2kos - Revision history

OCA at 08:15, 30 October 2024

2024-10-30T08:15:48Z

← Older revision		Revision as of 08:15, 30 October 2024
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	==NMR solution structures of octanoyl-ACP from Streptomyces coelicolor Fatty Acid Synthase==		==NMR solution structures of octanoyl-ACP from Streptomyces coelicolor Fatty Acid Synthase==
	<StructureSection load='2kos' size='340' side='right'caption='[[2kos~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='2kos' size='340' side='right'caption='[[2kos]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2kos]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"actinomyces_coelicolor"_(muller_1908)_lieske_1921 "actinomyces~~ coelicolor~~" (muller 1908) lieske 1921~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KOS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kos]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KOS FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SXO:S-[2-({N-[(2S)-2-HYDROXY-3~~,~~3-DIMETHYL-4-(PHOSPHONOOXY)BUTANOYL]-BETA-ALANYL}AMINO)ETHYL]+OCTANETHIOATE'>SXO</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;'>~~[[~~2koo\|2koo]]~~, ~~[[2kop\|2kop~~]]~~, [[2koq\|2koq]], [[2kor\|2kor]]</div></td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SXO:S-[2-({N-[(2S)-2-HYDROXY-3,3-DIMETHYL-4-(PHOSPHONOOXY)BUTANOYL]-BETA-ALANYL}AMINO)ETHYL]+OCTANETHIOATE'>SXO</scene></td></tr>
	~~<tr id='gene~~'>~~<td class="sblockLbl"><b>[[Gene\|Gene:]]~~</b>~~</td><td class="sblockDat">acpP, SCO2389, SC4A7.17 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1902 "Actinomyces coelicolor" (Muller 1908) Lieske 1921])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kos OCA], [https://pdbe.org/2kos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kos RCSB], [https://www.ebi.ac.uk/pdbsum/2kos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kos ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kos OCA], [https://pdbe.org/2kos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kos RCSB], [https://www.ebi.ac.uk/pdbsum/2kos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kos ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/P72393_STRCH P72393_STRCH]] Carrier of the growing fatty acid chain in fatty acid biosynthesis.[HAMAP-Rule:MF_01217][RuleBase:RU003545]		[https://www.uniprot.org/uniprot/P72393_STRCH P72393_STRCH] Carrier of the growing fatty acid chain in fatty acid biosynthesis.[HAMAP-Rule:MF_01217][RuleBase:RU003545]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ko/2kos_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ko/2kos_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Arthur, C~~]]		[[Category: Streptomyces coelicolor]]
	[[Category: ~~Crump, M P~~]]		[[Category: Arthur C]]
	[[Category: ~~Ploskon, E~~]]		[[Category: Crump MP]]
	[[Category: ~~Acyl carrier protein]]~~		[[Category: Ploskon E]]
	~~[[Category: Fatty acid synthase]]~~
	~~[[Category: Intermediate binding]]~~
	~~[[Category: Transport protein~~]]

