2m2e - Revision history

OCA at 05:58, 15 May 2024

2024-05-15T05:58:15Z

← Older revision		Revision as of 05:58, 15 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2m2e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M2E FirstGlance]. <br>		<table><tr><td colspan='2'>[[2m2e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M2E FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2e OCA], [https://pdbe.org/2m2e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m2e RCSB], [https://www.ebi.ac.uk/pdbsum/2m2e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m2e ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2e OCA], [https://pdbe.org/2m2e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m2e RCSB], [https://www.ebi.ac.uk/pdbsum/2m2e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m2e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 13:25, 22 February 2023

2023-02-22T13:25:16Z

← Older revision		Revision as of 13:25, 22 February 2023
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	==Solution NMR structure of the SANT domain of human DNAJC2, Northeast structural genomics consortium target HR8254a==		==Solution NMR structure of the SANT domain of human DNAJC2, Northeast structural genomics consortium target HR8254a==
	<StructureSection load='2m2e' size='340' side='right'caption='[[2m2e~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='2m2e' size='340' side='right'caption='[[2m2e]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2m2e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M2E FirstGlance]. <br>		<table><tr><td colspan='2'>[[2m2e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M2E FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DNAJC2, MPHOSPH11, MPP11, ZRF1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2e OCA], [https://pdbe.org/2m2e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m2e RCSB], [https://www.ebi.ac.uk/pdbsum/2m2e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m2e ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2e OCA], [https://pdbe.org/2m2e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m2e RCSB], [https://www.ebi.ac.uk/pdbsum/2m2e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m2e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/DNJC2_HUMAN DNJC2_HUMAN]] Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'.<ref>PMID:16002468</ref> <ref>PMID:15802566</ref> <ref>PMID:21179169</ref>		[https://www.uniprot.org/uniprot/DNJC2_HUMAN DNJC2_HUMAN] Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'.<ref>PMID:16002468</ref> <ref>PMID:15802566</ref> <ref>PMID:21179169</ref>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Arrowsmith, C]]		[[Category: Arrowsmith C]]
	[[Category: Garcia, M]]		[[Category: Garcia M]]
	[[Category: Houliston, S]]		[[Category: Houliston S]]
	[[Category: Lemak, A]]		[[Category: Lemak A]]
	[[Category: Montelione~~, G T]]~~		[[Category: Montelione GT]]
	~~[[Category: Structural genomic~~]]		[[Category: Ong M]]
	[[Category: Ong, M]]		[[Category: Yee A]]
	[[Category: Yee, A]]
	~~[[Category: Dna-binding]]~~
	~~[[Category: Nesg]]~~
	~~[[Category: Psi-biology]]~~
	~~[[Category: Sgc]]~~
	~~[[Category: Transcription regulator~~]]

OCA at 10:58, 19 May 2021

2021-05-19T10:58:24Z

← Older revision		Revision as of 10:58, 19 May 2021
Line 1:		Line 1:

	==Solution NMR structure of the SANT domain of human DNAJC2, Northeast structural genomics consortium target HR8254a==		==Solution NMR structure of the SANT domain of human DNAJC2, Northeast structural genomics consortium target HR8254a==
	<StructureSection load='2m2e' size='340' side='right' caption='[[2m2e]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2m2e' size='340' side='right'caption='[[2m2e]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2m2e]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2E OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2M2E FirstGlance]. <br>		<table><tr><td colspan='2'>[[2m2e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M2E FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DNAJC2, MPHOSPH11, MPP11, ZRF1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DNAJC2, MPHOSPH11, MPP11, ZRF1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2m2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2e OCA], [~~http~~://pdbe.org/2m2e PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2m2e RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2m2e PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2m2e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2e OCA], [https://pdbe.org/2m2e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m2e RCSB], [https://www.ebi.ac.uk/pdbsum/2m2e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m2e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/DNJC2_HUMAN DNJC2_HUMAN]] Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'.<ref>PMID:16002468</ref> <ref>PMID:15802566</ref> <ref>PMID:21179169</ref>		[[https://www.uniprot.org/uniprot/DNJC2_HUMAN DNJC2_HUMAN]] Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'.<ref>PMID:16002468</ref> <ref>PMID:15802566</ref> <ref>PMID:21179169</ref>

