2l68 - Revision history

OCA at 06:53, 1 May 2024

2024-05-01T06:53:40Z

← Older revision		Revision as of 06:53, 1 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2l68]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L68 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2l68]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L68 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l68 OCA], [https://pdbe.org/2l68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l68 RCSB], [https://www.ebi.ac.uk/pdbsum/2l68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l68 ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l68 OCA], [https://pdbe.org/2l68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l68 RCSB], [https://www.ebi.ac.uk/pdbsum/2l68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l68 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/FABPL_HUMAN FABPL_HUMAN] Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.		[https://www.uniprot.org/uniprot/FABPL_HUMAN FABPL_HUMAN] Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Liver fatty acid binding protein (L-FABP), a cytosolic protein most abundant in liver, is associated with intracellular transport of fatty acids, nuclear signaling, and regulation of intracellular lipolysis. Among the members of the intracellular lipid binding protein family, L-FABP is of particular interest as it can i), bind two fatty acid molecules simultaneously and ii), accommodate a variety of bulkier physiological ligands such as bilirubin and fatty acyl CoA. To better understand the promiscuous binding and transport properties of L-FABP, we investigated structure and dynamics of human L-FABP with and without bound ligands by means of heteronuclear NMR. The overall conformation of human L-FABP shows the typical beta-clam motif. Binding of two oleic acid (OA) molecules does not alter the protein conformation substantially, but perturbs the chemical shift of certain backbone and side-chain protons that are involved in OA binding according to the structure of the human L-FABP/OA complex. Comparison of the human apo and holo L-FABP structures revealed no evidence for an "open-cap" conformation or a "swivel-back" mechanism of the K90 side chain upon ligand binding, as proposed for rat L-FABP. Instead, we postulate that the lipid binding process in L-FABP is associated with backbone dynamics.

	Solution structure and backbone dynamics of human liver fatty acid binding protein: fatty acid binding revisited.,Cai J, Lucke C, Chen Z, Qiao Y, Klimtchuk E, Hamilton JA Biophys J. 2012 Jun 6;102(11):2585-94. doi: 10.1016/j.bpj.2012.04.039. Epub 2012 , Jun 5. PMID:22713574<ref>PMID:22713574</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 2l68" style="background-color:#fffaf0;"></div>~~

	==See Also==		==See Also==
	*[[Fatty acid-binding protein 3D structures\|Fatty acid-binding protein 3D structures]]		*[[Fatty acid-binding protein 3D structures\|Fatty acid-binding protein 3D structures]]
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:23, 18 January 2023

2023-01-18T08:23:04Z

← Older revision		Revision as of 08:23, 18 January 2023
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	==Solution Structure of Human Holo L-FABP==		==Solution Structure of Human Holo L-FABP==
	<StructureSection load='2l68' size='340' side='right'caption='[[2l68~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='2l68' size='340' side='right'caption='[[2l68]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2l68]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L68 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2l68]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L68 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1lfo\|1lfo]], [[2ju3\|2ju3]], [[2ju7\|2ju7]], [[2f73\|2f73]], [[2py1\|2py1]]</div></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l68 OCA], [https://pdbe.org/2l68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l68 RCSB], [https://www.ebi.ac.uk/pdbsum/2l68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l68 ProSAT]</span></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FABP1, FABPL ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l68 OCA], [https://pdbe.org/2l68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l68 RCSB], [https://www.ebi.ac.uk/pdbsum/2l68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l68 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/FABPL_HUMAN FABPL_HUMAN]] Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.		[https://www.uniprot.org/uniprot/FABPL_HUMAN FABPL_HUMAN] Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Cai, J]]		[[Category: Cai J]]
	[[Category: Chen, Z]]		[[Category: Chen Z]]
	[[Category: Hamilton~~, J A~~]]		[[Category: Hamilton JA]]
	[[Category: Klimtchuk~~, E S~~]]		[[Category: Klimtchuk ES]]
	[[Category: Luecke, C]]		[[Category: Luecke C]]
	[[Category: Qiao, Y]]		[[Category: Qiao Y]]
	~~[[Category: Fatty acid carrier]]~~
	~~[[Category: Holo form]]~~
	~~[[Category: Lipid binding protein~~]]