OCA at 07:29, 14 April 2021

2021-04-14T07:29:47Z

← Older revision		Revision as of 07:29, 14 April 2021
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	==NMR solution structures of octanoyl-ACP from Streptomyces coelicolor Fatty Acid Synthase==		==NMR solution structures of octanoyl-ACP from Streptomyces coelicolor Fatty Acid Synthase==
	<StructureSection load='2kos' size='340' side='right' caption='[[2kos]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2kos' size='340' side='right'caption='[[2kos]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2kos]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"actinomyces_coelicolor"_(muller_1908)_lieske_1921 "actinomyces coelicolor" (muller 1908) lieske 1921]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2KOS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kos]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"actinomyces_coelicolor"_(muller_1908)_lieske_1921 "actinomyces coelicolor" (muller 1908) lieske 1921]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KOS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SXO:S-[2-({N-[(2S)-2-HYDROXY-3,3-DIMETHYL-4-(PHOSPHONOOXY)BUTANOYL]-BETA-ALANYL}AMINO)ETHYL]+OCTANETHIOATE'>SXO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SXO:S-[2-({N-[(2S)-2-HYDROXY-3,3-DIMETHYL-4-(PHOSPHONOOXY)BUTANOYL]-BETA-ALANYL}AMINO)ETHYL]+OCTANETHIOATE'>SXO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2koo\|2koo]], [[2kop\|2kop]], [[2koq\|2koq]], [[2kor\|2kor]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2koo\|2koo]], [[2kop\|2kop]], [[2koq\|2koq]], [[2kor\|2kor]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">acpP, SCO2389, SC4A7.17 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1902 "Actinomyces coelicolor" (Muller 1908) Lieske 1921])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">acpP, SCO2389, SC4A7.17 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1902 "Actinomyces coelicolor" (Muller 1908) Lieske 1921])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2kos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kos OCA], [~~http~~://pdbe.org/2kos PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2kos RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2kos PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2kos ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kos OCA], [https://pdbe.org/2kos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kos RCSB], [https://www.ebi.ac.uk/pdbsum/2kos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kos ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/P72393_STRCH P72393_STRCH]] Carrier of the growing fatty acid chain in fatty acid biosynthesis.[HAMAP-Rule:MF_01217][RuleBase:RU003545]		[[https://www.uniprot.org/uniprot/P72393_STRCH P72393_STRCH]] Carrier of the growing fatty acid chain in fatty acid biosynthesis.[HAMAP-Rule:MF_01217][RuleBase:RU003545]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[Acyl carrier protein\|Acyl carrier protein]]		*[[Acyl carrier protein 3D structures\|Acyl carrier protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Arthur, C]]		[[Category: Arthur, C]]
	[[Category: Crump, M P]]		[[Category: Crump, M P]]

OCA at 08:00, 25 July 2018

2018-07-25T08:00:02Z

← Older revision		Revision as of 08:00, 25 July 2018
Line 1:		Line 1:

	==NMR solution structures of octanoyl-ACP from Streptomyces coelicolor Fatty Acid Synthase==		==NMR solution structures of octanoyl-ACP from Streptomyces coelicolor Fatty Acid Synthase==
	<StructureSection load='2kos' size='340' side='right' caption='[[2kos]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2kos' size='340' side='right' caption='[[2kos]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2koo\|2koo]], [[2kop\|2kop]], [[2koq\|2koq]], [[2kor\|2kor]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2koo\|2koo]], [[2kop\|2kop]], [[2koq\|2koq]], [[2kor\|2kor]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">acpP, SCO2389, SC4A7.17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1902 "Actinomyces coelicolor" (Muller 1908) Lieske 1921])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">acpP, SCO2389, SC4A7.17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1902 "Actinomyces coelicolor" (Muller 1908) Lieske 1921])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kos OCA], [http://pdbe.org/2kos PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kos RCSB], [http://www.ebi.ac.uk/pdbsum/2kos PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kos OCA], [http://pdbe.org/2kos PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kos RCSB], [http://www.ebi.ac.uk/pdbsum/2kos PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2kos ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ko/2kos_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ko/2kos_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kos ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:50, 11 September 2015

