2la1 - Revision history

OCA at 09:16, 6 November 2024

2024-11-06T09:16:21Z

← Older revision		Revision as of 09:16, 6 November 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2la1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dendroaspis_jamesoni_kaimosae Dendroaspis jamesoni kaimosae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LA1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2la1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dendroaspis_jamesoni_kaimosae Dendroaspis jamesoni kaimosae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LA1 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2la1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la1 OCA], [https://pdbe.org/2la1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2la1 RCSB], [https://www.ebi.ac.uk/pdbsum/2la1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2la1 ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2la1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la1 OCA], [https://pdbe.org/2la1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2la1 RCSB], [https://www.ebi.ac.uk/pdbsum/2la1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2la1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/3SPM_DENJA 3SPM_DENJA] Inhibits ADP-induced platelet aggregation and inhibits the binding of purified platelet fibrinogen receptor alpha-IIb/beta-3 (ITGA2B/ITGB3) to immobilized fibrinogen (PubMed:1591238). Has also been described to inhibit cell adhesion to fibrinogen, fibronectin, laminin and collagen (PubMed:~~16798616~~, PubMed:~~11336631~~).<ref>PMID:11336631</ref> <ref>PMID:1591238</ref> <ref>PMID:16798616</ref>		[https://www.uniprot.org/uniprot/3SPM_DENJA 3SPM_DENJA] Inhibits ADP-induced platelet aggregation and inhibits the binding of purified platelet fibrinogen receptor alpha-IIb/beta-3 (ITGA2B/ITGB3) to immobilized fibrinogen (PubMed:1591238). Has also been described to inhibit cell adhesion to fibrinogen, fibronectin, laminin and collagen (PubMed:11336631, PubMed:16798616).<ref>PMID:11336631</ref> <ref>PMID:1591238</ref> <ref>PMID:16798616</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 08:53, 14 June 2023

2023-06-14T08:53:59Z

← Older revision		Revision as of 08:53, 14 June 2023
Line 1:		Line 1:

	==Expression in Pichia pastoris and backbone dynamics of dendroaspin, a three finger toxin==		==Expression in Pichia pastoris and backbone dynamics of dendroaspin, a three finger toxin==
	<StructureSection load='2la1' size='340' side='right'caption='[[2la1~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='2la1' size='340' side='right'caption='[[2la1]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2la1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Denja Denja~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LA1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2la1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dendroaspis_jamesoni_kaimosae Dendroaspis jamesoni kaimosae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LA1 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2la1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la1 OCA], [https://pdbe.org/2la1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2la1 RCSB], [https://www.ebi.ac.uk/pdbsum/2la1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2la1 ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2la1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la1 OCA], [https://pdbe.org/2la1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2la1 RCSB], [https://www.ebi.ac.uk/pdbsum/2la1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2la1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/~~MAMB_DENJA MAMB_DENJA]~~] Inhibits ADP-induced platelet aggregation and inhibits the binding of purified platelet fibrinogen receptor alpha-IIb/beta-3 (ITGA2B/ITGB3) to immobilized fibrinogen.		[https://www.uniprot.org/uniprot/3SPM_DENJA 3SPM_DENJA] Inhibits ADP-induced platelet aggregation and inhibits the binding of purified platelet fibrinogen receptor alpha-IIb/beta-3 (ITGA2B/ITGB3) to immobilized fibrinogen (PubMed:1591238). Has also been described to inhibit cell adhesion to fibrinogen, fibronectin, laminin and collagen (PubMed:16798616, PubMed:11336631).<ref>PMID:11336631</ref> <ref>PMID:1591238</ref> <ref>PMID:16798616</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Denja~~]]		[[Category: Dendroaspis jamesoni kaimosae]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Chen~~, Y C~~]]		[[Category: Chen YC]]
	[[Category: Cheng~~, C H~~]]		[[Category: Cheng CH]]
	[[Category: Chuang~~, W J~~]]		[[Category: Chuang WJ]]
	[[Category: Shiu~~, J H]]~~		[[Category: Shiu JH]]
	~~[[Category: Dendroaspin]]~~
	~~[[Category: Disintegrin]]~~
	~~[[Category: Integrin]]~~
	~~[[Category: Snake toxin]]~~
	~~[[Category: Three-finger fold]]~~
	~~[[Category: Toxin~~]]

