2knu - Revision history

OCA at 05:36, 15 May 2024

2024-05-15T05:36:37Z

← Older revision		Revision as of 05:36, 15 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2knu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepacivirus_C Hepacivirus C]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KNU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KNU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2knu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepacivirus_C Hepacivirus C]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KNU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KNU FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2knu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2knu OCA], [https://pdbe.org/2knu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2knu RCSB], [https://www.ebi.ac.uk/pdbsum/2knu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2knu ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2knu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2knu OCA], [https://pdbe.org/2knu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2knu RCSB], [https://www.ebi.ac.uk/pdbsum/2knu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2knu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 08:46, 14 June 2023

2023-06-14T08:46:11Z

← Older revision		Revision as of 08:46, 14 June 2023
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	==Solution structure of the transmembrane proximal region of the hepatis C virus E1 glycoprotein==		==Solution structure of the transmembrane proximal region of the hepatis C virus E1 glycoprotein==
	<StructureSection load='2knu' size='340' side='right'caption='[[2knu~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>		<StructureSection load='2knu' size='340' side='right'caption='[[2knu]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2knu]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KNU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KNU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2knu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepacivirus_C Hepacivirus C]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KNU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KNU FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2knu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2knu OCA], [https://pdbe.org/2knu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2knu RCSB], [https://www.ebi.ac.uk/pdbsum/2knu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2knu ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2knu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2knu OCA], [https://pdbe.org/2knu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2knu RCSB], [https://www.ebi.ac.uk/pdbsum/2knu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2knu ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/POLG_HCVJ1 POLG_HCVJ1] Core protein packages viral RNA to form a viral nucleocapsid, and promotes virion budding. Modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit. Also regulates many host cellular functions such as signaling pathways and apoptosis. Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by inducing human STAT1 degradation. Thought to play a role in virus-mediated cell transformation leading to hepatocellular carcinomas. Interacts with, and activates STAT3 leading to cellular transformation. May repress the promoter of p53, and sequester CREB3 and SP110 isoform 3/Sp110b in the cytoplasm. Also represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle regulation. Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NK-kappaB activation, and activates AP-1. Could mediate apoptotic pathways through association with TNF-type receptors TNFRSF1A and LTBR, although its effect on death receptor-induced apoptosis remains controversial. Enhances TRAIL mediated apoptosis, suggesting that it might play a role in immune-mediated liver cell injury. Seric core protein is able to bind C1QR1 at the T-cell surface, resulting in down-regulation of T-lymphocytes proliferation. May transactivate human MYC, Rous sarcoma virus LTR, and SV40 promoters. May suppress the human FOS and HIV-1 LTR activity. Alters lipid metabolism by interacting with hepatocellular proteins involved in lipid accumulation and storage. Core protein induces up-regulation of FAS promoter activity, and thereby probably contributes to the increased triglyceride accumulation in hepatocytes (steatosis) (By similarity). E1 and E2 glycoproteins form a heterodimer that is involved in virus attachment to the host cell, virion internalization through clathrin-dependent endocytosis and fusion with host membrane. E1/E2 heterodimer binds to human LDLR, CD81 and SCARB1/SR-BI receptors, but this binding is not sufficient for infection, some additional liver specific cofactors may be needed. The fusion function may possibly be carried by E1. E2 inhibits human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow capture of circulating HCV particles by these cells and subsequent transmission to permissive cells. DCs act as sentinels in various tissues where they entrap pathogens and convey them to local lymphoid tissue or lymph node for establishment of immunity. Capture of circulating HCV particles by these SIGN+ cells may facilitate virus infection of proximal hepatocytes and lymphocyte subpopulations and may be essential for the establishment of persistent infection (By similarity). P7 seems to be a heptameric ion channel protein (viroporin) and is inhibited by the antiviral drug amantadine. Also inhibited by long-alkyl-chain iminosugar derivatives. Essential for infectivity (By similarity). Protease NS2-3 is a cysteine protease responsible for the autocatalytic cleavage of NS2-NS3. Seems to undergo self-inactivation following maturation (By similarity). NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS3/NS4A complex also prevents phosphorylation of human IRF3, thus preventing the establishment of dsRNA induced antiviral state. NS3 RNA helicase binds to RNA and unwinds dsRNA in the 3' to 5' direction, and likely RNA stable secondary structure in the template strand. Cleaves and inhibits the host antiviral protein MAVS (By similarity). NS4B induces a specific membrane alteration that serves as a scaffold for the virus replication complex. This membrane alteration gives rise to the so-called ER-derived membranous web that contains the replication complex (By similarity). NS5A is a component of the replication complex involved in RNA-binding. Its interaction with Human VAPB may target the viral replication complex to vesicles. Down-regulates viral IRES translation initiation. Mediates interferon resistance, presumably by interacting with and inhibiting human EIF2AK2/PKR. Seems to inhibit apoptosis by interacting with BIN1 and FKBP8. The hyperphosphorylated form of NS5A is an inhibitor of viral replication (By similarity). NS5B is a RNA-dependent RNA polymerase that plays an essential role in the virus replication (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Hepacivirus C]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Alessio, V D~~]]		[[Category: Bianchi A]]
	[[Category: ~~Bianchi, A~~]]		[[Category: D'Alessio V]]
	[[Category: Errico, G D]]		[[Category: D'Errico G]]
	[[Category: Merola, M]]		[[Category: Merola M]]
	[[Category: Notomista, E]]		[[Category: Notomista E]]
	[[Category: Picone, D]]		[[Category: Picone D]]
	[[Category: Spadaccini, R]]		[[Category: Spadaccini R]]
	~~[[Category: Envelope protein]]~~
	~~[[Category: Glycoprotein]]~~
	~~[[Category: Hcv]]~~
	~~[[Category: Membrane protein]]~~
	~~[[Category: Pretransmembrane]]~~
	~~[[Category: Transmembrane~~]]

