2ko2 - Revision history

OCA at 09:40, 22 May 2024

2024-05-22T09:40:43Z

← Older revision		Revision as of 09:40, 22 May 2024
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	==NOGO66==		==NOGO66==
	<StructureSection load='2ko2' size='340' side='right'caption='[[2ko2~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>		<StructureSection load='2ko2' size='340' side='right'caption='[[2ko2]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ko2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KO2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KO2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ko2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KO2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KO2 FirstGlance]. <br>
	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>Kiaa0886, Nogo, Rtn4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~10090 LK3 transgenic mice])~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ko2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ko2 OCA], [https://pdbe.org/2ko2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ko2 RCSB], [https://www.ebi.ac.uk/pdbsum/2ko2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ko2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ko2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ko2 OCA], [https://pdbe.org/2ko2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ko2 RCSB], [https://www.ebi.ac.uk/pdbsum/2ko2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ko2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/RTN4_MOUSE RTN4_MOUSE]] Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex. May inhibit BACE1 activity and amyloid precursor protein processing.<ref>PMID:20093372</ref> <ref>PMID:20573699</ref>		[https://www.uniprot.org/uniprot/RTN4_MOUSE RTN4_MOUSE] Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex. May inhibit BACE1 activity and amyloid precursor protein processing.<ref>PMID:20093372</ref> <ref>PMID:20573699</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Lk3 transgenic mice~~]]		[[Category: Mus musculus]]
	[[Category: Cocco~~, M J~~]]		[[Category: Cocco MJ]]
	[[Category: Schulz, J]]		[[Category: Schulz J]]
	[[Category: Vasudevan~~, S V]]~~		[[Category: Vasudevan SV]]
	~~[[Category: Dpc micelle]]~~
	~~[[Category: Endoplasmic reticulum]]~~
	~~[[Category: Membrane]]~~
	~~[[Category: Membrane protein]]~~
	~~[[Category: Myelin inhibitor]]~~
	~~[[Category: Nogo]]~~
	~~[[Category: Peripheral]]~~
	~~[[Category: Phosphoprotein]]~~
	~~[[Category: Transmembrane~~]]

OCA at 07:29, 14 April 2021

2021-04-14T07:29:21Z

← Older revision		Revision as of 07:29, 14 April 2021
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	==NOGO66==		==NOGO66==
	<StructureSection load='2ko2' size='340' side='right' caption='[[2ko2]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2ko2' size='340' side='right'caption='[[2ko2]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ko2]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KO2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2KO2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ko2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KO2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KO2 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Kiaa0886, Nogo, Rtn4 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Kiaa0886, Nogo, Rtn4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ko2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ko2 OCA], [~~http~~://pdbe.org/2ko2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ko2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ko2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ko2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ko2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ko2 OCA], [https://pdbe.org/2ko2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ko2 RCSB], [https://www.ebi.ac.uk/pdbsum/2ko2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ko2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/RTN4_MOUSE RTN4_MOUSE]] Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex. May inhibit BACE1 activity and amyloid precursor protein processing.<ref>PMID:20093372</ref> <ref>PMID:20573699</ref>		[[https://www.uniprot.org/uniprot/RTN4_MOUSE RTN4_MOUSE]] Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex. May inhibit BACE1 activity and amyloid precursor protein processing.<ref>PMID:20093372</ref> <ref>PMID:20573699</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Cocco, M J]]		[[Category: Cocco, M J]]

OCA at 08:17, 25 July 2018

2018-07-25T08:17:13Z

← Older revision		Revision as of 08:17, 25 July 2018
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	==NOGO66==		==NOGO66==
	<StructureSection load='2ko2' size='340' side='right' caption='[[2ko2]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2ko2' size='340' side='right' caption='[[2ko2]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
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	<table><tr><td colspan='2'>[[2ko2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KO2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KO2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ko2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KO2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KO2 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Kiaa0886, Nogo, Rtn4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Kiaa0886, Nogo, Rtn4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ko2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ko2 OCA], [http://pdbe.org/2ko2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ko2 RCSB], [http://www.ebi.ac.uk/pdbsum/2ko2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ko2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ko2 OCA], [http://pdbe.org/2ko2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ko2 RCSB], [http://www.ebi.ac.uk/pdbsum/2ko2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ko2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ko/2ko2_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ko/2ko2_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ko2 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:10, 10 September 2015

2015-09-10T07:10:52Z

← Older revision		Revision as of 07:10, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2ko2' size='340' side='right' caption='[[2ko2]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2ko2' size='340' side='right' caption='[[2ko2]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ko2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KO2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KO2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ko2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KO2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KO2 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Kiaa0886, Nogo, Rtn4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Kiaa0886, Nogo, Rtn4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ko2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ko2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ko2 RCSB], [http://www.ebi.ac.uk/pdbsum/2ko2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ko2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ko2 OCA], [http://pdbe.org/2ko2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ko2 RCSB], [http://www.ebi.ac.uk/pdbsum/2ko2 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2ko2" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Mus musculus~~]]		[[Category: Lk3 transgenic mice]]
	[[Category: Cocco, M J]]		[[Category: Cocco, M J]]
	[[Category: Schulz, J]]		[[Category: Schulz, J]]

