2jcd - Revision history

OCA at 09:36, 9 May 2024

2024-05-09T09:36:40Z

← Older revision		Revision as of 09:36, 9 May 2024
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	<StructureSection load='2jcd' size='340' side='right'caption='[[2jcd]], [[Resolution\|resolution]] 2.11Å' scene=''>		<StructureSection load='2jcd' size='340' side='right'caption='[[2jcd]], [[Resolution\|resolution]] 2.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jcd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JCD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jcd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_thioluteus Streptomyces thioluteus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JCD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.11Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jcd OCA], [https://pdbe.org/2jcd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jcd RCSB], [https://www.ebi.ac.uk/pdbsum/2jcd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jcd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jcd OCA], [https://pdbe.org/2jcd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jcd RCSB], [https://www.ebi.ac.uk/pdbsum/2jcd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jcd ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/AURF_STRTU AURF_STRTU] Involved in the biosynthesis of the polyketide antibiotic aureothin (PubMed:14700630, PubMed:15038705). Catalyzes the oxidation of p-aminobenzoate (pABA) to p-nitrobenzoate (pNBA), an unusual polyketide synthase starter unit (PubMed:15038705, PubMed:16927313, PubMed:20798054, PubMed:18458342). Reaction mechanism involves the generation of a peroxodiiron(III/III) intermediate, which effects the initial oxidation of p-aminobenzoate to p-hydroxylaminobenzoate (Ar-NHOH) (PubMed:19731912, PubMed:20798054). Ar-NHOH is then probably directly converted to the fully oxidized p-nitrobenzoate via a four-electron N-oxidation, bypassing the formation of a nitroso compound (PubMed:20798054).<ref>PMID:14700630</ref> <ref>PMID:15038705</ref> <ref>PMID:16927313</ref> <ref>PMID:18458342</ref> <ref>PMID:19731912</ref> <ref>PMID:20798054</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Hertweck, C~~]]		[[Category: Streptomyces thioluteus]]
	[[Category: ~~Schulz, G E~~]]		[[Category: Hertweck C]]
	[[Category: ~~Winkler, R~~]]		[[Category: Schulz GE]]
	[[Category: ~~Zocher, G E~~]]		[[Category: Winkler R]]
	[[Category: ~~Di-manganese mono-oxygenase]]~~		[[Category: Zocher GE]]
	~~[[Category: N-oxygenase]]~~
	~~[[Category: Oxidation of p-benzoic acid]]~~
	~~[[Category: Oxidoreductase~~]]

OCA at 10:07, 12 May 2021

2021-05-12T10:07:13Z

← Older revision		Revision as of 10:07, 12 May 2021
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	<StructureSection load='2jcd' size='340' side='right'caption='[[2jcd]], [[Resolution\|resolution]] 2.11Å' scene=''>		<StructureSection load='2jcd' size='340' side='right'caption='[[2jcd]], [[Resolution\|resolution]] 2.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jcd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JCD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JCD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jcd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JCD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jcd OCA], [~~http~~://pdbe.org/2jcd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2jcd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2jcd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2jcd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jcd OCA], [https://pdbe.org/2jcd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jcd RCSB], [https://www.ebi.ac.uk/pdbsum/2jcd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jcd ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:06, 7 August 2019

2019-08-07T07:06:44Z

← Older revision		Revision as of 07:06, 7 August 2019
Line 1:		Line 1:

	==Structure of the N-oxygenase AurF from Streptomyces thioluteus==		==Structure of the N-oxygenase AurF from Streptomyces thioluteus==
	<StructureSection load='2jcd' size='340' side='right' caption='[[2jcd]], [[Resolution\|resolution]] 2.11Å' scene=''>		<StructureSection load='2jcd' size='340' side='right'caption='[[2jcd]], [[Resolution\|resolution]] 2.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jcd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JCD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jcd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JCD FirstGlance]. <br>
Line 11:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jc/2jcd_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jc/2jcd_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 30:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Hertweck, C]]		[[Category: Hertweck, C]]
	[[Category: Schulz, G E]]		[[Category: Schulz, G E]]

