2led - Revision history

OCA at 05:42, 15 May 2024

2024-05-15T05:42:13Z

← Older revision		Revision as of 05:42, 15 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2led]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LED OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LED FirstGlance]. <br>		<table><tr><td colspan='2'>[[2led]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LED OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LED FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2led FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2led OCA], [https://pdbe.org/2led PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2led RCSB], [https://www.ebi.ac.uk/pdbsum/2led PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2led ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2led FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2led OCA], [https://pdbe.org/2led PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2led RCSB], [https://www.ebi.ac.uk/pdbsum/2led PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2led ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:57, 14 June 2023

2023-06-14T08:57:19Z

← Older revision		Revision as of 08:57, 14 June 2023
Line 1:		Line 1:

	==Unique structural features of interconverting monomeric and dimeric G-quadruplexes adopted by a sequence from intron of N-myc gene==		==Unique structural features of interconverting monomeric and dimeric G-quadruplexes adopted by a sequence from intron of N-myc gene==
	<StructureSection load='2led' size='340' side='right'caption='[[2led~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>		<StructureSection load='2led' size='340' side='right'caption='[[2led]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2led]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LED OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LED FirstGlance]. <br>		<table><tr><td colspan='2'>[[2led]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LED OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LED FirstGlance]. <br>
	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2lee\|2lee]]</div></td></tr>~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2led FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2led OCA], [https://pdbe.org/2led PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2led RCSB], [https://www.ebi.ac.uk/pdbsum/2led PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2led ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2led FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2led OCA], [https://pdbe.org/2led PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2led RCSB], [https://www.ebi.ac.uk/pdbsum/2led PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2led ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 21:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Plavec, J]]		[[Category: Plavec J]]
	[[Category: ~~Silva,~~ M ~~Webba da~~]]		[[Category: Trajkovski M]]
	[[Category: ~~Trajkovski,~~ M]]		[[Category: Webba da Silva M]]
	~~[[Category: Dna]]~~
	~~[[Category: G-quadruplex]]~~
	~~[[Category: Intron]]~~
	~~[[Category: Monomer-dimer equilibrium]]~~
	~~[[Category: N-myc~~]]

OCA at 07:51, 9 February 2022

2022-02-09T07:51:09Z

← Older revision		Revision as of 07:51, 9 February 2022
Line 3:		Line 3:
	<StructureSection load='2led' size='340' side='right'caption='[[2led]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2led' size='340' side='right'caption='[[2led]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2led]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LED OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2LED FirstGlance]. <br>		<table><tr><td colspan='2'>[[2led]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LED OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LED FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lee\|2lee]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2lee\|2lee]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2led FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2led OCA], [~~http~~://pdbe.org/2led PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2led RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2led PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2led ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2led FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2led OCA], [https://pdbe.org/2led PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2led RCSB], [https://www.ebi.ac.uk/pdbsum/2led PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2led ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:03, 6 May 2020

2020-05-06T07:03:17Z

← Older revision		Revision as of 07:03, 6 May 2020
Line 1:		Line 1:

	==Unique structural features of interconverting monomeric and dimeric G-quadruplexes adopted by a sequence from intron of N-myc gene==		==Unique structural features of interconverting monomeric and dimeric G-quadruplexes adopted by a sequence from intron of N-myc gene==
	<StructureSection load='2led' size='340' side='right' caption='[[2led]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2led' size='340' side='right'caption='[[2led]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2led]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LED OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2LED FirstGlance]. <br>		<table><tr><td colspan='2'>[[2led]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LED OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2LED FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lee\|2lee]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lee\|2lee]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2led FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2led OCA], [http://pdbe.org/2led PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2led RCSB], [http://www.ebi.ac.uk/pdbsum/2led PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2led ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2led FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2led OCA], [http://pdbe.org/2led PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2led RCSB], [http://www.ebi.ac.uk/pdbsum/2led PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2led ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Plavec, J]]		[[Category: Plavec, J]]
	[[Category: Silva, M Webba da]]		[[Category: Silva, M Webba da]]

