2m2d - Revision history

OCA at 08:18, 30 October 2024

2024-10-30T08:18:18Z

← Older revision		Revision as of 08:18, 30 October 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2m2d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M2D FirstGlance]. <br>		<table><tr><td colspan='2'>[[2m2d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M2D FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2d OCA], [https://pdbe.org/2m2d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m2d RCSB], [https://www.ebi.ac.uk/pdbsum/2m2d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m2d ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 35 models</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2d OCA], [https://pdbe.org/2m2d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m2d RCSB], [https://www.ebi.ac.uk/pdbsum/2m2d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m2d ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 13:25, 22 February 2023

2023-02-22T13:25:13Z

← Older revision		Revision as of 13:25, 22 February 2023
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	==Human programmed cell death 1 receptor==		==Human programmed cell death 1 receptor==
	<StructureSection load='2m2d' size='340' side='right'caption='[[2m2d~~]], [[NMR_Ensembles_of_Models \| 35 NMR models~~]]' scene=''>		<StructureSection load='2m2d' size='340' side='right'caption='[[2m2d]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2m2d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M2D FirstGlance]. <br>		<table><tr><td colspan='2'>[[2m2d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M2D FirstGlance]. <br>
	</td></tr>~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDCD1, PD1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2d OCA], [https://pdbe.org/2m2d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m2d RCSB], [https://www.ebi.ac.uk/pdbsum/2m2d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m2d ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2d OCA], [https://pdbe.org/2m2d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m2d RCSB], [https://www.ebi.ac.uk/pdbsum/2m2d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m2d ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[https://www.uniprot.org/uniprot/PDCD1_HUMAN PDCD1_HUMAN]] Systemic lupus erythematosus;Multiple sclerosis. Systemic lupus erythematosus 2 (SLEB2) [MIM:[https://omim.org/entry/605218 605218]]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.<ref>PMID:12402038</ref>		[https://www.uniprot.org/uniprot/PDCD1_HUMAN PDCD1_HUMAN] Systemic lupus erythematosus;Multiple sclerosis. Systemic lupus erythematosus 2 (SLEB2) [MIM:[https://omim.org/entry/605218 605218]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.<ref>PMID:12402038</ref>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/PDCD1_HUMAN PDCD1_HUMAN]] Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors.<ref>PMID:21276005</ref>		[https://www.uniprot.org/uniprot/PDCD1_HUMAN PDCD1_HUMAN] Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors.<ref>PMID:21276005</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Carr~~, M D~~]]		[[Category: Carr MD]]
	[[Category: Cheng, X]]		[[Category: Cheng X]]
	[[Category: Davis~~, S J~~]]		[[Category: Davis SJ]]
	[[Category: Griffin, R]]		[[Category: Griffin R]]
	[[Category: Griffiths, M]]		[[Category: Griffiths M]]
	[[Category: Henry~~, A J~~]]		[[Category: Henry AJ]]
	[[Category: Ikemizu, S]]		[[Category: Ikemizu S]]
	[[Category: Jansson, A]]		[[Category: Jansson A]]
	[[Category: Ladbury~~, J E~~]]		[[Category: Ladbury JE]]
	[[Category: Lesley, A]]		[[Category: Lesley A]]
	[[Category: Morgan, S]]		[[Category: Morgan S]]
	[[Category: Muskett~~, F W~~]]		[[Category: Muskett FW]]
	[[Category: Robinson~~, M K~~]]		[[Category: Robinson MK]]
	[[Category: Stubberfield, C]]		[[Category: Stubberfield C]]
	[[Category: Veverka, V]]		[[Category: Veverka V]]
	[[Category: Waters~~, L C]]~~		[[Category: Waters LC]]
	~~[[Category: Apoptosis]]~~
	~~[[Category: Pd-1~~]]

