2m2f - Revision history

OCA at 09:18, 6 November 2024

2024-11-06T09:18:02Z

← Older revision		Revision as of 09:18, 6 November 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2m2f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M2F FirstGlance]. <br>		<table><tr><td colspan='2'>[[2m2f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M2F FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2f OCA], [https://pdbe.org/2m2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m2f RCSB], [https://www.ebi.ac.uk/pdbsum/2m2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m2f ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2f OCA], [https://pdbe.org/2m2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m2f RCSB], [https://www.ebi.ac.uk/pdbsum/2m2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m2f ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 13:25, 22 February 2023

2023-02-22T13:25:36Z

← Older revision		Revision as of 13:25, 22 February 2023
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	==The membran-proximal domain of ADAM17==		==The membran-proximal domain of ADAM17==
	<StructureSection load='2m2f' size='340' side='right'caption='[[2m2f~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='2m2f' size='340' side='right'caption='[[2m2f]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2m2f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M2F FirstGlance]. <br>		<table><tr><td colspan='2'>[[2m2f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M2F FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADAM17, CSVP, TACE ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2f OCA], [https://pdbe.org/2m2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m2f RCSB], [https://www.ebi.ac.uk/pdbsum/2m2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m2f ProSAT]</span></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/ADAM_17_endopeptidase ADAM 17 endopeptidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.86 3.4.24.86] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2f OCA], [https://pdbe.org/2m2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m2f RCSB], [https://www.ebi.ac.uk/pdbsum/2m2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m2f ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[https://www.uniprot.org/uniprot/ADA17_HUMAN ADA17_HUMAN]] Defects in ADAM17 are a cause of neonatal inflammatory skin and bowel disease (NISBD) [MIM:[https://omim.org/entry/614328 614328]]. NISBD is a disorder characterized by inflammatory features with neonatal onset, involving the skin, hair, and gut. The skin lesions involve perioral and perianal erythema, psoriasiform erythroderma, with flares of erythema, scaling, and widespread pustules. Gastrointestinal symptoms include malabsorptive diarrhea that is exacerbated by intercurrent gastrointestinal infections. The hair is short or broken, and the eyelashes and eyebrows are wiry and disorganized.<ref>PMID:22010916</ref>		[https://www.uniprot.org/uniprot/ADA17_HUMAN ADA17_HUMAN] Defects in ADAM17 are a cause of neonatal inflammatory skin and bowel disease (NISBD) [MIM:[https://omim.org/entry/614328 614328]. NISBD is a disorder characterized by inflammatory features with neonatal onset, involving the skin, hair, and gut. The skin lesions involve perioral and perianal erythema, psoriasiform erythroderma, with flares of erythema, scaling, and widespread pustules. Gastrointestinal symptoms include malabsorptive diarrhea that is exacerbated by intercurrent gastrointestinal infections. The hair is short or broken, and the eyelashes and eyebrows are wiry and disorganized.<ref>PMID:22010916</ref>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/ADA17_HUMAN ADA17_HUMAN]] Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway (By similarity).<ref>PMID:12441351</ref> <ref>PMID:20592283</ref>		[https://www.uniprot.org/uniprot/ADA17_HUMAN ADA17_HUMAN] Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway (By similarity).<ref>PMID:12441351</ref> <ref>PMID:20592283</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~ADAM 17 endopeptidase]]~~		[[Category: Homo sapiens]]
	~~[[Category: Human~~]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Duesterhoeft, S]]		[[Category: Duesterhoeft S]]
	[[Category: Groetzinger, J]]		[[Category: Groetzinger J]]
	[[Category: Hung, C]]		[[Category: Hung C]]
	[[Category: Jung, S]]		[[Category: Jung S]]
	[[Category: Lorenzen, I]]		[[Category: Lorenzen I]]
	[[Category: Soennichsen~~, F D~~]]		[[Category: Soennichsen FD]]
	[[Category: Tholey, A]]		[[Category: Tholey A]]
	~~[[Category: Adam17]]~~
	~~[[Category: Closed conformer]]~~
	~~[[Category: Hydrolase regulator]]~~
	~~[[Category: Membrane-proximal domain~~]]

