2kbc - Revision history

OCA at 13:07, 26 July 2023

2023-07-26T13:07:53Z

← Older revision		Revision as of 13:07, 26 July 2023
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	==Solution structure of human insulin-like peptide 5 (INSL5)==		==Solution structure of human insulin-like peptide 5 (INSL5)==
	<StructureSection load='2kbc' size='340' side='right'caption='[[2kbc~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='2kbc' size='340' side='right'caption='[[2kbc]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2kbc]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KBC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kbc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_BL21(DE3) Escherichia coli BL21(DE3)]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KBC FirstGlance]. <br>
	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene~~></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height~~: ~~3em;~~'>~~[[2k1v\|2k1v]], [[2fhw\|2fhw]]~~</~~div~~></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kbc OCA], [https://pdbe.org/2kbc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kbc RCSB], [https://www.ebi.ac.uk/pdbsum/2kbc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kbc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kbc OCA], [https://pdbe.org/2kbc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kbc RCSB], [https://www.ebi.ac.uk/pdbsum/2kbc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kbc ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/INSL5_HUMAN INSL5_HUMAN] May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Haugaard-Jonsson~~, L M~~]]		[[Category: Haugaard-Jonsson LM]]
	[[Category: Rosengren~~, K J]]~~		[[Category: Rosengren KJ]]
	~~[[Category: Hormone]]~~
	~~[[Category: Insulin-like fold]]~~
	~~[[Category: Peptide hormone]]~~
	~~[[Category: Relaxin~~]]

OCA at 20:46, 20 October 2021

2021-10-20T20:46:58Z

← Older revision		Revision as of 20:46, 20 October 2021
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	<StructureSection load='2kbc' size='340' side='right'caption='[[2kbc]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2kbc' size='340' side='right'caption='[[2kbc]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2kbc]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2KBC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kbc]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KBC FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2k1v\|2k1v]], [[2fhw\|2fhw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2k1v\|2k1v]], [[2fhw\|2fhw]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2kbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kbc OCA], [~~http~~://pdbe.org/2kbc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2kbc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2kbc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2kbc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kbc OCA], [https://pdbe.org/2kbc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kbc RCSB], [https://www.ebi.ac.uk/pdbsum/2kbc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kbc ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 19:22, 11 December 2019

2019-12-11T19:22:32Z

← Older revision		Revision as of 19:22, 11 December 2019
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	==Solution structure of human insulin-like peptide 5 (INSL5)==		==Solution structure of human insulin-like peptide 5 (INSL5)==
	<StructureSection load='2kbc' size='340' side='right' caption='[[2kbc]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2kbc' size='340' side='right'caption='[[2kbc]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2kbc]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KBC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kbc]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KBC FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Haugaard-Jonsson, L M]]		[[Category: Haugaard-Jonsson, L M]]
	[[Category: Rosengren, K J]]		[[Category: Rosengren, K J]]

OCA at 06:29, 7 February 2018

2018-02-07T06:29:11Z

← Older revision		Revision as of 06:29, 7 February 2018
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	==Solution structure of human insulin-like peptide 5 (INSL5)==		==Solution structure of human insulin-like peptide 5 (INSL5)==
	<StructureSection load='2kbc' size='340' side='right' caption='[[2kbc]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2kbc' size='340' side='right' caption='[[2kbc]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
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	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2k1v\|2k1v]], [[2fhw\|2fhw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2k1v\|2k1v]], [[2fhw\|2fhw]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kbc OCA], [http://pdbe.org/2kbc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kbc RCSB], [http://www.ebi.ac.uk/pdbsum/2kbc PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kbc OCA], [http://pdbe.org/2kbc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kbc RCSB], [http://www.ebi.ac.uk/pdbsum/2kbc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2kbc ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:53, 9 September 2015

2015-09-09T22:53:15Z

← Older revision		Revision as of 22:53, 9 September 2015
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	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2k1v\|2k1v]], [[2fhw\|2fhw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2k1v\|2k1v]], [[2fhw\|2fhw]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kbc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kbc RCSB], [http://www.ebi.ac.uk/pdbsum/2kbc PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kbc OCA], [http://pdbe.org/2kbc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kbc RCSB], [http://www.ebi.ac.uk/pdbsum/2kbc PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2kbc" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:41, 19 January 2015

2015-01-19T16:41:08Z

← Older revision		Revision as of 16:41, 19 January 2015
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Haugaard-Jonsson, L M.]]		[[Category: Haugaard-Jonsson, L M]]
	[[Category: Rosengren, K J.]]		[[Category: Rosengren, K J]]
	[[Category: Hormone]]		[[Category: Hormone]]
	[[Category: Insulin-like fold]]		[[Category: Insulin-like fold]]
	[[Category: Peptide hormone]]		[[Category: Peptide hormone]]
	[[Category: Relaxin]]		[[Category: Relaxin]]

