2n2f - Revision history

OCA at 06:13, 15 May 2024

2024-05-15T06:13:46Z

← Older revision		Revision as of 06:13, 15 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2n2f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N2F FirstGlance]. <br>		<table><tr><td colspan='2'>[[2n2f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N2F FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n2f OCA], [https://pdbe.org/2n2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n2f RCSB], [https://www.ebi.ac.uk/pdbsum/2n2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n2f ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n2f OCA], [https://pdbe.org/2n2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n2f RCSB], [https://www.ebi.ac.uk/pdbsum/2n2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n2f ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 09:53, 14 June 2023

2023-06-14T09:53:29Z

← Older revision		Revision as of 09:53, 14 June 2023
Line 1:		Line 1:

	==Solution NMR structure of Dynorphin 1-13 bound to Kappa Opioid Receptor==		==Solution NMR structure of Dynorphin 1-13 bound to Kappa Opioid Receptor==
	<StructureSection load='2n2f' size='340' side='right'caption='[[2n2f~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>		<StructureSection load='2n2f' size='340' side='right'caption='[[2n2f]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2n2f]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N2F FirstGlance]. <br>		<table><tr><td colspan='2'>[[2n2f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N2F FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n2f OCA], [https://pdbe.org/2n2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n2f RCSB], [https://www.ebi.ac.uk/pdbsum/2n2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n2f ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n2f OCA], [https://pdbe.org/2n2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n2f RCSB], [https://www.ebi.ac.uk/pdbsum/2n2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n2f ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[https://www.uniprot.org/uniprot/PDYN_HUMAN PDYN_HUMAN]] Spinocerebellar ataxia type 23. The disease is caused by mutations affecting the gene represented in this entry.		[https://www.uniprot.org/uniprot/PDYN_HUMAN PDYN_HUMAN] Spinocerebellar ataxia type 23. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/PDYN_HUMAN PDYN_HUMAN]] Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity). Leumorphin has a typical opiod activity and may have anti-apoptotic effect.		[https://www.uniprot.org/uniprot/PDYN_HUMAN PDYN_HUMAN] Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity). Leumorphin has a typical opiod activity and may have anti-apoptotic effect.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Connor, C O]]~~		[[Category: Czaplicki G]]
	[[Category: Czaplicki, G]]		[[Category: Didenko T]]
	[[Category: Didenko, T]]		[[Category: Doncescu N]]
	[[Category: Doncescu, N]]		[[Category: Milon A]]
	[[Category: Milon, A]]		[[Category: O'Connor C]]
	[[Category: ~~Roth, B L~~]]		[[Category: Roth BL]]
	[[Category: ~~Stevens, R C~~]]		[[Category: Stevens RC]]
	[[Category: ~~White, K~~]]		[[Category: White K]]
	[[Category: ~~Wuthrich,~~ K]]		[[Category: Wuthrich K]]
	[[Category: ~~Gpcr]]~~
	~~[[Category: Hormone receptor~~]]

OCA at 09:04, 23 February 2022

2022-02-23T09:04:30Z

← Older revision		Revision as of 09:04, 23 February 2022
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	<StructureSection load='2n2f' size='340' side='right'caption='[[2n2f]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2n2f' size='340' side='right'caption='[[2n2f]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2n2f]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N2F OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2N2F FirstGlance]. <br>		<table><tr><td colspan='2'>[[2n2f]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N2F FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2n2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n2f OCA], [~~http~~://pdbe.org/2n2f PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2n2f RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2n2f PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2n2f ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n2f OCA], [https://pdbe.org/2n2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n2f RCSB], [https://www.ebi.ac.uk/pdbsum/2n2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n2f ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[~~http~~://www.uniprot.org/uniprot/PDYN_HUMAN PDYN_HUMAN]] Spinocerebellar ataxia type 23. The disease is caused by mutations affecting the gene represented in this entry.		[[https://www.uniprot.org/uniprot/PDYN_HUMAN PDYN_HUMAN]] Spinocerebellar ataxia type 23. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/PDYN_HUMAN PDYN_HUMAN]] Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity). Leumorphin has a typical opiod activity and may have anti-apoptotic effect.		[[https://www.uniprot.org/uniprot/PDYN_HUMAN PDYN_HUMAN]] Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity). Leumorphin has a typical opiod activity and may have anti-apoptotic effect.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 06:30, 20 May 2020

