2jgb - Revision history

OCA at 14:47, 13 December 2023

2023-12-13T14:47:11Z

← Older revision		Revision as of 14:47, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2jgb' size='340' side='right'caption='[[2jgb]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2jgb' size='340' side='right'caption='[[2jgb]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jgb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JGB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jgb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JGB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MGT:7N-METHYL-8-HYDROGUANOSINE-5-TRIPHOSPHATE'>MGT</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MGT:7N-METHYL-8-HYDROGUANOSINE-5-TRIPHOSPHATE'>MGT</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jgb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jgb OCA], [https://pdbe.org/2jgb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jgb RCSB], [https://www.ebi.ac.uk/pdbsum/2jgb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jgb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jgb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jgb OCA], [https://pdbe.org/2jgb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jgb RCSB], [https://www.ebi.ac.uk/pdbsum/2jgb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jgb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/~~4EBP1_HUMAN 4EBP1_HUMAN~~]~~] Regulates eIF4E activity by preventing its assembly into~~ the ~~eIF4F complex~~. ~~Mediates the regulation~~ of ~~protein~~ translation by ~~hormones, growth factors~~ and ~~other stimuli that signal through~~ the ~~MAP kinase and mTORC1 pathways~~.<ref>PMID:~~7935836~~</ref>		[https://www.uniprot.org/uniprot/IF4E2_HUMAN IF4E2_HUMAN] Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation (PubMed:9582349, PubMed:17368478, PubMed:25624349). Acts as a repressor of translation initiation (PubMed:22751931). In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap (By similarity).[UniProtKB:Q8BMB3]<ref>PMID:17368478</ref> <ref>PMID:22751931</ref> <ref>PMID:25624349</ref> <ref>PMID:9582349</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Cameron~~, A D~~]]		[[Category: Cameron AD]]
	[[Category: Knapp, S]]		[[Category: Knapp S]]
	[[Category: Rosettani, P]]		[[Category: Rosettani P]]
	[[Category: Rusconi, L]]		[[Category: Rusconi L]]
	[[Category: Vismara~~, M G]]~~		[[Category: Vismara MG]]
	~~[[Category: Acetylation]]~~
	~~[[Category: Cap-binding]]~~
	~~[[Category: Eif4e]]~~
	~~[[Category: Eukaryotic initiation factor]]~~
	~~[[Category: Initiation factor]]~~
	~~[[Category: Phosphorylation]]~~
	~~[[Category: Protein biosynthesis]]~~
	~~[[Category: Protein synthesis inhibitor]]~~
	~~[[Category: Rna-binding]]~~
	~~[[Category: Translation]]~~
	~~[[Category: Translation regulation~~]]

OCA at 20:45, 20 October 2021

2021-10-20T20:45:31Z

← Older revision		Revision as of 20:45, 20 October 2021
Line 3:		Line 3:
	<StructureSection load='2jgb' size='340' side='right'caption='[[2jgb]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2jgb' size='340' side='right'caption='[[2jgb]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jgb]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JGB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jgb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JGB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MGT:7N-METHYL-8-HYDROGUANOSINE-5-TRIPHOSPHATE'>MGT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MGT:7N-METHYL-8-HYDROGUANOSINE-5-TRIPHOSPHATE'>MGT</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jgb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jgb OCA], [~~http~~://pdbe.org/2jgb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2jgb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2jgb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2jgb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jgb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jgb OCA], [https://pdbe.org/2jgb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jgb RCSB], [https://www.ebi.ac.uk/pdbsum/2jgb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jgb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/4EBP1_HUMAN 4EBP1_HUMAN]] Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.<ref>PMID:7935836</ref>		[[https://www.uniprot.org/uniprot/4EBP1_HUMAN 4EBP1_HUMAN]] Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.<ref>PMID:7935836</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 13:21, 1 January 2020

2020-01-01T13:21:26Z

← Older revision		Revision as of 13:21, 1 January 2020
Line 1:		Line 1:

	==Structure of human eIF4E homologous protein 4EHP with m7GTP==		==Structure of human eIF4E homologous protein 4EHP with m7GTP==
	<StructureSection load='2jgb' size='340' side='right' caption='[[2jgb]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2jgb' size='340' side='right'caption='[[2jgb]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jgb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JGB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jgb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JGB FirstGlance]. <br>
Line 30:		Line 30:

	==See Also==		==See Also==
	*[[Eukaryotic initiation factor\|Eukaryotic initiation factor]]		*[[Eukaryotic initiation factor 3D structures\|Eukaryotic initiation factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Cameron, A D]]		[[Category: Cameron, A D]]
	[[Category: Knapp, S]]		[[Category: Knapp, S]]

