2la5 - Revision history

OCA at 06:54, 1 May 2024

2024-05-01T06:54:46Z

← Older revision		Revision as of 06:54, 1 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2la5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LA5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2la5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LA5 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2la5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la5 OCA], [https://pdbe.org/2la5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2la5 RCSB], [https://www.ebi.ac.uk/pdbsum/2la5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2la5 ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2la5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la5 OCA], [https://pdbe.org/2la5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2la5 RCSB], [https://www.ebi.ac.uk/pdbsum/2la5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2la5 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/FMR1_HUMAN FMR1_HUMAN] Translation repressor. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression (By similarity). RNA-binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C).		[https://www.uniprot.org/uniprot/FMR1_HUMAN FMR1_HUMAN] Translation repressor. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression (By similarity). RNA-binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C).
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	We have determined the solution structure of the complex between an arginine-glycine-rich RGG peptide from the human fragile X mental retardation protein (FMRP) and an in vitro-selected guanine-rich (G-rich) sc1 RNA. The bound RNA forms a newly discovered G-quadruplex separated from the flanking duplex stem by a mixed junctional tetrad. The RGG peptide is positioned along the major groove of the RNA duplex, with the G-quadruplex forcing a sharp turn of R(10)GGGGR(15) at the duplex-quadruplex junction. Arg10 and Arg15 form cross-strand specificity-determining intermolecular hydrogen bonds with the major-groove edges of guanines of adjacent Watson-Crick G*C pairs. Filter-binding assays on RNA and peptide mutations identify and validate contributions of peptide-RNA intermolecular contacts and shape complementarity to molecular recognition. These findings on FMRP RGG domain recognition by a combination of G-quadruplex and surrounding RNA sequences have implications for the recognition of other genomic G-rich RNAs.

	Structure-function studies of FMRP RGG peptide recognition of an RNA duplex-quadruplex junction.,Phan AT, Kuryavyi V, Darnell JC, Serganov A, Majumdar A, Ilin S, Raslin T, Polonskaia A, Chen C, Clain D, Darnell RB, Patel DJ Nat Struct Mol Biol. 2011 Jun 5;18(7):796-804. doi: 10.1038/nsmb.2064. PMID:21642970<ref>PMID:21642970</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 2la5" style="background-color:#fffaf0;"></div>~~
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:28, 18 January 2023