2015-09-11T09:50:55Z

← Older revision		Revision as of 09:50, 11 September 2015
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	<StructureSection load='2kos' size='340' side='right' caption='[[2kos]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2kos' size='340' side='right' caption='[[2kos]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2kos]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Streptomyces_coelicolor Streptomyces~~ coelicolor]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KOS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kos]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_coelicolor"_(muller_1908)_lieske_1921 "actinomyces coelicolor" (muller 1908) lieske 1921]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KOS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SXO:S-[2-({N-[(2S)-2-HYDROXY-3,3-DIMETHYL-4-(PHOSPHONOOXY)BUTANOYL]-BETA-ALANYL}AMINO)ETHYL]+OCTANETHIOATE'>SXO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SXO:S-[2-({N-[(2S)-2-HYDROXY-3,3-DIMETHYL-4-(PHOSPHONOOXY)BUTANOYL]-BETA-ALANYL}AMINO)ETHYL]+OCTANETHIOATE'>SXO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2koo\|2koo]], [[2kop\|2kop]], [[2koq\|2koq]], [[2kor\|2kor]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2koo\|2koo]], [[2kop\|2kop]], [[2koq\|2koq]], [[2kor\|2kor]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">acpP, SCO2389, SC4A7.17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1902 ~~Streptomyces~~ coelicolor])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">acpP, SCO2389, SC4A7.17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1902 "Actinomyces coelicolor" (Muller 1908) Lieske 1921])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kos RCSB], [http://www.ebi.ac.uk/pdbsum/2kos PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kos OCA], [http://pdbe.org/2kos PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kos RCSB], [http://www.ebi.ac.uk/pdbsum/2kos PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/P72393_STRCH P72393_STRCH]] Carrier of the growing fatty acid chain in fatty acid biosynthesis.[HAMAP-Rule:MF_01217][RuleBase:RU003545]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2kos" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Streptomyces coelicolor]]~~
	[[Category: Arthur, C]]		[[Category: Arthur, C]]
	[[Category: Crump, M P]]		[[Category: Crump, M P]]

OCA at 17:29, 19 January 2015

2015-01-19T17:29:49Z

← Older revision		Revision as of 17:29, 19 January 2015
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	</StructureSection>		</StructureSection>
	[[Category: Streptomyces coelicolor]]		[[Category: Streptomyces coelicolor]]
	[[Category: Arthur, C.]]		[[Category: Arthur, C]]
	[[Category: Crump, M P.]]		[[Category: Crump, M P]]
	[[Category: Ploskon, E.]]		[[Category: Ploskon, E]]
	[[Category: Acyl carrier protein]]		[[Category: Acyl carrier protein]]
	[[Category: Fatty acid synthase]]		[[Category: Fatty acid synthase]]
	[[Category: Intermediate binding]]		[[Category: Intermediate binding]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 15:34, 12 October 2014

2014-10-12T15:34:28Z

← Older revision		Revision as of 15:34, 12 October 2014
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	[[Image:~~2kos~~.~~png~~\|~~left~~\|~~200px~~]]		==NMR solution structures of octanoyl-ACP from Streptomyces coelicolor Fatty Acid Synthase==
			<StructureSection load='2kos' size='340' side='right' caption='[[2kos]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2kos]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KOS FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SXO:S-[2-({N-[(2S)-2-HYDROXY-3,3-DIMETHYL-4-(PHOSPHONOOXY)BUTANOYL]-BETA-ALANYL}AMINO)ETHYL]+OCTANETHIOATE'>SXO</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2koo\|2koo]], [[2kop\|2kop]], [[2koq\|2koq]], [[2kor\|2kor]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">acpP, SCO2389, SC4A7.17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1902 Streptomyces coelicolor])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kos RCSB], [http://www.ebi.ac.uk/pdbsum/2kos PDBsum]</span></td></tr>
			</table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ko/2kos_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			It remains unclear whether in a bacterial fatty acid synthase (FAS) acyl chain transfer is a programmed or diffusion controlled and random action. Acyl carrier protein (ACP), which delivers all intermediates and interacts with all synthase enzymes, is the key player in this process. High-resolution structures of intermediates covalently bound to an ACP representing each step in fatty acid biosynthesis have been solved by solution NMR. These include hexanoyl-, 3-oxooctanyl-, 3R-hydroxyoctanoyl-, 2-octenoyl-, and octanoyl-ACP from Streptomyces coelicolor FAS. The high-resolution structures reveal that the ACP adopts a unique conformation for each intermediate driven by changes in the internal fatty acid binding pocket. The binding of each intermediate shows conserved structural features that may ensure effective molecular recognition over subsequent rounds of fatty acid biosynthesis.

