2js7 - Revision history

OCA at 08:14, 30 October 2024

2024-10-30T08:14:25Z

← Older revision		Revision as of 08:14, 30 October 2024
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	==Solution NMR structure of human myeloid differentiation primary response (MyD88). Northeast Structural Genomics target HR2869A==		==Solution NMR structure of human myeloid differentiation primary response (MyD88). Northeast Structural Genomics target HR2869A==
	<StructureSection load='2js7' size='340' side='right'caption='[[2js7~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='2js7' size='340' side='right'caption='[[2js7]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2js7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JS7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JS7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2js7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JS7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JS7 FirstGlance]. <br>
	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>MYD88 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2js7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2js7 OCA], [https://pdbe.org/2js7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2js7 RCSB], [https://www.ebi.ac.uk/pdbsum/2js7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2js7 ProSAT], [https://www.topsan.org/Proteins/NESGC/2js7 TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2js7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2js7 OCA], [https://pdbe.org/2js7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2js7 RCSB], [https://www.ebi.ac.uk/pdbsum/2js7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2js7 ProSAT], [https://www.topsan.org/Proteins/NESGC/2js7 TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[https://www.uniprot.org/uniprot/MYD88_HUMAN MYD88_HUMAN]] Defects in MYD88 are the cause of MYD88 deficiency (MYD88D) [MIM:[https://omim.org/entry/612260 612260]]; also known as recurrent pyogenic bacterial infections due to MYD88 deficiency. Patients suffer from autosomal recessive, life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease, and die between 1 and 11 months of age. Surviving patients are otherwise healthy, with normal resistance to other microbes, and their clinical status improved with age.<ref>PMID:19506249</ref> <ref>PMID:18669862</ref>		[https://www.uniprot.org/uniprot/MYD88_HUMAN MYD88_HUMAN] Defects in MYD88 are the cause of MYD88 deficiency (MYD88D) [MIM:[https://omim.org/entry/612260 612260]; also known as recurrent pyogenic bacterial infections due to MYD88 deficiency. Patients suffer from autosomal recessive, life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease, and die between 1 and 11 months of age. Surviving patients are otherwise healthy, with normal resistance to other microbes, and their clinical status improved with age.<ref>PMID:19506249</ref> <ref>PMID:18669862</ref>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/MYD88_HUMAN MYD88_HUMAN]] Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity).<ref>PMID:9013863</ref> <ref>PMID:15361868</ref> <ref>PMID:18292575</ref> <ref>PMID:19506249</ref>		[https://www.uniprot.org/uniprot/MYD88_HUMAN MYD88_HUMAN] Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity).<ref>PMID:9013863</ref> <ref>PMID:15361868</ref> <ref>PMID:18292575</ref> <ref>PMID:19506249</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/2js7_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/2js7_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Acton~~, T B~~]]		[[Category: Acton TB]]
	[[Category: Ciano, M]]		[[Category: Ciano M]]
	[[Category: Ho, C]]		[[Category: Ho C]]
	[[Category: Kennedy~~, M A~~]]		[[Category: Kennedy MA]]
	[[Category: Ma, L C]]		[[Category: Ma L-C]]
	[[Category: Montelione~~, G T]]~~		[[Category: Montelione GT]]
	~~[[Category: Structural genomic~~]]		[[Category: Ramelot TA]]
	[[Category: Ramelot~~, T A~~]]		[[Category: Rossi P]]
	[[Category: Rossi, P]]		[[Category: Tao X]]
	[[Category: Tao, X]]		[[Category: Tong L]]
	[[Category: Tong, L]]		[[Category: Xiao R]]
	[[Category: Xiao, R]]
	~~[[Category: Innate immune signaling]]~~
	~~[[Category: Myd88_human]]~~
	~~[[Category: Nesg]]~~
	~~[[Category: PSI, Protein structure initiative]]~~
	~~[[Category: Signaling protein]]~~
	~~[[Category: Tir domain]]~~
	~~[[Category: Toll like receptor adaptor domain~~]]

