2kff - Revision history

OCA at 06:45, 1 May 2024

2024-05-01T06:45:33Z

← Older revision		Revision as of 06:45, 1 May 2024
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	==Structure of the C-terminal domain of EHD1 with FNYESTNPFTAK==		==Structure of the C-terminal domain of EHD1 with FNYESTNPFTAK==
	<StructureSection load='2kff' size='340' side='right'caption='[[2kff~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>		<StructureSection load='2kff' size='340' side='right'caption='[[2kff]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2kff]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KFF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KFF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kff]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KFF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KFF FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'>[[2kfh\|2kfh]], [[2kfg\|2kfg]]</div~~><~~/td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">EHD1, PAST, PAST1, CDABP0131 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kff OCA], [https://pdbe.org/2kff PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kff RCSB], [https://www.ebi.ac.uk/pdbsum/2kff PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kff ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kff OCA], [https://pdbe.org/2kff PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kff RCSB], [https://www.ebi.ac.uk/pdbsum/2kff PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kff ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/EHD1_HUMAN EHD1_HUMAN]] Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes.<ref>PMID:15020713</ref> <ref>PMID:17233914</ref>		[https://www.uniprot.org/uniprot/EHD1_HUMAN EHD1_HUMAN] Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes.<ref>PMID:15020713</ref> <ref>PMID:17233914</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kff ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kff ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Eps15 homology (EH)-domain containing proteins are regulators of endocytic membrane trafficking. EH-domain binding to proteins containing the tripeptide NPF has been well characterized, but recent studies have shown that EH-domains are also able to interact with ligands containing DPF or GPF motifs. We demonstrate that the three motifs interact in a similar way with the EH-domain of EHD1, with the NPF motif having the highest affinity due to the presence of an intermolecular hydrogen bond. The weaker affinity for the DPF and GPF motifs suggests that if complex formation occurs in vivo, they may require high ligand concentrations, the presence of successive motifs and/or specific flanking residues.

	Structural insight into the interaction of proteins containing NPF, DPF, and GPF motifs with the C-terminal EH-domain of EHD1.,Kieken F, Jovic M, Tonelli M, Naslavsky N, Caplan S, Sorgen PL Protein Sci. 2009 Dec;18(12):2471-9. PMID:19798736<ref>PMID:19798736</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 2kff" style="background-color:#fffaf0;"></div>~~
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Caplan, S]]		[[Category: Caplan S]]
	[[Category: Jovic, M]]		[[Category: Jovic M]]
	[[Category: Kieken, F]]		[[Category: Kieken F]]
	[[Category: Naslavsky, N]]		[[Category: Naslavsky N]]
	[[Category: Sorgen, P]]		[[Category: Sorgen P]]
	[[Category: Tonelli, M]]		[[Category: Tonelli M]]
	~~[[Category: Calcium]]~~
	~~[[Category: Cell membrane]]~~
	~~[[Category: Coiled coil]]~~
	~~[[Category: Ehd1]]~~
	~~[[Category: Endosome]]~~
	~~[[Category: Membrane]]~~
	~~[[Category: Nucleotide-binding]]~~
	~~[[Category: Phosphoprotein]]~~
	~~[[Category: Protein binding~~]]

OCA at 13:31, 24 November 2021

2021-11-24T13:31:24Z

← Older revision		Revision as of 13:31, 24 November 2021
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	<StructureSection load='2kff' size='340' side='right'caption='[[2kff]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2kff' size='340' side='right'caption='[[2kff]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2kff]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KFF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2KFF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kff]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KFF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KFF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kfh\|2kfh]], [[2kfg\|2kfg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2kfh\|2kfh]], [[2kfg\|2kfg]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EHD1, PAST, PAST1, CDABP0131 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EHD1, PAST, PAST1, CDABP0131 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2kff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kff OCA], [~~http~~://pdbe.org/2kff PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2kff RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2kff PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2kff ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kff OCA], [https://pdbe.org/2kff PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kff RCSB], [https://www.ebi.ac.uk/pdbsum/2kff PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kff ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/EHD1_HUMAN EHD1_HUMAN]] Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes.<ref>PMID:15020713</ref> <ref>PMID:17233914</ref>		[[https://www.uniprot.org/uniprot/EHD1_HUMAN EHD1_HUMAN]] Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes.<ref>PMID:15020713</ref> <ref>PMID:17233914</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 06:59, 19 February 2020