OCA at 20:03, 24 December 2014

2014-12-24T20:03:23Z

← Older revision		Revision as of 20:03, 24 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ko2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ko2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ko2 RCSB], [http://www.ebi.ac.uk/pdbsum/2ko2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ko2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ko2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ko2 RCSB], [http://www.ebi.ac.uk/pdbsum/2ko2 PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/RTN4_MOUSE RTN4_MOUSE]] Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex. May inhibit BACE1 activity and amyloid precursor protein processing.<ref>PMID:20093372</ref> <ref>PMID:20573699</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Cocco, M J.]]		[[Category: Cocco, M J]]
	[[Category: Schulz, J.]]		[[Category: Schulz, J]]
	[[Category: Vasudevan, S V.]]		[[Category: Vasudevan, S V]]
	[[Category: Dpc micelle]]		[[Category: Dpc micelle]]
	[[Category: Endoplasmic reticulum]]		[[Category: Endoplasmic reticulum]]

OCA at 15:28, 12 October 2014

2014-10-12T15:28:38Z

← Older revision		Revision as of 15:28, 12 October 2014
Line 1:		Line 1:
	[[Image:~~2ko2~~.~~png~~\|~~left~~\|~~200px~~]]		==NOGO66==
			<StructureSection load='2ko2' size='340' side='right' caption='[[2ko2]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2ko2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KO2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KO2 FirstGlance]. <br>
			</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Kiaa0886, Nogo, Rtn4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ko2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ko2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ko2 RCSB], [http://www.ebi.ac.uk/pdbsum/2ko2 PDBsum]</span></td></tr>
			</table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ko/2ko2_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Repair of damage to the central nervous system (CNS) is inhibited by the presence of myelin proteins that prevent axonal regrowth. Consequently, growth inhibitors and their common receptor have been identified as targets in the treatment of injury to the CNS. Here we describe the structure of the extracellular domain of the neurite outgrowth inhibitor (Nogo) in a membrane-like environment. Isoforms of Nogo are expressed with a common C terminus containing two transmembrane (TM) helices. The ectodomain between the two TM helices, Nogo-66, is active in preventing axonal growth [GrandPre T, Nakamura F, Vartanian T, Strittmatter SM (2000) Nature 403:439-444]. We studied the structure of Nogo-66 alone and in the presence of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) vesicles and dodecylphosphocholine (DPC) micelles as membrane mimetics. We find that Nogo-66 is largely disordered when free in solution. However, when bound to a phosphocholine surface Nogo-66 adopts a unique, stable fold, even in the absence of TM anchors. Using paramagnetic probes and protein-DPC nuclear Overhauser effects (NOEs), we define portions of the growth inhibitor likely to be accessible on the cell surface. With these data we predict that residues (28-58) are available to bind the Nogo receptor, which is entirely consistent with functional assays. Moreover, the conformations and relative positions of side chains recognized by the receptor are now defined and provide a foundation for antagonist design.

	~~{{STRUCTURE_2ko2\| PDB=2ko2 \| SCENE= }}~~		Protein folding at the membrane interface, the structure of Nogo-66 requires interactions with a phosphocholine surface.,Vasudevan SV, Schulz J, Zhou C, Cocco MJ Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6847-51. Epub 2010 Mar 29. PMID:20351248<ref>PMID:20351248</ref>

	~~===NOGO66===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_20351248}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2ko2]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2KO2 OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:020351248<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Cocco, M J.]]		[[Category: Cocco, M J.]]

OCA at 13:09, 7 January 2013

2013-01-07T13:09:45Z

← Older revision		Revision as of 13:09, 7 January 2013
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	[[Image:2ko2.png\|left\|200px]]		[[Image:2ko2.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2ko2", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2ko2\| PDB=2ko2 \| SCENE= }}		{{STRUCTURE_2ko2\| PDB=2ko2 \| SCENE= }}

	===NOGO66===		===NOGO66===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_20351248}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 20351248 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_20351248}}		{{ABSTRACT_PUBMED_20351248}}

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	==Reference==		==Reference==
	<ref group="xtra">PMID:~~20351248~~</ref><references group="xtra"/>		<ref group="xtra">PMID:020351248</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Cocco, M J.]]		[[Category: Cocco, M J.]]

OCA: Protected "2ko2" [edit=sysop:move=sysop]

2011-01-02T03:18:30Z

Protected "2ko2" [edit=sysop:move=sysop]

← Older revision	Revision as of 03:18, 2 January 2011
(No difference)

OCA at 03:18, 2 January 2011

2011-01-02T03:18:29Z

← Older revision		Revision as of 03:18, 2 January 2011
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	~~{{Seed}}~~
	[[Image:2ko2.png\|left\|200px]]		[[Image:2ko2.png\|left\|200px]]

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	==About this Structure==		==About this Structure==
	~~2KO2~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KO2 OCA].		[[2ko2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KO2 OCA].

	==Reference==		==Reference==
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	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Aug 12 00:03:08 2010''~~

OCA at 19:55, 11 August 2010

2010-08-11T19:55:52Z

← Older revision		Revision as of 19:55, 11 August 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
	[[Image:2ko2.~~jpg~~\|left\|200px]]		[[Image:2ko2.png\|left\|200px]]

	<!--		<!--
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	[[Category: Schulz, J.]]		[[Category: Schulz, J.]]
	[[Category: Vasudevan, S V.]]		[[Category: Vasudevan, S V.]]
	~~[[Category: Alternative splicing]]~~
	[[Category: Dpc micelle]]		[[Category: Dpc micelle]]
	[[Category: Endoplasmic reticulum]]		[[Category: Endoplasmic reticulum]]
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	[[Category: Transmembrane]]		[[Category: Transmembrane]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Apr 21 10~~:07:07 2010''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Aug 12 00:03:08 2010''