2mjs - Revision history

OCA at 01:12, 21 November 2024

2024-11-21T01:12:04Z

← Older revision		Revision as of 01:12, 21 November 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mjs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Anoplius_samariensis Anoplius samariensis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MJS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MJS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mjs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Anoplius_samariensis Anoplius samariensis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MJS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MJS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DPV:DODECYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>DPV</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2~~</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX~~</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DPV:DODECYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>DPV</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mjs OCA], [https://pdbe.org/2mjs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mjs RCSB], [https://www.ebi.ac.uk/pdbsum/2mjs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mjs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mjs OCA], [https://pdbe.org/2mjs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mjs RCSB], [https://www.ebi.ac.uk/pdbsum/2mjs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mjs ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:37, 14 June 2023

2023-06-14T09:37:07Z

← Older revision		Revision as of 09:37, 14 June 2023
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	==Anoplin R5K T8W in DPC micelles==		==Anoplin R5K T8W in DPC micelles==
	<StructureSection load='2mjs' size='340' side='right'caption='[[2mjs~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='2mjs' size='340' side='right'caption='[[2mjs]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mjs]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MJS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MJS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mjs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Anoplius_samariensis Anoplius samariensis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MJS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MJS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DPV:DODECYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>DPV</scene>, <scene name='pdbligand=~~UNX~~:~~UNKNOWN~~+~~ATOM+OR+ION~~'>~~UNX~~</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DPV:DODECYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>DPV</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=~~NH2~~:~~AMINO~~+~~GROUP~~'>~~NH2~~</scene~~></td></tr>~~
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2mjq\|2mjq]], [[2mjr\|2mjr]], [[2mjt\|2mjt]]</div~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mjs OCA], [https://pdbe.org/2mjs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mjs RCSB], [https://www.ebi.ac.uk/pdbsum/2mjs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mjs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mjs OCA], [https://pdbe.org/2mjs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mjs RCSB], [https://www.ebi.ac.uk/pdbsum/2mjs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mjs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/ANOP_ANOSM ANOP_ANOSM]] Exhibits potent activity in stimulating degranulation from rat peritoneal mast cells but not from RBL-2H3 cells. Exhibits broad-spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria. Has no hemolytic activity towards human erythrocytes.<ref>PMID:11738089</ref>		[https://www.uniprot.org/uniprot/ANOP_ANOSM ANOP_ANOSM] Exhibits potent activity in stimulating degranulation from rat peritoneal mast cells but not from RBL-2H3 cells. Exhibits broad-spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria. Has no hemolytic activity towards human erythrocytes.<ref>PMID:11738089</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Anoplius samariensis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Poulsen~~, T J~~]]		[[Category: Poulsen TJ]]
	[[Category: Uggerhoej, L]]		[[Category: Uggerhoej L]]
	[[Category: Wimmer, R]]		[[Category: Wimmer R]]
	~~[[Category: Amphipathic helix]]~~
	~~[[Category: Antimicrobial protein~~]]

OCA at 11:36, 16 February 2022

2022-02-16T11:36:37Z

← Older revision		Revision as of 11:36, 16 February 2022
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	<StructureSection load='2mjs' size='340' side='right'caption='[[2mjs]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2mjs' size='340' side='right'caption='[[2mjs]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mjs]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MJS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2MJS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mjs]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MJS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MJS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DPV:DODECYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>DPV</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DPV:DODECYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>DPV</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mjq\|2mjq]], [[2mjr\|2mjr]], [[2mjt\|2mjt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2mjq\|2mjq]], [[2mjr\|2mjr]], [[2mjt\|2mjt]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2mjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mjs OCA], [~~http~~://pdbe.org/2mjs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2mjs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2mjs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2mjs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mjs OCA], [https://pdbe.org/2mjs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mjs RCSB], [https://www.ebi.ac.uk/pdbsum/2mjs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mjs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/ANOP_ANOSM ANOP_ANOSM]] Exhibits potent activity in stimulating degranulation from rat peritoneal mast cells but not from RBL-2H3 cells. Exhibits broad-spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria. Has no hemolytic activity towards human erythrocytes.<ref>PMID:11738089</ref>		[[https://www.uniprot.org/uniprot/ANOP_ANOSM ANOP_ANOSM]] Exhibits potent activity in stimulating degranulation from rat peritoneal mast cells but not from RBL-2H3 cells. Exhibits broad-spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria. Has no hemolytic activity towards human erythrocytes.<ref>PMID:11738089</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 06:24, 13 May 2020

