immune response probably involves the degradation of proteins that are irreversibly oxidized, nitrated, or nitrosated.<ref>PMID:16468985</ref> <ref>PMID:18059281</ref>		[[http://www.uniprot.org/uniprot/PSB_MYCTO PSB_MYCTO]] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[Proteasome\|Proteasome]]		*[[Proteasome\|Proteasome]]
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Mycobacterium tuberculosis~~]]		[[Category: Myctu]]
	[[Category: Proteasome endopeptidase complex]]		[[Category: Proteasome endopeptidase complex]]
	[[Category: Bartunik, H D]]		[[Category: Bartunik, H D]]

OCA at 23:57, 24 December 2014

2014-12-24T23:57:27Z

← Older revision		Revision as of 23:57, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jay]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JAY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JAY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jay]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JAY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JAY FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fhg\|2fhg]], [[2fhh\|2fhh]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fhg\|2fhg]], [[2fhh\|2fhh]]</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proteasome_endopeptidase_complex Proteasome endopeptidase complex], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.25.1 3.4.25.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proteasome_endopeptidase_complex Proteasome endopeptidase complex], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.25.1 3.4.25.1] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jay FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jay OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jay RCSB], [http://www.ebi.ac.uk/pdbsum/2jay PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jay FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jay OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jay RCSB], [http://www.ebi.ac.uk/pdbsum/2jay PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/PSB_MYCTU PSB_MYCTU]] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The M.tuberculosis proteasome is able to cleave oligopeptides not only after hydrophobic but also after basic, acidic and small neutral residues. Among the identified substrates of the M.tuberculosis proteasome are the pupylated FabD, PanB and Mpa proteins. One function of the proteasome is to contribute to M.tuberculosis ability to resist killing by host macrophages, since the core proteasome is essential for persistence of the pathogen during the chronic phase of infection in mice. The mechanism of protection against bactericidal chemistries of the host's immune response probably involves the degradation of proteins that are irreversibly oxidized, nitrated, or nitrosated.<ref>PMID:16468985</ref> <ref>PMID:18059281</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 22:
	==See Also==		==See Also==
	*[[Proteasome\|Proteasome]]		*[[Proteasome\|Proteasome]]
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Proteasome endopeptidase complex]]		[[Category: Proteasome endopeptidase complex]]
	[[Category: Bartunik, H D.]]		[[Category: Bartunik, H D]]
	[[Category: Oberschall, A.]]		[[Category: Oberschall, A]]
	[[Category: Strizhov, N.]]		[[Category: Strizhov, N]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Proteasome]]		[[Category: Proteasome]]

OCA at 03:53, 29 September 2014

2014-09-29T03:53:33Z

← Older revision		Revision as of 03:53, 29 September 2014
Line 1:		Line 1:
	~~[[Image:2jay.png\|left\|200px]]~~		==PROTEASOME BETA SUBUNIT PRCB FROM MYCOBACTERIUM TUBERCULOSIS==
			<StructureSection load='2jay' size='340' side='right' caption='[[2jay]], [[Resolution\|resolution]] 1.99Å' scene=''>
	~~{{STRUCTURE_2jay\| PDB=2jay \| SCENE= }}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2jay]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JAY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JAY FirstGlance]. <br>
	===PROTEASOME BETA SUBUNIT PRCB FROM MYCOBACTERIUM TUBERCULOSIS===		</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fhg\|2fhg]], [[2fhh\|2fhh]]</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proteasome_endopeptidase_complex Proteasome endopeptidase complex], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.25.1 3.4.25.1] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jay FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jay OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jay RCSB], [http://www.ebi.ac.uk/pdbsum/2jay PDBsum]</span></td></tr>
	==~~About this Structure~~==		<table>
	[[2jay]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JAY OCA].		== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ja/2jay_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>

	==See Also==		==See Also==
	*[[Proteasome\|Proteasome]]		*[[Proteasome\|Proteasome]]
			__TOC__
			</StructureSection>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Proteasome endopeptidase complex]]		[[Category: Proteasome endopeptidase complex]]

OCA at 10:26, 20 October 2012

2012-10-20T10:26:23Z

← Older revision		Revision as of 10:26, 20 October 2012
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
	[[2jay]] is a 1 chain structure ~~of [[Proteasome]]~~ with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JAY OCA].		[[2jay]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JAY OCA].

	==See Also==		==See Also==

OCA: Protected "2jay" [edit=sysop:move=sysop]

2012-07-26T02:07:48Z

Protected "2jay" [edit=sysop:move=sysop]

← Older revision	Revision as of 02:07, 26 July 2012
(No difference)