2mtc - Revision history

OCA at 01:12, 21 November 2024

2024-11-21T01:12:24Z

← Older revision		Revision as of 01:12, 21 November 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mtc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Borreliella_burgdorferi_N40 Borreliella burgdorferi N40]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MTC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MTC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mtc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Borreliella_burgdorferi_N40 Borreliella burgdorferi N40]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MTC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MTC FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mtc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mtc OCA], [https://pdbe.org/2mtc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mtc RCSB], [https://www.ebi.ac.uk/pdbsum/2mtc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mtc ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mtc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mtc OCA], [https://pdbe.org/2mtc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mtc RCSB], [https://www.ebi.ac.uk/pdbsum/2mtc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mtc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 08:06, 8 March 2023

2023-03-08T08:06:21Z

← Older revision		Revision as of 08:06, 8 March 2023
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	==Structure of decorin binding protein A from strain N40 of Borrelia burgdorferi==		==Structure of decorin binding protein A from strain N40 of Borrelia burgdorferi==
	<StructureSection load='2mtc' size='340' side='right'caption='[[2mtc~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>		<StructureSection load='2mtc' size='340' side='right'caption='[[2mtc]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mtc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Borbn Borbn~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MTC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MTC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mtc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Borreliella_burgdorferi_N40 Borreliella burgdorferi N40]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MTC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MTC FirstGlance]. <br>
	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2mtd\|2mtd]]</div></td></tr>~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mtc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mtc OCA], [https://pdbe.org/2mtc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mtc RCSB], [https://www.ebi.ac.uk/pdbsum/2mtc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mtc ProSAT]</span></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BbuN40_A24, dbp ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=521007 BORBN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mtc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mtc OCA], [https://pdbe.org/2mtc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mtc RCSB], [https://www.ebi.ac.uk/pdbsum/2mtc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mtc ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/A0A0J9X1X0_BORBN A0A0J9X1X0_BORBN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Borbn~~]]		[[Category: Borreliella burgdorferi N40]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Morgan, A]]		[[Category: Morgan A]]
	[[Category: Wang, X]]		[[Category: Wang X]]
	~~[[Category: Adhesin]]~~
	~~[[Category: Glycosaminoglycan-binding protein]]~~
	~~[[Category: Lipoprotein]]~~
	~~[[Category: Protein binding~~]]

OCA at 15:20, 2 June 2021

2021-06-02T15:20:40Z

← Older revision		Revision as of 15:20, 2 June 2021
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	==Structure of decorin binding protein A from strain N40 of Borrelia burgdorferi==		==Structure of decorin binding protein A from strain N40 of Borrelia burgdorferi==
	<StructureSection load='2mtc' size='340' side='right' caption='[[2mtc]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2mtc' size='340' side='right'caption='[[2mtc]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mtc]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Borbn Borbn]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MTC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2MTC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mtc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Borbn Borbn]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MTC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MTC FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mtd\|2mtd]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2mtd\|2mtd]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BbuN40_A24, dbp ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=521007 BORBN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BbuN40_A24, dbp ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=521007 BORBN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2mtc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mtc OCA], [~~http~~://pdbe.org/2mtc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2mtc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2mtc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2mtc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mtc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mtc OCA], [https://pdbe.org/2mtc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mtc RCSB], [https://www.ebi.ac.uk/pdbsum/2mtc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mtc ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Borbn]]		[[Category: Borbn]]
			[[Category: Large Structures]]
	[[Category: Morgan, A]]		[[Category: Morgan, A]]
	[[Category: Wang, X]]		[[Category: Wang, X]]

OCA at 13:13, 7 November 2018

2018-11-07T13:13:20Z

← Older revision		Revision as of 13:13, 7 November 2018
Line 3:		Line 3:
	<StructureSection load='2mtc' size='340' side='right' caption='[[2mtc]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2mtc' size='340' side='right' caption='[[2mtc]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mtc]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MTC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MTC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mtc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Borbn Borbn]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MTC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MTC FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mtd\|2mtd]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mtd\|2mtd]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BbuN40_A24, dbp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=521007 BORBN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mtc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mtc OCA], [http://pdbe.org/2mtc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mtc RCSB], [http://www.ebi.ac.uk/pdbsum/2mtc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mtc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mtc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mtc OCA], [http://pdbe.org/2mtc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mtc RCSB], [http://www.ebi.ac.uk/pdbsum/2mtc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mtc ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Borbn]]
	[[Category: Morgan, A]]		[[Category: Morgan, A]]
	[[Category: Wang, X]]		[[Category: Wang, X]]

OCA at 18:36, 1 February 2017

2017-02-01T18:36:28Z

← Older revision		Revision as of 18:36, 1 February 2017
Line 1:		Line 1:

	==Structure of decorin binding protein A from strain N40 of Borrelia burgdorferi==		==Structure of decorin binding protein A from strain N40 of Borrelia burgdorferi==
	<StructureSection load='2mtc' size='340' side='right' caption='[[2mtc]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2mtc' size='340' side='right' caption='[[2mtc]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
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	<table><tr><td colspan='2'>[[2mtc]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MTC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MTC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mtc]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MTC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MTC FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mtd\|2mtd]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mtd\|2mtd]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mtc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mtc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mtc RCSB], [http://www.ebi.ac.uk/pdbsum/2mtc PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mtc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mtc OCA], [http://pdbe.org/2mtc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mtc RCSB], [http://www.ebi.ac.uk/pdbsum/2mtc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mtc ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2mtc" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:56, 26 March 2015

2015-03-26T13:56:01Z

← Older revision		Revision as of 13:56, 26 March 2015
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	'''~~Unreleased~~ structure'''		==Structure of decorin binding protein A from strain N40 of Borrelia burgdorferi==
			<StructureSection load='2mtc' size='340' side='right' caption='[[2mtc]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2mtc]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MTC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MTC FirstGlance]. <br>
			</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2mtd\|2mtd]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mtc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mtc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mtc RCSB], [http://www.ebi.ac.uk/pdbsum/2mtc PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Decorin binding protein A (DBPA) is an important surface adhesin of the bacterium Borrelia burgdorferi, the causative agent of Lyme disease. DBPA facilitates the bacteria's colonization of human tissue by adhering to glycosaminoglycan (GAG), a sulfated polysaccharide. Interestingly, DBPA sequence variation among different strains of Borrelia spirochetes is high, resulting in significant differences in their GAG affinities. However, the structural mechanisms contributing to these differences are unknown. We determined the solution structures of DBPAs from strain N40 of Borrelia burgdorferi and strain PBr of Borrelia gariini, two DBPA variants whose GAG affinities deviate significantly from strain B31, the most well studied version of DBPA. Our structures revealed that significant differences exist between PBr DBPA and B31/N40 DBPAs. In particular, the C-terminus of PBr DBPA, unlike C-termini from B31 and N40 DBPAs, is positioned away from the GAG-binding pocket, and the linker between helices one and two of PBr DBPA is highly structured and retracted from the GAG-binding pocket. The repositioning of the C-terminus allowed the formation of an extra GAG-binding epitope in PBr DBPA, and the retracted linker give GAG ligands more access to the GAG-binding epitopes than other DBPAs. Characterization of GAG ligands' interactions with wild type PBr and mutants confirmed the importance of the second major GAG-binding epitope and established the fact that the two epitopes are independent of one another and the new epitope is as important to GAG binding as the traditional epitope.

	~~The entry 2mtc is ON HOLD until Paper Publication~~		Structural Mechanisms Underlying Sequence-Dependent Variations in GAG Affinities of Decorin Binding Protein A, a Borrelia burgdorferi Adhesin.,Morgan AM, Wang X Biochem J. 2015 Feb 19. PMID:25695518<ref>PMID:25695518</ref>

	~~Authors: Wang~~, X.~~, Morgan, A~~.		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~Description: Structure of decorin binding protein A from strain N40 of Borrelia burgdorferi~~		== References ==
	~~[[Category: Unreleased Structures]]~~		<references/>
			__TOC__
			</StructureSection>
	[[Category: Morgan, A]]		[[Category: Morgan, A]]
	[[Category: Wang, X]]		[[Category: Wang, X]]
			[[Category: Adhesin]]
			[[Category: Glycosaminoglycan-binding protein]]
			[[Category: Lipoprotein]]
			[[Category: Protein binding]]

OCA at 12:22, 24 December 2014

2014-12-24T12:22:57Z

← Older revision		Revision as of 12:22, 24 December 2014
Line 6:		Line 6:

	Description: Structure of decorin binding protein A from strain N40 of Borrelia burgdorferi		Description: Structure of decorin binding protein A from strain N40 of Borrelia burgdorferi
			[[Category: Unreleased Structures]]
			[[Category: Morgan, A]]
			[[Category: Wang, X]]

OCA at 07:27, 24 September 2014

2014-09-24T07:27:59Z

← Older revision		Revision as of 07:27, 24 September 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 2mtc is ON HOLD		The entry 2mtc is ON HOLD until Paper Publication

	Authors: Wang, X., Morgan, A.		Authors: Wang, X., Morgan, A.

	Description: Structure of decorin binding protein A from strain N40 of Borrelia burgdorferi		Description: Structure of decorin binding protein A from strain N40 of Borrelia burgdorferi

OCA: Protected "2mtc" [edit=sysop:move=sysop]

2014-08-27T06:06:11Z

Protected "2mtc" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:06, 27 August 2014
(No difference)

OCA: New page: '''Unreleased structure''' The entry 2mtc is ON HOLD Authors: Wang, X., Morgan, A. Description: Structure of decorin binding protein A from strain N40 of Borrelia burgdorferi

2014-08-27T06:06:09Z

New page: '''Unreleased structure''' The entry 2mtc is ON HOLD Authors: Wang, X., Morgan, A. Description: Structure of decorin binding protein A from strain N40 of Borrelia burgdorferi

New page

'''Unreleased structure'''

The entry 2mtc is ON HOLD

Authors: Wang, X., Morgan, A.

Description: Structure of decorin binding protein A from strain N40 of Borrelia burgdorferi