2kvb - Revision history

OCA at 01:08, 21 November 2024

2024-11-21T01:08:49Z

← Older revision		Revision as of 01:08, 21 November 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2kvb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KVB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kvb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KVB FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kvb OCA], [https://pdbe.org/2kvb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kvb RCSB], [https://www.ebi.ac.uk/pdbsum/2kvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kvb ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kvb OCA], [https://pdbe.org/2kvb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kvb RCSB], [https://www.ebi.ac.uk/pdbsum/2kvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kvb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kv/2kvb_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kv/2kvb_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 08:48, 14 June 2023

2023-06-14T08:48:31Z

← Older revision		Revision as of 08:48, 14 June 2023
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	==Solution structure of CI-MPR domain 5 bound to N-acetylglucosaminyl 6-phosphomethylmannoside==		==Solution structure of CI-MPR domain 5 bound to N-acetylglucosaminyl 6-phosphomethylmannoside==
	<StructureSection load='2kvb' size='340' side='right'caption='[[2kvb~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='2kvb' size='340' side='right'caption='[[2kvb]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2kvb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Bovin Bovin~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KVB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kvb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KVB FirstGlance]. <br>
	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2kva\|2kva]]</div></td></tr>~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kvb OCA], [https://pdbe.org/2kvb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kvb RCSB], [https://www.ebi.ac.uk/pdbsum/2kvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kvb ProSAT]</span></td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IGF2R, M6P ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>~~
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kvb OCA], [https://pdbe.org/2kvb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kvb RCSB], [https://www.ebi.ac.uk/pdbsum/2kvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kvb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/MPRI_BOVIN MPRI_BOVIN]] Acts as a positive regulator of T-cell coactivation, by binding DPP4 (By similarity). Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2.		[https://www.uniprot.org/uniprot/MPRI_BOVIN MPRI_BOVIN] Acts as a positive regulator of T-cell coactivation, by binding DPP4 (By similarity). Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Bovin~~]]		[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Dahms~~, N M~~]]		[[Category: Dahms NM]]
	[[Category: Olson~~, L J~~]]		[[Category: Olson LJ]]
	[[Category: Peterson~~, F C~~]]		[[Category: Peterson FC]]
	[[Category: Volkman~~, B F]]~~		[[Category: Volkman BF]]
	~~[[Category: Disulfide bond]]~~
	~~[[Category: Glycoprotein]]~~
	~~[[Category: Lysosome]]~~
	~~[[Category: Mannose]]~~
	~~[[Category: Membrane]]~~
	~~[[Category: Phosphoprotein]]~~
	~~[[Category: Protein transport]]~~
	~~[[Category: Receptor]]~~
	~~[[Category: Sugar binding]]~~
	~~[[Category: Transmembrane]]~~
	~~[[Category: Transport~~]]

OCA at 08:30, 10 November 2021

2021-11-10T08:30:38Z

← Older revision		Revision as of 08:30, 10 November 2021
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	<StructureSection load='2kvb' size='340' side='right'caption='[[2kvb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2kvb' size='340' side='right'caption='[[2kvb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2kvb]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bovin Bovin]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KVB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2KVB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kvb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovin Bovin]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KVB FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kva\|2kva]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2kva\|2kva]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IGF2R, M6P ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IGF2R, M6P ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2kvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kvb OCA], [~~http~~://pdbe.org/2kvb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2kvb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2kvb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2kvb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kvb OCA], [https://pdbe.org/2kvb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kvb RCSB], [https://www.ebi.ac.uk/pdbsum/2kvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kvb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/MPRI_BOVIN MPRI_BOVIN]] Acts as a positive regulator of T-cell coactivation, by binding DPP4 (By similarity). Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2.		[[https://www.uniprot.org/uniprot/MPRI_BOVIN MPRI_BOVIN]] Acts as a positive regulator of T-cell coactivation, by binding DPP4 (By similarity). Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:26, 5 February 2020

2020-02-05T08:26:24Z

← Older revision		Revision as of 08:26, 5 February 2020
Line 1:		Line 1:

	==Solution structure of CI-MPR domain 5 bound to N-acetylglucosaminyl 6-phosphomethylmannoside==		==Solution structure of CI-MPR domain 5 bound to N-acetylglucosaminyl 6-phosphomethylmannoside==
	<StructureSection load='2kvb' size='340' side='right' caption='[[2kvb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2kvb' size='340' side='right'caption='[[2kvb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2kvb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KVB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KVB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2kvb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KVB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KVB FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Bovin]]		[[Category: Bovin]]
			[[Category: Large Structures]]
	[[Category: Dahms, N M]]		[[Category: Dahms, N M]]
	[[Category: Olson, L J]]		[[Category: Olson, L J]]