OCA at 15:39, 12 October 2014

2014-10-12T15:39:05Z

← Older revision		Revision as of 15:39, 12 October 2014
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	[[~~Image~~:~~2kbc~~.~~png~~\|~~left~~\|~~200px~~]]		==Solution structure of human insulin-like peptide 5 (INSL5)==
			<StructureSection load='2kbc' size='340' side='right' caption='[[2kbc]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2kbc]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KBC FirstGlance]. <br>
			</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2k1v\|2k1v]], [[2fhw\|2fhw]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kbc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kbc RCSB], [http://www.ebi.ac.uk/pdbsum/2kbc PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			INSL5 (insulin-like peptide 5) is a two-chain peptide hormone related to insulin and relaxin. It was recently discovered through searches of expressed sequence tag databases and, although the full biological significance of INSL5 is still being elucidated, high expression in peripheral tissues such as the colon, as well as in the brain and hypothalamus, suggests roles in gut contractility and neuroendocrine signalling. INSL5 activates the relaxin family peptide receptor 4 with high potency and appears to be the endogenous ligand for this receptor, on the basis of overlapping expression profiles and their apparent co-evolution. In the present study, we have used solution-state NMR to characterize the three-dimensional structure of synthetic human INSL5. The structure reveals an insulin/relaxin-like fold with three helical segments that are braced by three disulfide bonds and enclose a hydrophobic core. Furthermore, we characterized in detail the hydrogen-bond network and electrostatic interactions between charged groups in INSL5 by NMR-monitored temperature and pH titrations and undertook a comprehensive structural comparison with other members of the relaxin family, thus identifying the conserved structural features of the relaxin fold. The B-chain helix, which is the primary receptor-binding site of the relaxins, is longer in INSL5 than in its close relative relaxin-3. As this feature results in a different positioning of the receptor-activation domain Arg(B23) and Trp(B24), it may be an important contributor to the difference in biological activity observed for these two peptides. Overall, the structural studies provide mechanistic insights into the receptor selectivity of this important family of hormones.

	~~{{STRUCTURE_2kbc\| PDB=2kbc \| SCENE= }}~~		Structure of human insulin-like peptide 5 and characterization of conserved hydrogen bonds and electrostatic interactions within the relaxin framework.,Haugaard-Jonsson LM, Hossain MA, Daly NL, Craik DJ, Wade JD, Rosengren KJ Biochem J. 2009 May 1;419(3):619-27. PMID:19178384<ref>PMID:19178384</ref>

	~~===Solution structure~~ of ~~human insulin-like peptide 5 (INSL5)===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_19178384}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2kbc]] is a 2 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=2KBC OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:019178384<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Haugaard-Jonsson, L M.]]		[[Category: Haugaard-Jonsson, L M.]]
	[[Category: Rosengren, K J.]]		[[Category: Rosengren, K J.]]

OCA: Protected "2kbc" [edit=sysop:move=sysop]

2013-01-07T11:44:25Z

Protected "2kbc" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:44, 7 January 2013
(No difference)

OCA at 11:44, 7 January 2013

2013-01-07T11:44:22Z

← Older revision		Revision as of 11:44, 7 January 2013
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	~~{{Seed}}~~
	[[Image:2kbc.png\|left\|200px]]		[[Image:2kbc.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2kbc", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2kbc\| PDB=2kbc \| SCENE= }}		{{STRUCTURE_2kbc\| PDB=2kbc \| SCENE= }}

	===Solution structure of human insulin-like peptide 5 (INSL5)===		===Solution structure of human insulin-like peptide 5 (INSL5)===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_19178384}}, adds the Publication Abstract to the page~~
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	{{ABSTRACT_PUBMED_19178384}}		{{ABSTRACT_PUBMED_19178384}}

	==About this Structure==		==About this Structure==
	~~2KBC~~ is a 2 ~~chains~~ structure. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBC OCA].		[[2kbc]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBC OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~19178384~~</ref><references group="xtra"/>		<ref group="xtra">PMID:019178384</ref><references group="xtra"/>
	[[Category: Haugaard-Jonsson, L M.]]		[[Category: Haugaard-Jonsson, L M.]]
	[[Category: Rosengren, K J.]]		[[Category: Rosengren, K J.]]
			[[Category: Hormone]]
	[[Category: Insulin-like fold]]		[[Category: Insulin-like fold]]
	[[Category: Peptide hormone]]		[[Category: Peptide hormone]]
	[[Category: Relaxin]]		[[Category: Relaxin]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 22 10:48:52 2009''~~

OCA at 07:48, 22 April 2009

2009-04-22T07:48:52Z

← Older revision		Revision as of 07:48, 22 April 2009
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	{{Seed}}		{{Seed}}
	[[Image:2kbc.~~jpg~~\|left\|200px]]		[[Image:2kbc.png\|left\|200px]]

	<!--		<!--
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	[[Category: Relaxin]]		[[Category: Relaxin]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Mar 25 12~~:07:35 2009''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 22 10:48:52 2009''