2jun - Revision history

OCA at 19:06, 29 May 2024

2024-05-29T19:06:05Z

← Older revision		Revision as of 19:06, 29 May 2024
Line 1:		Line 1:

	==Structure of the MID1 tandem B-boxes reveals an interaction reminiscent of intermolecular RING heterodimers==		==Structure of the MID1 tandem B-boxes reveals an interaction reminiscent of intermolecular RING heterodimers==
	<StructureSection load='2jun' size='340' side='right'caption='[[2jun~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='2jun' size='340' side='right'caption='[[2jun]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jun]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JUN FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jun]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JUN FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~MID1, FXY, RNF59, TRIM18, XPRF ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jun OCA], [https://pdbe.org/2jun PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jun RCSB], [https://www.ebi.ac.uk/pdbsum/2jun PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jun ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jun OCA], [https://pdbe.org/2jun PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jun RCSB], [https://www.ebi.ac.uk/pdbsum/2jun PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jun ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[https://www.uniprot.org/uniprot/TRI18_HUMAN TRI18_HUMAN]] Defects in MID1 are the cause of Opitz GBBB syndrome 1 (OGS1) [MIM:[https://omim.org/entry/300000 300000]]. A congenital midline malformation syndrome characterized by hypertelorism, genital-urinary defects such as hypospadias in males and splayed labia in females, lip-palate-laryngotracheal clefts, imperforate anus, developmental delay and congenital heart defects. Note=MID1 mutations produce proteins with a decreased affinity for microtubules.<ref>PMID:9354791</ref> <ref>PMID:11030761</ref> <ref>PMID:9718340</ref> <ref>PMID:15558842</ref>		[https://www.uniprot.org/uniprot/TRI18_HUMAN TRI18_HUMAN] Defects in MID1 are the cause of Opitz GBBB syndrome 1 (OGS1) [MIM:[https://omim.org/entry/300000 300000]. A congenital midline malformation syndrome characterized by hypertelorism, genital-urinary defects such as hypospadias in males and splayed labia in females, lip-palate-laryngotracheal clefts, imperforate anus, developmental delay and congenital heart defects. Note=MID1 mutations produce proteins with a decreased affinity for microtubules.<ref>PMID:9354791</ref> <ref>PMID:11030761</ref> <ref>PMID:9718340</ref> <ref>PMID:15558842</ref>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/TRI18_HUMAN TRI18_HUMAN]] Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.<ref>PMID:10400985</ref> <ref>PMID:11685209</ref> <ref>PMID:22613722</ref>		[https://www.uniprot.org/uniprot/TRI18_HUMAN TRI18_HUMAN] Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.<ref>PMID:10400985</ref> <ref>PMID:11685209</ref> <ref>PMID:22613722</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Cox~~, T C~~]]		[[Category: Cox TC]]
	[[Category: Jakkidi, M]]		[[Category: Jakkidi M]]
	[[Category: Massiah~~, M A~~]]		[[Category: Massiah MA]]
	[[Category: Short~~, K M~~]]		[[Category: Short KM]]
	[[Category: Simmons~~, B N~~]]		[[Category: Simmons BN]]
	[[Category: Singireddy, S]]		[[Category: Singireddy S]]
	[[Category: Tao, H]]		[[Category: Tao H]]
	~~[[Category: Alternative splicing]]~~
	~~[[Category: B-box]]~~
	~~[[Category: Coiled coil]]~~
	~~[[Category: Cytoplasm]]~~
	~~[[Category: Cytoskeleton]]~~
	~~[[Category: Disease mutation]]~~
	~~[[Category: Ligase]]~~
	~~[[Category: Metal-binding]]~~
	~~[[Category: Microtubule]]~~
	~~[[Category: Midline 1]]~~
	~~[[Category: Phosphorylation]]~~
	~~[[Category: Ring finger]]~~
	~~[[Category: Trim]]~~
	~~[[Category: Ubl conjugation pathway]]~~
	~~[[Category: Zinc]]~~
	~~[[Category: Zinc-finger~~]]

OCA at 07:58, 7 April 2021

2021-04-07T07:58:05Z

← Older revision		Revision as of 07:58, 7 April 2021
Line 1:		Line 1:

	==Structure of the MID1 tandem B-boxes reveals an interaction reminiscent of intermolecular RING heterodimers==		==Structure of the MID1 tandem B-boxes reveals an interaction reminiscent of intermolecular RING heterodimers==
	<StructureSection load='2jun' size='340' side='right' caption='[[2jun]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2jun' size='340' side='right'caption='[[2jun]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jun]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JUN FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jun]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JUN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MID1, FXY, RNF59, TRIM18, XPRF ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MID1, FXY, RNF59, TRIM18, XPRF ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jun OCA], [~~http~~://pdbe.org/2jun PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2jun RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2jun PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2jun ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jun OCA], [https://pdbe.org/2jun PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jun RCSB], [https://www.ebi.ac.uk/pdbsum/2jun PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jun ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[~~http~~://www.uniprot.org/uniprot/TRI18_HUMAN TRI18_HUMAN]] Defects in MID1 are the cause of Opitz GBBB syndrome 1 (OGS1) [MIM:[~~http~~://omim.org/entry/300000 300000]]. A congenital midline malformation syndrome characterized by hypertelorism, genital-urinary defects such as hypospadias in males and splayed labia in females, lip-palate-laryngotracheal clefts, imperforate anus, developmental delay and congenital heart defects. Note=MID1 mutations produce proteins with a decreased affinity for microtubules.<ref>PMID:9354791</ref> <ref>PMID:11030761</ref> <ref>PMID:9718340</ref> <ref>PMID:15558842</ref>		[[https://www.uniprot.org/uniprot/TRI18_HUMAN TRI18_HUMAN]] Defects in MID1 are the cause of Opitz GBBB syndrome 1 (OGS1) [MIM:[https://omim.org/entry/300000 300000]]. A congenital midline malformation syndrome characterized by hypertelorism, genital-urinary defects such as hypospadias in males and splayed labia in females, lip-palate-laryngotracheal clefts, imperforate anus, developmental delay and congenital heart defects. Note=MID1 mutations produce proteins with a decreased affinity for microtubules.<ref>PMID:9354791</ref> <ref>PMID:11030761</ref> <ref>PMID:9718340</ref> <ref>PMID:15558842</ref>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/TRI18_HUMAN TRI18_HUMAN]] Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.<ref>PMID:10400985</ref> <ref>PMID:11685209</ref> <ref>PMID:22613722</ref>		[[https://www.uniprot.org/uniprot/TRI18_HUMAN TRI18_HUMAN]] Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.<ref>PMID:10400985</ref> <ref>PMID:11685209</ref> <ref>PMID:22613722</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Cox, T C]]		[[Category: Cox, T C]]
	[[Category: Jakkidi, M]]		[[Category: Jakkidi, M]]

OCA at 10:05, 18 July 2018

2018-07-18T10:05:46Z

← Older revision		Revision as of 10:05, 18 July 2018
Line 1:		Line 1:

	==Structure of the MID1 tandem B-boxes reveals an interaction reminiscent of intermolecular RING heterodimers==		==Structure of the MID1 tandem B-boxes reveals an interaction reminiscent of intermolecular RING heterodimers==
	<StructureSection load='2jun' size='340' side='right' caption='[[2jun]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2jun' size='340' side='right' caption='[[2jun]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MID1, FXY, RNF59, TRIM18, XPRF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MID1, FXY, RNF59, TRIM18, XPRF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jun OCA], [http://pdbe.org/2jun PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jun RCSB], [http://www.ebi.ac.uk/pdbsum/2jun PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jun OCA], [http://pdbe.org/2jun PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jun RCSB], [http://www.ebi.ac.uk/pdbsum/2jun PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jun ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/2jun_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/2jun_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 42:		Line 43:
	[[Category: Singireddy, S]]		[[Category: Singireddy, S]]
	[[Category: Tao, H]]		[[Category: Tao, H]]
			[[Category: Alternative splicing]]
	[[Category: B-box]]		[[Category: B-box]]
			[[Category: Coiled coil]]
			[[Category: Cytoplasm]]
	[[Category: Cytoskeleton]]		[[Category: Cytoskeleton]]
	[[Category: Disease mutation]]		[[Category: Disease mutation]]
Line 53:		Line 57:
	[[Category: Trim]]		[[Category: Trim]]
	[[Category: Ubl conjugation pathway]]		[[Category: Ubl conjugation pathway]]
			[[Category: Zinc]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

