2mcd - Revision history

OCA at 06:03, 15 May 2024

2024-05-15T06:03:57Z

← Older revision		Revision as of 06:03, 15 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mcd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Murine_norovirus_1 Murine norovirus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MCD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mcd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Murine_norovirus_1 Murine norovirus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MCD FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mcd OCA], [https://pdbe.org/2mcd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mcd RCSB], [https://www.ebi.ac.uk/pdbsum/2mcd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mcd ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mcd OCA], [https://pdbe.org/2mcd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mcd RCSB], [https://www.ebi.ac.uk/pdbsum/2mcd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mcd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 06:31, 2 March 2023

2023-03-02T06:31:20Z

← Older revision		Revision as of 06:31, 2 March 2023
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	==Backbone 1H, 13C, and 15N Chemical Shift Assignments for murine norovirus NS1/2 D94E mutant==		==Backbone 1H, 13C, and 15N Chemical Shift Assignments for murine norovirus NS1/2 D94E mutant==
	<StructureSection load='2mcd' size='340' side='right'caption='[[2mcd~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='2mcd' size='340' side='right'caption='[[2mcd]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mcd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Murine_norovirus_1 Murine norovirus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MCD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mcd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Murine_norovirus_1 Murine norovirus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MCD FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NS1/2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=223997 Murine norovirus 1])</td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mcd OCA], [https://pdbe.org/2mcd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mcd RCSB], [https://www.ebi.ac.uk/pdbsum/2mcd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mcd ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mcd OCA], [https://pdbe.org/2mcd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mcd RCSB], [https://www.ebi.ac.uk/pdbsum/2mcd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mcd ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/Q80J95_9CALI Q80J95_9CALI]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Murine norovirus 1]]		[[Category: Murine norovirus 1]]
	[[Category: Borin, B]]		[[Category: Borin B]]
	[[Category: Krezel~~, A M]]~~		[[Category: Krezel AM]]
	~~[[Category: Hydrolase]]~~
	~~[[Category: Norovirus]]~~
	~~[[Category: Ns1/2~~]]

OCA at 10:07, 26 May 2021

2021-05-26T10:07:26Z

← Older revision		Revision as of 10:07, 26 May 2021
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	==Backbone 1H, 13C, and 15N Chemical Shift Assignments for murine norovirus NS1/2 D94E mutant==		==Backbone 1H, 13C, and 15N Chemical Shift Assignments for murine norovirus NS1/2 D94E mutant==
	<StructureSection load='2mcd' size='340' side='right' caption='[[2mcd]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2mcd' size='340' side='right'caption='[[2mcd]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mcd]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Murine_norovirus_1 Murine norovirus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MCD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2MCD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mcd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Murine_norovirus_1 Murine norovirus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MCD FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NS1/2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=223997 Murine norovirus 1])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NS1/2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=223997 Murine norovirus 1])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2mcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mcd OCA], [~~http~~://pdbe.org/2mcd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2mcd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2mcd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2mcd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mcd OCA], [https://pdbe.org/2mcd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mcd RCSB], [https://www.ebi.ac.uk/pdbsum/2mcd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mcd ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Murine norovirus 1]]		[[Category: Murine norovirus 1]]
	[[Category: Borin, B]]		[[Category: Borin, B]]

OCA at 08:21, 12 December 2018

2018-12-12T08:21:37Z

← Older revision		Revision as of 08:21, 12 December 2018
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	<StructureSection load='2mcd' size='340' side='right' caption='[[2mcd]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2mcd' size='340' side='right' caption='[[2mcd]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mcd]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MCD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mcd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Murine_norovirus_1 Murine norovirus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MCD FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mcd OCA], [http://pdbe.org/2mcd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mcd RCSB], [http://www.ebi.ac.uk/pdbsum/2mcd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mcd ProSAT]</span></td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NS1/2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=223997 Murine norovirus 1])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mcd OCA], [http://pdbe.org/2mcd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mcd RCSB], [http://www.ebi.ac.uk/pdbsum/2mcd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mcd ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Murine norovirus 1]]
	[[Category: Borin, B]]		[[Category: Borin, B]]
	[[Category: Krezel, A M]]		[[Category: Krezel, A M]]

OCA at 08:20, 9 March 2017

2017-03-09T08:20:01Z

← Older revision		Revision as of 08:20, 9 March 2017
Line 1:		Line 1:

	==Backbone 1H, 13C, and 15N Chemical Shift Assignments for murine norovirus NS1/2 D94E mutant==		==Backbone 1H, 13C, and 15N Chemical Shift Assignments for murine norovirus NS1/2 D94E mutant==
	<StructureSection load='2mcd' size='340' side='right' caption='[[2mcd]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2mcd' size='340' side='right' caption='[[2mcd]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mcd]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Murine_norovirus_1 Murine norovirus 1]~~. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MCD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mcd]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MCD FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NS1/2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=223997 Murine norovirus 1])</td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mcd OCA], [http://pdbe.org/2mcd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mcd RCSB], [http://www.ebi.ac.uk/pdbsum/2mcd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mcd ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mcd OCA], [http://pdbe.org/2mcd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mcd RCSB], [http://www.ebi.ac.uk/pdbsum/2mcd PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Murine norovirus 1]]~~
	[[Category: Borin, B]]		[[Category: Borin, B]]
	[[Category: Krezel, A M]]		[[Category: Krezel, A M]]

OCA at 11:43, 11 September 2015

2015-09-11T11:43:23Z

← Older revision		Revision as of 11:43, 11 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2mcd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Murine_norovirus_1 Murine norovirus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MCD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mcd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Murine_norovirus_1 Murine norovirus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MCD FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NS1/2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=223997 Murine norovirus 1])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NS1/2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=223997 Murine norovirus 1])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mcd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mcd RCSB], [http://www.ebi.ac.uk/pdbsum/2mcd PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mcd OCA], [http://pdbe.org/2mcd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mcd RCSB], [http://www.ebi.ac.uk/pdbsum/2mcd PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2mcd" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 23:21, 3 January 2015

