2md2 - Revision history

OCA at 06:04, 15 May 2024

2024-05-15T06:04:13Z

← Older revision		Revision as of 06:04, 15 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2md2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MD2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MD2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2md2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MD2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MD2 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2md2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2md2 OCA], [https://pdbe.org/2md2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2md2 RCSB], [https://www.ebi.ac.uk/pdbsum/2md2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2md2 ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2md2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2md2 OCA], [https://pdbe.org/2md2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2md2 RCSB], [https://www.ebi.ac.uk/pdbsum/2md2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2md2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 09:33, 14 June 2023

2023-06-14T09:33:35Z

← Older revision		Revision as of 09:33, 14 June 2023
Line 1:		Line 1:

	==Fragment based approach and binding behavior of LFampinB with Lipopolysaccharide: biophysical aspects==		==Fragment based approach and binding behavior of LFampinB with Lipopolysaccharide: biophysical aspects==
	<StructureSection load='2md2' size='340' side='right'caption='[[2md2~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>		<StructureSection load='2md2' size='340' side='right'caption='[[2md2]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2md2]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MD2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MD2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2md2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MD2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MD2 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2md1\|2md1]], [[2md3\|2md3]], [[2md4\|2md4]]</div></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2md2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2md2 OCA], [https://pdbe.org/2md2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2md2 RCSB], [https://www.ebi.ac.uk/pdbsum/2md2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2md2 ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2md2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2md2 OCA], [https://pdbe.org/2md2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2md2 RCSB], [https://www.ebi.ac.uk/pdbsum/2md2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2md2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/TRFL_BOVIN TRFL_BOVIN]] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> Lactotransferrin has antimicrobial activity. The most effective inhibitory activity was seen against E.coli and P.aeruginosa.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> Lactoferricin B is an antimicrobial peptide. Inhibits the growth of Gram-negative and Gram-positive bacteria.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref>		[https://www.uniprot.org/uniprot/TRFL_BOVIN TRFL_BOVIN] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> Lactotransferrin has antimicrobial activity. The most effective inhibitory activity was seen against E.coli and P.aeruginosa.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> Lactoferricin B is an antimicrobial peptide. Inhibits the growth of Gram-negative and Gram-positive bacteria.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Bhunia, A]]		[[Category: Bhunia A]]
	[[Category: Chatterjee, S]]		[[Category: Chatterjee S]]
	[[Category: Ghosh, A]]		[[Category: Ghosh A]]
	[[Category: Jana, J]]		[[Category: Jana J]]
	~~[[Category: Antimicrobial protein~~]]

OCA at 11:35, 16 February 2022

2022-02-16T11:35:03Z

← Older revision		Revision as of 11:35, 16 February 2022
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	<StructureSection load='2md2' size='340' side='right'caption='[[2md2]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2md2' size='340' side='right'caption='[[2md2]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2md2]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MD2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2MD2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2md2]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MD2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MD2 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2md1\|2md1]], [[2md3\|2md3]], [[2md4\|2md4]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2md1\|2md1]], [[2md3\|2md3]], [[2md4\|2md4]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2md2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2md2 OCA], [~~http~~://pdbe.org/2md2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2md2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2md2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2md2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2md2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2md2 OCA], [https://pdbe.org/2md2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2md2 RCSB], [https://www.ebi.ac.uk/pdbsum/2md2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2md2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/TRFL_BOVIN TRFL_BOVIN]] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> Lactotransferrin has antimicrobial activity. The most effective inhibitory activity was seen against E.coli and P.aeruginosa.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> Lactoferricin B is an antimicrobial peptide. Inhibits the growth of Gram-negative and Gram-positive bacteria.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref>		[[https://www.uniprot.org/uniprot/TRFL_BOVIN TRFL_BOVIN]] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> Lactotransferrin has antimicrobial activity. The most effective inhibitory activity was seen against E.coli and P.aeruginosa.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> Lactoferricin B is an antimicrobial peptide. Inhibits the growth of Gram-negative and Gram-positive bacteria.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 06:22, 13 May 2020

2020-05-13T06:22:15Z

← Older revision		Revision as of 06:22, 13 May 2020
Line 1:		Line 1:

	==Fragment based approach and binding behavior of LFampinB with Lipopolysaccharide: biophysical aspects==		==Fragment based approach and binding behavior of LFampinB with Lipopolysaccharide: biophysical aspects==
	<StructureSection load='2md2' size='340' side='right' caption='[[2md2]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2md2' size='340' side='right'caption='[[2md2]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2md2]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MD2 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2MD2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2md2]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MD2 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2MD2 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2md1\|2md1]], [[2md3\|2md3]], [[2md4\|2md4]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2md1\|2md1]], [[2md3\|2md3]], [[2md4\|2md4]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2md2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2md2 OCA], [http://pdbe.org/2md2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2md2 RCSB], [http://www.ebi.ac.uk/pdbsum/2md2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2md2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2md2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2md2 OCA], [http://pdbe.org/2md2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2md2 RCSB], [http://www.ebi.ac.uk/pdbsum/2md2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2md2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Bhunia, A]]		[[Category: Bhunia, A]]
	[[Category: Chatterjee, S]]		[[Category: Chatterjee, S]]

OCA at 22:46, 9 August 2018

2018-08-09T22:46:24Z

← Older revision		Revision as of 22:46, 9 August 2018
Line 1:		Line 1:

	==Fragment based approach and binding behavior of LFampinB with Lipopolysaccharide: biophysical aspects==		==Fragment based approach and binding behavior of LFampinB with Lipopolysaccharide: biophysical aspects==
	<StructureSection load='2md2' size='340' side='right' caption='[[2md2]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2md2' size='340' side='right' caption='[[2md2]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2md2]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MD2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MD2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2md2]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MD2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MD2 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2md1\|2md1]], [[2md3\|2md3]], [[2md4\|2md4]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2md1\|2md1]], [[2md3\|2md3]], [[2md4\|2md4]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2md2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2md2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2md2 RCSB], [http://www.ebi.ac.uk/pdbsum/2md2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2md2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2md2 OCA], [http://pdbe.org/2md2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2md2 RCSB], [http://www.ebi.ac.uk/pdbsum/2md2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2md2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2md2" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:35, 2 September 2015

2015-09-02T06:35:04Z

← Older revision		Revision as of 06:35, 2 September 2015
Line 8:		Line 8:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/TRFL_BOVIN TRFL_BOVIN]] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> Lactotransferrin has antimicrobial activity. The most effective inhibitory activity was seen against E.coli and P.aeruginosa.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> Lactoferricin B is an antimicrobial peptide. Inhibits the growth of Gram-negative and Gram-positive bacteria.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref>		[[http://www.uniprot.org/uniprot/TRFL_BOVIN TRFL_BOVIN]] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> Lactotransferrin has antimicrobial activity. The most effective inhibitory activity was seen against E.coli and P.aeruginosa.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> Lactoferricin B is an antimicrobial peptide. Inhibits the growth of Gram-negative and Gram-positive bacteria.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Lactoferrampin (WR17, Trp 268-Arg 284), an antimicrobial peptide, is known to have significant antibacterial and candidacidal activities. However, there are no previous studies explaining how WR17 permeabilizes the outer membrane of Gram negative bacteria and neutralizes endotoxins. In this study we used a series of assays like antimicrobial activity, calcein leakage, NPN dye uptake and endotoxin neutralization assay to show that the sequence context of WR17 modulates its multi-faceted activities. We determined the high resolution NMR structure of WR17 in LPS and found that the N-ter region forms a helix (Trp1-Phe11) and orients itself at an angle of 45 degrees into the lipopolysaccharide (LPS) micelle, whereas the C-ter region (Lys13-Arg17) remains as a flexible extended random coil. We also verified this result through in silico molecular modeling simulation. Isothermal titration calorimetry showed that the interaction of WR17 and its analogues with LPS was primarily endothermic in nature. Using several fluorescence techniques such as anisotropy and red edge excitation shift assay we revealed motional restriction for Trp1 of WR17 in LPS. The distance between the indole ring of Trp1 of WR17 and the polar head group of LPS is around 7 A, as obtained from the depth of insertion assay. Additionally, MD simulation demonstrated that the incorporation of the peptide in LPS is achieved with the help of the K(13)xK(15)xR(17) motif at the C-terminus. This novel anchoring "K(13)NKSR(17)" motif is currently being utilized in our ongoing research to design novel anti-endotoxic molecules.

			Sequence context induced antimicrobial activity: insight into lipopolysaccharide permeabilization.,Ghosh A, Datta A, Jana J, Kar RK, Chatterjee C, Chatterjee S, Bhunia A Mol Biosyst. 2014 Jun;10(6):1596-612. doi: 10.1039/c4mb00111g. Epub 2014 Apr 9. PMID:24714742<ref>PMID:24714742</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:00, 24 December 2014

2014-12-24T16:00:53Z

← Older revision		Revision as of 16:00, 24 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2md2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2md2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2md2 RCSB], [http://www.ebi.ac.uk/pdbsum/2md2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2md2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2md2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2md2 RCSB], [http://www.ebi.ac.uk/pdbsum/2md2 PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/TRFL_BOVIN TRFL_BOVIN]] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> Lactotransferrin has antimicrobial activity. The most effective inhibitory activity was seen against E.coli and P.aeruginosa.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> Lactoferricin B is an antimicrobial peptide. Inhibits the growth of Gram-negative and Gram-positive bacteria.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 12:00, 18 December 2014

