2jtk - Revision history

OCA at 09:14, 6 November 2024

2024-11-06T09:14:13Z

← Older revision		Revision as of 09:14, 6 November 2024
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	==A functional domain of a Wnt signal protein==		==A functional domain of a Wnt signal protein==
	<StructureSection load='2jtk' size='340' side='right'caption='[[2jtk~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='2jtk' size='340' side='right'caption='[[2jtk]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jtk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JTK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JTK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jtk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JTK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JTK FirstGlance]. <br>
	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>Dkk2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~10090 Mus musculus])~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jtk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jtk OCA], [https://pdbe.org/2jtk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jtk RCSB], [https://www.ebi.ac.uk/pdbsum/2jtk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jtk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jtk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jtk OCA], [https://pdbe.org/2jtk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jtk RCSB], [https://www.ebi.ac.uk/pdbsum/2jtk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jtk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/DKK2_MOUSE DKK2_MOUSE]] Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.		[https://www.uniprot.org/uniprot/DKK2_MOUSE DKK2_MOUSE] Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jt/2jtk_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jt/2jtk_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
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	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Chen, L]]		[[Category: Chen L]]
	[[Category: Huang, J]]		[[Category: Huang J]]
	[[Category: Shao, Y]]		[[Category: Shao Y]]
	[[Category: Zheng, J]]		[[Category: Zheng J]]
	~~[[Category: Developmental protein]]~~
	~~[[Category: Glycoprotein]]~~
	~~[[Category: Protein]]~~
	~~[[Category: Secreted]]~~
	~~[[Category: Signaling protein]]~~
	~~[[Category: Wnt signaling pathway~~]]

OCA at 07:56, 7 April 2021

2021-04-07T07:56:37Z

← Older revision		Revision as of 07:56, 7 April 2021
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	==A functional domain of a Wnt signal protein==		==A functional domain of a Wnt signal protein==
	<StructureSection load='2jtk' size='340' side='right' caption='[[2jtk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2jtk' size='340' side='right'caption='[[2jtk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jtk]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JTK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JTK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jtk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JTK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JTK FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Dkk2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Dkk2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jtk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jtk OCA], [~~http~~://pdbe.org/2jtk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2jtk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2jtk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2jtk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jtk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jtk OCA], [https://pdbe.org/2jtk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jtk RCSB], [https://www.ebi.ac.uk/pdbsum/2jtk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jtk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/DKK2_MOUSE DKK2_MOUSE]] Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.		[[https://www.uniprot.org/uniprot/DKK2_MOUSE DKK2_MOUSE]] Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Chen, L]]		[[Category: Chen, L]]

OCA at 11:12, 18 July 2018

2018-07-18T11:12:25Z

← Older revision		Revision as of 11:12, 18 July 2018
Line 1:		Line 1:

	==A functional domain of a Wnt signal protein==		==A functional domain of a Wnt signal protein==
	<StructureSection load='2jtk' size='340' side='right' caption='[[2jtk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2jtk' size='340' side='right' caption='[[2jtk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2jtk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JTK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JTK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jtk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JTK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JTK FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Dkk2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Dkk2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jtk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jtk OCA], [http://pdbe.org/2jtk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jtk RCSB], [http://www.ebi.ac.uk/pdbsum/2jtk PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jtk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jtk OCA], [http://pdbe.org/2jtk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jtk RCSB], [http://www.ebi.ac.uk/pdbsum/2jtk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jtk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jt/2jtk_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jt/2jtk_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 10:14, 8 February 2016

2016-02-08T10:14:29Z

← Older revision		Revision as of 10:14, 8 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jtk ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:33, 10 September 2015

2015-09-10T10:33:32Z

← Older revision		Revision as of 10:33, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2jtk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JTK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JTK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jtk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JTK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JTK FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Dkk2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Dkk2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jtk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jtk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jtk RCSB], [http://www.ebi.ac.uk/pdbsum/2jtk PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jtk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jtk OCA], [http://pdbe.org/2jtk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jtk RCSB], [http://www.ebi.ac.uk/pdbsum/2jtk PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2jtk" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 22:36, 24 December 2014

2014-12-24T22:36:24Z

← Older revision		Revision as of 22:36, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jtk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JTK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JTK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jtk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JTK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JTK FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Dkk2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Dkk2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jtk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jtk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jtk RCSB], [http://www.ebi.ac.uk/pdbsum/2jtk PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jtk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jtk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jtk RCSB], [http://www.ebi.ac.uk/pdbsum/2jtk PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/DKK2_MOUSE DKK2_MOUSE]] Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Chen, L.]]		[[Category: Chen, L]]
	[[Category: Huang, J.]]		[[Category: Huang, J]]
	[[Category: Shao, Y.]]		[[Category: Shao, Y]]
	[[Category: Zheng, J.]]		[[Category: Zheng, J]]
	[[Category: Developmental protein]]		[[Category: Developmental protein]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]