2020-05-13T06:24:48Z

← Older revision		Revision as of 06:24, 13 May 2020
Line 1:		Line 1:

	==Anoplin R5K T8W in DPC micelles==		==Anoplin R5K T8W in DPC micelles==
	<StructureSection load='2mjs' size='340' side='right' caption='[[2mjs]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2mjs' size='340' side='right'caption='[[2mjs]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mjs]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MJS OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2MJS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mjs]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MJS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2MJS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DPV:DODECYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>DPV</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DPV:DODECYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>DPV</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mjq\|2mjq]], [[2mjr\|2mjr]], [[2mjt\|2mjt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mjq\|2mjq]], [[2mjr\|2mjr]], [[2mjt\|2mjt]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2mjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mjs OCA], [http://pdbe.org/2mjs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mjs RCSB], [http://www.ebi.ac.uk/pdbsum/2mjs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mjs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2mjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mjs OCA], [http://pdbe.org/2mjs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mjs RCSB], [http://www.ebi.ac.uk/pdbsum/2mjs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mjs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 24:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Poulsen, T J]]		[[Category: Poulsen, T J]]
	[[Category: Uggerhoej, L]]		[[Category: Uggerhoej, L]]

OCA at 22:52, 9 August 2018

2018-08-09T22:52:40Z

← Older revision		Revision as of 22:52, 9 August 2018
Line 1:		Line 1:

	==Anoplin R5K T8W in DPC micelles==		==Anoplin R5K T8W in DPC micelles==
	<StructureSection load='2mjs' size='340' side='right' caption='[[2mjs]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2mjs' size='340' side='right' caption='[[2mjs]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mjq\|2mjq]], [[2mjr\|2mjr]], [[2mjt\|2mjt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mjq\|2mjq]], [[2mjr\|2mjr]], [[2mjt\|2mjt]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mjs OCA], [http://pdbe.org/2mjs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mjs RCSB], [http://www.ebi.ac.uk/pdbsum/2mjs PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mjs OCA], [http://pdbe.org/2mjs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mjs RCSB], [http://www.ebi.ac.uk/pdbsum/2mjs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mjs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 02:37, 10 September 2015

2015-09-10T02:37:11Z

← Older revision		Revision as of 02:37, 10 September 2015
Line 6:		Line 6:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mjq\|2mjq]], [[2mjr\|2mjr]], [[2mjt\|2mjt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mjq\|2mjq]], [[2mjr\|2mjr]], [[2mjt\|2mjt]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mjs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mjs RCSB], [http://www.ebi.ac.uk/pdbsum/2mjs PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mjs OCA], [http://pdbe.org/2mjs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mjs RCSB], [http://www.ebi.ac.uk/pdbsum/2mjs PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2mjs" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:28, 14 January 2015