OCA at 03:37, 8 February 2016

2016-02-08T03:37:30Z

← Older revision		Revision as of 03:37, 8 February 2016
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jun ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:29, 10 September 2015

2015-09-10T07:29:49Z

← Older revision		Revision as of 07:29, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2jun' size='340' side='right' caption='[[2jun]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2jun' size='340' side='right' caption='[[2jun]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jun]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JUN FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jun]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JUN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MID1, FXY, RNF59, TRIM18, XPRF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MID1, FXY, RNF59, TRIM18, XPRF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jun OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jun RCSB], [http://www.ebi.ac.uk/pdbsum/2jun PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jun OCA], [http://pdbe.org/2jun PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jun RCSB], [http://www.ebi.ac.uk/pdbsum/2jun PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2jun" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Cox, T C]]		[[Category: Cox, T C]]
	[[Category: Jakkidi, M]]		[[Category: Jakkidi, M]]

OCA at 14:43, 19 January 2015

2015-01-19T14:43:15Z

← Older revision		Revision as of 14:43, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jun]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JUN FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jun]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JUN FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MID1, FXY, RNF59, TRIM18, XPRF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MID1, FXY, RNF59, TRIM18, XPRF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jun OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jun RCSB], [http://www.ebi.ac.uk/pdbsum/2jun PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jun OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jun RCSB], [http://www.ebi.ac.uk/pdbsum/2jun PDBsum]</span></td></tr>
	<table>		</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/TRI18_HUMAN TRI18_HUMAN]] Defects in MID1 are the cause of Opitz GBBB syndrome 1 (OGS1) [MIM:[http://omim.org/entry/300000 300000]]. A congenital midline malformation syndrome characterized by hypertelorism, genital-urinary defects such as hypospadias in males and splayed labia in females, lip-palate-laryngotracheal clefts, imperforate anus, developmental delay and congenital heart defects. Note=MID1 mutations produce proteins with a decreased affinity for microtubules.<ref>PMID:9354791</ref> <ref>PMID:11030761</ref> <ref>PMID:9718340</ref> <ref>PMID:15558842</ref>		[[http://www.uniprot.org/uniprot/TRI18_HUMAN TRI18_HUMAN]] Defects in MID1 are the cause of Opitz GBBB syndrome 1 (OGS1) [MIM:[http://omim.org/entry/300000 300000]]. A congenital midline malformation syndrome characterized by hypertelorism, genital-urinary defects such as hypospadias in males and splayed labia in females, lip-palate-laryngotracheal clefts, imperforate anus, developmental delay and congenital heart defects. Note=MID1 mutations produce proteins with a decreased affinity for microtubules.<ref>PMID:9354791</ref> <ref>PMID:11030761</ref> <ref>PMID:9718340</ref> <ref>PMID:15558842</ref>
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Cox, T C.]]		[[Category: Cox, T C]]
	[[Category: Jakkidi, M.]]		[[Category: Jakkidi, M]]
	[[Category: Massiah, M A.]]		[[Category: Massiah, M A]]
	[[Category: Short, K M.]]		[[Category: Short, K M]]
	[[Category: Simmons, B N.]]		[[Category: Simmons, B N]]
	[[Category: Singireddy, S.]]		[[Category: Singireddy, S]]
	[[Category: Tao, H.]]		[[Category: Tao, H]]
	[[Category: B-box]]		[[Category: B-box]]
	[[Category: Cytoskeleton]]		[[Category: Cytoskeleton]]