2020-05-20T06:30:12Z

← Older revision		Revision as of 06:30, 20 May 2020
Line 1:		Line 1:

	==Solution NMR structure of Dynorphin 1-13 bound to Kappa Opioid Receptor==		==Solution NMR structure of Dynorphin 1-13 bound to Kappa Opioid Receptor==
	<StructureSection load='2n2f' size='340' side='right' caption='[[2n2f]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2n2f' size='340' side='right'caption='[[2n2f]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2n2f]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N2F OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2N2F FirstGlance]. <br>		<table><tr><td colspan='2'>[[2n2f]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N2F OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2N2F FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca.weizmann~~.~~ac.il/oca-docs~~/fgij/fg.htm?mol=2n2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n2f OCA], [http://pdbe.org/2n2f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n2f RCSB], [http://www.ebi.ac.uk/pdbsum/2n2f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2n2f ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2n2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n2f OCA], [http://pdbe.org/2n2f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n2f RCSB], [http://www.ebi.ac.uk/pdbsum/2n2f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2n2f ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Connor, C O]]		[[Category: Connor, C O]]
	[[Category: Czaplicki, G]]		[[Category: Czaplicki, G]]

OCA at 17:24, 15 August 2018

2018-08-15T17:24:37Z

← Older revision		Revision as of 17:24, 15 August 2018
Line 1:		Line 1:

	==Solution NMR structure of Dynorphin 1-13 bound to Kappa Opioid Receptor==		==Solution NMR structure of Dynorphin 1-13 bound to Kappa Opioid Receptor==
	<StructureSection load='2n2f' size='340' side='right' caption='[[2n2f]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2n2f' size='340' side='right' caption='[[2n2f]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2n2f]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N2F FirstGlance]. <br>		<table><tr><td colspan='2'>[[2n2f]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N2F FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n2f OCA], [http://pdbe.org/2n2f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n2f RCSB], [http://www.ebi.ac.uk/pdbsum/2n2f PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n2f OCA], [http://pdbe.org/2n2f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n2f RCSB], [http://www.ebi.ac.uk/pdbsum/2n2f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2n2f ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 21:34, 15 October 2015

2015-10-15T21:34:58Z

← Older revision		Revision as of 21:34, 15 October 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2n2f]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N2F FirstGlance]. <br>		<table><tr><td colspan='2'>[[2n2f]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N2F FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n2f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2n2f RCSB], [http://www.ebi.ac.uk/pdbsum/2n2f PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n2f OCA], [http://pdbe.org/2n2f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n2f RCSB], [http://www.ebi.ac.uk/pdbsum/2n2f PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 9:		Line 9:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PDYN_HUMAN PDYN_HUMAN]] Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity). Leumorphin has a typical opiod activity and may have anti-apoptotic effect.		[[http://www.uniprot.org/uniprot/PDYN_HUMAN PDYN_HUMAN]] Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity). Leumorphin has a typical opiod activity and may have anti-apoptotic effect.
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The structure of the dynorphin (1-13) peptide (dynorphin) bound to the human kappa opioid receptor (KOR) has been determined by liquid-state NMR spectroscopy. (1)H and (15)N chemical shift variations indicated that free and bound peptide is in fast exchange in solutions containing 1 mM dynorphin and 0.01 mM KOR. Radioligand binding indicated an intermediate-affinity interaction, with a Kd of approximately 200 nM. Transferred nuclear Overhauser enhancement spectroscopy was used to determine the structure of bound dynorphin. The N-terminal opioid signature, YGGF, was observed to be flexibly disordered, the central part of the peptide from L5 to R9 to form a helical turn, and the C-terminal segment from P10 to K13 to be flexibly disordered in this intermediate-affinity bound state. Combining molecular modeling with NMR provided an initial framework for understanding multistep activation of a G protein-coupled receptor by its cognate peptide ligand.

