2la9 - Revision history

OCA at 05:40, 15 May 2024

2024-05-15T05:40:44Z

← Older revision		Revision as of 05:40, 15 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2la9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LA9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2la9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LA9 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2la9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la9 OCA], [https://pdbe.org/2la9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2la9 RCSB], [https://www.ebi.ac.uk/pdbsum/2la9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2la9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2la9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la9 OCA], [https://pdbe.org/2la9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2la9 RCSB], [https://www.ebi.ac.uk/pdbsum/2la9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2la9 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:54, 14 June 2023

2023-06-14T08:54:17Z

← Older revision		Revision as of 08:54, 14 June 2023
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	==NMR structure of Pseudouridine_ASL_Tyr==		==NMR structure of Pseudouridine_ASL_Tyr==
	<StructureSection load='2la9' size='340' side='right'caption='[[2la9~~]], [[NMR_Ensembles_of_Models \| 8 NMR models~~]]' scene=''>		<StructureSection load='2la9' size='340' side='right'caption='[[2la9]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2la9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LA9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2la9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LA9 FirstGlance]. <br>
	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene~~></td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2lac\|2lac]], [[2lbq\|2lbq]], [[2lbr\|2lbr]]</div~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2la9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la9 OCA], [https://pdbe.org/2la9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2la9 RCSB], [https://www.ebi.ac.uk/pdbsum/2la9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2la9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2la9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la9 OCA], [https://pdbe.org/2la9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2la9 RCSB], [https://www.ebi.ac.uk/pdbsum/2la9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2la9 ProSAT]</span></td></tr>
	</table>		</table>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Denmon~~, A P~~]]		[[Category: Denmon AP]]
	[[Category: Nikonowicz~~, E P~~]]		[[Category: Nikonowicz EP]]
	[[Category: Wang, J]]		[[Category: Wang J]]
	~~[[Category: Rna]]~~
	~~[[Category: Tyrosyl-trna~~]]

OCA at 07:49, 9 February 2022

2022-02-09T07:49:57Z

← Older revision		Revision as of 07:49, 9 February 2022
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	<StructureSection load='2la9' size='340' side='right'caption='[[2la9]], [[NMR_Ensembles_of_Models \| 8 NMR models]]' scene=''>		<StructureSection load='2la9' size='340' side='right'caption='[[2la9]], [[NMR_Ensembles_of_Models \| 8 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2la9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2LA9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2la9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LA9 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lac\|2lac]], [[2lbq\|2lbq]], [[2lbr\|2lbr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2lac\|2lac]], [[2lbq\|2lbq]], [[2lbr\|2lbr]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2la9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la9 OCA], [~~http~~://pdbe.org/2la9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2la9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2la9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2la9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2la9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la9 OCA], [https://pdbe.org/2la9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2la9 RCSB], [https://www.ebi.ac.uk/pdbsum/2la9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2la9 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:01, 6 May 2020

2020-05-06T07:01:24Z

← Older revision		Revision as of 07:01, 6 May 2020
Line 1:		Line 1:

	==NMR structure of Pseudouridine_ASL_Tyr==		==NMR structure of Pseudouridine_ASL_Tyr==
	<StructureSection load='2la9' size='340' side='right' caption='[[2la9]], [[NMR_Ensembles_of_Models \| 8 NMR models]]' scene=''>		<StructureSection load='2la9' size='340' side='right'caption='[[2la9]], [[NMR_Ensembles_of_Models \| 8 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2la9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA9 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2LA9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2la9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2LA9 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lac\|2lac]], [[2lbq\|2lbq]], [[2lbr\|2lbr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lac\|2lac]], [[2lbq\|2lbq]], [[2lbr\|2lbr]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2la9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la9 OCA], [http://pdbe.org/2la9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2la9 RCSB], [http://www.ebi.ac.uk/pdbsum/2la9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2la9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2la9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la9 OCA], [http://pdbe.org/2la9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2la9 RCSB], [http://www.ebi.ac.uk/pdbsum/2la9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2la9 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Denmon, A P]]		[[Category: Denmon, A P]]
	[[Category: Nikonowicz, E P]]		[[Category: Nikonowicz, E P]]

OCA at 19:33, 1 August 2018

2018-08-01T19:33:43Z

← Older revision		Revision as of 19:33, 1 August 2018
Line 1:		Line 1:

	==NMR structure of Pseudouridine_ASL_Tyr==		==NMR structure of Pseudouridine_ASL_Tyr==
	<StructureSection load='2la9' size='340' side='right' caption='[[2la9]], [[NMR_Ensembles_of_Models \| 8 NMR models]]' scene=''>		<StructureSection load='2la9' size='340' side='right' caption='[[2la9]], [[NMR_Ensembles_of_Models \| 8 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lac\|2lac]], [[2lbq\|2lbq]], [[2lbr\|2lbr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lac\|2lac]], [[2lbq\|2lbq]], [[2lbr\|2lbr]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2la9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la9 OCA], [http://pdbe.org/2la9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2la9 RCSB], [http://www.ebi.ac.uk/pdbsum/2la9 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2la9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la9 OCA], [http://pdbe.org/2la9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2la9 RCSB], [http://www.ebi.ac.uk/pdbsum/2la9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2la9 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 04:46, 10 September 2015

2015-09-10T04:46:42Z

← Older revision		Revision as of 04:46, 10 September 2015
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	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lac\|2lac]], [[2lbq\|2lbq]], [[2lbr\|2lbr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lac\|2lac]], [[2lbq\|2lbq]], [[2lbr\|2lbr]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2la9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2la9 RCSB], [http://www.ebi.ac.uk/pdbsum/2la9 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2la9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la9 OCA], [http://pdbe.org/2la9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2la9 RCSB], [http://www.ebi.ac.uk/pdbsum/2la9 PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2la9" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:07, 22 December 2014

2014-12-22T06:07:19Z

← Older revision		Revision as of 06:07, 22 December 2014
Line 2:		Line 2:
	<StructureSection load='2la9' size='340' side='right' caption='[[2la9]], [[NMR_Ensembles_of_Models \| 8 NMR models]]' scene=''>		<StructureSection load='2la9' size='340' side='right' caption='[[2la9]], [[NMR_Ensembles_of_Models \| 8 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2la9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA9 OCA]. <br>		<table><tr><td colspan='2'>[[2la9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LA9 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lac\|2lac]], [[2lbq\|2lbq]], [[2lbr\|2lbr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lac\|2lac]], [[2lbq\|2lbq]], [[2lbr\|2lbr]]</td></tr>
	<tr~~><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class~~='~~plainlinks~~'~~>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2la9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2la9 RCSB], [http://www.ebi.ac.uk/pdbsum/2la9 PDBsum]</span></td></tr>
	~~<tr~~><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2la9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2la9 RCSB], [http://www.ebi.ac.uk/pdbsum/2la9 PDBsum]</span></td></tr>		</table>
	<table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 13:
	Conformation Effects of Base Modification on the Anticodon Stem-Loop of Bacillus subtilis tRNA(Tyr).,Denmon AP, Wang J, Nikonowicz EP J Mol Biol. 2011 Sep 16;412(2):285-303. Epub 2011 Jul 19. PMID:21782828<ref>PMID:21782828</ref>		Conformation Effects of Base Modification on the Anticodon Stem-Loop of Bacillus subtilis tRNA(Tyr).,Denmon AP, Wang J, Nikonowicz EP J Mol Biol. 2011 Sep 16;412(2):285-303. Epub 2011 Jul 19. PMID:21782828<ref>PMID:21782828</ref>

	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 20:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Denmon, A P.]]		[[Category: Denmon, A P]]
	[[Category: Nikonowicz, E P.]]		[[Category: Nikonowicz, E P]]
	[[Category: Wang, J.]]		[[Category: Wang, J]]
	[[Category: Rna]]		[[Category: Rna]]
	[[Category: Tyrosyl-trna]]		[[Category: Tyrosyl-trna]]

