2mkf - Revision history

OCA at 06:06, 15 May 2024

2024-05-15T06:06:46Z

← Older revision		Revision as of 06:06, 15 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mkf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MKF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mkf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MKF FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkf OCA], [https://pdbe.org/2mkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mkf RCSB], [https://www.ebi.ac.uk/pdbsum/2mkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mkf ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkf OCA], [https://pdbe.org/2mkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mkf RCSB], [https://www.ebi.ac.uk/pdbsum/2mkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mkf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 07:59, 8 March 2023

2023-03-08T07:59:58Z

← Older revision		Revision as of 07:59, 8 March 2023
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	==Solution structure of the E81 deletion mutant of the tandem UIMs of RAP80==		==Solution structure of the E81 deletion mutant of the tandem UIMs of RAP80==
	<StructureSection load='2mkf' size='340' side='right'caption='[[2mkf~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='2mkf' size='340' side='right'caption='[[2mkf]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mkf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MKF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mkf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MKF FirstGlance]. <br>
	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3a1q\|3a1q]], [[2mkg\|2mkg]]</div></td></tr>~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkf OCA], [https://pdbe.org/2mkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mkf RCSB], [https://www.ebi.ac.uk/pdbsum/2mkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mkf ProSAT]</span></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UIMC1, RAP80, RXRIP110 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkf OCA], [https://pdbe.org/2mkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mkf RCSB], [https://www.ebi.ac.uk/pdbsum/2mkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mkf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/UIMC1_HUMAN UIMC1_HUMAN]] Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.<ref>PMID:12080054</ref> <ref>PMID:17621610</ref> <ref>PMID:17643121</ref> <ref>PMID:17525340</ref> <ref>PMID:17525341</ref> <ref>PMID:17525342</ref> <ref>PMID:19261748</ref> <ref>PMID:19015238</ref> <ref>PMID:19202061</ref>		[https://www.uniprot.org/uniprot/UIMC1_HUMAN UIMC1_HUMAN] Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.<ref>PMID:12080054</ref> <ref>PMID:17621610</ref> <ref>PMID:17643121</ref> <ref>PMID:17525340</ref> <ref>PMID:17525341</ref> <ref>PMID:17525342</ref> <ref>PMID:19261748</ref> <ref>PMID:19015238</ref> <ref>PMID:19202061</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Anamika]]		[[Category: Anamika]]
	[[Category: Markin~~, C J~~]]		[[Category: Markin CJ]]
	[[Category: Rout~~, M K~~]]		[[Category: Rout MK]]
	[[Category: Spyracopoulos, L]]		[[Category: Spyracopoulos L]]
	~~[[Category: Dna damage response]]~~
	~~[[Category: Signaling protein]]~~
	~~[[Category: Ubiquitin-interacting motif]]~~
	~~[[Category: Uim~~]]

OCA at 15:16, 2 June 2021

2021-06-02T15:16:13Z

← Older revision		Revision as of 15:16, 2 June 2021
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	==Solution structure of the E81 deletion mutant of the tandem UIMs of RAP80==		==Solution structure of the E81 deletion mutant of the tandem UIMs of RAP80==
	<StructureSection load='2mkf' size='340' side='right' caption='[[2mkf]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2mkf' size='340' side='right'caption='[[2mkf]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mkf]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2MKF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mkf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MKF FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3a1q\|3a1q]], [[2mkg\|2mkg]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3a1q\|3a1q]], [[2mkg\|2mkg]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UIMC1, RAP80, RXRIP110 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UIMC1, RAP80, RXRIP110 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2mkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkf OCA], [~~http~~://pdbe.org/2mkf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2mkf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2mkf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2mkf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkf OCA], [https://pdbe.org/2mkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mkf RCSB], [https://www.ebi.ac.uk/pdbsum/2mkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mkf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/UIMC1_HUMAN UIMC1_HUMAN]] Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.<ref>PMID:12080054</ref> <ref>PMID:17621610</ref> <ref>PMID:17643121</ref> <ref>PMID:17525340</ref> <ref>PMID:17525341</ref> <ref>PMID:17525342</ref> <ref>PMID:19261748</ref> <ref>PMID:19015238</ref> <ref>PMID:19202061</ref>		[[https://www.uniprot.org/uniprot/UIMC1_HUMAN UIMC1_HUMAN]] Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.<ref>PMID:12080054</ref> <ref>PMID:17621610</ref> <ref>PMID:17643121</ref> <ref>PMID:17525340</ref> <ref>PMID:17525341</ref> <ref>PMID:17525342</ref> <ref>PMID:19261748</ref> <ref>PMID:19015238</ref> <ref>PMID:19202061</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Anamika]]		[[Category: Anamika]]
	[[Category: Markin, C J]]		[[Category: Markin, C J]]

OCA at 23:13, 9 August 2018

2018-08-09T23:13:35Z

← Older revision		Revision as of 23:13, 9 August 2018
Line 1:		Line 1:

	==Solution structure of the E81 deletion mutant of the tandem UIMs of RAP80==		==Solution structure of the E81 deletion mutant of the tandem UIMs of RAP80==
	<StructureSection load='2mkf' size='340' side='right' caption='[[2mkf]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2mkf' size='340' side='right' caption='[[2mkf]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
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	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3a1q\|3a1q]], [[2mkg\|2mkg]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3a1q\|3a1q]], [[2mkg\|2mkg]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UIMC1, RAP80, RXRIP110 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UIMC1, RAP80, RXRIP110 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkf OCA], [http://pdbe.org/2mkf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mkf RCSB], [http://www.ebi.ac.uk/pdbsum/2mkf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkf OCA], [http://pdbe.org/2mkf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mkf RCSB], [http://www.ebi.ac.uk/pdbsum/2mkf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mkf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 05:05, 11 September 2015

2015-09-11T05:05:55Z

← Older revision		Revision as of 05:05, 11 September 2015
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	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3a1q\|3a1q]], [[2mkg\|2mkg]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3a1q\|3a1q]], [[2mkg\|2mkg]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UIMC1, RAP80, RXRIP110 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UIMC1, RAP80, RXRIP110 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mkf RCSB], [http://www.ebi.ac.uk/pdbsum/2mkf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkf OCA], [http://pdbe.org/2mkf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mkf RCSB], [http://www.ebi.ac.uk/pdbsum/2mkf PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2mkf" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:35, 25 December 2014

2014-12-25T11:35:17Z

← Older revision		Revision as of 11:35, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mkf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MKF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mkf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MKF FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3a1q\|3a1q]], [[2mkg\|2mkg]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3a1q\|3a1q]], [[2mkg\|2mkg]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UIMC1, RAP80, RXRIP110 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UIMC1, RAP80, RXRIP110 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mkf RCSB], [http://www.ebi.ac.uk/pdbsum/2mkf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mkf RCSB], [http://www.ebi.ac.uk/pdbsum/2mkf PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/UIMC1_HUMAN UIMC1_HUMAN]] Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.<ref>PMID:12080054</ref> <ref>PMID:17621610</ref> <ref>PMID:17643121</ref> <ref>PMID:17525340</ref> <ref>PMID:17525341</ref> <ref>PMID:17525342</ref> <ref>PMID:19261748</ref> <ref>PMID:19015238</ref> <ref>PMID:19202061</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	Molecular Basis for Impaired DNA Damage Response Function Associated with the RAP80 DeltaE81 Defect.,Anamika A, Markin CJ, Rout MK, Spyracopoulos L J Biol Chem. 2014 Mar 13. PMID:24627472<ref>PMID:24627472</ref>		Molecular Basis for Impaired DNA Damage Response Function Associated with the RAP80 DeltaE81 Defect.,Anamika A, Markin CJ, Rout MK, Spyracopoulos L J Biol Chem. 2014 Mar 13. PMID:24627472<ref>PMID:24627472</ref>

	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 21:		Line 23:
	[[Category: Human]]		[[Category: Human]]
	[[Category: Anamika]]		[[Category: Anamika]]
	[[Category: Markin, C J.]]		[[Category: Markin, C J]]
	[[Category: Rout, M K.]]		[[Category: Rout, M K]]
	[[Category: Spyracopoulos, L.]]		[[Category: Spyracopoulos, L]]
	[[Category: Dna damage response]]		[[Category: Dna damage response]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
	[[Category: Ubiquitin-interacting motif]]		[[Category: Ubiquitin-interacting motif]]
	[[Category: Uim]]		[[Category: Uim]]

OCA at 06:57, 21 May 2014

2014-05-21T06:57:53Z

← Older revision		Revision as of 06:57, 21 May 2014
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	~~{{STRUCTURE_2mkf\| PDB=2mkf \| SCENE= }}~~		==Solution structure of the E81 deletion mutant of the tandem UIMs of RAP80==
	===Solution structure of the E81 deletion mutant of the tandem UIMs of RAP80===		<StructureSection load='2mkf' size='340' side='right' caption='[[2mkf]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	~~{{ABSTRACT_PUBMED_24627472}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2mkf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MKF FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3a1q\|3a1q]], [[2mkg\|2mkg]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UIMC1, RAP80, RXRIP110 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mkf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mkf RCSB], [http://www.ebi.ac.uk/pdbsum/2mkf PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Signal transduction within the DNA damage response is driven by the flux of protein-protein interaction cascades that ultimately recruit repair complexes to sites of damage. The protein RAP80 plays a central role in the damage response by targeting BRCA1/BRCA2 tumor suppressors to DNA damage foci through multivalent binding of K63-linked polyubiquitin chains. Mutations within the high penetrance BRCA1/BRCA2 genes account for ~20% of familial breast cancers. The genetic basis for the remaining cancers remains unknown, but may involve defects in binding partners for BRCA1 and BRCA2 that lead to impaired targeting to foci and a concomittant role in the pathogenesis of cancer. Recently, an in-frame deletion mutation (DeltaE81) in a conserved region from the first ubiquitin interaction motif (UIM) of RAP80 has been linked to an increase in chromosomal abnormalities. Using NMR spectroscopy, we demonstrate that the N-cap motif within the Delta-helix of the first UIM from DeltaE81 undergoes a structural frameshift that leads to abolishment of multivalent binding of polyubiquitin chains. Loss of this single glutamate residue disrupts favorable electrostatic interactions between RAP80 and ubiquitin, establishing a plausible molecular basis for a potential predisposition to cancer unrelated to mutations within BRCA1/BRCA2 genes.

