2mic - Revision history

OCA at 05:21, 17 October 2024

2024-10-17T05:21:36Z

← Older revision		Revision as of 05:21, 17 October 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mic]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MIC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mic]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MIC FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mic OCA], [https://pdbe.org/2mic PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mic RCSB], [https://www.ebi.ac.uk/pdbsum/2mic PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mic ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mic OCA], [https://pdbe.org/2mic PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mic RCSB], [https://www.ebi.ac.uk/pdbsum/2mic PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mic ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 07:58, 8 March 2023

2023-03-08T07:58:19Z

← Older revision		Revision as of 07:58, 8 March 2023
Line 1:		Line 1:

	==NMR structure of p75 transmembrane domain in DPC micelles==		==NMR structure of p75 transmembrane domain in DPC micelles==
	<StructureSection load='2mic' size='340' side='right'caption='[[2mic~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>		<StructureSection load='2mic' size='340' side='right'caption='[[2mic]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mic]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MIC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mic]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MIC FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mic OCA], [https://pdbe.org/2mic PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mic RCSB], [https://www.ebi.ac.uk/pdbsum/2mic PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mic ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mic OCA], [https://pdbe.org/2mic PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mic RCSB], [https://www.ebi.ac.uk/pdbsum/2mic PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mic ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/TNR16_RAT TNR16_RAT]] Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.		[https://www.uniprot.org/uniprot/TNR16_RAT TNR16_RAT] Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Arseniev, A]]		[[Category: Rattus norvegicus]]
	[[Category: Goncharuk, S]]		[[Category: Arseniev A]]
	[[Category: Mineev, K]]		[[Category: Goncharuk S]]
	[[Category: Nadezhdin, K]]		[[Category: Mineev K]]
	~~[[Category: Dimer]]~~		[[Category: Nadezhdin K]]
	~~[[Category: Membrane protein]]~~
	~~[[Category: P75]]~~
	~~[[Category: Transmembrane~~]]

OCA at 15:15, 2 June 2021

2021-06-02T15:15:10Z

← Older revision		Revision as of 15:15, 2 June 2021
Line 3:		Line 3:
	<StructureSection load='2mic' size='340' side='right'caption='[[2mic]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2mic' size='340' side='right'caption='[[2mic]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mic]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2MIC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mic]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MIC FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2mic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mic OCA], [~~http~~://pdbe.org/2mic PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2mic RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2mic PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2mic ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mic OCA], [https://pdbe.org/2mic PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mic RCSB], [https://www.ebi.ac.uk/pdbsum/2mic PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mic ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/TNR16_RAT TNR16_RAT]] Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.		[[https://www.uniprot.org/uniprot/TNR16_RAT TNR16_RAT]] Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:

	==See Also==		==See Also==
	*[[Tumor necrosis factor receptor\|Tumor necrosis factor receptor]]		*[[Tumor necrosis factor receptor 3D structures\|Tumor necrosis factor receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:40, 12 June 2019

2019-06-12T06:40:58Z

← Older revision		Revision as of 06:40, 12 June 2019
Line 1:		Line 1:

	==NMR structure of p75 transmembrane domain in DPC micelles==		==NMR structure of p75 transmembrane domain in DPC micelles==
	<StructureSection load='2mic' size='340' side='right' caption='[[2mic]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2mic' size='340' side='right'caption='[[2mic]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mic]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MIC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mic]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MIC FirstGlance]. <br>
Line 17:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 2mic" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2mic" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Tumor necrosis factor receptor\|Tumor necrosis factor receptor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Arseniev, A]]		[[Category: Arseniev, A]]
	[[Category: Goncharuk, S]]		[[Category: Goncharuk, S]]

OCA at 03:46, 6 September 2017

2017-09-06T03:46:25Z

← Older revision		Revision as of 03:46, 6 September 2017
Line 1:		Line 1:

	==NMR structure of p75 transmembrane domain in DPC micelles==		==NMR structure of p75 transmembrane domain in DPC micelles==
	<StructureSection load='2mic' size='340' side='right' caption='[[2mic]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2mic' size='340' side='right' caption='[[2mic]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mic]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MIC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mic]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MIC FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mic OCA], [http://pdbe.org/2mic PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mic RCSB], [http://www.ebi.ac.uk/pdbsum/2mic PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mic OCA], [http://pdbe.org/2mic PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mic RCSB], [http://www.ebi.ac.uk/pdbsum/2mic PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mic ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/TNR16_RAT TNR16_RAT]] Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.		[[http://www.uniprot.org/uniprot/TNR16_RAT TNR16_RAT]] Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Dimerization of single span transmembrane receptors underlies their mechanism of activation. p75 neurotrophin receptor plays an important role in the nervous system, but the understanding of p75 activation mechanism is still incomplete. The transmembrane (TM) domain of p75 stabilizes the receptor dimers through a disulfide bond, essential for the NGF signaling. Here we solved by NMR the three-dimensional structure of the p75-TM-WT and the functionally inactive p75-TM-C257A dimers. Upon reconstitution in lipid micelles, p75-TM-WT forms the disulfide-linked dimers spontaneously. Under reducing conditions, p75-TM-WT is in a monomer-dimer equilibrium with the Cys(257) residue located on the dimer interface. In contrast, p75-TM-C257A forms dimers through the AXXXG motif on the opposite face of the alpha-helix. Biochemical and cross-linking experiments indicate that AXXXG motif is not on the dimer interface of p75-TM-WT, suggesting that the conformation of p75-TM-C257A may be not functionally relevant. However, rather than mediating p75 homodimerization, mutagenesis of the AXXXG motif reveals its functional role in the regulated intramembrane proteolysis of p75 catalyzed by the gamma-secretase complex. Our structural data provide an insight into the key role of the Cys(257) in stabilization of the weak transmembrane dimer in a conformation required for the NGF signaling.

			Structural Basis of p75 Transmembrane Domain Dimerization.,Nadezhdin KD, Garcia-Carpio I, Goncharuk SA, Mineev KS, Arseniev AS, Vilar M J Biol Chem. 2016 Jun 3;291(23):12346-57. doi: 10.1074/jbc.M116.723585. Epub 2016, Apr 7. PMID:27056327<ref>PMID:27056327</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 2mic" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 20:47, 10 September 2015

2015-09-10T20:47:28Z

← Older revision		Revision as of 20:47, 10 September 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mic]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MIC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mic]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MIC FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mic OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mic RCSB], [http://www.ebi.ac.uk/pdbsum/2mic PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mic OCA], [http://pdbe.org/2mic PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mic RCSB], [http://www.ebi.ac.uk/pdbsum/2mic PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 11:01, 24 December 2014

2014-12-24T11:01:48Z

← Older revision		Revision as of 11:01, 24 December 2014
Line 1:		Line 1:
	'''~~Unreleased structure~~'''		==NMR structure of p75 transmembrane domain in DPC micelles==
			<StructureSection load='2mic' size='340' side='right' caption='[[2mic]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	~~The entry~~ 2mic is ~~ON HOLD until Paper Publication~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2mic]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MIC FirstGlance]. <br>
	~~Authors~~: ~~Nadezhdin~~, K., Arseniev, A., Goncharuk, S., ~~Mineev~~, K.		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mic OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mic RCSB], [http://www.ebi.ac.uk/pdbsum/2mic PDBsum]</span></td></tr>
			</table>
	~~Description~~: ~~NMR structure of p75 transmembrane domain in DPC micelles~~		== Function ==
			[[http://www.uniprot.org/uniprot/TNR16_RAT TNR16_RAT]] Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
			__TOC__
			</StructureSection>
			[[Category: Arseniev, A]]
			[[Category: Goncharuk, S]]
			[[Category: Mineev, K]]
			[[Category: Nadezhdin, K]]
			[[Category: Dimer]]
			[[Category: Membrane protein]]
			[[Category: P75]]
			[[Category: Transmembrane]]

OCA at 06:34, 22 January 2014

2014-01-22T06:34:50Z

← Older revision		Revision as of 06:34, 22 January 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 2mic is ON HOLD		The entry 2mic is ON HOLD until Paper Publication

	Authors: Nadezhdin, K., Arseniev, A., Goncharuk, S., Mineev, K.		Authors: Nadezhdin, K., Arseniev, A., Goncharuk, S., Mineev, K.

	Description: NMR structure of p75 transmembrane domain in DPC micelles		Description: NMR structure of p75 transmembrane domain in DPC micelles

OCA: Protected "2mic" [edit=sysop:move=sysop]

2013-12-18T08:38:57Z

Protected "2mic" [edit=sysop:move=sysop]

← Older revision	Revision as of 08:38, 18 December 2013
(No difference)

OCA: New page: '''Unreleased structure''' The entry 2mic is ON HOLD Authors: Nadezhdin, K., Arseniev, A., Goncharuk, S., Mineev, K. Description: NMR structure of p75 transmembrane domain in DPC micel...

2013-12-18T08:38:56Z

New page: '''Unreleased structure''' The entry 2mic is ON HOLD Authors: Nadezhdin, K., Arseniev, A., Goncharuk, S., Mineev, K. Description: NMR structure of p75 transmembrane domain in DPC micel...

New page

'''Unreleased structure'''

The entry 2mic is ON HOLD

Authors: Nadezhdin, K., Arseniev, A., Goncharuk, S., Mineev, K.

Description: NMR structure of p75 transmembrane domain in DPC micelles