2mud - Revision history

OCA at 08:19, 30 October 2024

2024-10-30T08:19:48Z

← Older revision		Revision as of 08:19, 30 October 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mud]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MUD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mud]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MUD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 29 models</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mud OCA], [https://pdbe.org/2mud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mud RCSB], [https://www.ebi.ac.uk/pdbsum/2mud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mud ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mud OCA], [https://pdbe.org/2mud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mud RCSB], [https://www.ebi.ac.uk/pdbsum/2mud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mud ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:06, 8 March 2023

2023-03-08T08:06:56Z

← Older revision		Revision as of 08:06, 8 March 2023
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	==Structural modifications to a high-activity binding peptide located whitin the PfEMP1 NTS domain induce protection against P. falciparum malaria in Aotus monkeys==		==Structural modifications to a high-activity binding peptide located whitin the PfEMP1 NTS domain induce protection against P. falciparum malaria in Aotus monkeys==
	<StructureSection load='2mud' size='340' side='right'caption='[[2mud~~]], [[NMR_Ensembles_of_Models \| 29 NMR models~~]]' scene=''>		<StructureSection load='2mud' size='340' side='right'caption='[[2mud]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mud]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MUD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mud]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MUD FirstGlance]. <br>
	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mud OCA], [https://pdbe.org/2mud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mud RCSB], [https://www.ebi.ac.uk/pdbsum/2mud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mud ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mud OCA], [https://pdbe.org/2mud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mud RCSB], [https://www.ebi.ac.uk/pdbsum/2mud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mud ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/Q26031_PLAFA Q26031_PLAFA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Alba, M]]		[[Category: Plasmodium falciparum]]
	[[Category: Curtidor, H]]		[[Category: Alba M]]
	[[Category: Patarroyo, M]]		[[Category: Curtidor H]]
	[[Category: Torres, M]]		[[Category: Patarroyo M]]
	~~[[Category: Membrane protein]]~~		[[Category: Torres M]]
	~~[[Category: Pfemp-1~~]]

OCA at 15:21, 2 June 2021

2021-06-02T15:21:09Z

← Older revision		Revision as of 15:21, 2 June 2021
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	<StructureSection load='2mud' size='340' side='right'caption='[[2mud]], [[NMR_Ensembles_of_Models \| 29 NMR models]]' scene=''>		<StructureSection load='2mud' size='340' side='right'caption='[[2mud]], [[NMR_Ensembles_of_Models \| 29 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mud]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MUD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2MUD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mud]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MUD FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2mud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mud OCA], [~~http~~://pdbe.org/2mud PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2mud RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2mud PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2mud ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mud OCA], [https://pdbe.org/2mud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mud RCSB], [https://www.ebi.ac.uk/pdbsum/2mud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mud ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:23, 21 August 2019

2019-08-21T07:23:14Z

← Older revision		Revision as of 07:23, 21 August 2019
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	==Structural modifications to a high-activity binding peptide located whitin the PfEMP1 NTS domain induce protection against P. falciparum malaria in Aotus monkeys==		==Structural modifications to a high-activity binding peptide located whitin the PfEMP1 NTS domain induce protection against P. falciparum malaria in Aotus monkeys==
	<StructureSection load='2mud' size='340' side='right' caption='[[2mud]], [[NMR_Ensembles_of_Models \| 29 NMR models]]' scene=''>		<StructureSection load='2mud' size='340' side='right'caption='[[2mud]], [[NMR_Ensembles_of_Models \| 29 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2mud]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MUD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2mud]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MUD FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Alba, M]]		[[Category: Alba, M]]
	[[Category: Curtidor, H]]		[[Category: Curtidor, H]]

OCA at 15:02, 16 November 2017

2017-11-16T15:02:51Z

← Older revision		Revision as of 15:02, 16 November 2017
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	~~'''Unreleased structure'''~~