OCA at 10:58, 19 May 2021

2021-05-19T10:58:24Z

← Older revision		Revision as of 10:58, 19 May 2021
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	==The membran-proximal domain of ADAM17==		==The membran-proximal domain of ADAM17==
	<StructureSection load='2m2f' size='340' side='right' caption='[[2m2f]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2m2f' size='340' side='right'caption='[[2m2f]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2m2f]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2F OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2M2F FirstGlance]. <br>		<table><tr><td colspan='2'>[[2m2f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M2F FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADAM17, CSVP, TACE ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADAM17, CSVP, TACE ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/ADAM_17_endopeptidase ADAM 17 endopeptidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.86 3.4.24.86] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/ADAM_17_endopeptidase ADAM 17 endopeptidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.86 3.4.24.86] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2m2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2f OCA], [~~http~~://pdbe.org/2m2f PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2m2f RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2m2f PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2m2f ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2f OCA], [https://pdbe.org/2m2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m2f RCSB], [https://www.ebi.ac.uk/pdbsum/2m2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m2f ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[~~http~~://www.uniprot.org/uniprot/ADA17_HUMAN ADA17_HUMAN]] Defects in ADAM17 are a cause of neonatal inflammatory skin and bowel disease (NISBD) [MIM:[~~http~~://omim.org/entry/614328 614328]]. NISBD is a disorder characterized by inflammatory features with neonatal onset, involving the skin, hair, and gut. The skin lesions involve perioral and perianal erythema, psoriasiform erythroderma, with flares of erythema, scaling, and widespread pustules. Gastrointestinal symptoms include malabsorptive diarrhea that is exacerbated by intercurrent gastrointestinal infections. The hair is short or broken, and the eyelashes and eyebrows are wiry and disorganized.<ref>PMID:22010916</ref>		[[https://www.uniprot.org/uniprot/ADA17_HUMAN ADA17_HUMAN]] Defects in ADAM17 are a cause of neonatal inflammatory skin and bowel disease (NISBD) [MIM:[https://omim.org/entry/614328 614328]]. NISBD is a disorder characterized by inflammatory features with neonatal onset, involving the skin, hair, and gut. The skin lesions involve perioral and perianal erythema, psoriasiform erythroderma, with flares of erythema, scaling, and widespread pustules. Gastrointestinal symptoms include malabsorptive diarrhea that is exacerbated by intercurrent gastrointestinal infections. The hair is short or broken, and the eyelashes and eyebrows are wiry and disorganized.<ref>PMID:22010916</ref>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/ADA17_HUMAN ADA17_HUMAN]] Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway (By similarity).<ref>PMID:12441351</ref> <ref>PMID:20592283</ref>		[[https://www.uniprot.org/uniprot/ADA17_HUMAN ADA17_HUMAN]] Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway (By similarity).<ref>PMID:12441351</ref> <ref>PMID:20592283</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
	*[[A Disintegrin And Metalloproteinase\|A Disintegrin And Metalloproteinase]]		*[[A Disintegrin And Metalloproteinase 3D structures\|A Disintegrin And Metalloproteinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: ADAM 17 endopeptidase]]		[[Category: ADAM 17 endopeptidase]]
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Duesterhoeft, S]]		[[Category: Duesterhoeft, S]]
	[[Category: Groetzinger, J]]		[[Category: Groetzinger, J]]

OCA at 23:02, 9 August 2018

2018-08-09T23:02:09Z

← Older revision		Revision as of 23:02, 9 August 2018
Line 1:		Line 1:

	==The membran-proximal domain of ADAM17==		==The membran-proximal domain of ADAM17==
	<StructureSection load='2m2f' size='340' side='right' caption='[[2m2f]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2m2f' size='340' side='right' caption='[[2m2f]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
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	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADAM17, CSVP, TACE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADAM17, CSVP, TACE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ADAM_17_endopeptidase ADAM 17 endopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.86 3.4.24.86] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ADAM_17_endopeptidase ADAM 17 endopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.86 3.4.24.86] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2f OCA], [http://pdbe.org/2m2f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m2f RCSB], [http://www.ebi.ac.uk/pdbsum/2m2f PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2f OCA], [http://pdbe.org/2m2f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m2f RCSB], [http://www.ebi.ac.uk/pdbsum/2m2f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2m2f ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 12:51, 10 September 2015

