2jsi - Revision history

OCA at 09:14, 6 November 2024

2024-11-06T09:14:12Z

← Older revision		Revision as of 09:14, 6 November 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jsi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JSI FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jsi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JSI FirstGlance]. <br>
	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 25 models</td></tr>
	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jsi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsi OCA], [https://pdbe.org/2jsi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jsi RCSB], [https://www.ebi.ac.uk/pdbsum/2jsi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jsi ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jsi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsi OCA], [https://pdbe.org/2jsi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jsi RCSB], [https://www.ebi.ac.uk/pdbsum/2jsi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jsi ProSAT]</span></td></tr>

OCA at 12:48, 20 December 2023

2023-12-20T12:48:21Z

← Older revision		Revision as of 12:48, 20 December 2023
Line 1:		Line 1:

	==11-23 obestatin fragment in DPC/SDS micellar solution==		==11-23 obestatin fragment in DPC/SDS micellar solution==
	<StructureSection load='2jsi' size='340' side='right'caption='[[2jsi~~]], [[NMR_Ensembles_of_Models \| 25 NMR models~~]]' scene=''>		<StructureSection load='2jsi' size='340' side='right'caption='[[2jsi]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jsi]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JSI FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jsi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JSI FirstGlance]. <br>
	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=NH2:AMINO+GROUP'>NH2</scene~~></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2jsj\|2jsj]], [[2jsh\|2jsh]]~~</~~div~~></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jsi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsi OCA], [https://pdbe.org/2jsi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jsi RCSB], [https://www.ebi.ac.uk/pdbsum/2jsi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jsi ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jsi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsi OCA], [https://pdbe.org/2jsi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jsi RCSB], [https://www.ebi.ac.uk/pdbsum/2jsi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jsi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/GHRL_MOUSE GHRL_MOUSE]] Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity).		[https://www.uniprot.org/uniprot/GHRL_MOUSE GHRL_MOUSE] Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Campiglia, P~~]]		[[Category: Mus musculus]]
	[[Category: ~~Esposito, C]]~~		[[Category: Campiglia P]]
	~~[[Category: Scrima, M~~]]		[[Category: D'Ursi AM]]
	[[Category: Ursi~~, A M.D~~]]		[[Category: Esposito C]]
	[[Category: ~~11-23 obestatin fragment~~]]		[[Category: Scrima M]]
	[[Category: ~~Alternative splicing]]~~
	~~[[Category: Amidation]]~~
	~~[[Category: Dpc]]~~
	~~[[Category: Hormone]]~~
	~~[[Category: Lipoprotein]]~~
	~~[[Category: Micellar solution]]~~
	~~[[Category: Sd]]~~
	~~[[Category: Secreted~~]]

OCA at 08:16, 19 January 2022

2022-01-19T08:16:56Z

← Older revision		Revision as of 08:16, 19 January 2022
Line 3:		Line 3:
	<StructureSection load='2jsi' size='340' side='right'caption='[[2jsi]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>		<StructureSection load='2jsi' size='340' side='right'caption='[[2jsi]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jsi]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2JSI FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jsi]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JSI FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jsj\|2jsj]], [[2jsh\|2jsh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2jsj\|2jsj]], [[2jsh\|2jsh]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2jsi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsi OCA], [~~http~~://pdbe.org/2jsi PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2jsi RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2jsi PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2jsi ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jsi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsi OCA], [https://pdbe.org/2jsi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jsi RCSB], [https://www.ebi.ac.uk/pdbsum/2jsi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jsi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/GHRL_MOUSE GHRL_MOUSE]] Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity).		[[https://www.uniprot.org/uniprot/GHRL_MOUSE GHRL_MOUSE]] Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:58, 15 April 2020

2020-04-15T07:58:24Z

← Older revision		Revision as of 07:58, 15 April 2020
Line 1:		Line 1:

	==11-23 obestatin fragment in DPC/SDS micellar solution==		==11-23 obestatin fragment in DPC/SDS micellar solution==
	<StructureSection load='2jsi' size='340' side='right' caption='[[2jsi]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>		<StructureSection load='2jsi' size='340' side='right'caption='[[2jsi]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jsi]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSI OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JSI FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jsi]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSI OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2JSI FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jsj\|2jsj]], [[2jsh\|2jsh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jsj\|2jsj]], [[2jsh\|2jsh]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jsi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsi OCA], [http://pdbe.org/2jsi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jsi RCSB], [http://www.ebi.ac.uk/pdbsum/2jsi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jsi ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2jsi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsi OCA], [http://pdbe.org/2jsi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jsi RCSB], [http://www.ebi.ac.uk/pdbsum/2jsi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jsi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Campiglia, P]]		[[Category: Campiglia, P]]
	[[Category: Esposito, C]]		[[Category: Esposito, C]]

OCA at 07:09, 11 July 2018

2018-07-11T07:09:14Z

← Older revision		Revision as of 07:09, 11 July 2018
Line 1:		Line 1:

	==11-23 obestatin fragment in DPC/SDS micellar solution==		==11-23 obestatin fragment in DPC/SDS micellar solution==
	<StructureSection load='2jsi' size='340' side='right' caption='[[2jsi]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>		<StructureSection load='2jsi' size='340' side='right' caption='[[2jsi]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jsj\|2jsj]], [[2jsh\|2jsh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jsj\|2jsj]], [[2jsh\|2jsh]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jsi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsi OCA], [http://pdbe.org/2jsi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jsi RCSB], [http://www.ebi.ac.uk/pdbsum/2jsi PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jsi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsi OCA], [http://pdbe.org/2jsi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jsi RCSB], [http://www.ebi.ac.uk/pdbsum/2jsi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jsi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 28:
	[[Category: Ursi, A M.D]]		[[Category: Ursi, A M.D]]
	[[Category: 11-23 obestatin fragment]]		[[Category: 11-23 obestatin fragment]]
			[[Category: Alternative splicing]]
	[[Category: Amidation]]		[[Category: Amidation]]
	[[Category: Dpc]]		[[Category: Dpc]]

OCA at 04:23, 10 September 2015

2015-09-10T04:23:05Z

← Older revision		Revision as of 04:23, 10 September 2015
Line 5:		Line 5:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jsj\|2jsj]], [[2jsh\|2jsh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jsj\|2jsj]], [[2jsh\|2jsh]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jsi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jsi RCSB], [http://www.ebi.ac.uk/pdbsum/2jsi PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jsi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsi OCA], [http://pdbe.org/2jsi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jsi RCSB], [http://www.ebi.ac.uk/pdbsum/2jsi PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2jsi" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:44, 24 December 2014

2014-12-24T17:44:25Z

← Older revision		Revision as of 17:44, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jsi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jsi RCSB], [http://www.ebi.ac.uk/pdbsum/2jsi PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jsi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jsi RCSB], [http://www.ebi.ac.uk/pdbsum/2jsi PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/GHRL_MOUSE GHRL_MOUSE]] Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Campiglia, P.]]		[[Category: Campiglia, P]]
	[[Category: Esposito, C.]]		[[Category: Esposito, C]]
	[[Category: Scrima, M.]]		[[Category: Scrima, M]]
	[[Category: Ursi, A M.D.]]		[[Category: Ursi, A M.D]]
	[[Category: 11-23 obestatin fragment]]		[[Category: 11-23 obestatin fragment]]
	[[Category: Amidation]]		[[Category: Amidation]]