2023-01-18T08:28:13Z

← Older revision		Revision as of 08:28, 18 January 2023
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	==RNA Duplex-Quadruplex Junction Complex with FMRP RGG peptide==		==RNA Duplex-Quadruplex Junction Complex with FMRP RGG peptide==
	<StructureSection load='2la5' size='340' side='right'caption='[[2la5~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>		<StructureSection load='2la5' size='340' side='right'caption='[[2la5]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2la5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LA5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2la5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LA5 FirstGlance]. <br>
	</td></tr>~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FMR1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2la5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la5 OCA], [https://pdbe.org/2la5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2la5 RCSB], [https://www.ebi.ac.uk/pdbsum/2la5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2la5 ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2la5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la5 OCA], [https://pdbe.org/2la5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2la5 RCSB], [https://www.ebi.ac.uk/pdbsum/2la5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2la5 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[https://www.uniprot.org/uniprot/FMR1_HUMAN FMR1_HUMAN]] Defects in FMR1 are the cause of fragile X syndrome (FRAX) [MIM:[https://omim.org/entry/300624 300624]]. Fragile X syndrome is a common genetic disease (has a prevalence of one in every 2000 children) which is characterized by moderate to severe mental retardation, macroorchidism (enlargement of the testicles), large ears, prominent jaw, and high-pitched, jocular speech. The defect in most fragile X syndrome patients results from an amplification of a CGG repeat region which is directly in front of the coding region.<ref>PMID:18664458</ref> <ref>PMID:8401578</ref> <ref>PMID:7688265</ref> <ref>PMID:17850748</ref> <ref>PMID:8490650</ref> <ref>PMID:7633450</ref> <ref>PMID:9659908</ref> <ref>PMID:15805463</ref> Defects in FMR1 are the cause of fragile X tremor/ataxia syndrome (FXTAS) [MIM:[https://omim.org/entry/300623 300623]]. In FXTAS, the expanded repeats range in size from 55 to 200 repeats and are referred to as 'premutations'. Full repeat expansions with greater than 200 repeats results in fragile X mental retardation syndrome [MIM:[https://omim.org/entry/300624 300624]]. Carriers of the premutation typically do not show the full fragile X syndrome phenotype, but comprise a subgroup that may have some physical features of fragile X syndrome or mild cognitive and emotional problems.<ref>PMID:11445641</ref> Defects in FMR1 are the cause of premature ovarian failure syndrome type 1 (POF1) [MIM:[https://omim.org/entry/311360 311360]]. An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.<ref>PMID:9719368</ref>		[https://www.uniprot.org/uniprot/FMR1_HUMAN FMR1_HUMAN] Defects in FMR1 are the cause of fragile X syndrome (FRAX) [MIM:[https://omim.org/entry/300624 300624]. Fragile X syndrome is a common genetic disease (has a prevalence of one in every 2000 children) which is characterized by moderate to severe mental retardation, macroorchidism (enlargement of the testicles), large ears, prominent jaw, and high-pitched, jocular speech. The defect in most fragile X syndrome patients results from an amplification of a CGG repeat region which is directly in front of the coding region.<ref>PMID:18664458</ref> <ref>PMID:8401578</ref> <ref>PMID:7688265</ref> <ref>PMID:17850748</ref> <ref>PMID:8490650</ref> <ref>PMID:7633450</ref> <ref>PMID:9659908</ref> <ref>PMID:15805463</ref> Defects in FMR1 are the cause of fragile X tremor/ataxia syndrome (FXTAS) [MIM:[https://omim.org/entry/300623 300623]. In FXTAS, the expanded repeats range in size from 55 to 200 repeats and are referred to as 'premutations'. Full repeat expansions with greater than 200 repeats results in fragile X mental retardation syndrome [MIM:[https://omim.org/entry/300624 300624]. Carriers of the premutation typically do not show the full fragile X syndrome phenotype, but comprise a subgroup that may have some physical features of fragile X syndrome or mild cognitive and emotional problems.<ref>PMID:11445641</ref> Defects in FMR1 are the cause of premature ovarian failure syndrome type 1 (POF1) [MIM:[https://omim.org/entry/311360 311360]. An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.<ref>PMID:9719368</ref>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/FMR1_HUMAN FMR1_HUMAN]] Translation repressor. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression (By similarity). RNA-binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C).		[https://www.uniprot.org/uniprot/FMR1_HUMAN FMR1_HUMAN] Translation repressor. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression (By similarity). RNA-binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Darnell, J]]		[[Category: Darnell J]]
	[[Category: Darnell, R]]		[[Category: Darnell R]]
	[[Category: Ilin, S]]		[[Category: Ilin S]]
	[[Category: Kuryavyi, V]]		[[Category: Kuryavyi V]]
	[[Category: Majumdar, A]]		[[Category: Majumdar A]]
	[[Category: Patel, D]]		[[Category: Patel D]]
	[[Category: Phan, A]]		[[Category: Phan A]]
	[[Category: Serganov, A]]		[[Category: Serganov A]]
	~~[[Category: Rna binding protein-rna complex~~]]

OCA at 07:39, 14 April 2021

2021-04-14T07:39:06Z

← Older revision		Revision as of 07:39, 14 April 2021
Line 1:		Line 1:

	==RNA Duplex-Quadruplex Junction Complex with FMRP RGG peptide==		==RNA Duplex-Quadruplex Junction Complex with FMRP RGG peptide==
	<StructureSection load='2la5' size='340' side='right' caption='[[2la5]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2la5' size='340' side='right'caption='[[2la5]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2la5]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2LA5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2la5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LA5 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FMR1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FMR1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2la5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la5 OCA], [~~http~~://pdbe.org/2la5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2la5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2la5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2la5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2la5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la5 OCA], [https://pdbe.org/2la5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2la5 RCSB], [https://www.ebi.ac.uk/pdbsum/2la5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2la5 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[~~http~~://www.uniprot.org/uniprot/FMR1_HUMAN FMR1_HUMAN]] Defects in FMR1 are the cause of fragile X syndrome (FRAX) [MIM:[~~http~~://omim.org/entry/300624 300624]]. Fragile X syndrome is a common genetic disease (has a prevalence of one in every 2000 children) which is characterized by moderate to severe mental retardation, macroorchidism (enlargement of the testicles), large ears, prominent jaw, and high-pitched, jocular speech. The defect in most fragile X syndrome patients results from an amplification of a CGG repeat region which is directly in front of the coding region.<ref>PMID:18664458</ref> <ref>PMID:8401578</ref> <ref>PMID:7688265</ref> <ref>PMID:17850748</ref> <ref>PMID:8490650</ref> <ref>PMID:7633450</ref> <ref>PMID:9659908</ref> <ref>PMID:15805463</ref> Defects in FMR1 are the cause of fragile X tremor/ataxia syndrome (FXTAS) [MIM:[~~http~~://omim.org/entry/300623 300623]]. In FXTAS, the expanded repeats range in size from 55 to 200 repeats and are referred to as 'premutations'. Full repeat expansions with greater than 200 repeats results in fragile X mental retardation syndrome [MIM:[~~http~~://omim.org/entry/300624 300624]]. Carriers of the premutation typically do not show the full fragile X syndrome phenotype, but comprise a subgroup that may have some physical features of fragile X syndrome or mild cognitive and emotional problems.<ref>PMID:11445641</ref> Defects in FMR1 are the cause of premature ovarian failure syndrome type 1 (POF1) [MIM:[~~http~~://omim.org/entry/311360 311360]]. An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.<ref>PMID:9719368</ref>		[[https://www.uniprot.org/uniprot/FMR1_HUMAN FMR1_HUMAN]] Defects in FMR1 are the cause of fragile X syndrome (FRAX) [MIM:[https://omim.org/entry/300624 300624]]. Fragile X syndrome is a common genetic disease (has a prevalence of one in every 2000 children) which is characterized by moderate to severe mental retardation, macroorchidism (enlargement of the testicles), large ears, prominent jaw, and high-pitched, jocular speech. The defect in most fragile X syndrome patients results from an amplification of a CGG repeat region which is directly in front of the coding region.<ref>PMID:18664458</ref> <ref>PMID:8401578</ref> <ref>PMID:7688265</ref> <ref>PMID:17850748</ref> <ref>PMID:8490650</ref> <ref>PMID:7633450</ref> <ref>PMID:9659908</ref> <ref>PMID:15805463</ref> Defects in FMR1 are the cause of fragile X tremor/ataxia syndrome (FXTAS) [MIM:[https://omim.org/entry/300623 300623]]. In FXTAS, the expanded repeats range in size from 55 to 200 repeats and are referred to as 'premutations'. Full repeat expansions with greater than 200 repeats results in fragile X mental retardation syndrome [MIM:[https://omim.org/entry/300624 300624]]. Carriers of the premutation typically do not show the full fragile X syndrome phenotype, but comprise a subgroup that may have some physical features of fragile X syndrome or mild cognitive and emotional problems.<ref>PMID:11445641</ref> Defects in FMR1 are the cause of premature ovarian failure syndrome type 1 (POF1) [MIM:[https://omim.org/entry/311360 311360]]. An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.<ref>PMID:9719368</ref>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/FMR1_HUMAN FMR1_HUMAN]] Translation repressor. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression (By similarity). RNA-binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C).		[[https://www.uniprot.org/uniprot/FMR1_HUMAN FMR1_HUMAN]] Translation repressor. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression (By similarity). RNA-binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Darnell, J]]		[[Category: Darnell, J]]
	[[Category: Darnell, R]]		[[Category: Darnell, R]]

OCA at 19:24, 1 August 2018

2018-08-01T19:24:59Z

← Older revision		Revision as of 19:24, 1 August 2018
Line 1:		Line 1:

	==RNA Duplex-Quadruplex Junction Complex with FMRP RGG peptide==		==RNA Duplex-Quadruplex Junction Complex with FMRP RGG peptide==
	<StructureSection load='2la5' size='340' side='right' caption='[[2la5]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2la5' size='340' side='right' caption='[[2la5]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2la5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LA5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2la5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LA5 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FMR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FMR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2la5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la5 OCA], [http://pdbe.org/2la5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2la5 RCSB], [http://www.ebi.ac.uk/pdbsum/2la5 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2la5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la5 OCA], [http://pdbe.org/2la5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2la5 RCSB], [http://www.ebi.ac.uk/pdbsum/2la5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2la5 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 11:40, 10 September 2015