2020-02-19T06:59:31Z

← Older revision		Revision as of 06:59, 19 February 2020
Line 1:		Line 1:

	==Structure of the C-terminal domain of EHD1 with FNYESTNPFTAK==		==Structure of the C-terminal domain of EHD1 with FNYESTNPFTAK==
	<StructureSection load='2kff' size='340' side='right' caption='[[2kff]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2kff' size='340' side='right'caption='[[2kff]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2kff]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KFF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kff]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KFF FirstGlance]. <br>
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Caplan, S]]		[[Category: Caplan, S]]
	[[Category: Jovic, M]]		[[Category: Jovic, M]]

OCA at 11:15, 18 July 2018

2018-07-18T11:15:26Z

← Older revision		Revision as of 11:15, 18 July 2018
Line 1:		Line 1:

	==Structure of the C-terminal domain of EHD1 with FNYESTNPFTAK==		==Structure of the C-terminal domain of EHD1 with FNYESTNPFTAK==
	<StructureSection load='2kff' size='340' side='right' caption='[[2kff]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2kff' size='340' side='right' caption='[[2kff]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kfh\|2kfh]], [[2kfg\|2kfg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kfh\|2kfh]], [[2kfg\|2kfg]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EHD1, PAST, PAST1, CDABP0131 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EHD1, PAST, PAST1, CDABP0131 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kff OCA], [http://pdbe.org/2kff PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kff RCSB], [http://www.ebi.ac.uk/pdbsum/2kff PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kff OCA], [http://pdbe.org/2kff PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kff RCSB], [http://www.ebi.ac.uk/pdbsum/2kff PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2kff ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kf/2kff_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kf/2kff_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	[[Category: Sorgen, P]]		[[Category: Sorgen, P]]
	[[Category: Tonelli, M]]		[[Category: Tonelli, M]]
			[[Category: Calcium]]
	[[Category: Cell membrane]]		[[Category: Cell membrane]]
			[[Category: Coiled coil]]
	[[Category: Ehd1]]		[[Category: Ehd1]]
	[[Category: Endosome]]		[[Category: Endosome]]

OCA at 22:32, 8 February 2016

2016-02-08T22:32:33Z

← Older revision		Revision as of 22:32, 8 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kff ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:59, 10 September 2015

2015-09-10T15:59:10Z

← Older revision		Revision as of 15:59, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2kff' size='340' side='right' caption='[[2kff]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2kff' size='340' side='right' caption='[[2kff]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2kff]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KFF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kff]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KFF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kfh\|2kfh]], [[2kfg\|2kfg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kfh\|2kfh]], [[2kfg\|2kfg]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EHD1, PAST, PAST1, CDABP0131 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EHD1, PAST, PAST1, CDABP0131 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kff OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kff RCSB], [http://www.ebi.ac.uk/pdbsum/2kff PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kff OCA], [http://pdbe.org/2kff PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kff RCSB], [http://www.ebi.ac.uk/pdbsum/2kff PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2kff" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Caplan, S]]		[[Category: Caplan, S]]
	[[Category: Jovic, M]]		[[Category: Jovic, M]]

OCA at 02:35, 25 December 2014

2014-12-25T02:35:06Z

← Older revision		Revision as of 02:35, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2kff]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KFF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kff]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KFF FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kfh\|2kfh]], [[2kfg\|2kfg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kfh\|2kfh]], [[2kfg\|2kfg]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EHD1, PAST, PAST1, CDABP0131 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EHD1, PAST, PAST1, CDABP0131 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kff OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kff RCSB], [http://www.ebi.ac.uk/pdbsum/2kff PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kff OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kff RCSB], [http://www.ebi.ac.uk/pdbsum/2kff PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/EHD1_HUMAN EHD1_HUMAN]] Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes.<ref>PMID:15020713</ref> <ref>PMID:17233914</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Caplan, S.]]		[[Category: Caplan, S]]
	[[Category: Jovic, M.]]		[[Category: Jovic, M]]
	[[Category: Kieken, F.]]		[[Category: Kieken, F]]
	[[Category: Naslavsky, N.]]		[[Category: Naslavsky, N]]
	[[Category: Sorgen, P.]]		[[Category: Sorgen, P]]
	[[Category: Tonelli, M.]]		[[Category: Tonelli, M]]
	[[Category: Cell membrane]]		[[Category: Cell membrane]]
	[[Category: Ehd1]]		[[Category: Ehd1]]