OCA at 08:24, 30 September 2014

2014-09-30T08:24:52Z

← Older revision		Revision as of 08:24, 30 September 2014
Line 1:		Line 1:
	~~{{STRUCTURE_2jun\| PDB=2jun \| SCENE= }}~~		==Structure of the MID1 tandem B-boxes reveals an interaction reminiscent of intermolecular RING heterodimers==
	===Structure of the MID1 tandem B-boxes reveals an interaction reminiscent of intermolecular RING heterodimers===		<StructureSection load='2jun' size='340' side='right' caption='[[2jun]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	~~{{ABSTRACT_PUBMED_18220417}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2jun]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JUN FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MID1, FXY, RNF59, TRIM18, XPRF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jun OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jun RCSB], [http://www.ebi.ac.uk/pdbsum/2jun PDBsum]</span></td></tr>
			<table>
			== Disease ==
			[[http://www.uniprot.org/uniprot/TRI18_HUMAN TRI18_HUMAN]] Defects in MID1 are the cause of Opitz GBBB syndrome 1 (OGS1) [MIM:[http://omim.org/entry/300000 300000]]. A congenital midline malformation syndrome characterized by hypertelorism, genital-urinary defects such as hypospadias in males and splayed labia in females, lip-palate-laryngotracheal clefts, imperforate anus, developmental delay and congenital heart defects. Note=MID1 mutations produce proteins with a decreased affinity for microtubules.<ref>PMID:9354791</ref> <ref>PMID:11030761</ref> <ref>PMID:9718340</ref> <ref>PMID:15558842</ref>
			== Function ==
			[[http://www.uniprot.org/uniprot/TRI18_HUMAN TRI18_HUMAN]] Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.<ref>PMID:10400985</ref> <ref>PMID:11685209</ref> <ref>PMID:22613722</ref>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/2jun_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The tripartite motif (TRIM) protein family, defined by N-terminal RING, B-box, and coiled-coil (RBCC) domains, consists of either a single type 2 B-box domain or tandem B-box domains of type 1 and type 2 (B1B2). Here, we report the first structure of the B-box domains in their native tandem orientation. The B-boxes are from Midline-1, a putative ubiquitin E3 ligase that is required for the proteosomal degradation of the catalytic subunit of protein phosphatase 2A (PP2Ac). This function of MID1 is facilitated by the direct binding of Alpha4, a regulatory subunit of PP2Ac, to B-box1, while B-box2 appears to influence this interaction. Both B-box1 and B-box2 bind two zinc atoms in a cross-brace motif and adopt a similar betabetaalpha structure reminiscent of the RING, PHD, ZZ, and U-box domains, although they differ from each other and with RING domains in the spacing of their zinc-binding residues. The two B-box domains pack against each other with the interface formed by residues located on the structured loop consisting of the two antiparallel beta-strands. The surface area of the interface is 188 A2 (17% of the total surface). Consistent with the globular structure, the Tm of the tandem B-box domain (59 degrees C) is higher than the individual domains, supporting a stable interaction between the B-box 1 and 2 domains. Notably, the interaction is reminiscent of the interaction of recently determined RING dimers, suggesting the possibility of an evolutionarily conserved role for B-box2 domains in regulating functional RING-type folds.

	~~==Disease==~~		Structure of the MID1 Tandem B-Boxes Reveals an Interaction Reminiscent of Intermolecular Ring Heterodimers(,).,Tao H, Simmons BN, Singireddy S, Jakkidi M, Short KM, Cox TC, Massiah MA Biochemistry. 2008 Feb 26;47(8):2450-2457. Epub 2008 Jan 26. PMID:18220417<ref>PMID:18220417</ref>
	~~[[http://www.uniprot.org/uniprot/TRI18_HUMAN TRI18_HUMAN]] Defects in~~ MID1 ~~are the cause~~ of ~~Opitz GBBB syndrome 1~~ (~~OGS1~~) ~~[MIM:[http://omim~~.~~org/entry/300000 300000]]. A congenital midline malformation syndrome characterized by hypertelorism~~, ~~genital-urinary defects such as hypospadias in males and splayed labia in females~~, ~~lip-palate-laryngotracheal clefts~~, ~~imperforate anus~~, ~~developmental delay and congenital heart defects~~. ~~Note=MID1 mutations produce proteins with a decreased affinity for microtubules~~.~~<ref>PMID:9354791</ref><ref>~~PMID:~~11030761</ref><ref>PMID:9718340</ref>~~<ref>PMID:~~15558842~~</ref>

	~~==Function==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[http://www.uniprot.org/uniprot~~/~~TRI18_HUMAN TRI18_HUMAN]] Has E3 ubiquitin ligase activity towards IGBP1~~, ~~promoting its monoubiquitination, which results in deprotection~~ of the ~~catalytic subunit~~ of ~~protein phosphatase PP2A, and its subsequent degradation by polyubiquitination~~.<~~ref~~>~~PMID:10400985~~</~~ref~~>~~<ref>PMID:11685209</ref><ref>PMID:22613722</ref>~~		</div>
			== References ==
	==~~About this Structure~~==		<references/>
	[[2jun]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUN OCA].		__TOC__
			</StructureSection>
	~~==Reference==~~
	~~<ref group="xtra">PMID:018220417</ref>~~<references ~~group="xtra"~~/><~~references~~/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Cox, T C.]]		[[Category: Cox, T C.]]