2015-09-10T12:51:56Z

← Older revision		Revision as of 12:51, 10 September 2015
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	<StructureSection load='2m2f' size='340' side='right' caption='[[2m2f]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2m2f' size='340' side='right' caption='[[2m2f]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2m2f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M2F FirstGlance]. <br>		<table><tr><td colspan='2'>[[2m2f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M2F FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADAM17, CSVP, TACE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADAM17, CSVP, TACE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ADAM_17_endopeptidase ADAM 17 endopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.86 3.4.24.86] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ADAM_17_endopeptidase ADAM 17 endopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.86 3.4.24.86] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m2f RCSB], [http://www.ebi.ac.uk/pdbsum/2m2f PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2f OCA], [http://pdbe.org/2m2f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m2f RCSB], [http://www.ebi.ac.uk/pdbsum/2m2f PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2m2f" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 27:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: ADAM 17 endopeptidase]]		[[Category: ADAM 17 endopeptidase]]
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Duesterhoeft, S]]		[[Category: Duesterhoeft, S]]
	[[Category: Groetzinger, J]]		[[Category: Groetzinger, J]]

OCA at 06:36, 22 December 2014

2014-12-22T06:36:21Z

← Older revision		Revision as of 06:36, 22 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_2m2f\| PDB~~=2m2f \| ~~SCENE~~= }}		==The membran-proximal domain of ADAM17==
	===~~The membran~~-~~proximal domain of~~ ADAM17===		<StructureSection load='2m2f' size='340' side='right' caption='[[2m2f]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	~~{{ABSTRACT_PUBMED_23521534}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2m2f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M2F FirstGlance]. <br>
	==Disease==		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADAM17, CSVP, TACE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ADAM_17_endopeptidase ADAM 17 endopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.86 3.4.24.86] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m2f RCSB], [http://www.ebi.ac.uk/pdbsum/2m2f PDBsum]</span></td></tr>
			</table>
			== Disease ==
	[[http://www.uniprot.org/uniprot/ADA17_HUMAN ADA17_HUMAN]] Defects in ADAM17 are a cause of neonatal inflammatory skin and bowel disease (NISBD) [MIM:[http://omim.org/entry/614328 614328]]. NISBD is a disorder characterized by inflammatory features with neonatal onset, involving the skin, hair, and gut. The skin lesions involve perioral and perianal erythema, psoriasiform erythroderma, with flares of erythema, scaling, and widespread pustules. Gastrointestinal symptoms include malabsorptive diarrhea that is exacerbated by intercurrent gastrointestinal infections. The hair is short or broken, and the eyelashes and eyebrows are wiry and disorganized.<ref>PMID:22010916</ref>		[[http://www.uniprot.org/uniprot/ADA17_HUMAN ADA17_HUMAN]] Defects in ADAM17 are a cause of neonatal inflammatory skin and bowel disease (NISBD) [MIM:[http://omim.org/entry/614328 614328]]. NISBD is a disorder characterized by inflammatory features with neonatal onset, involving the skin, hair, and gut. The skin lesions involve perioral and perianal erythema, psoriasiform erythroderma, with flares of erythema, scaling, and widespread pustules. Gastrointestinal symptoms include malabsorptive diarrhea that is exacerbated by intercurrent gastrointestinal infections. The hair is short or broken, and the eyelashes and eyebrows are wiry and disorganized.<ref>PMID:22010916</ref>
			== Function ==
			[[http://www.uniprot.org/uniprot/ADA17_HUMAN ADA17_HUMAN]] Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway (By similarity).<ref>PMID:12441351</ref> <ref>PMID:20592283</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			A disintegrin and metalloprotease-17 (ADAM17) is a major sheddase responsible for the regulation of a wide range of biological processes, like cellular differentiation, regeneration, or cancer progression. Hitherto, the mechanism regulating the enzymatic activity of ADAM17 is poorly understood. Recently, protein-disulfide isomerase (PDI) was shown to interact with ADAM17 and to down-regulate its enzymatic activity. Here we demonstrate by NMR spectroscopy and tandem-mass spectrometry that PDI directly interacts with the membrane-proximal domain (MPD), a domain of ADAM17 involved in its dimerization and substrate recognition. PDI catalyzes an isomerization of disulfide bridges within the thioredoxin motif C600XXC603 of the MPD and results in a drastic structural change between an active open state and an inactive closed conformation. This conformational change of the MPD putatively acts as a molecular switch, facilitating a global reorientation of the extracellular domains in ADAM17 and regulating its shedding activity.