	~~{{STRUCTURE_2kos\| PDB=2kos \| SCENE= }}~~		Recognition of intermediate functionality by acyl carrier protein over a complete cycle of fatty acid biosynthesis.,Ploskon E, Arthur CJ, Kanari AL, Wattana-amorn P, Williams C, Crosby J, Simpson TJ, Willis CL, Crump MP Chem Biol. 2010 Jul 30;17(7):776-85. PMID:20659690<ref>PMID:20659690</ref>

	~~===NMR solution structures~~ of ~~octanoyl-ACP from Streptomyces coelicolor Fatty Acid Synthase===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	~~{{ABSTRACT_PUBMED_20659690}}~~		==See Also==
			*[[Acyl carrier protein\|Acyl carrier protein]]
	==~~About this Structure~~==		== References ==
	[[~~2kos]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor~~]~~. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOS OCA~~].		<references/>
			__TOC__
	==~~Reference~~==		</StructureSection>
	<~~ref group="xtra">PMID:020659690<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Streptomyces coelicolor]]		[[Category: Streptomyces coelicolor]]
	[[Category: Arthur, C.]]		[[Category: Arthur, C.]]

OCA: Protected "2kos" [edit=sysop:move=sysop]

2013-01-07T14:58:21Z

Protected "2kos" [edit=sysop:move=sysop]

← Older revision	Revision as of 14:58, 7 January 2013
(No difference)

OCA at 14:58, 7 January 2013

2013-01-07T14:58:15Z

← Older revision		Revision as of 14:58, 7 January 2013
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	~~{{Seed}}~~		[[Image:2kos.png\|left\|200px]]
	[[Image:2kos.~~jpg~~\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2kos", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2kos\| PDB=2kos \| SCENE= }}		{{STRUCTURE_2kos\| PDB=2kos \| SCENE= }}

	===NMR solution structures of octanoyl-ACP from Streptomyces coelicolor Fatty Acid Synthase===		===NMR solution structures of octanoyl-ACP from Streptomyces coelicolor Fatty Acid Synthase===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_20659690}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 20659690 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_20659690}}		{{ABSTRACT_PUBMED_20659690}}

	==About this Structure==		==About this Structure==
	~~2KOS~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOS OCA].		[[2kos]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOS OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~20659690~~</ref><references group="xtra"/>		<ref group="xtra">PMID:020659690</ref><references group="xtra"/>
	[[Category: Streptomyces coelicolor]]		[[Category: Streptomyces coelicolor]]
	[[Category: Arthur, C.]]		[[Category: Arthur, C.]]
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	[[Category: Intermediate binding]]		[[Category: Intermediate binding]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 18 11:34:28 2010''~~

OCA at 07:26, 18 August 2010

2010-08-18T07:26:58Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{Seed}}
-The entry 2kos is ON HOLD  until Paper Publication
+<!--
-Authors: Ploskon, E., Arthur, C., Crump, M.P.
+===NMR solution structures of octanoyl-ACP from Streptomyces coelicolor Fatty Acid Synthase===
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 21 09:54:33 2009''
+<!--

OCA at 07:54, 21 October 2009

2009-10-21T07:54:33Z

← Older revision		Revision as of 07:54, 21 October 2009
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 2kos is ON HOLD		The entry 2kos is ON HOLD until Paper Publication

	Authors: Ploskon, E., Arthur, C., Crump, M.P.		Authors: Ploskon, E., Arthur, C., Crump, M.P.
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	Description: NMR solution structures of octanoyl-ACP from Streptomyces coelicolor Fatty Acid Synthase		Description: NMR solution structures of octanoyl-ACP from Streptomyces coelicolor Fatty Acid Synthase

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct ~~7 13~~:38:15 2009''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 21 09:54:33 2009''