OCA at 19:48, 1 August 2018

2018-08-01T19:48:08Z

← Older revision		Revision as of 19:48, 1 August 2018
Line 1:		Line 1:

	==Unique structural features of interconverting monomeric and dimeric G-quadruplexes adopted by a sequence from intron of N-myc gene==		==Unique structural features of interconverting monomeric and dimeric G-quadruplexes adopted by a sequence from intron of N-myc gene==
	<StructureSection load='2led' size='340' side='right' caption='[[2led]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2led' size='340' side='right' caption='[[2led]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2led]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LED OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LED FirstGlance]. <br>		<table><tr><td colspan='2'>[[2led]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LED OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LED FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lee\|2lee]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lee\|2lee]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2led FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2led OCA], [http://pdbe.org/2led PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2led RCSB], [http://www.ebi.ac.uk/pdbsum/2led PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2led FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2led OCA], [http://pdbe.org/2led PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2led RCSB], [http://www.ebi.ac.uk/pdbsum/2led PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2led ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:04, 11 September 2015

2015-09-11T10:04:24Z

← Older revision		Revision as of 10:04, 11 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2led]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LED OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LED FirstGlance]. <br>		<table><tr><td colspan='2'>[[2led]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LED OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LED FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lee\|2lee]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lee\|2lee]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2led FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2led OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2led RCSB], [http://www.ebi.ac.uk/pdbsum/2led PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2led FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2led OCA], [http://pdbe.org/2led PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2led RCSB], [http://www.ebi.ac.uk/pdbsum/2led PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2led" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:28, 22 December 2014

2014-12-22T06:28:07Z

← Older revision		Revision as of 06:28, 22 December 2014
Line 2:		Line 2:
	<StructureSection load='2led' size='340' side='right' caption='[[2led]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2led' size='340' side='right' caption='[[2led]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2led]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LED OCA]. <br>		<table><tr><td colspan='2'>[[2led]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LED OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LED FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lee\|2lee]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lee\|2lee]]</td></tr>
	<tr~~><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class~~='~~plainlinks~~'~~>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2led FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2led OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2led RCSB], [http://www.ebi.ac.uk/pdbsum/2led PDBsum]</span></td></tr>
	~~<tr~~><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2led FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2led OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2led RCSB], [http://www.ebi.ac.uk/pdbsum/2led PDBsum]</span></td></tr>		</table>
	<table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 13:		Line 12:
	Unique Structural Features of Interconverting Monomeric and Dimeric G-Quadruplexes Adopted by a Sequence from the Intron of the N-myc Gene.,Trajkovski M, Webba da Silva M, Plavec J J Am Chem Soc. 2012 Mar 7;134(9):4132-41. Epub 2012 Feb 22. PMID:22303871<ref>PMID:22303871</ref>		Unique Structural Features of Interconverting Monomeric and Dimeric G-Quadruplexes Adopted by a Sequence from the Intron of the N-myc Gene.,Trajkovski M, Webba da Silva M, Plavec J J Am Chem Soc. 2012 Mar 7;134(9):4132-41. Epub 2012 Feb 22. PMID:22303871<ref>PMID:22303871</ref>

	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 19:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Plavec, J.]]		[[Category: Plavec, J]]
	[[Category: Silva, M Webba da.]]		[[Category: Silva, M Webba da]]
	[[Category: Trajkovski, M.]]		[[Category: Trajkovski, M]]
	[[Category: Dna]]		[[Category: Dna]]
	[[Category: G-quadruplex]]		[[Category: G-quadruplex]]