OCA at 13:25, 24 November 2021

2021-11-24T13:25:07Z

← Older revision		Revision as of 13:25, 24 November 2021
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	<StructureSection load='2js7' size='340' side='right'caption='[[2js7]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2js7' size='340' side='right'caption='[[2js7]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2js7]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JS7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JS7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2js7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JS7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JS7 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MYD88 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MYD88 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2js7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2js7 OCA], [~~http~~://pdbe.org/2js7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2js7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2js7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2js7 ProSAT], [~~http~~://www.topsan.org/Proteins/NESGC/2js7 TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2js7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2js7 OCA], [https://pdbe.org/2js7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2js7 RCSB], [https://www.ebi.ac.uk/pdbsum/2js7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2js7 ProSAT], [https://www.topsan.org/Proteins/NESGC/2js7 TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[~~http~~://www.uniprot.org/uniprot/MYD88_HUMAN MYD88_HUMAN]] Defects in MYD88 are the cause of MYD88 deficiency (MYD88D) [MIM:[~~http~~://omim.org/entry/612260 612260]]; also known as recurrent pyogenic bacterial infections due to MYD88 deficiency. Patients suffer from autosomal recessive, life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease, and die between 1 and 11 months of age. Surviving patients are otherwise healthy, with normal resistance to other microbes, and their clinical status improved with age.<ref>PMID:19506249</ref> <ref>PMID:18669862</ref>		[[https://www.uniprot.org/uniprot/MYD88_HUMAN MYD88_HUMAN]] Defects in MYD88 are the cause of MYD88 deficiency (MYD88D) [MIM:[https://omim.org/entry/612260 612260]]; also known as recurrent pyogenic bacterial infections due to MYD88 deficiency. Patients suffer from autosomal recessive, life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease, and die between 1 and 11 months of age. Surviving patients are otherwise healthy, with normal resistance to other microbes, and their clinical status improved with age.<ref>PMID:19506249</ref> <ref>PMID:18669862</ref>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/MYD88_HUMAN MYD88_HUMAN]] Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity).<ref>PMID:9013863</ref> <ref>PMID:15361868</ref> <ref>PMID:18292575</ref> <ref>PMID:19506249</ref>		[[https://www.uniprot.org/uniprot/MYD88_HUMAN MYD88_HUMAN]] Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity).<ref>PMID:9013863</ref> <ref>PMID:15361868</ref> <ref>PMID:18292575</ref> <ref>PMID:19506249</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 06:49, 19 February 2020

2020-02-19T06:49:35Z

← Older revision		Revision as of 06:49, 19 February 2020
Line 1:		Line 1:

	==Solution NMR structure of human myeloid differentiation primary response (MyD88). Northeast Structural Genomics target HR2869A==		==Solution NMR structure of human myeloid differentiation primary response (MyD88). Northeast Structural Genomics target HR2869A==
	<StructureSection load='2js7' size='340' side='right' caption='[[2js7]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2js7' size='340' side='right'caption='[[2js7]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2js7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JS7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JS7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2js7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JS7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JS7 FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Acton, T B]]		[[Category: Acton, T B]]
	[[Category: Ciano, M]]		[[Category: Ciano, M]]

OCA at 18:54, 24 January 2018

2018-01-24T18:54:50Z

← Older revision		Revision as of 18:54, 24 January 2018
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	==Solution NMR structure of human myeloid differentiation primary response (MyD88). Northeast Structural Genomics target HR2869A==		==Solution NMR structure of human myeloid differentiation primary response (MyD88). Northeast Structural Genomics target HR2869A==
	<StructureSection load='2js7' size='340' side='right' caption='[[2js7]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2js7' size='340' side='right' caption='[[2js7]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
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	<table><tr><td colspan='2'>[[2js7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JS7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JS7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2js7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JS7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JS7 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MYD88 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MYD88 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2js7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2js7 OCA], [http://pdbe.org/2js7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2js7 RCSB], [http://www.ebi.ac.uk/pdbsum/2js7 PDBsum], [http://www.topsan.org/Proteins/NESGC/2js7 TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2js7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2js7 OCA], [http://pdbe.org/2js7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2js7 RCSB], [http://www.ebi.ac.uk/pdbsum/2js7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2js7 ProSAT], [http://www.topsan.org/Proteins/NESGC/2js7 TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/2js7_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/2js7_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	[[Category: Ho, C]]		[[Category: Ho, C]]
	[[Category: Kennedy, M A]]		[[Category: Kennedy, M A]]
	[[Category: Ma, L-C]]		[[Category: Ma, L C]]
	[[Category: Montelione, G T]]		[[Category: Montelione, G T]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]

OCA at 16:17, 7 February 2016

2016-02-07T16:17:04Z

← Older revision		Revision as of 16:17, 7 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2js7 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	== References ==		== References ==