OCA at 09:26, 3 August 2017

2017-08-03T09:26:54Z

← Older revision		Revision as of 09:26, 3 August 2017
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	==~~STRUCTURE OF THE~~ N-~~OXYGENASE AURF FROM STREPTOMYCES THIOLUTEUS~~==
			==Structure of the N-oxygenase AurF from Streptomyces thioluteus==
	<StructureSection load='2jcd' size='340' side='right' caption='[[2jcd]], [[Resolution\|resolution]] 2.11Å' scene=''>		<StructureSection load='2jcd' size='340' side='right' caption='[[2jcd]], [[Resolution\|resolution]] 2.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jcd]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/"streptomyces_thioluteus"_okami_1952 "streptomyces thioluteus" okami 1952]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JCD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jcd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JCD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jcd OCA], [http://pdbe.org/2jcd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jcd RCSB], [http://www.ebi.ac.uk/pdbsum/2jcd PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jcd OCA], [http://pdbe.org/2jcd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jcd RCSB], [http://www.ebi.ac.uk/pdbsum/2jcd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jcd ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Streptomyces thioluteus okami 1952]]~~
	[[Category: Hertweck, C]]		[[Category: Hertweck, C]]
	[[Category: Schulz, G E]]		[[Category: Schulz, G E]]

OCA at 20:33, 8 February 2016

2016-02-08T20:33:45Z

← Older revision		Revision as of 20:33, 8 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jcd ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:09, 10 September 2015

2015-09-10T15:09:55Z

← Older revision		Revision as of 15:09, 10 September 2015
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	<StructureSection load='2jcd' size='340' side='right' caption='[[2jcd]], [[Resolution\|resolution]] 2.11Å' scene=''>		<StructureSection load='2jcd' size='340' side='right' caption='[[2jcd]], [[Resolution\|resolution]] 2.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jcd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Streptomyces_thioluteus Streptomyces~~ thioluteus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JCD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jcd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"streptomyces_thioluteus"_okami_1952 "streptomyces thioluteus" okami 1952]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JCD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jcd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jcd RCSB], [http://www.ebi.ac.uk/pdbsum/2jcd PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jcd OCA], [http://pdbe.org/2jcd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jcd RCSB], [http://www.ebi.ac.uk/pdbsum/2jcd PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2jcd" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Streptomyces thioluteus]]		[[Category: Streptomyces thioluteus okami 1952]]
	[[Category: Hertweck, C]]		[[Category: Hertweck, C]]
	[[Category: Schulz, G E]]		[[Category: Schulz, G E]]

OCA at 16:55, 19 January 2015

2015-01-19T16:55:52Z

← Older revision		Revision as of 16:55, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jcd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_thioluteus Streptomyces thioluteus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JCD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jcd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_thioluteus Streptomyces thioluteus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JCD FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jcd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jcd RCSB], [http://www.ebi.ac.uk/pdbsum/2jcd PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jcd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jcd RCSB], [http://www.ebi.ac.uk/pdbsum/2jcd PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Streptomyces thioluteus]]		[[Category: Streptomyces thioluteus]]
	[[Category: Hertweck, C.]]		[[Category: Hertweck, C]]
	[[Category: Schulz, G E.]]		[[Category: Schulz, G E]]
	[[Category: Winkler, R.]]		[[Category: Winkler, R]]
	[[Category: Zocher, G E.]]		[[Category: Zocher, G E]]
	[[Category: Di-manganese mono-oxygenase]]		[[Category: Di-manganese mono-oxygenase]]
	[[Category: N-oxygenase]]		[[Category: N-oxygenase]]
	[[Category: Oxidation of p-benzoic acid]]		[[Category: Oxidation of p-benzoic acid]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 09:42, 30 September 2014