OCA at 06:52, 28 March 2018

2018-03-28T06:52:55Z

← Older revision		Revision as of 06:52, 28 March 2018
Line 1:		Line 1:
	==~~STRUCTURE OF HUMAN EIF4E HOMOLOGOUS PROTEIN~~ 4EHP ~~WITH M7GTP~~==
			==Structure of human eIF4E homologous protein 4EHP with m7GTP==
	<StructureSection load='2jgb' size='340' side='right' caption='[[2jgb]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2jgb' size='340' side='right' caption='[[2jgb]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jgb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JGB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jgb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JGB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MGT:7N-METHYL-8-HYDROGUANOSINE-5-TRIPHOSPHATE'>MGT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MGT:7N-METHYL-8-HYDROGUANOSINE-5-TRIPHOSPHATE'>MGT</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jgb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jgb OCA], [http://pdbe.org/2jgb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jgb RCSB], [http://www.ebi.ac.uk/pdbsum/2jgb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jgb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jgb OCA], [http://pdbe.org/2jgb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jgb RCSB], [http://www.ebi.ac.uk/pdbsum/2jgb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jgb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jg/2jgb_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jg/2jgb_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jgb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 40:		Line 41:
	[[Category: Rusconi, L]]		[[Category: Rusconi, L]]
	[[Category: Vismara, M G]]		[[Category: Vismara, M G]]
			[[Category: Acetylation]]
	[[Category: Cap-binding]]		[[Category: Cap-binding]]
	[[Category: Eif4e]]		[[Category: Eif4e]]

OCA at 01:51, 12 September 2015

2015-09-12T01:51:27Z

← Older revision		Revision as of 01:51, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='2jgb' size='340' side='right' caption='[[2jgb]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2jgb' size='340' side='right' caption='[[2jgb]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jgb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JGB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jgb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JGB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MGT:7N-METHYL-8-HYDROGUANOSINE-5-TRIPHOSPHATE'>MGT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MGT:7N-METHYL-8-HYDROGUANOSINE-5-TRIPHOSPHATE'>MGT</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jgb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jgb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jgb RCSB], [http://www.ebi.ac.uk/pdbsum/2jgb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jgb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jgb OCA], [http://pdbe.org/2jgb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jgb RCSB], [http://www.ebi.ac.uk/pdbsum/2jgb PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2jgb" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Eukaryotic initiation factor\|Eukaryotic initiation factor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Cameron, A D]]		[[Category: Cameron, A D]]
	[[Category: Knapp, S]]		[[Category: Knapp, S]]

OCA at 22:16, 25 December 2014

2014-12-25T22:16:25Z

← Older revision		Revision as of 22:16, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jgb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JGB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jgb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JGB FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MGT:7N-METHYL-8-HYDROGUANOSINE-5-TRIPHOSPHATE'>MGT</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MGT:7N-METHYL-8-HYDROGUANOSINE-5-TRIPHOSPHATE'>MGT</scene></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jgb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jgb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jgb RCSB], [http://www.ebi.ac.uk/pdbsum/2jgb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jgb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jgb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jgb RCSB], [http://www.ebi.ac.uk/pdbsum/2jgb PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/4EBP1_HUMAN 4EBP1_HUMAN]] Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.<ref>PMID:7935836</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Cameron, A D.]]		[[Category: Cameron, A D]]
	[[Category: Knapp, S.]]		[[Category: Knapp, S]]
	[[Category: Rosettani, P.]]		[[Category: Rosettani, P]]
	[[Category: Rusconi, L.]]		[[Category: Rusconi, L]]
	[[Category: Vismara, M G~~.]]~~		[[Category: Vismara, M G]]
	~~[[Category: 4ehp~~]]
	[[Category: Cap-binding]]		[[Category: Cap-binding]]
	[[Category: Eif4e]]		[[Category: Eif4e]]