OCA at 03:09, 10 September 2015

2015-09-10T03:09:16Z

← Older revision		Revision as of 03:09, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2js7' size='340' side='right' caption='[[2js7]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2js7' size='340' side='right' caption='[[2js7]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2js7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JS7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JS7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2js7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JS7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JS7 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MYD88 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MYD88 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2js7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2js7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2js7 RCSB], [http://www.ebi.ac.uk/pdbsum/2js7 PDBsum], [http://www.topsan.org/Proteins/NESGC/2js7 TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2js7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2js7 OCA], [http://pdbe.org/2js7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2js7 RCSB], [http://www.ebi.ac.uk/pdbsum/2js7 PDBsum], [http://www.topsan.org/Proteins/NESGC/2js7 TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Acton, T B]]		[[Category: Acton, T B]]
	[[Category: Ciano, M]]		[[Category: Ciano, M]]

OCA at 17:21, 19 January 2015

2015-01-19T17:21:38Z

← Older revision		Revision as of 17:21, 19 January 2015
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2js7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JS7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JS7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2js7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JS7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JS7 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MYD88 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MYD88 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2js7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2js7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2js7 RCSB], [http://www.ebi.ac.uk/pdbsum/2js7 PDBsum], [http://www.topsan.org/Proteins/NESGC/2js7 TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2js7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2js7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2js7 RCSB], [http://www.ebi.ac.uk/pdbsum/2js7 PDBsum], [http://www.topsan.org/Proteins/NESGC/2js7 TOPSAN]</span></td></tr>
	<table>		</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/MYD88_HUMAN MYD88_HUMAN]] Defects in MYD88 are the cause of MYD88 deficiency (MYD88D) [MIM:[http://omim.org/entry/612260 612260]]; also known as recurrent pyogenic bacterial infections due to MYD88 deficiency. Patients suffer from autosomal recessive, life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease, and die between 1 and 11 months of age. Surviving patients are otherwise healthy, with normal resistance to other microbes, and their clinical status improved with age.<ref>PMID:19506249</ref> <ref>PMID:18669862</ref>		[[http://www.uniprot.org/uniprot/MYD88_HUMAN MYD88_HUMAN]] Defects in MYD88 are the cause of MYD88 deficiency (MYD88D) [MIM:[http://omim.org/entry/612260 612260]]; also known as recurrent pyogenic bacterial infections due to MYD88 deficiency. Patients suffer from autosomal recessive, life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease, and die between 1 and 11 months of age. Surviving patients are otherwise healthy, with normal resistance to other microbes, and their clinical status improved with age.<ref>PMID:19506249</ref> <ref>PMID:18669862</ref>
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Acton, T B.]]		[[Category: Acton, T B]]
	[[Category: Ciano, M.]]		[[Category: Ciano, M]]
	[[Category: Ho, C.]]		[[Category: Ho, C]]
	[[Category: Kennedy, M A.]]		[[Category: Kennedy, M A]]
	[[Category: Ma, L-C.]]		[[Category: Ma, L-C]]
	[[Category: Montelione, G T.]]		[[Category: Montelione, G T]]
	[[Category: ~~NESG, Northeast~~ Structural ~~Genomics Consortium.~~]]		[[Category: Structural genomic]]
	[[Category: Ramelot, T A.]]		[[Category: Ramelot, T A]]
	[[Category: Rossi, P.]]		[[Category: Rossi, P]]
	[[Category: Tao, X.]]		[[Category: Tao, X]]
	[[Category: Tong, L.]]		[[Category: Tong, L]]
	[[Category: Xiao, R.]]		[[Category: Xiao, R]]
	[[Category: Innate immune signaling]]		[[Category: Innate immune signaling]]
	[[Category: Myd88_human]]		[[Category: Myd88_human]]
	[[Category: Nesg]]		[[Category: Nesg]]
	[[Category: ~~Northeast structural genomics consortium]]~~		[[Category: PSI, Protein structure initiative]]
	~~[[Category:~~ Protein structure initiative]]
	~~[[Category: Psi-2~~]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
	~~[[Category: Structural genomic]]~~
	[[Category: Tir domain]]		[[Category: Tir domain]]
	[[Category: Toll like receptor adaptor domain]]		[[Category: Toll like receptor adaptor domain]]