OCA at 10:55, 30 September 2014

2014-09-30T10:55:07Z

← Older revision		Revision as of 10:55, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2kff~~.~~png~~\|~~left~~\|~~200px~~]]		==Structure of the C-terminal domain of EHD1 with FNYESTNPFTAK==
			<StructureSection load='2kff' size='340' side='right' caption='[[2kff]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2kff]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KFF FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kfh\|2kfh]], [[2kfg\|2kfg]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EHD1, PAST, PAST1, CDABP0131 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kff OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kff RCSB], [http://www.ebi.ac.uk/pdbsum/2kff PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kf/2kff_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Eps15 homology (EH)-domain containing proteins are regulators of endocytic membrane trafficking. EH-domain binding to proteins containing the tripeptide NPF has been well characterized, but recent studies have shown that EH-domains are also able to interact with ligands containing DPF or GPF motifs. We demonstrate that the three motifs interact in a similar way with the EH-domain of EHD1, with the NPF motif having the highest affinity due to the presence of an intermolecular hydrogen bond. The weaker affinity for the DPF and GPF motifs suggests that if complex formation occurs in vivo, they may require high ligand concentrations, the presence of successive motifs and/or specific flanking residues.

	~~{{STRUCTURE_2kff\| PDB=2kff \| SCENE= }}~~		Structural insight into the interaction of proteins containing NPF, DPF, and GPF motifs with the C-terminal EH-domain of EHD1.,Kieken F, Jovic M, Tonelli M, Naslavsky N, Caplan S, Sorgen PL Protein Sci. 2009 Dec;18(12):2471-9. PMID:19798736<ref>PMID:19798736</ref>

	~~===Structure~~ of the ~~C-terminal domain of EHD1 with FNYESTNPFTAK===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_19798736}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2kff]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2KFF OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:019798736<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Caplan, S.]]		[[Category: Caplan, S.]]

OCA: Protected "2kff" [edit=sysop:move=sysop]

2013-01-07T15:22:21Z

Protected "2kff" [edit=sysop:move=sysop]

← Older revision	Revision as of 15:22, 7 January 2013
(No difference)

OCA at 15:22, 7 January 2013

2013-01-07T15:22:17Z

← Older revision		Revision as of 15:22, 7 January 2013
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	~~{{Seed}}~~		[[Image:2kff.png\|left\|200px]]
	[[Image:2kff.~~jpg~~\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2kff", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2kff\| PDB=2kff \| SCENE= }}		{{STRUCTURE_2kff\| PDB=2kff \| SCENE= }}

	===Structure of the C-terminal domain of EHD1 with FNYESTNPFTAK===		===Structure of the C-terminal domain of EHD1 with FNYESTNPFTAK===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_19798736}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 19798736 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_19798736}}		{{ABSTRACT_PUBMED_19798736}}

	==About this Structure==		==About this Structure==
	~~2KFF~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KFF OCA].		[[2kff]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KFF OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~19798736~~</ref><references group="xtra"/>		<ref group="xtra">PMID:019798736</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Caplan, S.]]		[[Category: Caplan, S.]]
Line 31:		Line 19:
	[[Category: Sorgen, P.]]		[[Category: Sorgen, P.]]
	[[Category: Tonelli, M.]]		[[Category: Tonelli, M.]]
	~~[[Category: Calcium]]~~
	[[Category: Cell membrane]]		[[Category: Cell membrane]]
	~~[[Category: Coiled coil]]~~
	[[Category: Ehd1]]		[[Category: Ehd1]]
	[[Category: Endosome]]		[[Category: Endosome]]
Line 39:		Line 25:
	[[Category: Nucleotide-binding]]		[[Category: Nucleotide-binding]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
			[[Category: Protein binding]]
	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Thu Dec 24 07:35:27 2009''~~