OCA at 09:54, 1 May 2014

2014-05-01T09:54:10Z

← Older revision		Revision as of 09:54, 1 May 2014
Line 2:		Line 2:
	<StructureSection load='2la9' size='340' side='right' caption='[[2la9]], [[NMR_Ensembles_of_Models \| 8 NMR models]]' scene=''>		<StructureSection load='2la9' size='340' side='right' caption='[[2la9]], [[NMR_Ensembles_of_Models \| 8 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	[[2la9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA9 OCA]. <br>		<table><tr><td colspan='2'>[[2la9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA9 OCA]. <br>
	<b>[[Non-Standard_Residue\|NonStd Res:]]</b> <scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene><br>		</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene></td></tr>
	<b>[[Related_structure\|Related:]]</b> [[2lac\|2lac]], [[2lbq\|2lbq]], [[2lbr\|2lbr]]<br>		<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lac\|2lac]], [[2lbq\|2lbq]], [[2lbr\|2lbr]]</td></tr>
	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>		<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
	<b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2la9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2la9 RCSB], [http://www.ebi.ac.uk/pdbsum/2la9 PDBsum]</span><br>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2la9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2la9 RCSB], [http://www.ebi.ac.uk/pdbsum/2la9 PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
	tRNA molecules contain 93 chemically unique nucleotide base modifications that expand the chemical and biophysical diversity of RNA and contribute to the overall fitness of the cell. Nucleotide modifications of tRNA confer fidelity and efficiency to translation and are important in tRNA-dependent RNA-mediated regulatory processes. The three-dimensional structure of the anticodon is crucial to tRNA-mRNA specificity, and the diverse modifications of nucleotide bases in the anticodon region modulate this specificity. We have determined the solution structures and thermodynamic properties of Bacillus subtilis tRNA(Tyr) anticodon arms containing the natural base modifications N(6)-dimethylallyl adenine (i(6)A(37)) and pseudouridine (psi(39)). UV melting and differential scanning calorimetry indicate that the modifications stabilize the stem and may enhance base stacking in the loop. The i(6)A(37) modification disrupts the hydrogen bond network of the unmodified anticodon loop including a C(32)-A(38)(+) base pair and an A(37)-U(33) base-base interaction. Although the i(6)A(37) modification increases the dynamic nature of the loop nucleotides, metal ion coordination reestablishes conformational homogeneity. Interestingly, the i(6)A(37) modification and Mg(2+) are sufficient to promote the U-turn fold of the anticodon loop of Escherichia coli tRNA(Phe), but these elements do not result in this signature feature of the anticodon loop in tRNA(Tyr).		tRNA molecules contain 93 chemically unique nucleotide base modifications that expand the chemical and biophysical diversity of RNA and contribute to the overall fitness of the cell. Nucleotide modifications of tRNA confer fidelity and efficiency to translation and are important in tRNA-dependent RNA-mediated regulatory processes. The three-dimensional structure of the anticodon is crucial to tRNA-mRNA specificity, and the diverse modifications of nucleotide bases in the anticodon region modulate this specificity. We have determined the solution structures and thermodynamic properties of Bacillus subtilis tRNA(Tyr) anticodon arms containing the natural base modifications N(6)-dimethylallyl adenine (i(6)A(37)) and pseudouridine (psi(39)). UV melting and differential scanning calorimetry indicate that the modifications stabilize the stem and may enhance base stacking in the loop. The i(6)A(37) modification disrupts the hydrogen bond network of the unmodified anticodon loop including a C(32)-A(38)(+) base pair and an A(37)-U(33) base-base interaction. Although the i(6)A(37) modification increases the dynamic nature of the loop nucleotides, metal ion coordination reestablishes conformational homogeneity. Interestingly, the i(6)A(37) modification and Mg(2+) are sufficient to promote the U-turn fold of the anticodon loop of Escherichia coli tRNA(Phe), but these elements do not result in this signature feature of the anticodon loop in tRNA(Tyr).
Line 13:		Line 15:

	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>		From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
			</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:18, 30 April 2014

2014-04-30T10:18:55Z

← Older revision		Revision as of 10:18, 30 April 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	[[2la9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA9 OCA]. <br>		[[2la9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA9 OCA]. <br>
	<b>Related:</b> [[2lac\|2lac]], [[2lbq\|2lbq]], [[2lbr\|2lbr]]<br>		<b>[[Non-Standard_Residue\|NonStd Res:]]</b> <scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene><br>
			<b>[[Related_structure\|Related:]]</b> [[2lac\|2lac]], [[2lbq\|2lbq]], [[2lbr\|2lbr]]<br>
	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>		<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
			<b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2la9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2la9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2la9 RCSB], [http://www.ebi.ac.uk/pdbsum/2la9 PDBsum]</span><br>
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
	tRNA molecules contain 93 chemically unique nucleotide base modifications that expand the chemical and biophysical diversity of RNA and contribute to the overall fitness of the cell. Nucleotide modifications of tRNA confer fidelity and efficiency to translation and are important in tRNA-dependent RNA-mediated regulatory processes. The three-dimensional structure of the anticodon is crucial to tRNA-mRNA specificity, and the diverse modifications of nucleotide bases in the anticodon region modulate this specificity. We have determined the solution structures and thermodynamic properties of Bacillus subtilis tRNA(Tyr) anticodon arms containing the natural base modifications N(6)-dimethylallyl adenine (i(6)A(37)) and pseudouridine (psi(39)). UV melting and differential scanning calorimetry indicate that the modifications stabilize the stem and may enhance base stacking in the loop. The i(6)A(37) modification disrupts the hydrogen bond network of the unmodified anticodon loop including a C(32)-A(38)(+) base pair and an A(37)-U(33) base-base interaction. Although the i(6)A(37) modification increases the dynamic nature of the loop nucleotides, metal ion coordination reestablishes conformational homogeneity. Interestingly, the i(6)A(37) modification and Mg(2+) are sufficient to promote the U-turn fold of the anticodon loop of Escherichia coli tRNA(Phe), but these elements do not result in this signature feature of the anticodon loop in tRNA(Tyr).		tRNA molecules contain 93 chemically unique nucleotide base modifications that expand the chemical and biophysical diversity of RNA and contribute to the overall fitness of the cell. Nucleotide modifications of tRNA confer fidelity and efficiency to translation and are important in tRNA-dependent RNA-mediated regulatory processes. The three-dimensional structure of the anticodon is crucial to tRNA-mRNA specificity, and the diverse modifications of nucleotide bases in the anticodon region modulate this specificity. We have determined the solution structures and thermodynamic properties of Bacillus subtilis tRNA(Tyr) anticodon arms containing the natural base modifications N(6)-dimethylallyl adenine (i(6)A(37)) and pseudouridine (psi(39)). UV melting and differential scanning calorimetry indicate that the modifications stabilize the stem and may enhance base stacking in the loop. The i(6)A(37) modification disrupts the hydrogen bond network of the unmodified anticodon loop including a C(32)-A(38)(+) base pair and an A(37)-U(33) base-base interaction. Although the i(6)A(37) modification increases the dynamic nature of the loop nucleotides, metal ion coordination reestablishes conformational homogeneity. Interestingly, the i(6)A(37) modification and Mg(2+) are sufficient to promote the U-turn fold of the anticodon loop of Escherichia coli tRNA(Phe), but these elements do not result in this signature feature of the anticodon loop in tRNA(Tyr).