2015-09-10T11:40:39Z

← Older revision		Revision as of 11:40, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2la5' size='340' side='right' caption='[[2la5]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2la5' size='340' side='right' caption='[[2la5]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2la5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LA5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2la5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LA5 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FMR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FMR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2la5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2la5 RCSB], [http://www.ebi.ac.uk/pdbsum/2la5 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2la5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la5 OCA], [http://pdbe.org/2la5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2la5 RCSB], [http://www.ebi.ac.uk/pdbsum/2la5 PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 18:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2la5" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Darnell, J]]		[[Category: Darnell, J]]
	[[Category: Darnell, R]]		[[Category: Darnell, R]]

OCA at 11:39, 18 December 2014

2014-12-18T11:39:25Z

← Older revision		Revision as of 11:39, 18 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_2la5\| PDB=2la5 \| SCENE= }}~~		==RNA Duplex-Quadruplex Junction Complex with FMRP RGG peptide==
	===RNA Duplex-Quadruplex Junction Complex with FMRP RGG peptide===		<StructureSection load='2la5' size='340' side='right' caption='[[2la5]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	~~{{ABSTRACT_PUBMED_21642970}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2la5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LA5 FirstGlance]. <br>
	==Disease==		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FMR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	[[http://www.uniprot.org/uniprot/FMR1_HUMAN FMR1_HUMAN]] Defects in FMR1 are the cause of fragile X syndrome (FRAX) [MIM:[http://omim.org/entry/300624 300624]]. Fragile X syndrome is a common genetic disease (has a prevalence of one in every 2000 children) which is characterized by moderate to severe mental retardation, macroorchidism (enlargement of the testicles), large ears, prominent jaw, and high-pitched, jocular speech. The defect in most fragile X syndrome patients results from an amplification of a CGG repeat region which is directly in front of the coding region.<ref>PMID:18664458</ref><ref>PMID:8401578</ref><ref>PMID:7688265</ref><ref>PMID:17850748</ref><ref>PMID:8490650</ref><ref>PMID:7633450</ref><ref>PMID:9659908</ref><ref>PMID:15805463</ref> Defects in FMR1 are the cause of fragile X tremor/ataxia syndrome (FXTAS) [MIM:[http://omim.org/entry/300623 300623]]. In FXTAS, the expanded repeats range in size from 55 to 200 repeats and are referred to as 'premutations'. Full repeat expansions with greater than 200 repeats results in fragile X mental retardation syndrome [MIM:[http://omim.org/entry/300624 300624]]. Carriers of the premutation typically do not show the full fragile X syndrome phenotype, but comprise a subgroup that may have some physical features of fragile X syndrome or mild cognitive and emotional problems.<ref>PMID:11445641</ref> Defects in FMR1 are the cause of premature ovarian failure syndrome type 1 (POF1) [MIM:[http://omim.org/entry/311360 311360]]. An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.<ref>PMID:9719368</ref>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2la5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2la5 RCSB], [http://www.ebi.ac.uk/pdbsum/2la5 PDBsum]</span></td></tr>
			</table>
	==Function==		== Disease ==
			[[http://www.uniprot.org/uniprot/FMR1_HUMAN FMR1_HUMAN]] Defects in FMR1 are the cause of fragile X syndrome (FRAX) [MIM:[http://omim.org/entry/300624 300624]]. Fragile X syndrome is a common genetic disease (has a prevalence of one in every 2000 children) which is characterized by moderate to severe mental retardation, macroorchidism (enlargement of the testicles), large ears, prominent jaw, and high-pitched, jocular speech. The defect in most fragile X syndrome patients results from an amplification of a CGG repeat region which is directly in front of the coding region.<ref>PMID:18664458</ref> <ref>PMID:8401578</ref> <ref>PMID:7688265</ref> <ref>PMID:17850748</ref> <ref>PMID:8490650</ref> <ref>PMID:7633450</ref> <ref>PMID:9659908</ref> <ref>PMID:15805463</ref> Defects in FMR1 are the cause of fragile X tremor/ataxia syndrome (FXTAS) [MIM:[http://omim.org/entry/300623 300623]]. In FXTAS, the expanded repeats range in size from 55 to 200 repeats and are referred to as 'premutations'. Full repeat expansions with greater than 200 repeats results in fragile X mental retardation syndrome [MIM:[http://omim.org/entry/300624 300624]]. Carriers of the premutation typically do not show the full fragile X syndrome phenotype, but comprise a subgroup that may have some physical features of fragile X syndrome or mild cognitive and emotional problems.<ref>PMID:11445641</ref> Defects in FMR1 are the cause of premature ovarian failure syndrome type 1 (POF1) [MIM:[http://omim.org/entry/311360 311360]]. An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.<ref>PMID:9719368</ref>
			== Function ==
	[[http://www.uniprot.org/uniprot/FMR1_HUMAN FMR1_HUMAN]] Translation repressor. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression (By similarity). RNA-binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C).		[[http://www.uniprot.org/uniprot/FMR1_HUMAN FMR1_HUMAN]] Translation repressor. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression (By similarity). RNA-binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C).
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			We have determined the solution structure of the complex between an arginine-glycine-rich RGG peptide from the human fragile X mental retardation protein (FMRP) and an in vitro-selected guanine-rich (G-rich) sc1 RNA. The bound RNA forms a newly discovered G-quadruplex separated from the flanking duplex stem by a mixed junctional tetrad. The RGG peptide is positioned along the major groove of the RNA duplex, with the G-quadruplex forcing a sharp turn of R(10)GGGGR(15) at the duplex-quadruplex junction. Arg10 and Arg15 form cross-strand specificity-determining intermolecular hydrogen bonds with the major-groove edges of guanines of adjacent Watson-Crick G*C pairs. Filter-binding assays on RNA and peptide mutations identify and validate contributions of peptide-RNA intermolecular contacts and shape complementarity to molecular recognition. These findings on FMRP RGG domain recognition by a combination of G-quadruplex and surrounding RNA sequences have implications for the recognition of other genomic G-rich RNAs.

