2jsd - Revision history

OCA at 19:04, 29 May 2024

2024-05-29T19:04:46Z

← Older revision		Revision as of 19:04, 29 May 2024
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	==Solution structure of MMP20 complexed with NNGH==		==Solution structure of MMP20 complexed with NNGH==
	<StructureSection load='2jsd' size='340' side='right'caption='[[2jsd~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='2jsd' size='340' side='right'caption='[[2jsd]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jsd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JSD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jsd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JSD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NGH:N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL+HYDROXAMIC+ACID'>NGH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MMP20 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NGH:N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL+HYDROXAMIC+ACID'>NGH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsd OCA], [https://pdbe.org/2jsd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jsd RCSB], [https://www.ebi.ac.uk/pdbsum/2jsd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jsd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsd OCA], [https://pdbe.org/2jsd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jsd RCSB], [https://www.ebi.ac.uk/pdbsum/2jsd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jsd ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[https://www.uniprot.org/uniprot/MMP20_HUMAN MMP20_HUMAN]] Defects in MMP20 are the cause of amelogenesis imperfecta hypomaturation type 2A2 (AI2A2) [MIM:[https://omim.org/entry/612529 612529]]. AI2A2 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.<ref>PMID:15744043</ref>		[https://www.uniprot.org/uniprot/MMP20_HUMAN MMP20_HUMAN] Defects in MMP20 are the cause of amelogenesis imperfecta hypomaturation type 2A2 (AI2A2) [MIM:[https://omim.org/entry/612529 612529]. AI2A2 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.<ref>PMID:15744043</ref>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/MMP20_HUMAN MMP20_HUMAN]] Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation.<ref>PMID:9398237</ref> <ref>PMID:10922468</ref>		[https://www.uniprot.org/uniprot/MMP20_HUMAN MMP20_HUMAN] Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation.<ref>PMID:9398237</ref> <ref>PMID:10922468</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Arendt, Y]]		[[Category: Arendt Y]]
	[[Category: Banci, L]]		[[Category: Banci L]]
	[[Category: Bertini, I]]		[[Category: Bertini I]]
	[[Category: Cantini, F]]		[[Category: Cantini F]]
	[[Category: ~~Conte,~~ R ~~Del~~]]		[[Category: Cozzi R]]
	[[Category: ~~Cozzi,~~ R]]		[[Category: Del Conte R]]
	[[Category: Gonnelli, L]]		[[Category: Gonnelli L]]
	~~[[Category: SPINE, Structural Proteomics in Europe]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: Mmp-nngh]]~~
	~~[[Category: Spine]]~~
	~~[[Category: Spine-2]]~~
	~~[[Category: Spine2-complex]]~~
	~~[[Category: Structural genomic]]~~
	~~[[Category: Structural proteomics in europe~~]]

OCA at 07:55, 7 April 2021

2021-04-07T07:55:20Z

← Older revision		Revision as of 07:55, 7 April 2021
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	==Solution structure of MMP20 complexed with NNGH==		==Solution structure of MMP20 complexed with NNGH==
	<StructureSection load='2jsd' size='340' side='right' caption='[[2jsd]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2jsd' size='340' side='right'caption='[[2jsd]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jsd]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JSD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jsd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JSD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NGH:N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL+HYDROXAMIC+ACID'>NGH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NGH:N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL+HYDROXAMIC+ACID'>NGH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MMP20 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MMP20 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsd OCA], [~~http~~://pdbe.org/2jsd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2jsd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2jsd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2jsd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsd OCA], [https://pdbe.org/2jsd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jsd RCSB], [https://www.ebi.ac.uk/pdbsum/2jsd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jsd ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[~~http~~://www.uniprot.org/uniprot/MMP20_HUMAN MMP20_HUMAN]] Defects in MMP20 are the cause of amelogenesis imperfecta hypomaturation type 2A2 (AI2A2) [MIM:[~~http~~://omim.org/entry/612529 612529]]. AI2A2 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.<ref>PMID:15744043</ref>		[[https://www.uniprot.org/uniprot/MMP20_HUMAN MMP20_HUMAN]] Defects in MMP20 are the cause of amelogenesis imperfecta hypomaturation type 2A2 (AI2A2) [MIM:[https://omim.org/entry/612529 612529]]. AI2A2 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.<ref>PMID:15744043</ref>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/MMP20_HUMAN MMP20_HUMAN]] Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation.<ref>PMID:9398237</ref> <ref>PMID:10922468</ref>		[[https://www.uniprot.org/uniprot/MMP20_HUMAN MMP20_HUMAN]] Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation.<ref>PMID:9398237</ref> <ref>PMID:10922468</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[Matrix metalloproteinase\|Matrix metalloproteinase]]		*[[Matrix metalloproteinase 3D structures\|Matrix metalloproteinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Arendt, Y]]		[[Category: Arendt, Y]]
	[[Category: Banci, L]]		[[Category: Banci, L]]