OCA at 08:37, 30 April 2014

2014-04-30T08:37:09Z

← Older revision		Revision as of 08:37, 30 April 2014
Line 1:		Line 1:
	[[~~Image~~:~~2la9~~.~~png~~\|~~left~~\|~~200px~~]]		==NMR structure of Pseudouridine_ASL_Tyr==
			<StructureSection load='2la9' size='340' side='right' caption='[[2la9]], [[NMR_Ensembles_of_Models \| 8 NMR models]]' scene=''>
			== Structural highlights ==
			[[2la9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA9 OCA]. <br>
			<b>Related:</b> [[2lac\|2lac]], [[2lbq\|2lbq]], [[2lbr\|2lbr]]<br>
			<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
			== Publication Abstract from PubMed ==
			tRNA molecules contain 93 chemically unique nucleotide base modifications that expand the chemical and biophysical diversity of RNA and contribute to the overall fitness of the cell. Nucleotide modifications of tRNA confer fidelity and efficiency to translation and are important in tRNA-dependent RNA-mediated regulatory processes. The three-dimensional structure of the anticodon is crucial to tRNA-mRNA specificity, and the diverse modifications of nucleotide bases in the anticodon region modulate this specificity. We have determined the solution structures and thermodynamic properties of Bacillus subtilis tRNA(Tyr) anticodon arms containing the natural base modifications N(6)-dimethylallyl adenine (i(6)A(37)) and pseudouridine (psi(39)). UV melting and differential scanning calorimetry indicate that the modifications stabilize the stem and may enhance base stacking in the loop. The i(6)A(37) modification disrupts the hydrogen bond network of the unmodified anticodon loop including a C(32)-A(38)(+) base pair and an A(37)-U(33) base-base interaction. Although the i(6)A(37) modification increases the dynamic nature of the loop nucleotides, metal ion coordination reestablishes conformational homogeneity. Interestingly, the i(6)A(37) modification and Mg(2+) are sufficient to promote the U-turn fold of the anticodon loop of Escherichia coli tRNA(Phe), but these elements do not result in this signature feature of the anticodon loop in tRNA(Tyr).

	<!--		Conformation Effects of Base Modification on the Anticodon Stem-Loop of Bacillus subtilis tRNA(Tyr).,Denmon AP, Wang J, Nikonowicz EP J Mol Biol. 2011 Sep 16;412(2):285-303. Epub 2011 Jul 19. PMID:21782828<ref>PMID:21782828</ref>
	~~The line below this paragraph~~, ~~containing "STRUCTURE_2la9"~~, ~~creates the "Structure Box" on the page~~.
	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display~~.
	-->
	~~{{STRUCTURE_2la9\| PDB=2la9 \| SCENE= }}~~

	~~===NMR structure~~ of ~~Pseudouridine_ASL_Tyr===~~		From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
			== References ==
			<references/>
	~~<!--~~		__TOC__
	~~The line below this paragraph, {{ABSTRACT_PUBMED_21782828}}, adds the Publication Abstract to~~ the ~~page~~		</StructureSection>
	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21782828 is the PubMed ID number~~.
	-->
	~~{{ABSTRACT_PUBMED_21782828}}~~

	==~~About this Structure~~==
	~~[[2la9]] is a 1 chain structure. Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2LA9 OCA].~~

	~~==Reference==~~
	<~~ref group="xtra">PMID:021782828</ref><references group="xtra"~~/>
	[[Category: Denmon, A P.]]		[[Category: Denmon, A P.]]
	[[Category: Nikonowicz, E P.]]		[[Category: Nikonowicz, E P.]]