2014-12-18T12:00:15Z

← Older revision		Revision as of 12:00, 18 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_2md2\| PDB=2md2 \| SCENE= }}~~		==Fragment based approach and binding behavior of LFampinB with Lipopolysaccharide: biophysical aspects==
	===Fragment based approach and binding behavior of LFampinB with Lipopolysaccharide: biophysical aspects===		<StructureSection load='2md2' size='340' side='right' caption='[[2md2]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
			== Structural highlights ==
	==~~Function~~==		<table><tr><td colspan='2'>[[2md2]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MD2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MD2 FirstGlance]. <br>
	[[http://~~www~~.~~uniprot~~.~~org~~/~~uniprot~~/~~TRFL_BOVIN TRFL_BOVIN]~~] ~~Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate~~.<~~ref~~>~~PMID:8980754~~</~~ref~~> ~~<ref>PMID~~:~~15222473<~~/~~ref> Lactotransferrin has antimicrobial activity~~. ~~The most effective inhibitory activity was seen against E~~.~~coli and P~~.~~aeruginosa~~.<~~ref~~>~~PMID:8980754~~</~~ref~~> <~~ref~~>~~PMID:15222473~~<~~/ref~~> ~~Lactoferricin B is an antimicrobial peptide. Inhibits the growth of Gram-negative and Gram-positive bacteria.~~<~~ref~~>~~PMID~~:~~8980754~~</~~ref~~> <~~ref~~>~~PMID:15222473~~</~~ref~~> ~~The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.~~<~~ref~~>~~PMID:8980754~~<~~/ref~~> <~~ref~~>~~PMID~~:~~15222473~~</~~ref~~>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2md1\|2md1]], [[2md3\|2md3]], [[2md4\|2md4]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2md2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2md2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2md2 RCSB], [http://www.ebi.ac.uk/pdbsum/2md2 PDBsum]</span></td></tr>
	==~~About this Structure=~~=		</table>
	[[2md2]~~] is a 1 chain structure. Full experimental information is available from~~ [http://oca.weizmann.ac.il/oca-bin/~~ocashort~~?id=~~2MD2~~ OCA].		__TOC__
			</StructureSection>
	~~==Reference=~~=		[[Category: Bhunia, A]]
	<~~references group="xtra"~~/><~~references~~/>		[[Category: Chatterjee, S]]
	[[Category: Bhunia, A.]]		[[Category: Ghosh, A]]
	[[Category: Chatterjee, S.]]		[[Category: Jana, J]]
	[[Category: Ghosh, A.]]
	[[Category: Jana, J.]]
	[[Category: Antimicrobial protein]]		[[Category: Antimicrobial protein]]

OCA at 08:14, 29 September 2013

2013-09-29T08:14:13Z

← Older revision		Revision as of 08:14, 29 September 2013
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	~~'''Unreleased structure'''~~		{{STRUCTURE_2md2\| PDB=2md2 \| SCENE= }}
			===Fragment based approach and binding behavior of LFampinB with Lipopolysaccharide: biophysical aspects===

	The ~~entry 2md2~~ is ~~ON HOLD~~		==Function==
			[[http://www.uniprot.org/uniprot/TRFL_BOVIN TRFL_BOVIN]] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> Lactotransferrin has antimicrobial activity. The most effective inhibitory activity was seen against E.coli and P.aeruginosa.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> Lactoferricin B is an antimicrobial peptide. Inhibits the growth of Gram-negative and Gram-positive bacteria.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref>

	~~Authors~~: ~~Bhunia, A~~.~~, Chatterjee, S~~.~~, Ghosh, A~~.~~, Jana, J~~.		==About this Structure==
			[[2md2]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MD2 OCA].

	~~Description~~: ~~Fragment based approach and binding behavior of LFampinB with Lipopolysaccharide~~: ~~biophysical aspects~~		==Reference==
			<references group="xtra"/><references/>
			[[Category: Bhunia, A.]]
			[[Category: Chatterjee, S.]]
			[[Category: Ghosh, A.]]
			[[Category: Jana, J.]]
			[[Category: Antimicrobial protein]]

OCA: Protected "2md2" [edit=sysop:move=sysop]

2013-09-04T09:20:26Z

Protected "2md2" [edit=sysop:move=sysop]

← Older revision	Revision as of 09:20, 4 September 2013
(No difference)