OCA at 07:37, 14 April 2021

2021-04-14T07:37:12Z

← Older revision		Revision as of 07:37, 14 April 2021
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	==Solution Structure of Human Holo L-FABP==		==Solution Structure of Human Holo L-FABP==
	<StructureSection load='2l68' size='340' side='right' caption='[[2l68]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2l68' size='340' side='right'caption='[[2l68]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2l68]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L68 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2L68 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2l68]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L68 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lfo\|1lfo]], [[2ju3\|2ju3]], [[2ju7\|2ju7]], [[2f73\|2f73]], [[2py1\|2py1]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1lfo\|1lfo]], [[2ju3\|2ju3]], [[2ju7\|2ju7]], [[2f73\|2f73]], [[2py1\|2py1]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FABP1, FABPL ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FABP1, FABPL ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2l68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l68 OCA], [~~http~~://pdbe.org/2l68 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2l68 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2l68 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2l68 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l68 OCA], [https://pdbe.org/2l68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l68 RCSB], [https://www.ebi.ac.uk/pdbsum/2l68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l68 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/FABPL_HUMAN FABPL_HUMAN]] Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.		[[https://www.uniprot.org/uniprot/FABPL_HUMAN FABPL_HUMAN]] Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:

	==See Also==		==See Also==
	*[[Fatty acid-binding protein\|Fatty acid-binding protein]]		*[[Fatty acid-binding protein 3D structures\|Fatty acid-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Cai, J]]		[[Category: Cai, J]]
	[[Category: Chen, Z]]		[[Category: Chen, Z]]

OCA at 19:36, 1 August 2018

2018-08-01T19:36:47Z

← Older revision		Revision as of 19:36, 1 August 2018
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	==Solution Structure of Human Holo L-FABP==		==Solution Structure of Human Holo L-FABP==
	<StructureSection load='2l68' size='340' side='right' caption='[[2l68]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2l68' size='340' side='right' caption='[[2l68]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
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	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lfo\|1lfo]], [[2ju3\|2ju3]], [[2ju7\|2ju7]], [[2f73\|2f73]], [[2py1\|2py1]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lfo\|1lfo]], [[2ju3\|2ju3]], [[2ju7\|2ju7]], [[2f73\|2f73]], [[2py1\|2py1]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FABP1, FABPL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FABP1, FABPL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l68 OCA], [http://pdbe.org/2l68 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l68 RCSB], [http://www.ebi.ac.uk/pdbsum/2l68 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l68 OCA], [http://pdbe.org/2l68 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l68 RCSB], [http://www.ebi.ac.uk/pdbsum/2l68 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2l68 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 15:14, 11 September 2015

2015-09-11T15:14:34Z

← Older revision		Revision as of 15:14, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2l68' size='340' side='right' caption='[[2l68]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2l68' size='340' side='right' caption='[[2l68]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2l68]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L68 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L68 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2l68]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L68 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L68 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lfo\|1lfo]], [[2ju3\|2ju3]], [[2ju7\|2ju7]], [[2f73\|2f73]], [[2py1\|2py1]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lfo\|1lfo]], [[2ju3\|2ju3]], [[2ju7\|2ju7]], [[2f73\|2f73]], [[2py1\|2py1]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FABP1, FABPL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FABP1, FABPL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l68 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l68 RCSB], [http://www.ebi.ac.uk/pdbsum/2l68 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l68 OCA], [http://pdbe.org/2l68 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l68 RCSB], [http://www.ebi.ac.uk/pdbsum/2l68 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2l68" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Cai, J]]		[[Category: Cai, J]]
	[[Category: Chen, Z]]		[[Category: Chen, Z]]

OCA at 18:14, 25 December 2014

2014-12-25T18:14:47Z

← Older revision		Revision as of 18:14, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l68 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l68 RCSB], [http://www.ebi.ac.uk/pdbsum/2l68 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l68 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l68 RCSB], [http://www.ebi.ac.uk/pdbsum/2l68 PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/FABPL_HUMAN FABPL_HUMAN]] Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 08:52, 26 November 2014