OCA at 09:41, 1 May 2014

2014-05-01T09:41:52Z

← Older revision		Revision as of 09:41, 1 May 2014
Line 2:		Line 2:
	<StructureSection load='2led' size='340' side='right' caption='[[2led]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2led' size='340' side='right' caption='[[2led]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	[[2led]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LED OCA]. <br>		<table><tr><td colspan='2'>[[2led]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LED OCA]. <br>
	<b>[[Related_structure\|Related:]]</b> [[2lee\|2lee]]<br>		</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lee\|2lee]]</td></tr>
	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>		<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
	<b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2led FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2led OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2led RCSB], [http://www.ebi.ac.uk/pdbsum/2led PDBsum]</span><br>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2led FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2led OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2led RCSB], [http://www.ebi.ac.uk/pdbsum/2led PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
	A multidimensional heteronuclear NMR study has demonstrated that a guanine-rich DNA oligonucleotide originating from the N-myc gene folds into G-quadruplex structures in the presence of K(+), NH(4)(+), and Na(+) ions. A monomeric G-quadruplex formed in K(+) ion containing solution exhibits three G-quartets and flexible propeller-type loops. The 3D structure with three single nucleotide loops represents a missing element in structures of parallel G-quadruplexes. The structural features together with the high temperature stability are suggestive of the specific biological role of G-quadruplex formation within the intron of the N-myc gene. An increase in K(+) ion and oligonucleotide concentrations resulted in transformation of the monomeric G-quadruplex into a dimeric form. The dimeric G-quadruplex exhibits six stacked G-quartets, parallel strand orientations, and propeller-type loops. A link between the third and the fourth G-quartets consists of two adenine residues that are flipped out to facilitate consecutive stacking of six G-quartets.		A multidimensional heteronuclear NMR study has demonstrated that a guanine-rich DNA oligonucleotide originating from the N-myc gene folds into G-quadruplex structures in the presence of K(+), NH(4)(+), and Na(+) ions. A monomeric G-quadruplex formed in K(+) ion containing solution exhibits three G-quartets and flexible propeller-type loops. The 3D structure with three single nucleotide loops represents a missing element in structures of parallel G-quadruplexes. The structural features together with the high temperature stability are suggestive of the specific biological role of G-quadruplex formation within the intron of the N-myc gene. An increase in K(+) ion and oligonucleotide concentrations resulted in transformation of the monomeric G-quadruplex into a dimeric form. The dimeric G-quadruplex exhibits six stacked G-quartets, parallel strand orientations, and propeller-type loops. A link between the third and the fourth G-quartets consists of two adenine residues that are flipped out to facilitate consecutive stacking of six G-quartets.
Line 12:		Line 14:

	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>		From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
			</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:02, 30 April 2014

2014-04-30T10:02:39Z

← Older revision		Revision as of 10:02, 30 April 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	[[2led]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LED OCA]. <br>		[[2led]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LED OCA]. <br>
	<b>Related:</b> [[2lee\|2lee]]<br>		<b>[[Related_structure\|Related:]]</b> [[2lee\|2lee]]<br>
	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>		<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
			<b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2led FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2led OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2led RCSB], [http://www.ebi.ac.uk/pdbsum/2led PDBsum]</span><br>
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
	A multidimensional heteronuclear NMR study has demonstrated that a guanine-rich DNA oligonucleotide originating from the N-myc gene folds into G-quadruplex structures in the presence of K(+), NH(4)(+), and Na(+) ions. A monomeric G-quadruplex formed in K(+) ion containing solution exhibits three G-quartets and flexible propeller-type loops. The 3D structure with three single nucleotide loops represents a missing element in structures of parallel G-quadruplexes. The structural features together with the high temperature stability are suggestive of the specific biological role of G-quadruplex formation within the intron of the N-myc gene. An increase in K(+) ion and oligonucleotide concentrations resulted in transformation of the monomeric G-quadruplex into a dimeric form. The dimeric G-quadruplex exhibits six stacked G-quartets, parallel strand orientations, and propeller-type loops. A link between the third and the fourth G-quartets consists of two adenine residues that are flipped out to facilitate consecutive stacking of six G-quartets.		A multidimensional heteronuclear NMR study has demonstrated that a guanine-rich DNA oligonucleotide originating from the N-myc gene folds into G-quadruplex structures in the presence of K(+), NH(4)(+), and Na(+) ions. A monomeric G-quadruplex formed in K(+) ion containing solution exhibits three G-quartets and flexible propeller-type loops. The 3D structure with three single nucleotide loops represents a missing element in structures of parallel G-quadruplexes. The structural features together with the high temperature stability are suggestive of the specific biological role of G-quadruplex formation within the intron of the N-myc gene. An increase in K(+) ion and oligonucleotide concentrations resulted in transformation of the monomeric G-quadruplex into a dimeric form. The dimeric G-quadruplex exhibits six stacked G-quartets, parallel strand orientations, and propeller-type loops. A link between the third and the fourth G-quartets consists of two adenine residues that are flipped out to facilitate consecutive stacking of six G-quartets.