OCA at 10:58, 19 May 2021

2021-05-19T10:58:22Z

← Older revision		Revision as of 10:58, 19 May 2021
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	==Human programmed cell death 1 receptor==		==Human programmed cell death 1 receptor==
	<StructureSection load='2m2d' size='340' side='right' caption='[[2m2d]], [[NMR_Ensembles_of_Models \| 35 NMR models]]' scene=''>		<StructureSection load='2m2d' size='340' side='right'caption='[[2m2d]], [[NMR_Ensembles_of_Models \| 35 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2m2d]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2D OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2M2D FirstGlance]. <br>		<table><tr><td colspan='2'>[[2m2d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M2D FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDCD1, PD1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDCD1, PD1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2m2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2d OCA], [~~http~~://pdbe.org/2m2d PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2m2d RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2m2d PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2m2d ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2d OCA], [https://pdbe.org/2m2d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m2d RCSB], [https://www.ebi.ac.uk/pdbsum/2m2d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m2d ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[~~http~~://www.uniprot.org/uniprot/PDCD1_HUMAN PDCD1_HUMAN]] Systemic lupus erythematosus;Multiple sclerosis. Systemic lupus erythematosus 2 (SLEB2) [MIM:[~~http~~://omim.org/entry/605218 605218]]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.<ref>PMID:12402038</ref>		[[https://www.uniprot.org/uniprot/PDCD1_HUMAN PDCD1_HUMAN]] Systemic lupus erythematosus;Multiple sclerosis. Systemic lupus erythematosus 2 (SLEB2) [MIM:[https://omim.org/entry/605218 605218]]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.<ref>PMID:12402038</ref>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/PDCD1_HUMAN PDCD1_HUMAN]] Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors.<ref>PMID:21276005</ref>		[[https://www.uniprot.org/uniprot/PDCD1_HUMAN PDCD1_HUMAN]] Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors.<ref>PMID:21276005</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
	*[[Cell death protein\|Cell death protein]]		*[[Cell death protein 3D structures\|Cell death protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Carr, M D]]		[[Category: Carr, M D]]
	[[Category: Cheng, X]]		[[Category: Cheng, X]]

OCA at 23:11, 9 August 2018

2018-08-09T23:11:43Z

← Older revision		Revision as of 23:11, 9 August 2018
Line 1:		Line 1:

	==Human programmed cell death 1 receptor==		==Human programmed cell death 1 receptor==
	<StructureSection load='2m2d' size='340' side='right' caption='[[2m2d]], [[NMR_Ensembles_of_Models \| 35 NMR models]]' scene=''>		<StructureSection load='2m2d' size='340' side='right' caption='[[2m2d]], [[NMR_Ensembles_of_Models \| 35 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2m2d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M2D FirstGlance]. <br>		<table><tr><td colspan='2'>[[2m2d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M2D FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDCD1, PD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDCD1, PD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2d OCA], [http://pdbe.org/2m2d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m2d RCSB], [http://www.ebi.ac.uk/pdbsum/2m2d PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2d OCA], [http://pdbe.org/2m2d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m2d RCSB], [http://www.ebi.ac.uk/pdbsum/2m2d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2m2d ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 23:45, 10 September 2015

2015-09-10T23:45:05Z

← Older revision		Revision as of 23:45, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2m2d' size='340' side='right' caption='[[2m2d]], [[NMR_Ensembles_of_Models \| 35 NMR models]]' scene=''>		<StructureSection load='2m2d' size='340' side='right' caption='[[2m2d]], [[NMR_Ensembles_of_Models \| 35 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2m2d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M2D FirstGlance]. <br>		<table><tr><td colspan='2'>[[2m2d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M2D FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDCD1, PD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDCD1, PD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m2d RCSB], [http://www.ebi.ac.uk/pdbsum/2m2d PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2d OCA], [http://pdbe.org/2m2d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m2d RCSB], [http://www.ebi.ac.uk/pdbsum/2m2d PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 18:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2m2d" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Carr, M D]]		[[Category: Carr, M D]]
	[[Category: Cheng, X]]		[[Category: Cheng, X]]