			NMR structure and dynamics of the agonist dynorphin peptide bound to the human kappa opioid receptor.,O'Connor C, White KL, Doncescu N, Didenko T, Roth BL, Czaplicki G, Stevens RC, Wuthrich K, Milon A Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):11852-7. doi:, 10.1073/pnas.1510117112. Epub 2015 Sep 8. PMID:26372966<ref>PMID:26372966</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 2n2f" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 11:16, 9 September 2015

2015-09-09T11:16:59Z

← Older revision		Revision as of 11:16, 9 September 2015
Line 1:		Line 1:
	'''~~Unreleased structure~~'''		==Solution NMR structure of Dynorphin 1-13 bound to Kappa Opioid Receptor==
			<StructureSection load='2n2f' size='340' side='right' caption='[[2n2f]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	~~The entry~~ 2n2f is ~~ON HOLD until Paper Publication~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2n2f]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N2F FirstGlance]. <br>
	~~Authors~~: O'~~Connor~~, C., ~~White, K~~.~~, Doncescu, N~~.~~, Didenko, T~~., ~~Roth, B~~.L.~~, Czaplicki, G~~.~~, Stevens, R~~.C.~~, Wuthrich, K~~.~~, Milon, A~~.		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n2f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2n2f RCSB], [http://www.ebi.ac.uk/pdbsum/2n2f PDBsum]</span></td></tr>
			</table>
	~~Description~~: ~~Solution NMR structure~~ of Dynorphin 1-13 ~~bound to Kappa Opioid Receptor~~		== Disease ==
	[[Category: ~~Unreleased Structures~~]]		[[http://www.uniprot.org/uniprot/PDYN_HUMAN PDYN_HUMAN]] Spinocerebellar ataxia type 23. The disease is caused by mutations affecting the gene represented in this entry.
			== Function ==
			[[http://www.uniprot.org/uniprot/PDYN_HUMAN PDYN_HUMAN]] Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity). Leumorphin has a typical opiod activity and may have anti-apoptotic effect.
			__TOC__
			</StructureSection>
			[[Category: Connor, C O]]
			[[Category: Czaplicki, G]]
			[[Category: Didenko, T]]
	[[Category: Doncescu, N]]		[[Category: Doncescu, N]]
	[[Category: Milon, A]]		[[Category: Milon, A]]
	[[Category: ~~Czaplicki~~, G]]		[[Category: Roth, B L]]
			[[Category: Stevens, R C]]
			[[Category: White, K]]
	[[Category: Wuthrich, K]]		[[Category: Wuthrich, K]]
	[[Category: ~~Roth, B.L~~]]		[[Category: Gpcr]]
	[[Category: ~~Stevens, R.C]]~~		[[Category: Hormone receptor]]
	~~[[Category: White, K]]~~
	~~[[Category: Didenko, T]]~~
	~~[[Category: O'Connor, C~~]]

OCA at 09:04, 12 August 2015

2015-08-12T09:04:04Z

← Older revision		Revision as of 09:04, 12 August 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 2n2f is ON HOLD		The entry 2n2f is ON HOLD until Paper Publication

	Authors: O'Connor, C., White, K., Doncescu, N., Didenko, T., Roth, B.L., Czaplicki, G., Stevens, R.C., Wuthrich, K., Milon, A.		Authors: O'Connor, C., White, K., Doncescu, N., Didenko, T., Roth, B.L., Czaplicki, G., Stevens, R.C., Wuthrich, K., Milon, A.

OCA at 09:23, 17 June 2015

2015-06-17T09:23:53Z

← Older revision		Revision as of 09:23, 17 June 2015
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	The entry 2n2f is ON HOLD		The entry 2n2f is ON HOLD

	Authors: White, K., Doncescu, N., Didenko, T., Roth, B.L., Czaplicki, G., Stevens, R.C., Wuthrich, K., Milon, A.		Authors: O'Connor, C., White, K., Doncescu, N., Didenko, T., Roth, B.L., Czaplicki, G., Stevens, R.C., Wuthrich, K., Milon, A.

	Description: Solution NMR structure of Dynorphin 1-13 bound to Kappa Opioid Receptor		Description: Solution NMR structure of Dynorphin 1-13 bound to Kappa Opioid Receptor
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	[[Category: White, K]]		[[Category: White, K]]
	[[Category: Didenko, T]]		[[Category: Didenko, T]]
			[[Category: O'Connor, C]]

OCA: Protected "2n2f" [edit=sysop:move=sysop]

2015-05-13T06:50:10Z

Protected "2n2f" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:50, 13 May 2015
(No difference)