2015-01-14T08:28:07Z

← Older revision		Revision as of 08:28, 14 January 2015
Line 10:		Line 10:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/ANOP_ANOSM ANOP_ANOSM]] Exhibits potent activity in stimulating degranulation from rat peritoneal mast cells but not from RBL-2H3 cells. Exhibits broad-spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria. Has no hemolytic activity towards human erythrocytes.<ref>PMID:11738089</ref>		[[http://www.uniprot.org/uniprot/ANOP_ANOSM ANOP_ANOSM]] Exhibits potent activity in stimulating degranulation from rat peritoneal mast cells but not from RBL-2H3 cells. Exhibits broad-spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria. Has no hemolytic activity towards human erythrocytes.<ref>PMID:11738089</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Antimicrobial peptides (AMPs) are promising candidates for battling multiresistant bacteria. Despite extensive research, structure-activity relationships of AMPs are not fully understood, and there is a lack of structural data relating to AMPs in lipids. Here we present the NMR structure of anoplin (GLLKRIKTLL-NH2 ) in a micellar environment. A vast library of substitutions was designed and tested for antimicrobial and hemolytic activity, as well as for changes in structure and lipid interactions. This showed that improvement of antimicrobial activity without concomitant introduction of strong hemolytic activity can be achieved through subtle increases in the hydrophobicity of the hydrophobic face or through subtle increases in the polarity of the hydrophilic face of the helix, or-most efficiently-a combination of both. A set of guidelines based on the results is given, for assistance in how to modify cationic alpha-helical AMPs in order to control activity and selectivity. The guidelines are finally tested on a different peptide.

			Rational Design of Alpha-Helical Antimicrobial Peptides: Do's and Don'ts.,Uggerhoj LE, Poulsen TJ, Munk JK, Fredborg M, Sondergaard TE, Frimodt-Moller N, Hansen PR, Wimmer R Chembiochem. 2015 Jan 19;16(2):242-53. doi: 10.1002/cbic.201402581. Epub 2014 Dec, 21. PMID:25530580<ref>PMID:25530580</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:06, 24 December 2014

2014-12-24T16:06:01Z

← Older revision		Revision as of 16:06, 24 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mjs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mjs RCSB], [http://www.ebi.ac.uk/pdbsum/2mjs PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mjs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mjs RCSB], [http://www.ebi.ac.uk/pdbsum/2mjs PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/ANOP_ANOSM ANOP_ANOSM]] Exhibits potent activity in stimulating degranulation from rat peritoneal mast cells but not from RBL-2H3 cells. Exhibits broad-spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria. Has no hemolytic activity towards human erythrocytes.<ref>PMID:11738089</ref>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 09:35, 3 December 2014

2014-12-03T09:35:57Z

← Older revision		Revision as of 09:35, 3 December 2014
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	'''~~Unreleased structure~~'''		==Anoplin R5K T8W in DPC micelles==
			<StructureSection load='2mjs' size='340' side='right' caption='[[2mjs]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	~~The entry~~ 2mjs is ~~ON HOLD until Paper Publication~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2mjs]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MJS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MJS FirstGlance]. <br>
	~~Authors~~: ~~Uggerhoej~~, L., Poulsen, T.J., Wimmer, R.		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DPV:DODECYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>DPV</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
			<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	~~Description~~: ~~Anoplin R5K T8W in DPC micelles~~		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mjq\|2mjq]], [[2mjr\|2mjr]], [[2mjt\|2mjt]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mjs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mjs RCSB], [http://www.ebi.ac.uk/pdbsum/2mjs PDBsum]</span></td></tr>
			</table>
			__TOC__
			</StructureSection>
			[[Category: Poulsen, T J]]
			[[Category: Uggerhoej, L]]
			[[Category: Wimmer, R]]
			[[Category: Amphipathic helix]]
			[[Category: Antimicrobial protein]]

OCA at 11:30, 12 March 2014

2014-03-12T11:30:23Z

← Older revision		Revision as of 11:30, 12 March 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 2mjs is ON HOLD		The entry 2mjs is ON HOLD until Paper Publication

	Authors: Uggerhoej, L., Poulsen, T.J., Wimmer, R.		Authors: Uggerhoej, L., Poulsen, T.J., Wimmer, R.

	Description: Anoplin R5K T8W in DPC micelles		Description: Anoplin R5K T8W in DPC micelles