OCA at 15:34, 12 October 2014

2014-10-12T15:34:05Z

← Older revision		Revision as of 15:34, 12 October 2014
Line 1:		Line 1:
	[[~~Image~~:~~2jsi~~.~~png~~\|~~left~~\|~~200px~~]]		==11-23 obestatin fragment in DPC/SDS micellar solution==
			<StructureSection load='2jsi' size='340' side='right' caption='[[2jsi]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2jsi]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JSI FirstGlance]. <br>
			</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jsj\|2jsj]], [[2jsh\|2jsh]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jsi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jsi RCSB], [http://www.ebi.ac.uk/pdbsum/2jsi PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Obestatin and its derivative Ob(11-23) are recently discovered peptides produced in the rat stomach. They have proven to be involved in the regulation of energy balance, inhibiting feeding, causing reductions in food intake, body weight and jejunal contraction in rodents. The G-protein coupled receptor, GPR39, was originally proposed as being an obestatin target receptor, but this remains controversial. As such, the molecular mechanism for obestatin's effects in vivo is still uncertain. Here we report the CD and NMR conformational analysis of obestatin and Ob(11-23). Both peptides assume a regular secondary structure in the C-terminal region of the molecule. In this region, structural elements similar to other GPCR binding neuropeptides support the identity of obestatin as a new and functionally autonomous GPCR ligand. Conversely sequence and conformational specificity point to a new farmacoforic structure, on which innovative derivatives with a potential role in the treatment of obesity can be designed and synthetized.

	~~{{STRUCTURE_2jsi\| PDB=2jsi \| SCENE= }}~~		Obestatin conformational features: a strategy to unveil obestatin's biological role?,Scrima M, Campiglia P, Esposito C, Gomez-Monterrey I, Novellino E, D'Ursi AM Biochem Biophys Res Commun. 2007 Nov 23;363(3):500-5. Epub 2007 Sep 19. PMID:17904104<ref>PMID:17904104</ref>

	~~===11-23 obestatin fragment in DPC~~/~~SDS micellar solution===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_17904104}}~~		== References ==
			<references/>
	==~~About this Structure~~==		__TOC__
	~~[[2jsi]] is a 1 chain structure. Full experimental information is available from [http:~~//~~oca.weizmann.ac.il/oca-bin/ocashort?id=2JSI OCA].~~		</StructureSection>
	[[Category: Campiglia, P.]]		[[Category: Campiglia, P.]]
	[[Category: Esposito, C.]]		[[Category: Esposito, C.]]

OCA: Protected "2jsi" [edit=sysop:move=sysop]

2013-01-07T10:40:22Z

Protected "2jsi" [edit=sysop:move=sysop]

← Older revision	Revision as of 10:40, 7 January 2013
(No difference)

OCA at 10:40, 7 January 2013

2013-01-07T10:40:18Z

← Older revision		Revision as of 10:40, 7 January 2013
Line 1:		Line 1:
	~~{{Seed}}~~		[[Image:2jsi.png\|left\|200px]]
	[[Image:2jsi.~~jpg~~\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2jsi", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2jsi\| PDB=2jsi \| SCENE= }}		{{STRUCTURE_2jsi\| PDB=2jsi \| SCENE= }}

	===11-23 obestatin fragment in DPC/SDS micellar solution===		===11-23 obestatin fragment in DPC/SDS micellar solution===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_17904104}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 17904104 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_17904104}}		{{ABSTRACT_PUBMED_17904104}}

	==About this Structure==		==About this Structure==
	~~2JSI is a~~ [[~~Single protein~~]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSI OCA].		[[2jsi]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSI OCA].

	~~==Reference==~~
	Obestatin conformational features: a strategy to unveil obestatin's biological role?, Scrima M, Campiglia P, Esposito C, Gomez-Monterrey I, Novellino E, D'Ursi AM, Biochem Biophys Res Commun. 2007 Nov 23;363(3):500-5. Epub 2007 Sep 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17904104 17904104]
	~~[[Category: Single protein]]~~
	[[Category: Campiglia, P.]]		[[Category: Campiglia, P.]]
	[[Category: Esposito, C.]]		[[Category: Esposito, C.]]
Line 30:		Line 14:
	[[Category: Ursi, A M.D.]]		[[Category: Ursi, A M.D.]]
	[[Category: 11-23 obestatin fragment]]		[[Category: 11-23 obestatin fragment]]
	~~[[Category: Alternative splicing]]~~
	[[Category: Amidation]]		[[Category: Amidation]]
	[[Category: Dpc]]		[[Category: Dpc]]
Line 38:		Line 21:
	[[Category: Sd]]		[[Category: Sd]]
	[[Category: Secreted]]		[[Category: Secreted]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 22 10:34:02 2008''~~