2014-09-30T09:42:21Z

← Older revision		Revision as of 09:42, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2jcd~~.~~png~~\|~~left~~\|~~200px~~]]		==STRUCTURE OF THE N-OXYGENASE AURF FROM STREPTOMYCES THIOLUTEUS==
			<StructureSection load='2jcd' size='340' side='right' caption='[[2jcd]], [[Resolution\|resolution]] 2.11Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2jcd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_thioluteus Streptomyces thioluteus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JCD FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene><br>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jcd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jcd RCSB], [http://www.ebi.ac.uk/pdbsum/2jcd PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jc/2jcd_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Nitro groups are found in a number of bioactive compounds. Most of them arise by a stepwise mono-oxygenation of amino groups. One of the involved enzymes is AurF participating in the biosynthesis of aureothin. Its structure was established at 2.1 A resolution showing a homodimer with a binuclear manganese cluster. The enzyme preparation, which yielded the analyzed crystals, showed activity using in vitro and in vivo assays. Chain fold and cluster are homologous with ribonucleotide reductase subunit R2 and related enzymes. The two manganese ions and an iron content of about 15% were established by anomalous X-ray diffraction. A comparison of the cluster with more common di-iron clusters suggested an additional histidine in the coordination sphere to cause the preference for manganese over iron. There is no oxo-bridge. The substrate p-amino-benzoate was modeled into the active center. The model is supported by mutant activity measurements. It shows the geometry of the reaction and explains the established substrate spectrum.

	~~{{STRUCTURE_2jcd\| PDB=2jcd \| SCENE= }}~~		Structure and action of the N-oxygenase AurF from Streptomyces thioluteus.,Zocher G, Winkler R, Hertweck C, Schulz GE J Mol Biol. 2007 Oct 12;373(1):65-74. Epub 2007 Jun 9. PMID:17765264<ref>PMID:17765264</ref>

	~~===STRUCTURE OF THE N-OXYGENASE AURF FROM STREPTOMYCES THIOLUTEUS===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_17765264}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2jcd]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Streptomyces_thioluteus Streptomyces thioluteus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2JCD OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:017765264<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Streptomyces thioluteus]]		[[Category: Streptomyces thioluteus]]
	[[Category: Hertweck, C.]]		[[Category: Hertweck, C.]]

OCA: Protected "2jcd" [edit=sysop:move=sysop]

2013-01-07T14:33:55Z

Protected "2jcd" [edit=sysop:move=sysop]

← Older revision	Revision as of 14:33, 7 January 2013
(No difference)

OCA at 14:33, 7 January 2013

2013-01-07T14:33:52Z

← Older revision		Revision as of 14:33, 7 January 2013
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	~~{{Seed}}~~
	[[Image:2jcd.png\|left\|200px]]		[[Image:2jcd.png\|left\|200px]]

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	{{STRUCTURE_2jcd\| PDB=2jcd \| SCENE= }}		{{STRUCTURE_2jcd\| PDB=2jcd \| SCENE= }}

	===STRUCTURE OF THE N-OXYGENASE AURF FROM STREPTOMYCES THIOLUTEUS===		===STRUCTURE OF THE N-OXYGENASE AURF FROM STREPTOMYCES THIOLUTEUS===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_17765264}}, adds the Publication Abstract to the page~~
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	{{ABSTRACT_PUBMED_17765264}}		{{ABSTRACT_PUBMED_17765264}}

	==About this Structure==		==About this Structure==
	~~2JCD~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Streptomyces_thioluteus Streptomyces thioluteus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JCD OCA].		[[2jcd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_thioluteus Streptomyces thioluteus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JCD OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~17765264~~</ref><references group="xtra"/>		<ref group="xtra">PMID:017765264</ref><references group="xtra"/>
	[[Category: Streptomyces thioluteus]]		[[Category: Streptomyces thioluteus]]
	[[Category: Hertweck, C.]]		[[Category: Hertweck, C.]]
Line 31:		Line 19:
	[[Category: Di-manganese mono-oxygenase]]		[[Category: Di-manganese mono-oxygenase]]
	[[Category: N-oxygenase]]		[[Category: N-oxygenase]]
	[[Category: Oxidation of p-benzoic acid~~,oxidoreductase~~]]		[[Category: Oxidation of p-benzoic acid]]
			[[Category: Oxidoreductase]]
	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 02:54:15 2009''~~