OCA at 06:36, 11 July 2018

2018-07-11T06:36:28Z

← Older revision		Revision as of 06:36, 11 July 2018
Line 1:		Line 1:

	==Solution structure of MMP20 complexed with NNGH==		==Solution structure of MMP20 complexed with NNGH==
	<StructureSection load='2jsd' size='340' side='right' caption='[[2jsd]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2jsd' size='340' side='right' caption='[[2jsd]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NGH:N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL+HYDROXAMIC+ACID'>NGH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NGH:N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL+HYDROXAMIC+ACID'>NGH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MMP20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MMP20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsd OCA], [http://pdbe.org/2jsd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jsd RCSB], [http://www.ebi.ac.uk/pdbsum/2jsd PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsd OCA], [http://pdbe.org/2jsd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jsd RCSB], [http://www.ebi.ac.uk/pdbsum/2jsd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jsd ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/2jsd_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/2jsd_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 21:49, 9 February 2016

2016-02-09T21:49:07Z

← Older revision		Revision as of 21:49, 9 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jsd ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 02:21, 11 September 2015

2015-09-11T02:21:26Z

← Older revision		Revision as of 02:21, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2jsd' size='340' side='right' caption='[[2jsd]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2jsd' size='340' side='right' caption='[[2jsd]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jsd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JSD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jsd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JSD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NGH:N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL+HYDROXAMIC+ACID'>NGH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NGH:N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL+HYDROXAMIC+ACID'>NGH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MMP20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MMP20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jsd RCSB], [http://www.ebi.ac.uk/pdbsum/2jsd PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsd OCA], [http://pdbe.org/2jsd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jsd RCSB], [http://www.ebi.ac.uk/pdbsum/2jsd PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2jsd" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Arendt, Y]]		[[Category: Arendt, Y]]
	[[Category: Banci, L]]		[[Category: Banci, L]]

OCA at 15:02, 19 January 2015

2015-01-19T15:02:27Z

← Older revision		Revision as of 15:02, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jsd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JSD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jsd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JSD FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NGH:N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL+HYDROXAMIC+ACID'>NGH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NGH:N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL+HYDROXAMIC+ACID'>NGH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MMP20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MMP20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jsd RCSB], [http://www.ebi.ac.uk/pdbsum/2jsd PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jsd RCSB], [http://www.ebi.ac.uk/pdbsum/2jsd PDBsum]</span></td></tr>
	<table>		</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/MMP20_HUMAN MMP20_HUMAN]] Defects in MMP20 are the cause of amelogenesis imperfecta hypomaturation type 2A2 (AI2A2) [MIM:[http://omim.org/entry/612529 612529]]. AI2A2 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.<ref>PMID:15744043</ref>		[[http://www.uniprot.org/uniprot/MMP20_HUMAN MMP20_HUMAN]] Defects in MMP20 are the cause of amelogenesis imperfecta hypomaturation type 2A2 (AI2A2) [MIM:[http://omim.org/entry/612529 612529]]. AI2A2 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.<ref>PMID:15744043</ref>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arendt, Y.]]		[[Category: Arendt, Y]]
	[[Category: Banci, L.]]		[[Category: Banci, L]]
	[[Category: Bertini, I.]]		[[Category: Bertini, I]]
	[[Category: Cantini, F.]]		[[Category: Cantini, F]]
	[[Category: Conte, R Del.]]		[[Category: Conte, R Del]]
	[[Category: Cozzi, R.]]		[[Category: Cozzi, R]]
	[[Category: Gonnelli, L.]]		[[Category: Gonnelli, L]]
	[[Category: SPINE, Structural Proteomics in Europe.]]		[[Category: SPINE, Structural Proteomics in Europe]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Mmp-nngh]]		[[Category: Mmp-nngh]]