OCA at 07:08, 1 December 2021

2021-12-01T07:08:08Z

← Older revision		Revision as of 07:08, 1 December 2021
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	<StructureSection load='2knu' size='340' side='right'caption='[[2knu]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2knu' size='340' side='right'caption='[[2knu]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2knu]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KNU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2KNU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2knu]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KNU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KNU FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2knu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2knu OCA], [~~http~~://pdbe.org/2knu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2knu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2knu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2knu ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2knu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2knu OCA], [https://pdbe.org/2knu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2knu RCSB], [https://www.ebi.ac.uk/pdbsum/2knu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2knu ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:41, 26 February 2020

2020-02-26T09:41:15Z

← Older revision		Revision as of 09:41, 26 February 2020
Line 1:		Line 1:

	==Solution structure of the transmembrane proximal region of the hepatis C virus E1 glycoprotein==		==Solution structure of the transmembrane proximal region of the hepatis C virus E1 glycoprotein==
	<StructureSection load='2knu' size='340' side='right' caption='[[2knu]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2knu' size='340' side='right'caption='[[2knu]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2knu]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KNU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KNU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2knu]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KNU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KNU FirstGlance]. <br>
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Alessio, V D]]		[[Category: Alessio, V D]]
	[[Category: Bianchi, A]]		[[Category: Bianchi, A]]

OCA at 08:27, 25 July 2018

2018-07-25T08:27:41Z

← Older revision		Revision as of 08:27, 25 July 2018
Line 1:		Line 1:

	==Solution structure of the transmembrane proximal region of the hepatis C virus E1 glycoprotein==		==Solution structure of the transmembrane proximal region of the hepatis C virus E1 glycoprotein==
	<StructureSection load='2knu' size='340' side='right' caption='[[2knu]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2knu' size='340' side='right' caption='[[2knu]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2knu]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KNU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KNU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2knu]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KNU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KNU FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2knu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2knu OCA], [http://pdbe.org/2knu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2knu RCSB], [http://www.ebi.ac.uk/pdbsum/2knu PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2knu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2knu OCA], [http://pdbe.org/2knu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2knu RCSB], [http://www.ebi.ac.uk/pdbsum/2knu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2knu ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:01, 11 September 2015

2015-09-11T08:01:29Z

← Older revision		Revision as of 08:01, 11 September 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2knu]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KNU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KNU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2knu]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KNU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KNU FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2knu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2knu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2knu RCSB], [http://www.ebi.ac.uk/pdbsum/2knu PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2knu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2knu OCA], [http://pdbe.org/2knu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2knu RCSB], [http://www.ebi.ac.uk/pdbsum/2knu PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2knu" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:14, 19 January 2015

2015-01-19T14:14:18Z

← Older revision		Revision as of 14:14, 19 January 2015
Line 17:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Alessio, V D.]]		[[Category: Alessio, V D]]
	[[Category: Bianchi, A.]]		[[Category: Bianchi, A]]
	[[Category: Errico, G D.]]		[[Category: Errico, G D]]
	[[Category: Merola, M.]]		[[Category: Merola, M]]
	[[Category: Notomista, E.]]		[[Category: Notomista, E]]
	[[Category: Picone, D.]]		[[Category: Picone, D]]
	[[Category: Spadaccini, R.]]		[[Category: Spadaccini, R]]
	[[Category: Envelope protein]]		[[Category: Envelope protein]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]