OCA at 08:25, 30 April 2014

2014-04-30T08:25:21Z

← Older revision		Revision as of 08:25, 30 April 2014
Line 1:		Line 1:
	[[~~Image~~:~~2led~~.~~jpg~~\|~~left\|200px~~]]		==Unique structural features of interconverting monomeric and dimeric G-quadruplexes adopted by a sequence from intron of N-myc gene==
			<StructureSection load='2led' size='340' side='right' caption='[[2led]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
			== Structural highlights ==
			[[2led]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LED OCA]. <br>
			<b>Related:</b> [[2lee\|2lee]]<br>
			<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
			== Publication Abstract from PubMed ==
			A multidimensional heteronuclear NMR study has demonstrated that a guanine-rich DNA oligonucleotide originating from the N-myc gene folds into G-quadruplex structures in the presence of K(+), NH(4)(+), and Na(+) ions. A monomeric G-quadruplex formed in K(+) ion containing solution exhibits three G-quartets and flexible propeller-type loops. The 3D structure with three single nucleotide loops represents a missing element in structures of parallel G-quadruplexes. The structural features together with the high temperature stability are suggestive of the specific biological role of G-quadruplex formation within the intron of the N-myc gene. An increase in K(+) ion and oligonucleotide concentrations resulted in transformation of the monomeric G-quadruplex into a dimeric form. The dimeric G-quadruplex exhibits six stacked G-quartets, parallel strand orientations, and propeller-type loops. A link between the third and the fourth G-quartets consists of two adenine residues that are flipped out to facilitate consecutive stacking of six G-quartets.

	<!--		Unique Structural Features of Interconverting Monomeric and Dimeric G-Quadruplexes Adopted by a Sequence from the Intron of the N-myc Gene.,Trajkovski M, Webba da Silva M, Plavec J J Am Chem Soc. 2012 Mar 7;134(9):4132-41. Epub 2012 Feb 22. PMID:22303871<ref>PMID:22303871</ref>
	~~The line below this paragraph~~, ~~containing "STRUCTURE_2led"~~, ~~creates the "Structure Box" on the page~~.
	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display~~.
	-->
	~~{{STRUCTURE_2led\| PDB=2led \| SCENE= }}~~

	~~===Unique structural features of interconverting monomeric and dimeric G-quadruplexes adopted by~~ a ~~sequence from intron~~ of ~~N-myc gene===~~		From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
			== References ==
			<references/>
	~~<!--~~		__TOC__
	~~The line below this paragraph, {{ABSTRACT_PUBMED_22303871}}, adds the Publication Abstract to~~ the ~~page~~		</StructureSection>
	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22303871 is the PubMed ID number~~.
	-->
	~~{{ABSTRACT_PUBMED_22303871}}~~

	==~~About this Structure~~==
	~~[[2led]] is a 2 chain structure. Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2LED OCA].~~

	~~==Reference==~~
	<~~ref group="xtra">PMID:022303871</ref><references group="xtra"~~/>
	[[Category: Plavec, J.]]		[[Category: Plavec, J.]]
	[[Category: Silva, M Webba da.]]		[[Category: Silva, M Webba da.]]