	==Function==		Molecular Basis for Impaired DNA Damage Response Function Associated with the RAP80 DeltaE81 Defect.,Anamika A, Markin CJ, Rout MK, Spyracopoulos L J Biol Chem. 2014 Mar 13. PMID:24627472<ref>PMID:24627472</ref>
	~~[[http://www~~.~~uniprot.org/uniprot/UIMC1_HUMAN UIMC1_HUMAN]] Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-~~A ~~complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites~~, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. ~~Does not bind Lys-48'-linked ubiquitin~~. ~~May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.<ref>PMID:12080054</ref> <ref>PMID:17621610</ref> <ref>~~PMID:~~17643121</ref> <ref>PMID:17525340</ref> <ref>PMID:17525341</ref> <ref>PMID:17525342</ref> <ref>PMID:19261748</ref> <ref>PMID:19015238</ref>~~ <ref>PMID:~~19202061~~</ref>

	~~==About this Structure==~~		From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
	~~[[2mkf]] is~~ a ~~1 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=2MKF OCA].~~		</div>
			== References ==
	==~~Reference~~==		<references/>
	~~<ref group="xtra">PMID:024627472</ref>~~<references ~~group="xtra"~~/><~~references~~/>		__TOC__
			</StructureSection>
			[[Category: Human]]
	[[Category: Anamika]]		[[Category: Anamika]]
	[[Category: Markin, C J.]]		[[Category: Markin, C J.]]

OCA at 07:32, 2 April 2014

2014-04-02T07:32:56Z

← Older revision		Revision as of 07:32, 2 April 2014
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	{{STRUCTURE_2mkf\| PDB=2mkf \| SCENE= }}		{{STRUCTURE_2mkf\| PDB=2mkf \| SCENE= }}
	===Solution structure of the E81 deletion mutant of the tandem UIMs of RAP80===		===Solution structure of the E81 deletion mutant of the tandem UIMs of RAP80===
			{{ABSTRACT_PUBMED_24627472}}

	==Function==		==Function==
Line 9:		Line 10:

	==Reference==		==Reference==
	<references group="xtra"/><references/>		<ref group="xtra">PMID:024627472</ref><references group="xtra"/><references/>
	[[Category: Anamika]]		[[Category: Anamika]]
	[[Category: Markin, C J.]]		[[Category: Markin, C J.]]

OCA at 09:23, 19 March 2014

2014-03-19T09:23:18Z

← Older revision		Revision as of 09:23, 19 March 2014
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	~~'''Unreleased~~ structure~~'''~~		{{STRUCTURE_2mkf\| PDB=2mkf \| SCENE= }}
			===Solution structure of the E81 deletion mutant of the tandem UIMs of RAP80===

	The ~~entry 2mkf~~ is ~~ON HOLD~~ ~~until Paper Publication~~		==Function==
			[[http://www.uniprot.org/uniprot/UIMC1_HUMAN UIMC1_HUMAN]] Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.<ref>PMID:12080054</ref> <ref>PMID:17621610</ref> <ref>PMID:17643121</ref> <ref>PMID:17525340</ref> <ref>PMID:17525341</ref> <ref>PMID:17525342</ref> <ref>PMID:19261748</ref> <ref>PMID:19015238</ref> <ref>PMID:19202061</ref>

	~~Authors~~: ~~Anamika, A., Markin, C.J~~.~~, Rout, M~~.K.~~, Spyracopoulos, L~~.		==About this Structure==
			[[2mkf]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MKF OCA].

	~~Description~~: ~~Solution structure of the E81 deletion mutant of the tandem UIMs of RAP80~~		==Reference==
			<references group="xtra"/><references/>
			[[Category: Anamika]]
			[[Category: Markin, C J.]]
			[[Category: Rout, M K.]]
			[[Category: Spyracopoulos, L.]]
			[[Category: Dna damage response]]
			[[Category: Signaling protein]]
			[[Category: Ubiquitin-interacting motif]]
			[[Category: Uim]]

OCA at 16:03, 3 March 2014

2014-03-03T16:03:29Z

← Older revision		Revision as of 16:03, 3 March 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 2mkf is ON HOLD		The entry 2mkf is ON HOLD until Paper Publication

	Authors: Anamika, A., Markin, C.J., Rout, M.K., Spyracopoulos, L.		Authors: Anamika, A., Markin, C.J., Rout, M.K., Spyracopoulos, L.

	Description: ~~Backbone chemical shifts for~~ the E81 deletion mutant ~~from RAP80~~ tandem UIMs		Description: Solution structure of the E81 deletion mutant of the tandem UIMs of RAP80