2014-11-26T08:52:29Z

← Older revision		Revision as of 08:52, 26 November 2014
Line 1:		Line 1:
	[[~~Image~~:~~2l68~~.~~png~~\|~~left~~\|~~200px~~]]		==Solution Structure of Human Holo L-FABP==
			<StructureSection load='2l68' size='340' side='right' caption='[[2l68]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2l68]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L68 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L68 FirstGlance]. <br>
			</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lfo\|1lfo]], [[2ju3\|2ju3]], [[2ju7\|2ju7]], [[2f73\|2f73]], [[2py1\|2py1]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FABP1, FABPL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l68 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l68 RCSB], [http://www.ebi.ac.uk/pdbsum/2l68 PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Liver fatty acid binding protein (L-FABP), a cytosolic protein most abundant in liver, is associated with intracellular transport of fatty acids, nuclear signaling, and regulation of intracellular lipolysis. Among the members of the intracellular lipid binding protein family, L-FABP is of particular interest as it can i), bind two fatty acid molecules simultaneously and ii), accommodate a variety of bulkier physiological ligands such as bilirubin and fatty acyl CoA. To better understand the promiscuous binding and transport properties of L-FABP, we investigated structure and dynamics of human L-FABP with and without bound ligands by means of heteronuclear NMR. The overall conformation of human L-FABP shows the typical beta-clam motif. Binding of two oleic acid (OA) molecules does not alter the protein conformation substantially, but perturbs the chemical shift of certain backbone and side-chain protons that are involved in OA binding according to the structure of the human L-FABP/OA complex. Comparison of the human apo and holo L-FABP structures revealed no evidence for an "open-cap" conformation or a "swivel-back" mechanism of the K90 side chain upon ligand binding, as proposed for rat L-FABP. Instead, we postulate that the lipid binding process in L-FABP is associated with backbone dynamics.

	~~{{STRUCTURE_2l68\| PDB=2l68 \| SCENE= }}~~		Solution structure and backbone dynamics of human liver fatty acid binding protein: fatty acid binding revisited.,Cai J, Lucke C, Chen Z, Qiao Y, Klimtchuk E, Hamilton JA Biophys J. 2012 Jun 6;102(11):2585-94. doi: 10.1016/j.bpj.2012.04.039. Epub 2012 , Jun 5. PMID:22713574<ref>PMID:22713574</ref>

	~~===Solution Structure~~ of ~~Human Holo L-FABP===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_22713574}}~~

	~~==About this Structure==~~
	~~[[2l68]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full experimental information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=2L68 OCA].~~

	==See Also==		==See Also==
	*[[Fatty acid-binding protein\|Fatty acid-binding protein]]		*[[Fatty acid-binding protein\|Fatty acid-binding protein]]
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Cai, J.]]		[[Category: Cai, J]]
	[[Category: Chen, Z.]]		[[Category: Chen, Z]]
	[[Category: Hamilton, J A.]]		[[Category: Hamilton, J A]]
	[[Category: Klimtchuk, E S.]]		[[Category: Klimtchuk, E S]]
	[[Category: Luecke, C.]]		[[Category: Luecke, C]]
	[[Category: Qiao, Y.]]		[[Category: Qiao, Y]]
	[[Category: Fatty acid carrier]]		[[Category: Fatty acid carrier]]
	[[Category: Holo form]]		[[Category: Holo form]]
	[[Category: Lipid binding protein]]		[[Category: Lipid binding protein]]

OCA at 12:49, 20 February 2013

2013-02-20T12:49:36Z

← Older revision		Revision as of 12:49, 20 February 2013
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	===Solution Structure of Human Holo L-FABP===		===Solution Structure of Human Holo L-FABP===

			{{ABSTRACT_PUBMED_22713574}}

	==About this Structure==		==About this Structure==

OCA at 19:51, 20 October 2012

2012-10-20T19:51:45Z

← Older revision		Revision as of 19:51, 20 October 2012
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	==About this Structure==		==About this Structure==
	[[2l68]] is a 1 chain structure ~~of [[Fatty acid-binding protein]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L68 OCA].		[[2l68]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L68 OCA].

	==See Also==		==See Also==

OCA at 08:42, 27 July 2012

2012-07-27T08:42:38Z

← Older revision		Revision as of 08:42, 27 July 2012
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	[[Image:2l68.png\|left\|200px]]		[[Image:2l68.png\|left\|200px]]

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