			==See Also==
			*[[DnaJ homolog 3D structures\|DnaJ homolog 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 14:		Line 17:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Arrowsmith, C]]		[[Category: Arrowsmith, C]]
	[[Category: Garcia, M]]		[[Category: Garcia, M]]

OCA at 22:53, 9 August 2018

2018-08-09T22:53:57Z

← Older revision		Revision as of 22:53, 9 August 2018
Line 1:		Line 1:

	==Solution NMR structure of the SANT domain of human DNAJC2, Northeast structural genomics consortium target HR8254a==		==Solution NMR structure of the SANT domain of human DNAJC2, Northeast structural genomics consortium target HR8254a==
	<StructureSection load='2m2e' size='340' side='right' caption='[[2m2e]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2m2e' size='340' side='right' caption='[[2m2e]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2m2e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M2E FirstGlance]. <br>		<table><tr><td colspan='2'>[[2m2e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M2E FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DNAJC2, MPHOSPH11, MPP11, ZRF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DNAJC2, MPHOSPH11, MPP11, ZRF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2e OCA], [http://pdbe.org/2m2e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m2e RCSB], [http://www.ebi.ac.uk/pdbsum/2m2e PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2e OCA], [http://pdbe.org/2m2e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m2e RCSB], [http://www.ebi.ac.uk/pdbsum/2m2e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2m2e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 22:12, 11 September 2015

2015-09-11T22:12:20Z

← Older revision		Revision as of 22:12, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2m2e' size='340' side='right' caption='[[2m2e]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2m2e' size='340' side='right' caption='[[2m2e]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2m2e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M2E FirstGlance]. <br>		<table><tr><td colspan='2'>[[2m2e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M2E FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DNAJC2, MPHOSPH11, MPP11, ZRF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DNAJC2, MPHOSPH11, MPP11, ZRF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m2e RCSB], [http://www.ebi.ac.uk/pdbsum/2m2e PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2e OCA], [http://pdbe.org/2m2e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m2e RCSB], [http://www.ebi.ac.uk/pdbsum/2m2e PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Arrowsmith, C]]		[[Category: Arrowsmith, C]]
	[[Category: Garcia, M]]		[[Category: Garcia, M]]

OCA at 20:12, 25 December 2014

2014-12-25T20:12:37Z

← Older revision		Revision as of 20:12, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m2e RCSB], [http://www.ebi.ac.uk/pdbsum/2m2e PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m2e RCSB], [http://www.ebi.ac.uk/pdbsum/2m2e PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/DNJC2_HUMAN DNJC2_HUMAN]] Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'.<ref>PMID:16002468</ref> <ref>PMID:15802566</ref> <ref>PMID:21179169</ref>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 12:14, 18 December 2014

2014-12-18T12:14:44Z

← Older revision		Revision as of 12:14, 18 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_2m2e\| PDB=2m2e \| SCENE= }}~~		==Solution NMR structure of the SANT domain of human DNAJC2, Northeast structural genomics consortium target HR8254a==
	===Solution NMR structure of the SANT domain of human DNAJC2, Northeast structural genomics consortium target HR8254a===		<StructureSection load='2m2e' size='340' side='right' caption='[[2m2e]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
			== Structural highlights ==
	==~~Function~~==		<table><tr><td colspan='2'>[[2m2e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M2E FirstGlance]. <br>
	[[~~http://www.uniprot.org/uniprot/DNJC2_HUMAN DNJC2_HUMAN~~]] ~~Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic~~, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at '~~Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5~~'~~-GTCAAGC-3~~'~~.<ref~~>~~PMID:16002468~~<~~/ref~~> <~~ref~~>~~PMID:15802566~~<~~/ref> <ref>PMID:21179169</ref~~>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DNAJC2, MPHOSPH11, MPP11, ZRF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m2e RCSB], [http://www.ebi.ac.uk/pdbsum/2m2e PDBsum]</span></td></tr>
	~~==About this Structure==~~		</table>
	[[2m2e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2E OCA].		__TOC__
			</StructureSection>
	==~~Reference~~==
	<~~references group~~="~~xtra~~"/><~~references~~/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith, C.]]		[[Category: Arrowsmith, C]]
	[[Category: Garcia, M.]]		[[Category: Garcia, M]]
	[[Category: Houliston, S.]]		[[Category: Houliston, S]]
	[[Category: Lemak, A.]]		[[Category: Lemak, A]]
	[[Category: Montelione, G T.]]		[[Category: Montelione, G T]]
	[[Category: ~~NESG, Northeast~~ Structural ~~Genomics Consortium.~~]]		[[Category: Structural genomic]]
	[[Category: Ong, M~~.]]~~		[[Category: Ong, M]]
	~~[[Category: SGC, Structural Genomics Consortium.~~]]		[[Category: Yee, A]]
	[[Category: Yee, A.]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]
	[[Category: Nesg]]		[[Category: Nesg]]
	~~[[Category: Northeast structural genomics consortium]]~~
	[[Category: Psi-biology]]		[[Category: Psi-biology]]
	[[Category: Sgc]]		[[Category: Sgc]]
	~~[[Category: Structural genomics consortium]]~~
	[[Category: Transcription regulator]]		[[Category: Transcription regulator]]