OCA at 08:17, 25 July 2018

2018-07-25T08:17:22Z

← Older revision		Revision as of 08:17, 25 July 2018
Line 1:		Line 1:

	==Solution structure of CI-MPR domain 5 bound to N-acetylglucosaminyl 6-phosphomethylmannoside==		==Solution structure of CI-MPR domain 5 bound to N-acetylglucosaminyl 6-phosphomethylmannoside==
	<StructureSection load='2kvb' size='340' side='right' caption='[[2kvb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2kvb' size='340' side='right' caption='[[2kvb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
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	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kva\|2kva]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kva\|2kva]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IGF2R, M6P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IGF2R, M6P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kvb OCA], [http://pdbe.org/2kvb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kvb RCSB], [http://www.ebi.ac.uk/pdbsum/2kvb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kvb OCA], [http://pdbe.org/2kvb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kvb RCSB], [http://www.ebi.ac.uk/pdbsum/2kvb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2kvb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kv/2kvb_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kv/2kvb_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kvb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 13:53, 11 September 2015

2015-09-11T13:53:57Z

← Older revision		Revision as of 13:53, 11 September 2015
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	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kva\|2kva]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kva\|2kva]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IGF2R, M6P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IGF2R, M6P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kvb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kvb RCSB], [http://www.ebi.ac.uk/pdbsum/2kvb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kvb OCA], [http://pdbe.org/2kvb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kvb RCSB], [http://www.ebi.ac.uk/pdbsum/2kvb PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2kvb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 17:21, 25 December 2014

2014-12-25T17:21:32Z

← Older revision		Revision as of 17:21, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kvb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kvb RCSB], [http://www.ebi.ac.uk/pdbsum/2kvb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kvb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kvb RCSB], [http://www.ebi.ac.uk/pdbsum/2kvb PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/MPRI_BOVIN MPRI_BOVIN]] Acts as a positive regulator of T-cell coactivation, by binding DPP4 (By similarity). Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 05:39, 22 December 2014

2014-12-22T05:39:18Z

← Older revision		Revision as of 05:39, 22 December 2014
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	~~{{STRUCTURE_2kvb~~\| ~~PDB~~=2kvb \| ~~SCENE~~= }}		==Solution structure of CI-MPR domain 5 bound to N-acetylglucosaminyl 6-phosphomethylmannoside==
	===~~Solution~~ structure of CI-MPR domain 5 bound to N-acetylglucosaminyl 6-phosphomethylmannoside~~===~~		<StructureSection load='2kvb' size='340' side='right' caption='[[2kvb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	~~{{ABSTRACT_PUBMED_20615935}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2kvb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KVB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KVB FirstGlance]. <br>
			</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kva\|2kva]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IGF2R, M6P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kvb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kvb RCSB], [http://www.ebi.ac.uk/pdbsum/2kvb PDBsum]</span></td></tr>
			</table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kv/2kvb_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Mannose 6-phosphate (Man-6-P)-dependent trafficking is vital for normal development. The biogenesis of lysosomes, a major cellular site of protein, carbohydrate, and lipid catabolism, depends on the 300-kDa cation-independent Man-6-P receptor (CI-MPR) that transports newly synthesized acid hydrolases from the Golgi. The CI-MPR recognizes lysosomal enzymes bearing the Man-6-P modification, which arises by the addition of GlcNAc-1-phosphate to mannose residues and subsequent removal of GlcNAc by the uncovering enzyme (UCE). The CI-MPR also recognizes lysosomal enzymes that elude UCE maturation and instead display the Man-P-GlcNAc phosphodiester. This ability of the CI-MPR to target phosphodiester-containing enzymes ensures lysosomal delivery when UCE activity is deficient. The extracellular region of the CI-MPR is comprised of 15 repetitive domains and contains three distinct Man-6-P binding sites located in domains 3, 5, and 9, with only domain 5 exhibiting a marked preference for phosphodiester-containing lysosomal enzymes. To determine how the CI-MPR recognizes phosphodiesters, the structure of domain 5 was determined by NMR spectroscopy. Although domain 5 contains only three of the four disulfide bonds found in the other seven domains whose structures have been determined to date, it adopts the same fold consisting of a flattened beta-barrel. Structure determination of domain 5 bound to N-acetylglucosaminyl 6-phosphomethylmannoside, along with mutagenesis studies, revealed the residues involved in diester recognition, including Y679. These results show the mechanism by which the CI-MPR recognizes Man-P-GlcNAc-containing ligands and provides new avenues to investigate the role of phosphodiester-containing lysosomal enzymes in the biogenesis of lysosomes.