OCA at 07:49, 9 February 2022

2022-02-09T07:49:54Z

← Older revision		Revision as of 07:49, 9 February 2022
Line 3:		Line 3:
	<StructureSection load='2la1' size='340' side='right'caption='[[2la1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2la1' size='340' side='right'caption='[[2la1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2la1]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Denja Denja]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2LA1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2la1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Denja Denja]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LA1 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2la1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la1 OCA], [~~http~~://pdbe.org/2la1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2la1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2la1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2la1 ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2la1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la1 OCA], [https://pdbe.org/2la1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2la1 RCSB], [https://www.ebi.ac.uk/pdbsum/2la1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2la1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/MAMB_DENJA MAMB_DENJA]] Inhibits ADP-induced platelet aggregation and inhibits the binding of purified platelet fibrinogen receptor alpha-IIb/beta-3 (ITGA2B/ITGB3) to immobilized fibrinogen.		[[https://www.uniprot.org/uniprot/MAMB_DENJA MAMB_DENJA]] Inhibits ADP-induced platelet aggregation and inhibits the binding of purified platelet fibrinogen receptor alpha-IIb/beta-3 (ITGA2B/ITGB3) to immobilized fibrinogen.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:01, 6 May 2020

2020-05-06T07:01:19Z

← Older revision		Revision as of 07:01, 6 May 2020
Line 1:		Line 1:

	==Expression in Pichia pastoris and backbone dynamics of dendroaspin, a three finger toxin==		==Expression in Pichia pastoris and backbone dynamics of dendroaspin, a three finger toxin==
	<StructureSection load='2la1' size='340' side='right' caption='[[2la1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2la1' size='340' side='right'caption='[[2la1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2la1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Denja Denja]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA1 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2LA1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2la1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Denja Denja]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2LA1 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca.weizmann~~.~~ac.il/oca-docs~~/fgij/fg.htm?mol=2la1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la1 OCA], [http://pdbe.org/2la1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2la1 RCSB], [http://www.ebi.ac.uk/pdbsum/2la1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2la1 ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2la1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la1 OCA], [http://pdbe.org/2la1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2la1 RCSB], [http://www.ebi.ac.uk/pdbsum/2la1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2la1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Denja]]		[[Category: Denja]]
			[[Category: Large Structures]]
	[[Category: Chen, Y C]]		[[Category: Chen, Y C]]
	[[Category: Cheng, C H]]		[[Category: Cheng, C H]]

OCA at 19:46, 1 August 2018

2018-08-01T19:46:44Z

← Older revision		Revision as of 19:46, 1 August 2018
Line 1:		Line 1:

	==Expression in Pichia pastoris and backbone dynamics of dendroaspin, a three finger toxin==		==Expression in Pichia pastoris and backbone dynamics of dendroaspin, a three finger toxin==
	<StructureSection load='2la1' size='340' side='right' caption='[[2la1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2la1' size='340' side='right' caption='[[2la1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2la1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Denja Denja]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LA1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2la1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Denja Denja]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LA1 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2la1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la1 OCA], [http://pdbe.org/2la1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2la1 RCSB], [http://www.ebi.ac.uk/pdbsum/2la1 PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2la1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la1 OCA], [http://pdbe.org/2la1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2la1 RCSB], [http://www.ebi.ac.uk/pdbsum/2la1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2la1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 02:24, 12 September 2015

2015-09-12T02:24:15Z

← Older revision		Revision as of 02:24, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='2la1' size='340' side='right' caption='[[2la1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2la1' size='340' side='right' caption='[[2la1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2la1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Dendroaspis_jamesoni_kaimosae Dendroaspis jamesoni kaimosae~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LA1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2la1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Denja Denja]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LA1 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2la1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2la1 RCSB], [http://www.ebi.ac.uk/pdbsum/2la1 PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2la1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la1 OCA], [http://pdbe.org/2la1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2la1 RCSB], [http://www.ebi.ac.uk/pdbsum/2la1 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2la1" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Dendroaspis jamesoni kaimosae~~]]		[[Category: Denja]]
	[[Category: Chen, Y C]]		[[Category: Chen, Y C]]
	[[Category: Cheng, C H]]		[[Category: Cheng, C H]]

OCA at 22:39, 25 December 2014

2014-12-25T22:39:51Z

← Older revision		Revision as of 22:39, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2la1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dendroaspis_jamesoni_kaimosae Dendroaspis jamesoni kaimosae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LA1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2la1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dendroaspis_jamesoni_kaimosae Dendroaspis jamesoni kaimosae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LA1 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2la1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2la1 RCSB], [http://www.ebi.ac.uk/pdbsum/2la1 PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2la1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2la1 RCSB], [http://www.ebi.ac.uk/pdbsum/2la1 PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/MAMB_DENJA MAMB_DENJA]] Inhibits ADP-induced platelet aggregation and inhibits the binding of purified platelet fibrinogen receptor alpha-IIb/beta-3 (ITGA2B/ITGB3) to immobilized fibrinogen.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Dendroaspis jamesoni kaimosae]]		[[Category: Dendroaspis jamesoni kaimosae]]
	[[Category: Chen, Y C.]]		[[Category: Chen, Y C]]
	[[Category: Cheng, C H.]]		[[Category: Cheng, C H]]
	[[Category: Chuang, W J.]]		[[Category: Chuang, W J]]
	[[Category: Shiu, J H.]]		[[Category: Shiu, J H]]
	[[Category: Dendroaspin]]		[[Category: Dendroaspin]]
	[[Category: Disintegrin]]		[[Category: Disintegrin]]