OCA at 12:48, 18 December 2014

2014-12-18T12:48:22Z

← Older revision		Revision as of 12:48, 18 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_2m2d\| PDB~~=2m2d \| ~~SCENE~~= }}		==Human programmed cell death 1 receptor==
	===~~Human programmed cell death~~ 1 ~~receptor~~===		<StructureSection load='2m2d' size='340' side='right' caption='[[2m2d]], [[NMR_Ensembles_of_Models \| 35 NMR models]]' scene=''>
	~~{{ABSTRACT_PUBMED_23417675}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2m2d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M2D FirstGlance]. <br>
	==Disease==		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDCD1, PD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m2d RCSB], [http://www.ebi.ac.uk/pdbsum/2m2d PDBsum]</span></td></tr>
			</table>
			== Disease ==
	[[http://www.uniprot.org/uniprot/PDCD1_HUMAN PDCD1_HUMAN]] Systemic lupus erythematosus;Multiple sclerosis. Systemic lupus erythematosus 2 (SLEB2) [MIM:[http://omim.org/entry/605218 605218]]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.<ref>PMID:12402038</ref>		[[http://www.uniprot.org/uniprot/PDCD1_HUMAN PDCD1_HUMAN]] Systemic lupus erythematosus;Multiple sclerosis. Systemic lupus erythematosus 2 (SLEB2) [MIM:[http://omim.org/entry/605218 605218]]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.<ref>PMID:12402038</ref>
			== Function ==
			[[http://www.uniprot.org/uniprot/PDCD1_HUMAN PDCD1_HUMAN]] Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors.<ref>PMID:21276005</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			PD-1, a receptor expressed by T-cells, B-cells and monocytes, is a potent regulator of immune responses and a promising therapeutic target. The structure and interactions of human PD-1 are, however, incompletely characterized. We present the solution nuclear magnetic resonance (NMR)-based structure of the human PD-1 extracellular region and detailed analyses of its interactions with its ligands, PD-L1 and PD-L2. PD-1 has typical immunoglobulin superfamily topology, but differs at the edge of the GFCC' sheet which is flexible and completely lacks a C'' strand. Changes in PD-1 backbone NMR signals induced by ligand binding suggest that, whilst binding is centred on the GFCC' sheet, PD-1 is engaged by its two ligands differently and in ways incompletely explained by crystal structures of mouse PD-1/ligand complexes. The affinities of these interactions and that of PD-L1 with the costimulatory protein B7-1, measured using surface plasmon resonance, are significantly weaker than expected. The three- to four-fold greater affinity of PD-L2 versus PD-L1 for human PD-1 is principally due to the three-fold smaller dissociation rate for PD-L2 binding. Isothermal titration calorimetry revealed that the PD-1/PD-L1 interaction is entropically driven, whereas PD-1/PD-L2 binding has a large enthalpic component. Mathematical simulations based on the biophysical data and quantitative expression data suggest an unexpectedly limited contribution of PD-L2 to PD-1 ligation during interactions of activated T-cells with antigen presenting cells. These findings provide a rigorous structural and biophysical framework for interpreting the important functions of PD-1, and reveal that potent inhibitory signalling can be initiated by weakly interacting receptors.

	~~==Function==~~		Structure and interactions of the human programmed cell death 1 receptor.,Cheng X, Veverka V, Radhakrishnan A, Waters LC, Muskett FW, Morgan S, Huo J, Yu C, Evans EJ, Leslie AJ, Griffiths M, Stubberfield C, Griffin R, Henry AJ, Jansson A, Ladbury JE, Ikemizu S, Carr MD, Davis SJ J Biol Chem. 2013 Feb 15. PMID:23417675<ref>PMID:23417675</ref>
	~~[[http://www.uniprot.org/uniprot/PDCD1_HUMAN PDCD1_HUMAN]] Inhibitory~~ cell ~~surface~~ receptor ~~involved in the regulation of T-cell function during immunity and tolerance~~. ~~Upon ligand binding~~, ~~inhibits T-cell effector functions in an antigen-specific manner~~. ~~Possible cell death inducer, in association with other factors~~.<ref>PMID:~~21276005~~</ref>

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[2m2d]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full experimental information is available from [http:/~~/~~oca.weizmann.ac.il/oca-bin/ocashort?id=2M2D OCA].~~		</div>

	==~~Reference~~==		==See Also==
	<references ~~group="xtra"~~/><~~references~~/>		*[[Cell death protein\|Cell death protein]]
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Carr, M D.]]		[[Category: Carr, M D]]
	[[Category: Cheng, X.]]		[[Category: Cheng, X]]
	[[Category: Davis, S J.]]		[[Category: Davis, S J]]
	[[Category: Griffin, R.]]		[[Category: Griffin, R]]
	[[Category: Griffiths, M.]]		[[Category: Griffiths, M]]
	[[Category: Henry, A J.]]		[[Category: Henry, A J]]
	[[Category: Ikemizu, S.]]		[[Category: Ikemizu, S]]
	[[Category: Jansson, A.]]		[[Category: Jansson, A]]
	[[Category: Ladbury, J E.]]		[[Category: Ladbury, J E]]
	[[Category: Lesley, A.]]		[[Category: Lesley, A]]
	[[Category: Morgan, S.]]		[[Category: Morgan, S]]
	[[Category: Muskett, F W.]]		[[Category: Muskett, F W]]
	[[Category: Robinson, M K.]]		[[Category: Robinson, M K]]
	[[Category: Stubberfield, C.]]		[[Category: Stubberfield, C]]
	[[Category: Veverka, V.]]		[[Category: Veverka, V]]
	[[Category: Waters, L C.]]		[[Category: Waters, L C]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]
	[[Category: Pd-1]]		[[Category: Pd-1]]

