2md6 - Revision history

OCA at 09:18, 6 November 2024

2024-11-06T09:18:50Z

← Older revision		Revision as of 09:18, 6 November 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2md6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conasprella_longurionis Conasprella longurionis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MD6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MD6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2md6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conasprella_longurionis Conasprella longurionis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MD6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MD6 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2md6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2md6 OCA], [https://pdbe.org/2md6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2md6 RCSB], [https://www.ebi.ac.uk/pdbsum/2md6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2md6 ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 15 models</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2md6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2md6 OCA], [https://pdbe.org/2md6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2md6 RCSB], [https://www.ebi.ac.uk/pdbsum/2md6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2md6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 09:33, 14 June 2023

2023-06-14T09:33:41Z

← Older revision		Revision as of 09:33, 14 June 2023
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	==NMR SOLUTION STRUCTURE OF ALPHA CONOTOXIN LO1A FROM Conus longurionis==		==NMR SOLUTION STRUCTURE OF ALPHA CONOTOXIN LO1A FROM Conus longurionis==
	<StructureSection load='2md6' size='340' side='right'caption='[[2md6~~]], [[NMR_Ensembles_of_Models \| 15 NMR models~~]]' scene=''>		<StructureSection load='2md6' size='340' side='right'caption='[[2md6]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2md6]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MD6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MD6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2md6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conasprella_longurionis Conasprella longurionis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MD6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MD6 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2md6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2md6 OCA], [https://pdbe.org/2md6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2md6 RCSB], [https://www.ebi.ac.uk/pdbsum/2md6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2md6 ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2md6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2md6 OCA], [https://pdbe.org/2md6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2md6 RCSB], [https://www.ebi.ac.uk/pdbsum/2md6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2md6 ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/CA1A_CONLG CA1A_CONLG]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Conasprella longurionis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Herdewijn, P]]		[[Category: D'Souza L]]
	[[Category: Lebbe~~, E K.M~~]]		[[Category: Herdewijn P]]
	[[Category: Lescrinier, E]]		[[Category: Lebbe EKM]]
	[[Category: Maiti, M]]		[[Category: Lescrinier E]]
	[[Category: Peigneur, S]]		[[Category: Maiti M]]
	~~[[Category: Souza, L D~~]]		[[Category: Peigneur S]]
	[[Category: Tytgat, J]]		[[Category: Tytgat J]]
	~~[[Category: Alpha conotoxin]]~~
	~~[[Category: Conotoxin]]~~
	~~[[Category: Toxin~~]]

OCA at 11:35, 16 February 2022

2022-02-16T11:35:07Z

← Older revision		Revision as of 11:35, 16 February 2022
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	<StructureSection load='2md6' size='340' side='right'caption='[[2md6]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='2md6' size='340' side='right'caption='[[2md6]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2md6]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MD6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2MD6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2md6]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MD6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MD6 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2md6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2md6 OCA], [~~http~~://pdbe.org/2md6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2md6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2md6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2md6 ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2md6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2md6 OCA], [https://pdbe.org/2md6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2md6 RCSB], [https://www.ebi.ac.uk/pdbsum/2md6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2md6 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:22, 13 May 2020

2020-05-13T06:22:22Z

← Older revision		Revision as of 06:22, 13 May 2020
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	==NMR SOLUTION STRUCTURE OF ALPHA CONOTOXIN LO1A FROM Conus longurionis==		==NMR SOLUTION STRUCTURE OF ALPHA CONOTOXIN LO1A FROM Conus longurionis==
	<StructureSection load='2md6' size='340' side='right' caption='[[2md6]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='2md6' size='340' side='right'caption='[[2md6]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2md6]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MD6 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2MD6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2md6]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MD6 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2MD6 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca.weizmann~~.~~ac.il/oca-docs~~/fgij/fg.htm?mol=2md6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2md6 OCA], [http://pdbe.org/2md6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2md6 RCSB], [http://www.ebi.ac.uk/pdbsum/2md6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2md6 ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2md6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2md6 OCA], [http://pdbe.org/2md6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2md6 RCSB], [http://www.ebi.ac.uk/pdbsum/2md6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2md6 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Herdewijn, P]]		[[Category: Herdewijn, P]]
	[[Category: Lebbe, E K.M]]		[[Category: Lebbe, E K.M]]

OCA at 22:54, 9 August 2018

2018-08-09T22:54:40Z

← Older revision		Revision as of 22:54, 9 August 2018
Line 1:		Line 1:

	==NMR SOLUTION STRUCTURE OF ALPHA CONOTOXIN LO1A FROM Conus longurionis==		==NMR SOLUTION STRUCTURE OF ALPHA CONOTOXIN LO1A FROM Conus longurionis==
	<StructureSection load='2md6' size='340' side='right' caption='[[2md6]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='2md6' size='340' side='right' caption='[[2md6]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2md6]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MD6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MD6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2md6]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MD6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MD6 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2md6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2md6 OCA], [http://pdbe.org/2md6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2md6 RCSB], [http://www.ebi.ac.uk/pdbsum/2md6 PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2md6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2md6 OCA], [http://pdbe.org/2md6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2md6 RCSB], [http://www.ebi.ac.uk/pdbsum/2md6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2md6 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:21, 11 September 2015

2015-09-11T00:21:28Z

← Older revision		Revision as of 00:21, 11 September 2015
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2md6]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MD6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MD6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2md6]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MD6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MD6 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2md6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2md6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2md6 RCSB], [http://www.ebi.ac.uk/pdbsum/2md6 PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2md6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2md6 OCA], [http://pdbe.org/2md6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2md6 RCSB], [http://www.ebi.ac.uk/pdbsum/2md6 PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 13:		Line 13:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2md6" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 21:43, 3 January 2015

2015-01-03T21:43:10Z

← Older revision		Revision as of 21:43, 3 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2md6]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MD6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MD6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2md6]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MD6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MD6 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2md6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2md6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2md6 RCSB], [http://www.ebi.ac.uk/pdbsum/2md6 PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2md6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2md6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2md6 RCSB], [http://www.ebi.ac.uk/pdbsum/2md6 PDBsum]</span></td></tr>
	<table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 11:		Line 11:
	Structure-Function Elucidation of a New alpha-Conotoxin, Lo1a, from Conus longurionis.,Lebbe EK, Peigneur S, Maiti M, Devi P, Ravichandran S, Lescrinier E, Ulens C, Waelkens E, D'Souza L, Herdewijn P, Tytgat J J Biol Chem. 2014 Apr 4;289(14):9573-83. doi: 10.1074/jbc.M114.556175. Epub 2014 , Feb 24. PMID:24567324<ref>PMID:24567324</ref>		Structure-Function Elucidation of a New alpha-Conotoxin, Lo1a, from Conus longurionis.,Lebbe EK, Peigneur S, Maiti M, Devi P, Ravichandran S, Lescrinier E, Ulens C, Waelkens E, D'Souza L, Herdewijn P, Tytgat J J Biol Chem. 2014 Apr 4;289(14):9573-83. doi: 10.1074/jbc.M114.556175. Epub 2014 , Feb 24. PMID:24567324<ref>PMID:24567324</ref>

	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 17:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Herdewijn, P.]]		[[Category: Herdewijn, P]]
	[[Category: Lebbe, E K.M.]]		[[Category: Lebbe, E K.M]]
	[[Category: Lescrinier, E.]]		[[Category: Lescrinier, E]]
	[[Category: Maiti, M.]]		[[Category: Maiti, M]]
	[[Category: Peigneur, S.]]		[[Category: Peigneur, S]]
	[[Category: Souza, L D.]]		[[Category: Souza, L D]]
	[[Category: Tytgat, J.]]		[[Category: Tytgat, J]]
	[[Category: Alpha conotoxin]]		[[Category: Alpha conotoxin]]
	[[Category: Conotoxin]]		[[Category: Conotoxin]]
	[[Category: Toxin]]		[[Category: Toxin]]

OCA at 11:42, 18 May 2014

2014-05-18T11:42:20Z

← Older revision		Revision as of 11:42, 18 May 2014
Line 2:		Line 2:
	<StructureSection load='2md6' size='340' side='right' caption='[[2md6]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='2md6' size='340' side='right' caption='[[2md6]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2md6]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MD6 OCA]. ~~<br>~~		<table><tr><td colspan='2'>[[2md6]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MD6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MD6 FirstGlance]. <br>
	~~</td></tr><tr><td class="sblockLbl">~~<b>~~Activity:~~</b>~~</td><td class="sblockDat"><span class='plainlinks'>~~[http://en.~~wikipedia~~.~~org/wiki/Glucokinase Glucokinase], with EC number [http:/~~/~~www.brenda~~-~~enzymes.info~~/~~php~~/~~result_flat~~.~~php4~~?~~ecno~~=2.~~7.1.2 2.7.1.2]~~ <~~/span~~></td></tr>		</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2md6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2md6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2md6 RCSB], [http://www.ebi.ac.uk/pdbsum/2md6 PDBsum]</span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2md6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2md6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2md6 RCSB], [http://www.ebi.ac.uk/pdbsum/2md6 PDBsum]</span></td></tr>
	<table>		<table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:33, 1 May 2014