OCA at 08:32, 30 September 2014

2014-09-30T08:32:28Z

← Older revision		Revision as of 08:32, 30 September 2014
Line 1:		Line 1:
	~~{{STRUCTURE_2jsd~~\| ~~PDB~~=2jsd \| ~~SCENE~~= }}		==Solution structure of MMP20 complexed with NNGH==
	===~~Solution~~ structure of ~~MMP20 complexed with NNGH~~===		<StructureSection load='2jsd' size='340' side='right' caption='[[2jsd]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	~~{{ABSTRACT_PUBMED_17869250}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2jsd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JSD FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NGH:N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL+HYDROXAMIC+ACID'>NGH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MMP20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jsd RCSB], [http://www.ebi.ac.uk/pdbsum/2jsd PDBsum]</span></td></tr>
			<table>
			== Disease ==
			[[http://www.uniprot.org/uniprot/MMP20_HUMAN MMP20_HUMAN]] Defects in MMP20 are the cause of amelogenesis imperfecta hypomaturation type 2A2 (AI2A2) [MIM:[http://omim.org/entry/612529 612529]]. AI2A2 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.<ref>PMID:15744043</ref>
			== Function ==
			[[http://www.uniprot.org/uniprot/MMP20_HUMAN MMP20_HUMAN]] Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation.<ref>PMID:9398237</ref> <ref>PMID:10922468</ref>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/2jsd_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The solution structure of the catalytic domain of MMP-20, a member of the matrix metalloproteinases family not yet structurally characterized, complexed with N-Isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid (NNGH), is here reported and compared with other MMPs-NNGH adducts. The backbone dynamic has been characterized as well. We have found that, despite the same fold and very high overall similarity, the present structure experiences specific structural and dynamical similarities with some MMPs and differences with others, around the catalytic cavity. The present solution structure, not only contributes to fill the gap of structural knowledge on human MMPs, but also provides further information to design more selective and efficient inhibitors for a specific member of this class of proteins.

	~~==Disease==~~		Catalytic domain of MMP20 (Enamelysin) - the NMR structure of a new matrix metalloproteinase.,Arendt Y, Banci L, Bertini I, Cantini F, Cozzi R, Del Conte R, Gonnelli L FEBS Lett. 2007 Oct 2;581(24):4723-6. Epub 2007 Sep 6. PMID:17869250<ref>PMID:17869250</ref>
	~~[[http://www.uniprot.org/uniprot/MMP20_HUMAN MMP20_HUMAN]] Defects in~~ MMP20 ~~are~~ the ~~cause~~ of ~~amelogenesis imperfecta hypomaturation type 2A2~~ (~~AI2A2~~) ~~[MIM:[http~~:~~//omim~~.org/entry/612529 612529]]. AI2A2 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.<ref>PMID:~~15744043~~</ref>

	~~==Function==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[http://www.uniprot.org/uniprot~~/~~MMP20_HUMAN MMP20_HUMAN]] Degrades amelogenin~~, ~~the major protein component~~ of the ~~enamel matrix and two~~ of ~~the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation~~.<~~ref~~>~~PMID:9398237</ref><ref>PMID:10922468~~</~~ref~~>		</div>

	~~==About this Structure==~~
	[[2jsd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSD OCA].

	==See Also==		==See Also==
	*[[Matrix metalloproteinase\|Matrix metalloproteinase]]		*[[Matrix metalloproteinase\|Matrix metalloproteinase]]
			== References ==
	==~~Reference~~==		<references/>
	~~<ref group="xtra">PMID:017869250</ref>~~<references ~~group="xtra"~~/><~~references~~/>		__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arendt, Y.]]		[[Category: Arendt, Y.]]

OCA at 19:29, 24 March 2013

2013-03-24T19:29:16Z

← Older revision		Revision as of 19:29, 24 March 2013
Line 1:		Line 1:
	~~[[Image:2jsd.png\|left\|200px]]~~

	{{STRUCTURE_2jsd\| PDB=2jsd \| SCENE= }}		{{STRUCTURE_2jsd\| PDB=2jsd \| SCENE= }}
			===Solution structure of MMP20 complexed with NNGH===
			{{ABSTRACT_PUBMED_17869250}}

	===~~Solution structure~~ of ~~MMP20 complexed with NNGH===~~		==Disease==
			[[http://www.uniprot.org/uniprot/MMP20_HUMAN MMP20_HUMAN]] Defects in MMP20 are the cause of amelogenesis imperfecta hypomaturation type 2A2 (AI2A2) [MIM:[http://omim.org/entry/612529 612529]]. AI2A2 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.<ref>PMID:15744043</ref>

	~~{{ABSTRACT_PUBMED_17869250}}~~		==Function==
			[[http://www.uniprot.org/uniprot/MMP20_HUMAN MMP20_HUMAN]] Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation.<ref>PMID:9398237</ref><ref>PMID:10922468</ref>

	==About this Structure==		==About this Structure==
Line 14:		Line 16:

	==Reference==		==Reference==
	<ref group="xtra">PMID:017869250</ref><references group="xtra"/>		<ref group="xtra">PMID:017869250</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arendt, Y.]]		[[Category: Arendt, Y.]]

OCA at 15:15, 20 October 2012

2012-10-20T15:15:29Z

← Older revision		Revision as of 15:15, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[2jsd]] is a 1 chain structure ~~of [[Matrix metalloproteinase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSD OCA].		[[2jsd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSD OCA].

	==See Also==		==See Also==

OCA: Protected "2jsd" [edit=sysop:move=sysop]

2012-07-26T17:47:22Z

Protected "2jsd" [edit=sysop:move=sysop]

← Older revision	Revision as of 17:47, 26 July 2012
(No difference)