	~~==About this~~ Structure==		Structure-function studies of FMRP RGG peptide recognition of an RNA duplex-quadruplex junction.,Phan AT, Kuryavyi V, Darnell JC, Serganov A, Majumdar A, Ilin S, Raslin T, Polonskaia A, Chen C, Clain D, Darnell RB, Patel DJ Nat Struct Mol Biol. 2011 Jun 5;18(7):796-804. doi: 10.1038/nsmb.2064. PMID:21642970<ref>PMID:21642970</ref>
	~~[[2la5]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full experimental information is available from [http~~:/~~/oca~~.~~weizmann~~.~~ac.il/oca-bin~~/~~ocashort?id=2LA5 OCA].~~

	==~~Reference~~==		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~<ref group="xtra">PMID:021642970</ref>~~<references ~~group="xtra"~~/><~~references~~/>		</div>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Darnell, J.]]		[[Category: Darnell, J]]
	[[Category: Darnell, R.]]		[[Category: Darnell, R]]
	[[Category: Ilin, S.]]		[[Category: Ilin, S]]
	[[Category: Kuryavyi, V.]]		[[Category: Kuryavyi, V]]
	[[Category: Majumdar, A.]]		[[Category: Majumdar, A]]
	[[Category: Patel, D.]]		[[Category: Patel, D]]
	[[Category: Phan, A.]]		[[Category: Phan, A]]
	[[Category: Serganov, A.]]		[[Category: Serganov, A]]
	[[Category: Rna binding protein-rna complex]]		[[Category: Rna binding protein-rna complex]]

OCA at 12:11, 24 March 2013

2013-03-24T12:11:57Z

← Older revision		Revision as of 12:11, 24 March 2013
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	~~[[Image:2la5.png\|left\|200px]]~~

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2la5", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2la5\| PDB=2la5 \| SCENE= }}		{{STRUCTURE_2la5\| PDB=2la5 \| SCENE= }}

	===RNA Duplex-Quadruplex Junction Complex with FMRP RGG peptide===		===RNA Duplex-Quadruplex Junction Complex with FMRP RGG peptide===
			{{ABSTRACT_PUBMED_21642970}}