OCA at 08:17, 30 September 2014

2014-09-30T08:17:10Z

← Older revision		Revision as of 08:17, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2jtk~~.~~png~~\|~~left~~\|~~200px~~]]		==A functional domain of a Wnt signal protein==
			<StructureSection load='2jtk' size='340' side='right' caption='[[2jtk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2jtk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JTK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JTK FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Dkk2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jtk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jtk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jtk RCSB], [http://www.ebi.ac.uk/pdbsum/2jtk PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jt/2jtk_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Dickkopf (Dkk) proteins are antagonists of the canonical Wnt signaling pathway and are crucial for embryonic cell fate and bone formation. Wnt antagonism of Dkk requires the binding of the C-terminal cysteine-rich domain of Dkk to the Wnt coreceptor, LRP5/6. However, the structural basis of the interaction between Dkk and low density lipoprotein receptor-related protein (LRP) 5/6 is unknown. In this study, we examined the structure of the Dkk functional domain and elucidated its interactions with LRP5/6. Using NMR spectroscopy, we determined the solution structure of the C-terminal cysteine-rich domain of mouse Dkk2 (Dkk2C). Then, guided by mutagenesis studies, we docked Dkk2C to the YWTD beta-propeller domains of LRP5/6 and showed that the ligand binding site of the third LRP5/6 beta-propeller domain matches Dkk2C best, suggesting that this domain binds to Dkk2C with higher affinity. Such differential binding affinity is likely to play an essential role in Dkk function in the canonical Wnt pathway.

	~~{{STRUCTURE_2jtk\| PDB=2jtk \| SCENE= }}~~		Structural insight into the mechanisms of Wnt signaling antagonism by Dkk.,Chen L, Wang K, Shao Y, Huang J, Li X, Shan J, Wu D, Zheng JJ J Biol Chem. 2008 Aug 22;283(34):23364-70. Epub 2008 Jun 3. PMID:18524778<ref>PMID:18524778</ref>

	~~===A functional domain~~ of ~~a Wnt signal protein===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_18524778}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2jtk]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2JTK OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:018524778<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Chen, L.]]		[[Category: Chen, L.]]

OCA: Protected "2jtk" [edit=sysop:move=sysop]

2013-01-07T10:43:44Z

Protected "2jtk" [edit=sysop:move=sysop]

← Older revision	Revision as of 10:43, 7 January 2013
(No difference)

OCA at 10:43, 7 January 2013

2013-01-07T10:43:42Z

← Older revision		Revision as of 10:43, 7 January 2013
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	~~{{Seed}}~~
	[[Image:2jtk.png\|left\|200px]]		[[Image:2jtk.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2jtk", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2jtk\| PDB=2jtk \| SCENE= }}		{{STRUCTURE_2jtk\| PDB=2jtk \| SCENE= }}

	===A functional domain of a Wnt signal protein===		===A functional domain of a Wnt signal protein===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_18524778}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 18524778 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_18524778}}		{{ABSTRACT_PUBMED_18524778}}

	==About this Structure==		==About this Structure==
	~~2JTK~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JTK OCA].		[[2jtk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JTK OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~18524778~~</ref><references group="xtra"/>		<ref group="xtra">PMID:018524778</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Chen, L.]]		[[Category: Chen, L.]]
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	[[Category: Zheng, J.]]		[[Category: Zheng, J.]]
	[[Category: Developmental protein]]		[[Category: Developmental protein]]
	~~[[Category: Domain]]~~
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]
	[[Category: Protein]]		[[Category: Protein]]
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	[[Category: Signaling protein]]		[[Category: Signaling protein]]
	[[Category: Wnt signaling pathway]]		[[Category: Wnt signaling pathway]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 21:15:18 2009''~~

OCA at 19:15, 16 February 2009

2009-02-16T19:15:21Z

← Older revision		Revision as of 19:15, 16 February 2009
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	==About this Structure==		==About this Structure==
	2JTK is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JTK OCA].		2JTK is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JTK OCA].

	==Reference==		==Reference==
	~~Structural insight into the mechanisms of Wnt signaling antagonism by Dkk., Chen L, Wang K, Shao Y, Huang J, Li X, Shan J, Wu D, Zheng JJ, J Biol Chem. 2008 Jun 3;.~~ PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~18524778 18524778]~~		<ref group="xtra">PMID:18524778</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	~~[[Category: Single protein]]~~
	[[Category: Chen, L.]]		[[Category: Chen, L.]]
	[[Category: Huang, J.]]		[[Category: Huang, J.]]
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	[[Category: Wnt signaling pathway]]		[[Category: Wnt signaling pathway]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon ~~Jul 28 02~~:05:~~14 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 21:15:18 2009''