	~~The entry~~ 2mud is ~~ON HOLD~~		==Structural modifications to a high-activity binding peptide located whitin the PfEMP1 NTS domain induce protection against P. falciparum malaria in Aotus monkeys==
			<StructureSection load='2mud' size='340' side='right' caption='[[2mud]], [[NMR_Ensembles_of_Models \| 29 NMR models]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2mud]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MUD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MUD FirstGlance]. <br>
			</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mud OCA], [http://pdbe.org/2mud PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mud RCSB], [http://www.ebi.ac.uk/pdbsum/2mud PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mud ProSAT]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Binding of P. falciparum-infected erythrocytes to vascular endothelium and to uninfected erythrocytes is mediated by the parasite-derived variant erythrocyte membrane protein PfEMP-1 and various receptors, both on the vascular endothelium and on the erythrocyte surface. Consecutive, non-overlapping peptides spanning the N-terminal segment (NTS) and Duffy-binding-like PfEMP1 sequence alpha-domain (DBLalpha) of this protein were tested in erythrocyte and C32 cell binding assays. Eight peptides specifically bound to C32 cells, and were named high-activity binding peptides (HABPs). No erythrocyte binding HABPs were found in this region. Strikingly, three HABPs [6504 ((1)MVELA KMGPK EAAGG DDIED(20)), 6505 ((21)ESAKH MFDRI GKDVY DKVKE(40)) and 6506 ((41)YRAKE RGKGL QGRLS EAKFEK(60))] are located within the NTS, for which no specific function has yet been described. HABP 6505 is neither immunogenic nor protection-inducing; therefore, based on our previous reports, critical amino acids (shown in bold) in HABP-C32 cell binding were identified and replaced to modify HABP immunogenicity and protectivity. Analogue peptide 12722 (ESAKH KFDRI GKDVY DMVKE) produced high antibody titres and completely protected three out of 12 vaccinated Aotus monkeys and 23410 (KHKFD FIGKI VYDMV KER) also produced high protection-inducing titres and completely protected one out of eight monkeys. (1)H NMR studies showed that all peptides were helical. Binding of these peptides to isolated HLADRbeta1 molecules did not reveal any preference, suggesting that they could bind to molecules not studied here.

	~~Authors:~~ Curtidor, H., Torres~~, M.~~, Alba, M.~~, Patarroyo, M~~.		Structural modifications to a high-activity binding peptide located within the PfEMP1 NTS domain induce protection against P. falciparum malaria in Aotus monkeys.,Curtidor H, Torres MH, Alba MP, Patarroyo ME Biol Chem. 2007 Jan;388(1):25-36. PMID:17214546<ref>PMID:17214546</ref>

	~~Description: Structural modifications to~~ a ~~high-activity binding peptide located whitin~~ the ~~PfEMP1 NTS domain induce protection against P~~. ~~falciparum malaria in Aotus monkeys~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	[[Category: ~~Unreleased Structures~~]]		</div>
			<div class="pdbe-citations 2mud" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Alba, M]]
			[[Category: Curtidor, H]]
	[[Category: Patarroyo, M]]		[[Category: Patarroyo, M]]
	~~[[Category: Alba, M]]~~
	[[Category: Torres, M]]		[[Category: Torres, M]]
	[[Category: ~~Curtidor, H~~]]		[[Category: Membrane protein]]
			[[Category: Pfemp-1]]

OCA at 13:58, 5 August 2015

2015-08-05T13:58:04Z

← Older revision		Revision as of 13:58, 5 August 2015
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	Description: Structural modifications to a high-activity binding peptide located whitin the PfEMP1 NTS domain induce protection against P. falciparum malaria in Aotus monkeys		Description: Structural modifications to a high-activity binding peptide located whitin the PfEMP1 NTS domain induce protection against P. falciparum malaria in Aotus monkeys
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
			[[Category: Patarroyo, M]]
	[[Category: Alba, M]]		[[Category: Alba, M]]
	~~[[Category: Patarroyo, M]]~~
	[[Category: Torres, M]]		[[Category: Torres, M]]
	[[Category: Curtidor, H]]		[[Category: Curtidor, H]]

OCA at 12:25, 24 December 2014

2014-12-24T12:25:45Z

← Older revision		Revision as of 12:25, 24 December 2014
Line 6:		Line 6:

	Description: Structural modifications to a high-activity binding peptide located whitin the PfEMP1 NTS domain induce protection against P. falciparum malaria in Aotus monkeys		Description: Structural modifications to a high-activity binding peptide located whitin the PfEMP1 NTS domain induce protection against P. falciparum malaria in Aotus monkeys
			[[Category: Unreleased Structures]]
			[[Category: Alba, M]]
			[[Category: Patarroyo, M]]
			[[Category: Torres, M]]
			[[Category: Curtidor, H]]

OCA: Protected "2mud" [edit=sysop:move=sysop]

2014-09-24T07:28:56Z

Protected "2mud" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:28, 24 September 2014
(No difference)

OCA: New page: '''Unreleased structure''' The entry 2mud is ON HOLD Authors: Curtidor, H., Torres, M., Alba, M., Patarroyo, M. Description: Structural modifications to a high-activity binding peptide...

2014-09-24T07:28:54Z

New page: '''Unreleased structure''' The entry 2mud is ON HOLD Authors: Curtidor, H., Torres, M., Alba, M., Patarroyo, M. Description: Structural modifications to a high-activity binding peptide...

New page

'''Unreleased structure'''

The entry 2mud is ON HOLD

Authors: Curtidor, H., Torres, M., Alba, M., Patarroyo, M.

Description: Structural modifications to a high-activity binding peptide located whitin the PfEMP1 NTS domain induce protection against P. falciparum malaria in Aotus monkeys