	~~==Function==~~		Structural basis for recognition of phosphodiester-containing lysosomal enzymes by the cation-independent mannose 6-phosphate receptor.,Olson LJ, Peterson FC, Castonguay A, Bohnsack RN, Kudo M, Gotschall RR, Canfield WM, Volkman BF, Dahms NM Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12493-8. Epub 2010 Jun 30. PMID:20615935<ref>PMID:20615935</ref>
	~~[[http://www.uniprot.org/uniprot/MPRI_BOVIN MPRI_BOVIN]] Acts as a positive regulator~~ of T-~~cell coactivation, by binding DPP4 (By similarity). Transport of phosphorylated~~ lysosomal enzymes ~~from~~ the ~~Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to~~ mannose-6-phosphate ~~receptors in the Golgi apparatus and the resulting~~ receptor-~~ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex~~. ~~This receptor also binds IGF2~~.

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[2kvb]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bovin Bovin]~~. ~~Full experimental information is available from [http:/~~/~~oca.weizmann.ac.il/oca-bin/ocashort?id=2KVB OCA].~~		</div>

	==See Also==		==See Also==
	*[[Insulin-like growth factor receptor\|Insulin-like growth factor receptor]]		*[[Insulin-like growth factor receptor\|Insulin-like growth factor receptor]]
			== References ==
	==~~Reference~~==		<references/>
	~~<ref group="xtra">PMID:020615935</ref>~~<references ~~group="xtra"~~/><~~references~~/>		__TOC__
			</StructureSection>
	[[Category: Bovin]]		[[Category: Bovin]]
	[[Category: Dahms, N M.]]		[[Category: Dahms, N M]]
	[[Category: Olson, L J.]]		[[Category: Olson, L J]]
	[[Category: Peterson, F C.]]		[[Category: Peterson, F C]]
	[[Category: Volkman, B F.]]		[[Category: Volkman, B F]]
	[[Category: Disulfide bond]]		[[Category: Disulfide bond]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]

OCA at 08:41, 25 December 2013

2013-12-25T08:41:59Z

← Older revision		Revision as of 08:41, 25 December 2013
Line 1:		Line 1:
	~~[[Image:2kvb.png\|left\|200px]]~~

	{{STRUCTURE_2kvb\| PDB=2kvb \| SCENE= }}		{{STRUCTURE_2kvb\| PDB=2kvb \| SCENE= }}

	===Solution structure of CI-MPR domain 5 bound to N-acetylglucosaminyl 6-phosphomethylmannoside===		===Solution structure of CI-MPR domain 5 bound to N-acetylglucosaminyl 6-phosphomethylmannoside===
			{{ABSTRACT_PUBMED_20615935}}

	~~{{ABSTRACT_PUBMED_20615935}}~~		==Function==
			[[http://www.uniprot.org/uniprot/MPRI_BOVIN MPRI_BOVIN]] Acts as a positive regulator of T-cell coactivation, by binding DPP4 (By similarity). Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2.

	==About this Structure==		==About this Structure==
	[[2kvb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bos_taurus Bos taurus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KVB OCA].		[[2kvb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KVB OCA].

	==See Also==		==See Also==
Line 14:		Line 13:

	==Reference==		==Reference==
	<ref group="xtra">PMID:020615935</ref><references group="xtra"/>		<ref group="xtra">PMID:020615935</ref><references group="xtra"/><references/>
	[[Category: ~~Bos taurus~~]]		[[Category: Bovin]]
	[[Category: Dahms, N M.]]		[[Category: Dahms, N M.]]
	[[Category: Olson, L J.]]		[[Category: Olson, L J.]]

OCA: Protected "2kvb" [edit=sysop:move=sysop]

2012-10-20T19:23:21Z

Protected "2kvb" [edit=sysop:move=sysop]

← Older revision	Revision as of 19:23, 20 October 2012
(No difference)