OCA at 00:54, 2 October 2014

2014-10-02T00:54:04Z

← Older revision		Revision as of 00:54, 2 October 2014
Line 1:		Line 1:
	[[~~Image~~:2la1.~~png\|left\|200px~~]]		==Expression in Pichia pastoris and backbone dynamics of dendroaspin, a three finger toxin==
			<StructureSection load='2la1' size='340' side='right' caption='[[2la1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2la1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dendroaspis_jamesoni_kaimosae Dendroaspis jamesoni kaimosae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LA1 FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2la1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2la1 RCSB], [http://www.ebi.ac.uk/pdbsum/2la1 PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Dendroaspin (Den) and rhodostomin (Rho) are snake venom proteins containing a PRGDMP motif. Although Den and Rho have different 3D structures, they are highly potent integrin inhibitors. To study their structure, function, and dynamics relationships, we expressed Den and Rho in Pichia pastoris. The recombinant Den and Rho inhibited platelet aggregation with the K(I) values of 149.8 and 83.2 nM. Cell adhesion analysis showed that Den was 3.7 times less active than Rho when inhibiting the integrin alphaIIbbeta3 and 2.5 times less active when inhibiting the integrin alphavbeta3. In contrast, Den and Rho were similarly active when inhibiting the integrin alpha5beta1 with the IC(50) values of 239.8 and 256.8 nM. NMR analysis showed that recombinant Den and Rho have different 3D conformations for their arginyl-glycyl-aspartic acid (RGD) motif. However, the comparison with Rho showed that the docking of Den into integrin alphavbeta3 resulted in a similar number of contacts. Analysis of the dynamic properties of the RGD loop in Den and Rho showed that they also had different dynamic properties. These results demonstrate that protein scaffolds affect the function, structure, and dynamics of their RGD motif.

	~~{{STRUCTURE_2la1\| PDB=2la1 \| SCENE= }}~~		Dynamics and functional differences between dendroaspin and rhodostomin: Insights into protein scaffolds in integrin recognition.,Cheng CH, Chen YC, Shiu JH, Chang YT, Chang YS, Huang CH, Chen CY, Chuang WJ Protein Sci. 2012 Dec;21(12):1872-84. doi: 10.1002/pro.2169. Epub 2012 Nov 6. PMID:23033223<ref>PMID:23033223</ref>

	~~===Expression in Pichia pastoris and backbone dynamics of dendroaspin~~, a ~~three finger toxin===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_23033223}}~~		== References ==
			<references/>
	==~~About this Structure~~==		__TOC__
	~~[[2la1]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Dendroaspis_jamesoni_kaimosae Dendroaspis jamesoni kaimosae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA1 OCA].~~		</StructureSection>
	[[Category: Dendroaspis jamesoni kaimosae]]		[[Category: Dendroaspis jamesoni kaimosae]]
	[[Category: Chen, Y C.]]		[[Category: Chen, Y C.]]

OCA at 10:30, 19 December 2012

2012-12-19T10:30:12Z

← Older revision		Revision as of 10:30, 19 December 2012
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	[[Image:2la1.~~jpg~~\|left\|200px]]		[[Image:2la1.png\|left\|200px]]

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	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
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	{{STRUCTURE_2la1\| PDB=2la1 \| SCENE= }}		{{STRUCTURE_2la1\| PDB=2la1 \| SCENE= }}

	===Expression in Pichia pastoris and backbone dynamics of dendroaspin, a three finger toxin===		===Expression in Pichia pastoris and backbone dynamics of dendroaspin, a three finger toxin===

			{{ABSTRACT_PUBMED_23033223}}

	==About this Structure==		==About this Structure==

OCA at 05:50, 8 March 2012

2012-03-08T05:50:08Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:2la1.jpg|left|200px]]
-The entry 2la1 is ON HOLD  until Paper Publication
+<!--
-Authors: Chuang, W.J., Cheng, C.H., Chen, Y.C., Shiu, J.H.
+===Expression in Pichia pastoris and backbone dynamics of dendroaspin, a three finger toxin===
-Description: Expression in Pichia pastoris and backbone dynamics of dendroaspin, a three finger toxin