OCA at 10:24, 30 September 2014

2014-09-30T10:24:45Z

← Older revision		Revision as of 10:24, 30 September 2014
Line 1:		Line 1:
	~~{{STRUCTURE_2js7\| PDB=2js7 \| SCENE= }}~~		==Solution NMR structure of human myeloid differentiation primary response (MyD88). Northeast Structural Genomics target HR2869A==
	===Solution NMR structure of human myeloid differentiation primary response (MyD88). Northeast Structural Genomics target HR2869A===		<StructureSection load='2js7' size='340' side='right' caption='[[2js7]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
			== Structural highlights ==
	==Disease==		<table><tr><td colspan='2'>[[2js7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JS7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JS7 FirstGlance]. <br>
	[[http://www.uniprot.org/uniprot/MYD88_HUMAN MYD88_HUMAN]] Defects in MYD88 are the cause of MYD88 deficiency (MYD88D) [MIM:[http://omim.org/entry/612260 612260]]; also known as recurrent pyogenic bacterial infections due to MYD88 deficiency. Patients suffer from autosomal recessive, life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease, and die between 1 and 11 months of age. Surviving patients are otherwise healthy, with normal resistance to other microbes, and their clinical status improved with age.<ref>PMID:19506249</ref><ref>PMID:18669862</ref>		</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MYD88 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2js7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2js7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2js7 RCSB], [http://www.ebi.ac.uk/pdbsum/2js7 PDBsum], [http://www.topsan.org/Proteins/NESGC/2js7 TOPSAN]</span></td></tr>
	==Function==		<table>
	[[http://www.uniprot.org/uniprot/MYD88_HUMAN MYD88_HUMAN]] Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity).<ref>PMID:9013863</ref><ref>PMID:15361868</ref><ref>PMID:18292575</ref><ref>PMID:19506249</ref>		== Disease ==
			[[http://www.uniprot.org/uniprot/MYD88_HUMAN MYD88_HUMAN]] Defects in MYD88 are the cause of MYD88 deficiency (MYD88D) [MIM:[http://omim.org/entry/612260 612260]]; also known as recurrent pyogenic bacterial infections due to MYD88 deficiency. Patients suffer from autosomal recessive, life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease, and die between 1 and 11 months of age. Surviving patients are otherwise healthy, with normal resistance to other microbes, and their clinical status improved with age.<ref>PMID:19506249</ref> <ref>PMID:18669862</ref>
	==~~About this Structure~~==		== Function ==
	[[~~2js7~~]] ~~is a 1 chain~~ structure ~~with sequence from~~ [http://en.~~wikipedia~~.~~org/wiki~~/~~Homo_sapiens Homo sapiens~~]. ~~Full experimental information is~~ available from [http://~~oca~~.~~weizmann~~.ac.il/~~oca-bin~~/~~ocashort~~?id=~~2JS7 OCA~~].		[[http://www.uniprot.org/uniprot/MYD88_HUMAN MYD88_HUMAN]] Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity).<ref>PMID:9013863</ref> <ref>PMID:15361868</ref> <ref>PMID:18292575</ref> <ref>PMID:19506249</ref>
			== Evolutionary Conservation ==
	==~~Reference~~==		[[Image:Consurf_key_small.gif\|200px\|right]]
	<references ~~group="xtra"~~/><~~references~~/>		Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/2js7_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Acton, T B.]]		[[Category: Acton, T B.]]

OCA at 21:42, 24 March 2013

2013-03-24T21:42:20Z

← Older revision		Revision as of 21:42, 24 March 2013
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	~~[[Image:2js7.png\|left\|200px]]~~

	{{STRUCTURE_2js7\| PDB=2js7 \| SCENE= }}		{{STRUCTURE_2js7\| PDB=2js7 \| SCENE= }}
			===Solution NMR structure of human myeloid differentiation primary response (MyD88). Northeast Structural Genomics target HR2869A===

	===~~Solution NMR structure~~ of ~~human myeloid differentiation primary response~~ (~~MyD88~~). ~~Northeast Structural Genomics target HR2869A===~~		==Disease==
			[[http://www.uniprot.org/uniprot/MYD88_HUMAN MYD88_HUMAN]] Defects in MYD88 are the cause of MYD88 deficiency (MYD88D) [MIM:[http://omim.org/entry/612260 612260]]; also known as recurrent pyogenic bacterial infections due to MYD88 deficiency. Patients suffer from autosomal recessive, life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease, and die between 1 and 11 months of age. Surviving patients are otherwise healthy, with normal resistance to other microbes, and their clinical status improved with age.<ref>PMID:19506249</ref><ref>PMID:18669862</ref>

			==Function==
			[[http://www.uniprot.org/uniprot/MYD88_HUMAN MYD88_HUMAN]] Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity).<ref>PMID:9013863</ref><ref>PMID:15361868</ref><ref>PMID:18292575</ref><ref>PMID:19506249</ref>

	==About this Structure==		==About this Structure==
	[[2js7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JS7 OCA].		[[2js7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JS7 OCA].

			==Reference==
			<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Acton, T B.]]		[[Category: Acton, T B.]]

OCA: Protected "2js7" [edit=sysop:move=sysop]

2012-06-27T04:46:31Z

Protected "2js7" [edit=sysop:move=sysop]

← Older revision	Revision as of 04:46, 27 June 2012
(No difference)