OCA at 08:08, 30 October 2013

2013-10-30T08:08:53Z

← Older revision		Revision as of 08:08, 30 October 2013
Line 1:		Line 1:
	~~[[Image:2m2e.jpg\|left\|200px]]~~

	{{STRUCTURE_2m2e\| PDB=2m2e \| SCENE= }}		{{STRUCTURE_2m2e\| PDB=2m2e \| SCENE= }}

	===Solution NMR structure of the SANT domain of human DNAJC2, Northeast structural genomics consortium target HR8254a===		===Solution NMR structure of the SANT domain of human DNAJC2, Northeast structural genomics consortium target HR8254a===

			==Function==
			[[http://www.uniprot.org/uniprot/DNJC2_HUMAN DNJC2_HUMAN]] Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'.<ref>PMID:16002468</ref> <ref>PMID:15802566</ref> <ref>PMID:21179169</ref>

	==About this Structure==		==About this Structure==
	[[2m2e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2E OCA].		[[2m2e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2E OCA].

			==Reference==
			<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith, C.]]		[[Category: Arrowsmith, C.]]

OCA at 13:55, 20 February 2013

2013-02-20T13:55:09Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+[[Image:2m2e.jpg|left|200px]]
-The entry 2m2e is ON HOLD  until Feb 20 2014
+{{STRUCTURE_2m2e|  PDB=2m2e  |  SCENE=  }}
-Authors: Lemak, A., Yee, A., Houliston, S., Garcia, M., Ong, M., Montelione, G.T., Arrowsmith, C., Northeast Structural Genomics Consortium (NESG), Structural Genomics Consortium (SGC)
+===Solution NMR structure of the SANT domain of human DNAJC2, Northeast structural genomics consortium target HR8254a===
-Description: Solution NMR structure of the SANT domain of human DNAJC2, Northeast structural genomics consortium target HR8254a (CASD-NMR Target)

OCA at 09:47, 13 February 2013

2013-02-13T09:47:58Z

← Older revision		Revision as of 09:47, 13 February 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 2m2e is ON HOLD until Feb 12 2014		The entry 2m2e is ON HOLD until Feb 20 2014

	Authors: Lemak, A., Yee, A., Houliston, S., Garcia, M., Ong, M., Montelione, G.T., Arrowsmith, C., Northeast Structural Genomics Consortium (NESG), Structural Genomics Consortium (SGC)		Authors: Lemak, A., Yee, A., Houliston, S., Garcia, M., Ong, M., Montelione, G.T., Arrowsmith, C., Northeast Structural Genomics Consortium (NESG), Structural Genomics Consortium (SGC)

	Description: Solution NMR structure of the SANT domain of human DNAJC2, Northeast structural genomics consortium target HR8254a (CASD-NMR Target)		Description: Solution NMR structure of the SANT domain of human DNAJC2, Northeast structural genomics consortium target HR8254a (CASD-NMR Target)