OCA at 15:34, 12 October 2014

2014-10-12T15:34:01Z

← Older revision		Revision as of 15:34, 12 October 2014
Line 1:		Line 1:
	[[~~Image~~:2knu.~~png\|left\|200px~~]]		==Solution structure of the transmembrane proximal region of the hepatis C virus E1 glycoprotein==
			<StructureSection load='2knu' size='340' side='right' caption='[[2knu]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2knu]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KNU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KNU FirstGlance]. <br>
			</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2knu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2knu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2knu RCSB], [http://www.ebi.ac.uk/pdbsum/2knu PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			A detailed knowledge of the mechanism of virus entry represents one of the most promising approaches to develop new therapeutic strategies. However, viral fusion is a very complex process involving fusion glycoproteins present on the viral envelope. In the two hepatitis C virus envelope proteins, E1 and E2, several membranotropic regions with a potential role in the fusion process have been identified. Among these, we have selected the 314-342 E1 region. Circular Dichroism data indicate that the peptide exhibits a clear propensity to adopt a helical folding in different membrane mimicking media, such as mixtures of water with fluorinated alcohols and phospholipids, with a slight preference for negative charged bilayers. The 3D structure of E1(314-342) peptide, calculated by 2D-NMR in a low-polarity environment, consists of two helical stretches encompassing residues 319-323 and 329-338 respectively. The peptide, presenting a largely apolar character, interacts with liposomes, as indicated by fluorescence and electron spin resonance spectra. The strength of the interaction and the deepness of peptide insertion in the phospholipid membrane are modulated by the bilayer composition, the interaction with anionic phospholipids being among the strongest ever observed. The presence of cholesterol also affects the peptide-bilayer interaction, favoring the peptide positioning close to the bilayer surface. Overall, the experimental data support the idea that this region of E1 might be involved in membrane destabilization and viral fusion; therefore it may represent a good target to develop anti-viral molecules.

	~~{{STRUCTURE_2knu\| PDB=2knu \| SCENE= }}~~		Structural characterization of the transmembrane proximal region of the hepatitis C virus E1 glycoprotein.,Spadaccini R, D'Errico G, D'Alessio V, Notomista E, Bianchi A, Merola M, Picone D Biochim Biophys Acta. 2010 Mar;1798(3):344-53. Epub 2009 Nov 3. PMID:19891955<ref>PMID:19891955</ref>

	~~===Solution structure~~ of the ~~transmembrane proximal region of the hepatis C virus E1 glycoprotein===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_19891955}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2knu]] is a 1 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=2KNU OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:019891955<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Alessio, V D.]]		[[Category: Alessio, V D.]]
	[[Category: Bianchi, A.]]		[[Category: Bianchi, A.]]

OCA: Protected "2knu" [edit=sysop:move=sysop]

2013-01-07T13:16:45Z

Protected "2knu" [edit=sysop:move=sysop]

← Older revision	Revision as of 13:16, 7 January 2013
(No difference)

OCA at 13:16, 7 January 2013

2013-01-07T13:16:40Z

← Older revision		Revision as of 13:16, 7 January 2013
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	~~{{Seed}}~~		[[Image:2knu.png\|left\|200px]]
	[[Image:2knu.~~jpg~~\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2knu", creates the "Structure Box" on the page.~~
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	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
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	{{STRUCTURE_2knu\| PDB=2knu \| SCENE= }}		{{STRUCTURE_2knu\| PDB=2knu \| SCENE= }}

	===Solution structure of the transmembrane proximal region of the hepatis C virus E1 glycoprotein===		===Solution structure of the transmembrane proximal region of the hepatis C virus E1 glycoprotein===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_19891955}}, adds the Publication Abstract to the page~~
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	{{ABSTRACT_PUBMED_19891955}}		{{ABSTRACT_PUBMED_19891955}}

	==About this Structure==		==About this Structure==
	~~2KNU~~ is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KNU OCA].		[[2knu]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KNU OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~19891955~~</ref><references group="xtra"/>		<ref group="xtra">PMID:019891955</ref><references group="xtra"/>
	[[Category: Alessio, V D.]]		[[Category: Alessio, V D.]]
	[[Category: Bianchi, A.]]		[[Category: Bianchi, A.]]
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	[[Category: Pretransmembrane]]		[[Category: Pretransmembrane]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]

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