2015-01-03T23:21:11Z

← Older revision		Revision as of 23:21, 3 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mcd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Murine_norovirus_1 Murine norovirus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MCD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mcd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Murine_norovirus_1 Murine norovirus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MCD FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NS1/2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=223997 Murine norovirus 1])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NS1/2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=223997 Murine norovirus 1])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mcd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mcd RCSB], [http://www.ebi.ac.uk/pdbsum/2mcd PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mcd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mcd RCSB], [http://www.ebi.ac.uk/pdbsum/2mcd PDBsum]</span></td></tr>
	<table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	</StructureSection>		</StructureSection>
	[[Category: Murine norovirus 1]]		[[Category: Murine norovirus 1]]
	[[Category: Borin, B.]]		[[Category: Borin, B]]
	[[Category: Krezel, A M.]]		[[Category: Krezel, A M]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Norovirus]]		[[Category: Norovirus]]
	[[Category: Ns1/2]]		[[Category: Ns1/2]]

OCA at 05:19, 25 June 2014

2014-06-25T05:19:30Z

← Older revision		Revision as of 05:19, 25 June 2014
Line 1:		Line 1:
	~~{{STRUCTURE_2mcd\| PDB=2mcd \| SCENE= }}~~		==Backbone 1H, 13C, and 15N Chemical Shift Assignments for murine norovirus NS1/2 D94E mutant==
	===Backbone 1H, 13C, and 15N Chemical Shift Assignments for murine norovirus NS1/2 D94E mutant===		<StructureSection load='2mcd' size='340' side='right' caption='[[2mcd]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	~~{{ABSTRACT_PUBMED_24273131}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2mcd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Murine_norovirus_1 Murine norovirus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MCD FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NS1/2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=223997 Murine norovirus 1])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mcd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mcd RCSB], [http://www.ebi.ac.uk/pdbsum/2mcd PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Compact viral genomes such as those found in noroviruses, which cause significant enteric disease in humans, often encode only a few proteins, but affect a wide range of processes in their hosts and ensure efficient propagation of the virus. Both human and mouse noroviruses persistently replicate and are shed in stool, a highly effective strategy for spreading between hosts. For mouse norovirus (MNV), the presence of a glutamate rather than an aspartate at position 94 of the NS1/2 protein was previously shown to be essential for persistent replication and shedding. Here, we analyze these critical sequences of NS1/2 at the structural level. Using solution NMR methods we determined folded NS1/2 domain structures from a nonpersistent murine norovirus strain CW3, a persistent strain CR6, and a persistent mutant strain CW3D94E . We found an unstructured PEST-like domain followed by a novel folded domain in the N-terminus of NS1/2. All three forms of the domain are stable and monomeric in solution. Residue 94, critical for determining persistence, is located in a reverse turn following an alpha-helix in the folded domain. The longer sidechain of glutamate, but not aspartate, allows interaction with the indole group of the nearby tryptophan, reshaping the surface of the domain. The discrimination between glutamyl and aspartyl residue is imposed by the stable tertiary conformation. These structural requirements correlate with the in vivo function of NS1/2 in persistence, a key element of norovirus biology and infection. (c) Proteins 2013;. (c) 2013 Wiley Periodicals, Inc.

	~~==About this Structure==~~		Murine norovirus protein NS1/2 aspartate to glutamate mutation sufficient for persistence reorients sidechain of surface exposed tryptophan within a novel structured domain.,Borin BN, Tang W, Nice TJ, McCune BT, Virgin HW, Krezel AM Proteins. 2013 Nov 25. doi: 10.1002/prot.24484. PMID:24273131<ref>PMID:24273131</ref>
	~~[[2mcd]] is~~ a ~~1 chain structure~~. ~~Full experimental information is available from [http~~:/~~/oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=2MCD OCA].~~

	==~~Reference~~==		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~<ref group="xtra">PMID:024273131</ref>~~<references ~~group="xtra"~~/><~~references~~/>		</div>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Murine norovirus 1]]
	[[Category: Borin, B.]]		[[Category: Borin, B.]]
	[[Category: Krezel, A M.]]		[[Category: Krezel, A M.]]

OCA at 10:25, 18 December 2013

2013-12-18T10:25:23Z

← Older revision		Revision as of 10:25, 18 December 2013
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	~~'''Unreleased structure'''~~		{{STRUCTURE_2mcd\| PDB=2mcd \| SCENE= }}
			===Backbone 1H, 13C, and 15N Chemical Shift Assignments for murine norovirus NS1/2 D94E mutant===
			{{ABSTRACT_PUBMED_24273131}}

	~~The entry~~ 2mcd is ~~ON HOLD~~		==About this Structure==
			[[2mcd]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MCD OCA].

	~~Authors~~: Borin, B., Krezel, A.M.		==Reference==
			<ref group="xtra">PMID:024273131</ref><references group="xtra"/><references/>
	~~Description~~: ~~Backbone 1H, 13C, and 15N Chemical Shift Assignments for murine norovirus NS1~~/2 ~~D94E mutant~~		[[Category: Borin, B.]]
			[[Category: Krezel, A M.]]
			[[Category: Hydrolase]]
			[[Category: Norovirus]]
			[[Category: Ns1/2]]

OCA: Protected "2mcd" [edit=sysop:move=sysop]

2013-08-28T06:12:10Z

Protected "2mcd" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:12, 28 August 2013
(No difference)