			==Disease==
			[[http://www.uniprot.org/uniprot/FMR1_HUMAN FMR1_HUMAN]] Defects in FMR1 are the cause of fragile X syndrome (FRAX) [MIM:[http://omim.org/entry/300624 300624]]. Fragile X syndrome is a common genetic disease (has a prevalence of one in every 2000 children) which is characterized by moderate to severe mental retardation, macroorchidism (enlargement of the testicles), large ears, prominent jaw, and high-pitched, jocular speech. The defect in most fragile X syndrome patients results from an amplification of a CGG repeat region which is directly in front of the coding region.<ref>PMID:18664458</ref><ref>PMID:8401578</ref><ref>PMID:7688265</ref><ref>PMID:17850748</ref><ref>PMID:8490650</ref><ref>PMID:7633450</ref><ref>PMID:9659908</ref><ref>PMID:15805463</ref> Defects in FMR1 are the cause of fragile X tremor/ataxia syndrome (FXTAS) [MIM:[http://omim.org/entry/300623 300623]]. In FXTAS, the expanded repeats range in size from 55 to 200 repeats and are referred to as 'premutations'. Full repeat expansions with greater than 200 repeats results in fragile X mental retardation syndrome [MIM:[http://omim.org/entry/300624 300624]]. Carriers of the premutation typically do not show the full fragile X syndrome phenotype, but comprise a subgroup that may have some physical features of fragile X syndrome or mild cognitive and emotional problems.<ref>PMID:11445641</ref> Defects in FMR1 are the cause of premature ovarian failure syndrome type 1 (POF1) [MIM:[http://omim.org/entry/311360 311360]]. An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.<ref>PMID:9719368</ref>

	~~<!--~~		==Function==
	~~The line below this paragraph, {{ABSTRACT_PUBMED_21642970}}, adds the Publication Abstract to the page~~		[[http://www.uniprot.org/uniprot/FMR1_HUMAN FMR1_HUMAN]] Translation repressor. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression (By similarity). RNA-binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C).
	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov), where 21642970 is~~ the ~~PubMed ID number~~.
	-->
	~~{{ABSTRACT_PUBMED_21642970}}~~

	==About this Structure==		==About this Structure==
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	==Reference==		==Reference==
	<ref group="xtra">PMID:021642970</ref><references group="xtra"/>		<ref group="xtra">PMID:021642970</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Darnell, J.]]		[[Category: Darnell, J.]]

OCA at 05:38, 20 July 2011

2011-07-20T05:38:58Z

← Older revision		Revision as of 05:38, 20 July 2011
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	[[Image:2la5.~~jpg~~\|left\|200px]]		[[Image:2la5.png\|left\|200px]]

	<!--		<!--
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	===RNA Duplex-Quadruplex Junction Complex with FMRP RGG peptide===		===RNA Duplex-Quadruplex Junction Complex with FMRP RGG peptide===


			<!--
			The line below this paragraph, {{ABSTRACT_PUBMED_21642970}}, adds the Publication Abstract to the page
			(as it appears on PubMed at http://www.pubmed.gov), where 21642970 is the PubMed ID number.
			-->
			{{ABSTRACT_PUBMED_21642970}}

	==About this Structure==		==About this Structure==
	[[2la5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA5 OCA].		[[2la5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA5 OCA].

			==Reference==
			<ref group="xtra">PMID:021642970</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Darnell, J.]]		[[Category: Darnell, J.]]
Line 23:		Line 32:
	[[Category: Phan, A.]]		[[Category: Phan, A.]]
	[[Category: Serganov, A.]]		[[Category: Serganov, A.]]
			[[Category: Rna binding protein-rna complex]]

OCA at 05:14, 8 June 2011

2011-06-08T05:14:24Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:2la5.jpg|left|200px]]
-The entry 2la5 is ON HOLD  until Paper Publication
+<!--
-Authors: Phan, A., Kuryavyi, V., Darnell, J., Serganov, A., Majumdar, A., Ilin, S., Darnell, R., Patel, D.
+===RNA Duplex-Quadruplex Junction Complex with FMRP RGG peptide===
-Description: RNA Duplex-Quadruplex Junction Complex with FMRP RGG peptide

OCA at 06:42, 27 April 2011

2011-04-27T06:42:23Z

← Older revision		Revision as of 06:42, 27 April 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 2la5 is ON HOLD		The entry 2la5 is ON HOLD until Paper Publication

	Authors: Phan, A., Kuryavyi, V., Darnell, J., Serganov, A., Majumdar, A., Ilin, S., Darnell, R., Patel, D.		Authors: Phan, A., Kuryavyi, V., Darnell, J., Serganov, A., Majumdar, A., Ilin, S., Darnell, R., Patel, D.

	Description: RNA Duplex-Quadruplex Junction Complex with FMRP RGG peptide		Description: RNA Duplex-Quadruplex Junction Complex with FMRP RGG peptide