OCA at 04:12, 25 March 2013

2013-03-25T04:12:38Z

← Older revision		Revision as of 04:12, 25 March 2013
Line 1:		Line 1:
	~~[[Image:2jun.png\|left\|200px]]~~

	{{STRUCTURE_2jun\| PDB=2jun \| SCENE= }}		{{STRUCTURE_2jun\| PDB=2jun \| SCENE= }}
			===Structure of the MID1 tandem B-boxes reveals an interaction reminiscent of intermolecular RING heterodimers===
			{{ABSTRACT_PUBMED_18220417}}

	===~~Structure~~ of ~~the MID1 tandem B~~-~~boxes reveals an interaction reminiscent of intermolecular RING heterodimers==~~=		==Disease==
			[[http://www.uniprot.org/uniprot/TRI18_HUMAN TRI18_HUMAN]] Defects in MID1 are the cause of Opitz GBBB syndrome 1 (OGS1) [MIM:[http://omim.org/entry/300000 300000]]. A congenital midline malformation syndrome characterized by hypertelorism, genital-urinary defects such as hypospadias in males and splayed labia in females, lip-palate-laryngotracheal clefts, imperforate anus, developmental delay and congenital heart defects. Note=MID1 mutations produce proteins with a decreased affinity for microtubules.<ref>PMID:9354791</ref><ref>PMID:11030761</ref><ref>PMID:9718340</ref><ref>PMID:15558842</ref>

	~~{{ABSTRACT_PUBMED_18220417}}~~		==Function==
			[[http://www.uniprot.org/uniprot/TRI18_HUMAN TRI18_HUMAN]] Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.<ref>PMID:10400985</ref><ref>PMID:11685209</ref><ref>PMID:22613722</ref>

	==About this Structure==		==About this Structure==
Line 11:		Line 13:

	==Reference==		==Reference==
	<ref group="xtra">PMID:018220417</ref><references group="xtra"/>		<ref group="xtra">PMID:018220417</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Cox, T C.]]		[[Category: Cox, T C.]]

OCA: Protected "2jun" [edit=sysop:move=sysop]

2013-01-07T13:26:26Z

Protected "2jun" [edit=sysop:move=sysop]

← Older revision	Revision as of 13:26, 7 January 2013
(No difference)

OCA at 13:26, 7 January 2013

2013-01-07T13:26:21Z

← Older revision		Revision as of 13:26, 7 January 2013
Line 1:		Line 1:
	~~{{Seed}}~~
	[[Image:2jun.png\|left\|200px]]		[[Image:2jun.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2jun", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2jun\| PDB=2jun \| SCENE= }}		{{STRUCTURE_2jun\| PDB=2jun \| SCENE= }}

	===Structure of the MID1 tandem B-boxes reveals an interaction reminiscent of intermolecular RING heterodimers===		===Structure of the MID1 tandem B-boxes reveals an interaction reminiscent of intermolecular RING heterodimers===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_18220417}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 18220417 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_18220417}}		{{ABSTRACT_PUBMED_18220417}}

	==About this Structure==		==About this Structure==
	~~2JUN~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUN OCA].		[[2jun]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUN OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~18220417~~</ref><references group="xtra"/>		<ref group="xtra">PMID:018220417</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Cox, T C.]]		[[Category: Cox, T C.]]
Line 32:		Line 20:
	[[Category: Singireddy, S.]]		[[Category: Singireddy, S.]]
	[[Category: Tao, H.]]		[[Category: Tao, H.]]
	~~[[Category: Alternative splicing]]~~
	[[Category: B-box]]		[[Category: B-box]]
	~~[[Category: Coiled coil]]~~
	~~[[Category: Cytoplasm]]~~
	[[Category: Cytoskeleton]]		[[Category: Cytoskeleton]]
	[[Category: Disease mutation]]		[[Category: Disease mutation]]
Line 46:		Line 31:
	[[Category: Trim]]		[[Category: Trim]]
	[[Category: Ubl conjugation pathway]]		[[Category: Ubl conjugation pathway]]
	~~[[Category: Zinc]]~~
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:31:52 2009''~~