	~~==Function==~~		Membrane-Proximal Domain of a Disintegrin and Metalloprotease-17 Represents the Putative Molecular Switch of Its Shedding Activity Operated by Protein-disulfide Isomerase.,Dusterhoft S, Jung S, Hung CW, Tholey A, Sonnichsen FD, Grotzinger J, Lorenzen I J Am Chem Soc. 2013 Apr 5. PMID:23521534<ref>PMID:23521534</ref>
	~~[[http://www.uniprot.org/uniprot/ADA17_HUMAN ADA17_HUMAN]] Cleaves the membrane~~-~~bound precursor~~ of ~~TNF~~-~~alpha to its mature soluble form. Responsible for~~ the ~~proteolytical release~~ of ~~soluble JAM3 from endothelial cells surface~~. ~~Responsible for the proteolytic release of several other cell-surface proteins~~, ~~including p75 TNF-receptor~~, ~~interleukin 1 receptor type II~~, ~~p55 TNF-receptor~~, ~~transforming growth factor-alpha~~, ~~L-selectin~~, ~~growth hormone receptor~~, ~~MUC1 and the amyloid precursor protein~~. ~~Also involved in the activation of Notch pathway (By similarity)~~.~~<ref>~~PMID:~~12441351</ref>~~ <ref>PMID:~~20592283~~</ref>

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[2m2f]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full experimental information is available from [http:/~~/~~oca.weizmann.ac.il/oca-bin/ocashort?id=2M2F OCA].~~		</div>

	==~~Reference~~==		==See Also==
	~~<ref group~~=~~"xtra">PMID:023521534</ref>~~<references ~~group="xtra"~~/><~~references~~/>		*[[A Disintegrin And Metalloproteinase\|A Disintegrin And Metalloproteinase]]
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: ADAM 17 endopeptidase]]		[[Category: ADAM 17 endopeptidase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Duesterhoeft, S.]]		[[Category: Duesterhoeft, S]]
	[[Category: Groetzinger, J.]]		[[Category: Groetzinger, J]]
	[[Category: Hung, C.]]		[[Category: Hung, C]]
	[[Category: Jung, S.]]		[[Category: Jung, S]]
	[[Category: Lorenzen, I.]]		[[Category: Lorenzen, I]]
	[[Category: Soennichsen, F D.]]		[[Category: Soennichsen, F D]]
	[[Category: Tholey, A.]]		[[Category: Tholey, A]]
	[[Category: Adam17]]		[[Category: Adam17]]
	[[Category: Closed conformer]]		[[Category: Closed conformer]]
	[[Category: Hydrolase regulator]]		[[Category: Hydrolase regulator]]
	[[Category: Membrane-proximal domain]]		[[Category: Membrane-proximal domain]]

OCA at 08:37, 19 June 2013

2013-06-19T08:37:17Z

← Older revision		Revision as of 08:37, 19 June 2013
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	==Reference==		==Reference==
	<references group="xtra"/><references/>		<ref group="xtra">PMID:023521534</ref><references group="xtra"/><references/>
	[[Category: ADAM 17 endopeptidase]]		[[Category: ADAM 17 endopeptidase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 22:36, 10 April 2013

2013-04-10T22:36:39Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_2m2f|  PDB=2m2f  |  SCENE=  }}
-The entry 2m2f is ON HOLD  until Paper Publication
+==Disease==
-Authors: Duesterhoeft, S., Jung, S., Hung, C., Tholey, A., Soennichsen, F.D., Groetzinger, J., Lorenzen, I.
+==Function==
-Description: The membran-proximal domain of ADAM17
+==About this Structure==

OCA at 09:33, 13 March 2013

2013-03-13T09:33:48Z

← Older revision		Revision as of 09:33, 13 March 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 2m2f is ON HOLD		The entry 2m2f is ON HOLD until Paper Publication

	Authors: ~~Dsterhft~~, S., Jung, S., Hung, C., ~~Thoely~~, A., ~~Sonnichsen~~, F.D., ~~Grotzinger~~, J., Lorenzen, I.		Authors: Duesterhoeft, S., Jung, S., Hung, C., Tholey, A., Soennichsen, F.D., Groetzinger, J., Lorenzen, I.

	Description: The membran-proximal domain of ADAM17		Description: The membran-proximal domain of ADAM17

OCA at 12:09, 6 February 2013

2013-02-06T12:09:28Z

← Older revision		Revision as of 12:09, 6 February 2013
Line 3:		Line 3:
	The entry 2m2f is ON HOLD		The entry 2m2f is ON HOLD

	Authors: ~~D sterh ft~~, S., Jung, S., Hung, C., Thoely, A., ~~S nnichsen~~, F.D., ~~Gr tzinger~~, J., Lorenzen, I.		Authors: Dsterhft, S., Jung, S., Hung, C., Thoely, A., Sonnichsen, F.D., Grotzinger, J., Lorenzen, I.

	Description: The membran-proximal domain of ADAM17		Description: The membran-proximal domain of ADAM17