OCA at 10:11, 30 September 2014

2014-09-30T10:11:19Z

← Older revision		Revision as of 10:11, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2jgb~~.~~png~~\|~~left~~\|~~200px~~]]		==STRUCTURE OF HUMAN EIF4E HOMOLOGOUS PROTEIN 4EHP WITH M7GTP==
			<StructureSection load='2jgb' size='340' side='right' caption='[[2jgb]], [[Resolution\|resolution]] 1.70Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2jgb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JGB FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MGT:7N-METHYL-8-HYDROGUANOSINE-5-TRIPHOSPHATE'>MGT</scene><br>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jgb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jgb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jgb RCSB], [http://www.ebi.ac.uk/pdbsum/2jgb PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jg/2jgb_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			All eukaryotic cellular mRNAs contain a 5' m(7)GpppN cap. In addition to conferring stability to the mRNA, the cap is required for pre-mRNA splicing, nuclear export and translation by providing an anchor point for protein binding. In translation, the interaction between the cap and the eukaryotic initiation factor 4E (eIF4E) is important in the recruitment of the mRNAs to the ribosome. Human 4EHP (h4EHP) is a homologue of eIF4E. Like eIF4E it is able to bind the cap but it appears to play a different cellular role, possibly being involved in the fine-tuning of protein expression levels. Here we use X-ray crystallography and isothermal titration calorimetry (ITC) to investigate further the binding of cap analogues and peptides to h4EHP. m(7)GTP binds to 4EHP 200-fold more weakly than it does to eIF4E with the guanine base sandwiched by a tyrosine and a tryptophan instead of two tryptophan residues as seen in eIF4E. The tyrosine resides on a loop that is longer in h4EHP than in eIF4E. The consequent conformational difference between the proteins allows the tyrosine to mimic the six-membered ring of the tryptophan in eIF4E and adopt an orientation that is similar to that seen for equivalent residues in other non-homologous cap-binding proteins. In the absence of ligand the binding site is incompletely formed with one of the aromatic residues being disordered and the side-chain of the other adopting a novel conformation. A peptide derived from the eIF4E inhibitory protein, 4E-BP1 binds h4EHP 100-fold less strongly than eIF4E but in a similar manner. Overall the data, combined with sequence analyses of 4EHP from evolutionary diverse species, strongly support the hypothesis that 4EHP plays a physiological role utilizing both cap-binding and protein-binding functions but which is distinct from eIF4E.

	~~{{STRUCTURE_2jgb\| PDB=2jgb \| SCENE= }}~~		Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms.,Rosettani P, Knapp S, Vismara MG, Rusconi L, Cameron AD J Mol Biol. 2007 May 4;368(3):691-705. Epub 2007 Feb 20. PMID:17368478<ref>PMID:17368478</ref>

	~~===STRUCTURE OF HUMAN EIF4E HOMOLOGOUS PROTEIN 4EHP WITH M7GTP===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_17368478}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2jgb]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2JGB OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:017368478<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Cameron, A D.]]		[[Category: Cameron, A D.]]

OCA: Protected "2jgb" [edit=sysop:move=sysop]

2013-01-07T14:39:37Z

Protected "2jgb" [edit=sysop:move=sysop]

← Older revision	Revision as of 14:39, 7 January 2013
(No difference)

OCA at 14:39, 7 January 2013

2013-01-07T14:39:34Z

← Older revision		Revision as of 14:39, 7 January 2013
Line 1:		Line 1:
	~~{{Seed}}~~
	[[Image:2jgb.png\|left\|200px]]		[[Image:2jgb.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2jgb", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2jgb\| PDB=2jgb \| SCENE= }}		{{STRUCTURE_2jgb\| PDB=2jgb \| SCENE= }}

	===STRUCTURE OF HUMAN EIF4E HOMOLOGOUS PROTEIN 4EHP WITH M7GTP===		===STRUCTURE OF HUMAN EIF4E HOMOLOGOUS PROTEIN 4EHP WITH M7GTP===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_17368478}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 17368478 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_17368478}}		{{ABSTRACT_PUBMED_17368478}}

	==About this Structure==		==About this Structure==
	~~2JGB~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGB OCA].		[[2jgb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGB OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~17368478~~</ref><references group="xtra"/>		<ref group="xtra">PMID:017368478</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Cameron, A D.]]		[[Category: Cameron, A D.]]
Line 31:		Line 19:
	[[Category: Vismara, M G.]]		[[Category: Vismara, M G.]]
	[[Category: 4ehp]]		[[Category: 4ehp]]
	~~[[Category: Acetylation]]~~
	[[Category: Cap-binding]]		[[Category: Cap-binding]]
	[[Category: Eif4e]]		[[Category: Eif4e]]
Line 42:		Line 29:
	[[Category: Translation]]		[[Category: Translation]]
	[[Category: Translation regulation]]		[[Category: Translation regulation]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:31:42 2009''~~

OCA at 07:31, 18 February 2009

2009-02-18T07:31:44Z

← Older revision		Revision as of 07:31, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
	2JGB is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGB OCA].		2JGB is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGB OCA].

	==Reference==		==Reference==
	Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms., Rosettani P, Knapp S, Vismara MG, Rusconi L, Cameron AD, J Mol Biol. 2007 May 4;368(3):691-705. Epub 2007 Feb 20. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17368478 17368478]~~		<ref group="xtra">PMID:17368478</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	~~[[Category: Protein complex]]~~
	[[Category: Cameron, A D.]]		[[Category: Cameron, A D.]]
	[[Category: Knapp, S.]]		[[Category: Knapp, S.]]
Line 44:		Line 43:
	[[Category: Translation regulation]]		[[Category: Translation regulation]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 15~~:47:~~52 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:31:42 2009''