OCA at 06:18, 16 May 2013

2013-05-16T06:18:50Z

← Older revision		Revision as of 06:18, 16 May 2013
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	~~[[Image:2m2d.png\|left\|200px]]~~

	{{STRUCTURE_2m2d\| PDB=2m2d \| SCENE= }}		{{STRUCTURE_2m2d\| PDB=2m2d \| SCENE= }}
			===Human programmed cell death 1 receptor===
			{{ABSTRACT_PUBMED_23417675}}

	==~~=Human programmed cell death 1 receptor~~===		==Disease==
			[[http://www.uniprot.org/uniprot/PDCD1_HUMAN PDCD1_HUMAN]] Systemic lupus erythematosus;Multiple sclerosis. Systemic lupus erythematosus 2 (SLEB2) [MIM:[http://omim.org/entry/605218 605218]]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.<ref>PMID:12402038</ref>

	~~{{ABSTRACT_PUBMED_23417675}}~~		==Function==
			[[http://www.uniprot.org/uniprot/PDCD1_HUMAN PDCD1_HUMAN]] Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors.<ref>PMID:21276005</ref>

	==About this Structure==		==About this Structure==
	[[2m2d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2D OCA].		[[2m2d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2D OCA].

			==Reference==
			<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Carr, M D.]]		[[Category: Carr, M D.]]

OCA at 13:10, 6 March 2013

2013-03-06T13:10:29Z

← Older revision		Revision as of 13:10, 6 March 2013
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	[[Image:2m2d.~~jpg~~\|left\|200px]]		[[Image:2m2d.png\|left\|200px]]

	{{STRUCTURE_2m2d\| PDB=2m2d \| SCENE= }}		{{STRUCTURE_2m2d\| PDB=2m2d \| SCENE= }}
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	===Human programmed cell death 1 receptor===		===Human programmed cell death 1 receptor===

			{{ABSTRACT_PUBMED_23417675}}

	==About this Structure==		==About this Structure==

OCA at 14:49, 27 February 2013

2013-02-27T14:49:52Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:2m2d.jpg|left|200px]]
-The entry 2m2d is ON HOLD  until Paper Publication
+{{STRUCTURE_2m2d|  PDB=2m2d  |  SCENE=  }}
-Authors: Veverka, V., Cheng, X., Waters, L.C., Muskett, F.W., Morgan, S., Lesley, A., Griffiths, M., Stubberfield, C., Griffin, R., Henry, A.J., Robinson, M.K., Jansson, A., Ladbury, J.E., Ikemizu, S., Davis, S.J., Carr, M.D.
+===Human programmed cell death 1 receptor===
-Description: Human programmed cell death 1 receptor

OCA at 11:43, 30 January 2013

2013-01-30T11:43:41Z

← Older revision		Revision as of 11:43, 30 January 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 2m2d is ON HOLD		The entry 2m2d is ON HOLD until Paper Publication

	Authors: Veverka, V., Cheng, X., Waters, L.C., Muskett, F.W., Morgan, S., Lesley, A., Griffiths, M., Stubberfield, C., Griffin, R., Henry, A.J., Robinson, M.K., Jansson, A., Ladbury, J.E., Ikemizu, S., Davis, S.J., Carr, M.D.		Authors: Veverka, V., Cheng, X., Waters, L.C., Muskett, F.W., Morgan, S., Lesley, A., Griffiths, M., Stubberfield, C., Griffin, R., Henry, A.J., Robinson, M.K., Jansson, A., Ladbury, J.E., Ikemizu, S., Davis, S.J., Carr, M.D.

	Description: Human programmed cell death 1 receptor		Description: Human programmed cell death 1 receptor