2014-05-01T09:33:38Z

← Older revision		Revision as of 09:33, 1 May 2014
Line 2:		Line 2:
	<StructureSection load='2md6' size='340' side='right' caption='[[2md6]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='2md6' size='340' side='right' caption='[[2md6]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	[[2md6]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MD6 OCA]. <br>		<table><tr><td colspan='2'>[[2md6]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MD6 OCA]. <br>
	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>		</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
	<b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2md6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2md6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2md6 RCSB], [http://www.ebi.ac.uk/pdbsum/2md6 PDBsum]</span><br>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2md6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2md6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2md6 RCSB], [http://www.ebi.ac.uk/pdbsum/2md6 PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
	alpha-Conotoxins are peptide toxins found in the venom of marine cone snails and potent antagonists of various subtypes of nicotinic acetylcholine receptors (nAChRs). nAChRs are cholinergic receptors forming ligand-gated ion channels in the plasma membranes of certain neurons and the neuromuscular junction. Because nAChRs have an important role in regulating transmitter release, cell excitability, and neuronal integration, nAChR dysfunctions have been implicated in a variety of severe pathologies such as epilepsy, myasthenic syndromes, schizophrenia, Parkinson disease, and Alzheimer disease. To expand the knowledge concerning cone snail toxins, we examined the venom of Conus longurionis. We isolated an 18-amino acid peptide named alpha-conotoxin Lo1a, which is active on nAChRs. To the best of our knowledge, this is the first characterization of a conotoxin from this species. The peptide was characterized by electrophysiological screening against several types of cloned nAChRs expressed in Xenopus laevis oocytes. The three-dimensional solution structure of the alpha-conotoxin Lo1a was determined by NMR spectroscopy. Lo1a, a member of the alpha4/7 family, blocks the response to acetylcholine in oocytes expressing alpha7 nAChRs with an IC50 of 3.24 +/- 0.7 mum. Furthermore, Lo1a shows a high selectivity for neuronal versus muscle subtype nAChRs. Because Lo1a has an unusual C terminus, we designed two mutants, Lo1a-DeltaD and Lo1a-RRR, to investigate the influence of the C-terminal residue. Lo1a-DeltaD has a C-terminal Asp deletion, whereas in Lo1a-RRR, a triple-Arg tail replaces the Asp. They blocked the neuronal nAChR alpha7 with a lower IC50 value, but remarkably, both adopted affinity for the muscle subtype alpha1beta1deltaepsilon.		alpha-Conotoxins are peptide toxins found in the venom of marine cone snails and potent antagonists of various subtypes of nicotinic acetylcholine receptors (nAChRs). nAChRs are cholinergic receptors forming ligand-gated ion channels in the plasma membranes of certain neurons and the neuromuscular junction. Because nAChRs have an important role in regulating transmitter release, cell excitability, and neuronal integration, nAChR dysfunctions have been implicated in a variety of severe pathologies such as epilepsy, myasthenic syndromes, schizophrenia, Parkinson disease, and Alzheimer disease. To expand the knowledge concerning cone snail toxins, we examined the venom of Conus longurionis. We isolated an 18-amino acid peptide named alpha-conotoxin Lo1a, which is active on nAChRs. To the best of our knowledge, this is the first characterization of a conotoxin from this species. The peptide was characterized by electrophysiological screening against several types of cloned nAChRs expressed in Xenopus laevis oocytes. The three-dimensional solution structure of the alpha-conotoxin Lo1a was determined by NMR spectroscopy. Lo1a, a member of the alpha4/7 family, blocks the response to acetylcholine in oocytes expressing alpha7 nAChRs with an IC50 of 3.24 +/- 0.7 mum. Furthermore, Lo1a shows a high selectivity for neuronal versus muscle subtype nAChRs. Because Lo1a has an unusual C terminus, we designed two mutants, Lo1a-DeltaD and Lo1a-RRR, to investigate the influence of the C-terminal residue. Lo1a-DeltaD has a C-terminal Asp deletion, whereas in Lo1a-RRR, a triple-Arg tail replaces the Asp. They blocked the neuronal nAChR alpha7 with a lower IC50 value, but remarkably, both adopted affinity for the muscle subtype alpha1beta1deltaepsilon.
Line 11:		Line 13:

	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>		From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
			</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:08, 30 April 2014

2014-04-30T10:08:55Z

← Older revision		Revision as of 10:08, 30 April 2014
Line 4:		Line 4:
	[[2md6]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MD6 OCA]. <br>		[[2md6]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MD6 OCA]. <br>
	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>		<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
			<b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2md6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2md6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2md6 RCSB], [http://www.ebi.ac.uk/pdbsum/2md6 PDBsum]</span><br>
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
	alpha-Conotoxins are peptide toxins found in the venom of marine cone snails and potent antagonists of various subtypes of nicotinic acetylcholine receptors (nAChRs). nAChRs are cholinergic receptors forming ligand-gated ion channels in the plasma membranes of certain neurons and the neuromuscular junction. Because nAChRs have an important role in regulating transmitter release, cell excitability, and neuronal integration, nAChR dysfunctions have been implicated in a variety of severe pathologies such as epilepsy, myasthenic syndromes, schizophrenia, Parkinson disease, and Alzheimer disease. To expand the knowledge concerning cone snail toxins, we examined the venom of Conus longurionis. We isolated an 18-amino acid peptide named alpha-conotoxin Lo1a, which is active on nAChRs. To the best of our knowledge, this is the first characterization of a conotoxin from this species. The peptide was characterized by electrophysiological screening against several types of cloned nAChRs expressed in Xenopus laevis oocytes. The three-dimensional solution structure of the alpha-conotoxin Lo1a was determined by NMR spectroscopy. Lo1a, a member of the alpha4/7 family, blocks the response to acetylcholine in oocytes expressing alpha7 nAChRs with an IC50 of 3.24 +/- 0.7 mum. Furthermore, Lo1a shows a high selectivity for neuronal versus muscle subtype nAChRs. Because Lo1a has an unusual C terminus, we designed two mutants, Lo1a-DeltaD and Lo1a-RRR, to investigate the influence of the C-terminal residue. Lo1a-DeltaD has a C-terminal Asp deletion, whereas in Lo1a-RRR, a triple-Arg tail replaces the Asp. They blocked the neuronal nAChR alpha7 with a lower IC50 value, but remarkably, both adopted affinity for the muscle subtype alpha1beta1deltaepsilon.		alpha-Conotoxins are peptide toxins found in the venom of marine cone snails and potent antagonists of various subtypes of nicotinic acetylcholine receptors (nAChRs). nAChRs are cholinergic receptors forming ligand-gated ion channels in the plasma membranes of certain neurons and the neuromuscular junction. Because nAChRs have an important role in regulating transmitter release, cell excitability, and neuronal integration, nAChR dysfunctions have been implicated in a variety of severe pathologies such as epilepsy, myasthenic syndromes, schizophrenia, Parkinson disease, and Alzheimer disease. To expand the knowledge concerning cone snail toxins, we examined the venom of Conus longurionis. We isolated an 18-amino acid peptide named alpha-conotoxin Lo1a, which is active on nAChRs. To the best of our knowledge, this is the first characterization of a conotoxin from this species. The peptide was characterized by electrophysiological screening against several types of cloned nAChRs expressed in Xenopus laevis oocytes. The three-dimensional solution structure of the alpha-conotoxin Lo1a was determined by NMR spectroscopy. Lo1a, a member of the alpha4/7 family, blocks the response to acetylcholine in oocytes expressing alpha7 nAChRs with an IC50 of 3.24 +/- 0.7 mum. Furthermore, Lo1a shows a high selectivity for neuronal versus muscle subtype nAChRs. Because Lo1a has an unusual C terminus, we designed two mutants, Lo1a-DeltaD and Lo1a-RRR, to investigate the influence of the C-terminal residue. Lo1a-DeltaD has a C-terminal Asp deletion, whereas in Lo1a-RRR, a triple-Arg tail replaces the Asp. They blocked the neuronal nAChR alpha7 with a lower IC50 value, but remarkably, both adopted affinity for the muscle subtype alpha1beta1deltaepsilon.